Darrell N. Kotton Center for Regenerative Medicine Boston University and Boston Medical Center Biography Publications Institution JoVE Articles Darrell N. Kotton has not added a biography. If you are Darrell N. Kotton and would like to personalize this page please email our Author Liaison for assistance. Publications Human Distal Airways Contain a Multipotent Secretory Cell That Can Regenerate Alveoli Nature. Apr, 2022 | Pubmed ID: 35355013 Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration Frontiers in Endocrinology. 2022 | Pubmed ID: 35211095 Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease Cell Reports. Aug, 2021 | Pubmed ID: 34469722 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34413211 Differentiation of Human Pluripotent Stem Cells into Functional Airway Basal Stem Cells STAR Protocols. 09, 2021 | Pubmed ID: 34355203 Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine Frontiers in Endocrinology. 2021 | Pubmed ID: 33959101 Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell. 01, 2021 | Pubmed ID: 33098807 Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration Annual Review of Physiology. 02, 2021 | Pubmed ID: 33074772 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell. 12, 2020 | Pubmed ID: 32979316 Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell. 10, 2020 | Pubmed ID: 32891189 The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors Nature Communications. 01, 2020 | Pubmed ID: 32005814 Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors Cell Stem Cell. 04, 2020 | Pubmed ID: 32004478 Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells Nature Protocols. 12, 2019 | Pubmed ID: 31732721 Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering Stem Cell Reports. 09, 2019 | Pubmed ID: 31422908 Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity Journal of Immunology (Baltimore, Md. : 1950). 04, 2019 | Pubmed ID: 30796179 Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium Stem Cell Reports. 05, 2018 | Pubmed ID: 29657097 Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation The Journal of Clinical Investigation. 03, 2018 | Pubmed ID: 29400691 Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells Cell Stem Cell. 10, 2017 | Pubmed ID: 28965766 Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification Development (Cambridge, England). 11, 2017 | Pubmed ID: 28947536 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463226 Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling Cell Stem Cell. 06, 2017 | Pubmed ID: 28366587 Regenerative Therapy for Hypothyroidism: Mechanisms and Possibilities Molecular and Cellular Endocrinology. 04, 2017 | Pubmed ID: 27876515 Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells Cell Stem Cell. Nov, 2015 | Pubmed ID: 26593959 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Embryonic and Induced Pluripotent Stem Cells for Lung Regeneration Annals of the American Thoracic Society. Mar, 2015 | Pubmed ID: 25830836 Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells Stem Cell Reports. Apr, 2015 | Pubmed ID: 25772471 Derivation of Endodermal Progenitors From Pluripotent Stem Cells Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25160562 Lung Regeneration: Mechanisms, Applications and Emerging Stem Cell Populations Nature Medicine. Aug, 2014 | Pubmed ID: 25100528 KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development Cell Stem Cell. Jun, 2013 | Pubmed ID: 23746980 The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation Blood. Jul, 2013 | Pubmed ID: 23723449 Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23403494 Induzierte Pluripotente Stammzellen Verwendet, Droge-Aktionen in Der Familie Ein Long QT-Syndrom Mit Komplexen Genetik Zu Offenbaren The Journal of General Physiology. Jan, 2013 | Pubmed ID: 23277474 Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors Bio-protocol. Nov, 2012 | Pubmed ID: 27453901 The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers American Journal of Respiratory and Critical Care Medicine. Dec, 2012 | Pubmed ID: 23204376 Die Transkription Faktoren Grainyhead-wie 2 Und NK2-Homeobox 1 Bilden Eine Regulatorische Schleife, Die Lunge Epithelzellen Morphogenese Und Differenzierung Koordiniert The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955271 Modellierung Supravalvuläre Aortenstenose Syndrom Mit Menschlichen Induzierten Pluripotenten Stammzellen Circulation. Oct, 2012 | Pubmed ID: 22914687 Regenerierung Der Nächsten Generation: Die Hoffnung Und Den Hype Der Lunge Stammzellenforschung American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22517787 Effiziente Ableitung Der Gereinigten Lunge Und Schilddrüse Vorläuferzellen Aus Embryonalen Stammzellen Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482505 Erneuernde Endodermalen Vorläuferzellen Linien Aus Menschlichen Pluripotenten Stammzellen Erzeugt Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Instandhaltung Und Reparatur Der Lunge Endothels Darf Nicht Mit Beiträgen Von Knochenmark Abgeleitete Endothelialen Vorläuferzellen American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22323363 Anfragedatensätze Des Massachusetts General Hospital. Fall 2-2012. Eine 63 Jahre Alte Frau Mit Dyspnoe Und Schnell Fortschreitenden Ateminsuffizienz The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22256809 Sind Embryonale Stammzellen Und Induzierten Pluripotenten Stammzellen, Die Dieselben Oder Unterschiedliche? Auswirkungen Auf Ihre Möglichen Therapeutischen Einsatz Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22186787 Die Rolle Der Nanog in Der Pflege Von Knochenmark Stromal Stammzellen Während Post Natal Knochenregeneration Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142851 Biophysikalische Eigenschaften Des Langsamen Kaliumkanäle in Den Menschlichen Embryonalen Stammzellen Abgeleitet Cardiomyocytes Implizieren Untereinheit Stöchiometrie The Journal of Physiology. Dec, 2011 | Pubmed ID: 22025662 Programmgesteuerte Änderung: Lunge-Krankheit-Forschung in Der Ära Der Induzierten Pluripotenz American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 Eine Verschiebung Von Zellkulturen Zu Kreaturen: In-vivo Imaging Bei Kleintieren in Experimentelle Regenerative Medizin Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21952170 Handy-Plastizität in Respiratory Distress Syndrome Und Reparatur: Bericht Aus Einem Workshop Ein NHLBI, April 15, 2010 Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653526 Maus ES Und IPS-Zellen Können ähnliche Endgültige Endodermis Trotz Unterschiedlicher Eingeprägten Gene Bilden The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 FOXO1 Moduliert Osteoblasten Differenzierung Bone. May, 2011 | Pubmed ID: 21281751 Generation Von Transgen-freie Lunge Krankheitsspezifische Menschlichen Induzierten Pluripotenten Stammzellen, Die Mit Eine Einzigen Verbrauchsteuerpflichtiger Lentivirale Stammzell-Kassette Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 Die Rolle Des Haut-abgeleitete Dendritische Zellen in CD8 + T-Zelle-Grundierung Nach Immunisierung Mit Lentivectors Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20357252 Verbesserung Des Emphysems Bei Mäusen Durch Lentivirale Transduktion Der Langlebigen Pulmonale Alveoläre Makrophagen The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20038801 Exzision Der Reprogrammierung Transgene Verbessert Das Differenzierung Potenzial Von IPS-Zellen, Die Mit Einem Einzigen Verbrauchsteuerpflichtiger Vektor Erzeugt Stem Cells (Dayton, Ohio). Jan, 2010 | Pubmed ID: 19904830 Alveolarproteinose: Eine Bank-zu-Bett-Geschichte Der Granulozyten-Makrophagen-Kolonie-stimulierende Faktor Dysfunktion Chest. Aug, 2009 | Pubmed ID: 19666756 Transkriptionelle Analyse Der Bruch Zu Heilen Und Die Induktion Von Embryonalen Stammzellen-bezogenen Gene PloS One. 2009 | Pubmed ID: 19415118 Induzierte Pluripotente Stammzellen-Generierung Mit Eine Einzigen Lentivirale Stammzell-Kassette Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19096035 Nachhaltig Ausdruck Der Alpha1-Antitrypsin Nach Der Transplantation Von Manipulierten Hematopoietic Stammzellen American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323534 Eine Weitere Kerbe in Stammzellbiologie: Drosophila Intestinale Stammzellen Und Die Spezifikation Der Zelle Schicksale BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008 | Pubmed ID: 18200564 Die Verlängerte Lebensdauer Der Alveolären Makrophagen American Journal of Respiratory Cell and Molecular Biology. Apr, 2008 | Pubmed ID: 18192503 Dual-Projektträger Lentivirale System Ermöglicht Durch Induktion Ausdruck Der Schädliche Proteine in Makrophagen Journal of Immunological Methods. Jan, 2008 | Pubmed ID: 17967462 Lung Stammzellen Cell and Tissue Research. Jan, 2008 | Pubmed ID: 17805578 Exogenen Kontrolle Der Säugetier-Genexpression über Modulation Translational Kündigung Nature Medicine. Sep, 2006 | Pubmed ID: 16892063 Ausfall Des Knochenmark, Lunge Epithel Zu Rekonstituieren American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 15961722 Effizienz Der Transduktion Von Hochreinem Murine Hämatopoetische Stammzellen Zellen Von Lentiviralen / Oncoretroviral Vektoren Unter Bedingungen Der Minimal In-vitro-Manipulation Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2005 | Pubmed ID: 15922964 Eine Neuartige Stammzellen-Population in Erwachsenen Leber Mit Potenten Hämatopoetischen Rekonstitution Aktivität Blood. Sep, 2005 | Pubmed ID: 15870171 Embryonale Lungenzellen Seite Bevölkerung Sind Hämatopoetischen Und Vaskuläre Vorstufen American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15802552 Lunge-Stammzellen: Neue Paradigmen Experimental Hematology. Apr, 2004 | Pubmed ID: 15050743 Translational Physiology: Origin and Phenotype of Lung Side Population Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2004 | Pubmed ID: 15047566 Seite Bevölkerung Zellen Und Bcrp1 Ausdruck in Der Lunge American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12626330 Stammzellen-Antigen-1 Ausdruck in Der Pulmonalen Vaskulären Endothel American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003 | Pubmed ID: 12611818 Erzeugung von 3D-Kugeln und 2D-Luft-Flüssig-Grenzflächenkulturen von humanen induzierten pluripotenten Stammzell-abgeleiteten alveolären Epithelzellen vom Typ 2 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology Generation of Human induzierten pluripotenten Stammzellen aus dem peripheren Blut mit dem STEMCCA Lentivirusvektor Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
Erzeugung von 3D-Kugeln und 2D-Luft-Flüssig-Grenzflächenkulturen von humanen induzierten pluripotenten Stammzell-abgeleiteten alveolären Epithelzellen vom Typ 2 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology
Generation of Human induzierten pluripotenten Stammzellen aus dem peripheren Blut mit dem STEMCCA Lentivirusvektor Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
