Darrell N. Kotton Center for Regenerative Medicine Boston University and Boston Medical Center Biography Publications Institution JoVE Articles Darrell N. Kotton has not added a biography. If you are Darrell N. Kotton and would like to personalize this page please email our Author Liaison for assistance. Publications Human Distal Airways Contain a Multipotent Secretory Cell That Can Regenerate Alveoli Nature. Apr, 2022 | Pubmed ID: 35355013 Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration Frontiers in Endocrinology. 2022 | Pubmed ID: 35211095 Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease Cell Reports. Aug, 2021 | Pubmed ID: 34469722 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34413211 Differentiation of Human Pluripotent Stem Cells into Functional Airway Basal Stem Cells STAR Protocols. 09, 2021 | Pubmed ID: 34355203 Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine Frontiers in Endocrinology. 2021 | Pubmed ID: 33959101 Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell. 01, 2021 | Pubmed ID: 33098807 Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration Annual Review of Physiology. 02, 2021 | Pubmed ID: 33074772 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell. 12, 2020 | Pubmed ID: 32979316 Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell. 10, 2020 | Pubmed ID: 32891189 The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors Nature Communications. 01, 2020 | Pubmed ID: 32005814 Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors Cell Stem Cell. 04, 2020 | Pubmed ID: 32004478 Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells Nature Protocols. 12, 2019 | Pubmed ID: 31732721 Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering Stem Cell Reports. 09, 2019 | Pubmed ID: 31422908 Circulating Truncated Alpha-1 Antitrypsin Glycoprotein in Patient Plasma Retains Anti-Inflammatory Capacity Journal of Immunology (Baltimore, Md. : 1950). 04, 2019 | Pubmed ID: 30796179 Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium Stem Cell Reports. 05, 2018 | Pubmed ID: 29657097 Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation The Journal of Clinical Investigation. 03, 2018 | Pubmed ID: 29400691 Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells Cell Stem Cell. 10, 2017 | Pubmed ID: 28965766 Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification Development (Cambridge, England). 11, 2017 | Pubmed ID: 28947536 Vascular Smooth Muscle Cells Derived from Inbred Swine Induced Pluripotent Stem Cells for Vascular Tissue Engineering Biomaterials. Dec, 2017 | Pubmed ID: 28942128 Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463226 Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling Cell Stem Cell. 06, 2017 | Pubmed ID: 28366587 Regenerative Therapy for Hypothyroidism: Mechanisms and Possibilities Molecular and Cellular Endocrinology. 04, 2017 | Pubmed ID: 27876515 Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells Cell Stem Cell. Nov, 2015 | Pubmed ID: 26593959 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Embryonic and Induced Pluripotent Stem Cells for Lung Regeneration Annals of the American Thoracic Society. Mar, 2015 | Pubmed ID: 25830836 Targeted Correction and Restored Function of the CFTR Gene in Cystic Fibrosis Induced Pluripotent Stem Cells Stem Cell Reports. Apr, 2015 | Pubmed ID: 25772471 Derivation of Endodermal Progenitors From Pluripotent Stem Cells Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25160562 Lung Regeneration: Mechanisms, Applications and Emerging Stem Cell Populations Nature Medicine. Aug, 2014 | Pubmed ID: 25100528 KDR Identifies a Conserved Human and Murine Hepatic Progenitor and Instructs Early Liver Development Cell Stem Cell. Jun, 2013 | Pubmed ID: 23746980 The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation Blood. Jul, 2013 | Pubmed ID: 23723449 Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23403494 誘導多能性幹細胞を使用する複雑な遺伝学と長い QT シンドローム家族の薬物アクションを明らかにします。 The Journal of General Physiology. Jan, 2013 | Pubmed ID: 23277474 Mouse ESC Differentiation to Nkx2.1+ Lung and Thyroid Progenitors Bio-protocol. Nov, 2012 | Pubmed ID: 27453901 The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers American Journal of Respiratory and Critical Care Medicine. Dec, 2012 | Pubmed ID: 23204376 転写因子 Grainyhead のような 2 と NK2 ホメオ ボックス 1 規制のループは、その座標の肺上皮細胞の形態形成と分化形成します。 The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955271 大動脈弁上部大動脈狭窄症候群ひと誘導多能性幹細胞のモデリング。 Circulation. Oct, 2012 | Pubmed ID: 22914687 次世代再生： 希望と肺幹細胞研究の誇大宣伝。 American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22517787 浄化された肺、甲状腺の前駆細胞から胚性幹細胞の効率的な導出。 Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482505 ひと多能性幹細胞から生成された取って代われる内皮前駆行。 Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 肺血管内皮のメンテナンスと修理は骨髄由来内皮前駆細胞からの貢献を関与しません。 American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22323363 マサチューセッツ総合病院のケース レコード。ケース 2-2012年。63 歳の女性, 呼吸困難と急速進行性呼吸不全。 The New England Journal of Medicine. Jan, 2012 | Pubmed ID: 22256809 胚性幹細胞と誘導された多能性幹細胞、同じまたは異なるですか？その潜在的な治療上の使用のための含意。 Cell Cycle (Georgetown, Tex.). Jan, 2012 | Pubmed ID: 22186787 骨髄間質幹細胞ポスト ナタール骨再生過程の維持における Nanog の役割 Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142851 ヒトの胚性幹細胞由来の心筋細胞における遅いカリウム チャネルの年会プロパティ サブユニット組成比を巻き込みます。 The Journal of Physiology. Dec, 2011 | Pubmed ID: 22025662 プログラム的な変更：誘導多能性の時代における肺疾患の研究 American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 細胞培養からの生き物へのシフト: in Vivo 実験的再生医療における小動物イメージングします。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21952170 細胞の可塑性の肺傷害と修復： レポートを NHLBI のワーク ショップは、2010 年 4 月 19-20 日から。 Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653526 マウス ES と IPS 細胞類似の決定的な内胚葉の捺印された遺伝子の違いにもかかわらずを形成できます。 The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 FOXO1 骨芽細胞分化を調節します。 Bone. May, 2011 | Pubmed ID: 21281751 単一のレンチ ウイルス幹細胞が物品税課税対象のカセットを使用して無料の Transgene 肺疾患特異ひと誘導多能性幹細胞の世代。 Stem Cells (Dayton, Ohio). Oct, 2010 | Pubmed ID: 20715179 皮膚由来の樹状細胞 Lentivectors を接種 Cd8 陽性 T 細胞のプライミングにおけるの役割。 Journal of Immunology (Baltimore, Md. : 1950). May, 2010 | Pubmed ID: 20357252 長寿命における肺胞マクロファージのレンチ ウイルス伝達を介してマウスで肺気腫の改善。 The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20038801 Transgenes リプログラミング切除 1 つが物品税課税対象ベクトルとされた IPS 細胞の分化ポテンシャルを向上させます。 Stem Cells (Dayton, Ohio). Jan, 2010 | Pubmed ID: 19904830 肺胞蛋白症: ベンチのベッドサイド ストーリー顆粒球マクロファージコロニー コロニー刺激因子機能障害。 Chest. Aug, 2009 | Pubmed ID: 19666756 骨折治癒の転写解析および萌芽期の幹細胞関連遺伝子の誘導。 PloS One. 2009 | Pubmed ID: 19415118 誘導多能性幹細胞の世代レンチウイルスベクター幹細胞 1 つのカセットを使用して。 Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19096035 操作された造血幹細胞移植後の持続的な式のアルファ 1-アンチトリプシン。 American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323534 別のノッチの幹細胞生物学： ショウジョウバエ腸管幹細胞と細胞運命の仕様。 BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008 | Pubmed ID: 18200564 肺胞マクロファージの長期生命スパン。 American Journal of Respiratory Cell and Molecular Biology. Apr, 2008 | Pubmed ID: 18192503 デュアル プロモーター レンチ ウイルス システム有害なタンパク質の発現におけるマクロファージができます。 Journal of Immunological Methods. Jan, 2008 | Pubmed ID: 17967462 肺幹細胞。 Cell and Tissue Research. Jan, 2008 | Pubmed ID: 17805578 外因性哺乳類遺伝子発現制御の並進終端の変調を介して。 Nature Medicine. Sep, 2006 | Pubmed ID: 16892063 肺上皮を再構成する骨髄の失敗。 American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 15961722 高純度のマウス造血幹の情報伝達の効率をレンチ ウイルスによる細胞し、最小限の in Vitro の操作条件下での Oncoretroviral のベクトルします。 Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2005 | Pubmed ID: 15922964 強力な造血機能再構築活性をもつ成人肝の小説の茎セル人口。 Blood. Sep, 2005 | Pubmed ID: 15870171 萌芽期の肺側人口細胞造血・血管の前駆体です。 American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15802552 肺幹細胞: 新しいパラダイム。 Experimental Hematology. Apr, 2004 | Pubmed ID: 15050743 Translational Physiology: Origin and Phenotype of Lung Side Population Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Sep, 2004 | Pubmed ID: 15047566 側人口細胞と肺における Bcrp1 式。 American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12626330 肺血管内皮細胞内の幹細胞抗原 1 の式。 American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003 | Pubmed ID: 12611818 ヒト人工多能性幹細胞由来2型肺胞上皮細胞の3Dスフェアおよび2D気液界面培養物の生成 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology STEMCCAレンチウイルスベクターを用いた末梢血からのヒト人工多能性幹細胞の生成 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
ヒト人工多能性幹細胞由来2型肺胞上皮細胞の3Dスフェアおよび2D気液界面培養物の生成 Rhiannon B. Werder*1,2,3, Jessie Huang*1,2, Kristine M. Abo1,2, Olivia T. Hix1,2, Kasey Minakin1,2, Konstantinos-Dionysios Alysandratos1,2, Carly Merritt1,2, Kayleigh Berthiaume1,2, Andrea B. Alber1,2, Claire L. Burgess1,2, Darrell N. Kotton*1,2, Andrew A. Wilson*1,2 1Center for Regenerative Medicine, Boston University and Boston Medical Center, 2The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 3QIMR Berghofer Medical Research Institute JoVE 63875 Developmental Biology
STEMCCAレンチウイルスベクターを用いた末梢血からのヒト人工多能性幹細胞の生成 Andreia Gianotti Sommer1, Sarah S. Rozelle1, Spencer Sullivan2, Jason A. Mills3, Seon-Mi Park1, Brenden W. Smith1, Amulya M. Iyer1, Deborah L. French3, Darrell N. Kotton1, Paul Gadue3, George J. Murphy1, Gustavo Mostoslavsky1 1Center for Regenerative Medicine (CReM), Boston University School of Medicine, 2Department of Hematology, Children's Hospital of Philadelphia, 3Center for Cellular and Molecular Therapeutics, Children's Hospital of Philadelphia JoVE 4327 Biology
