Darrell Kotton

Publications

• Air-liquid Interface Culture Promotes Maturation and Allows Environmental Exposure of Pluripotent Stem Cell-derived Alveolar Epithelium
  JCI Insight. 03, 2022  |   Pubmed ID: 35315362
• Specific Mesoderm Subset Derived from Human Pluripotent Stem Cells Ameliorates Microvascular Pathology in Type 2 Diabetic Mice
  Science Advances. 03, 2022  |   Pubmed ID: 35245116
• Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration
  Frontiers in Endocrinology. 2022  |   Pubmed ID: 35211095
• CoSpar Identifies Early Cell Fate Biases from Single-cell Transcriptomic and Lineage Information
  Nature Biotechnology. Feb, 2022  |   Pubmed ID: 35190690
• Epithelial LIF Signaling Limits Apoptosis and Lung Injury During Bacterial Pneumonia
  American Journal of Physiology. Lung Cellular and Molecular Physiology. 04, 2022  |   Pubmed ID: 35137631
• Recombinant Lloviu Virus As a Tool to Study Viral Replication and Host Responses
  PLoS Pathogens. 02, 2022  |   Pubmed ID: 35120176
• Human Airway Lineages Derived from Pluripotent Stem Cells Reveal the Epithelial Responses to SARS-CoV-2 Infection
  American Journal of Physiology. Lung Cellular and Molecular Physiology. 03, 2022  |   Pubmed ID: 35020534
• Human Alveolar Type 2 Epithelium Transdifferentiates into Metaplastic KRT5 Basal Cells
  Nature Cell Biology. 01, 2022  |   Pubmed ID: 34969962
• Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can I(PSCs) Do?
  Genes. 10, 2021  |   Pubmed ID: 34828274
• Sequence Logic at Enhancers Governs a Dual Mechanism of Endodermal Organ Fate Induction by FOXA Pioneer Factors
  Nature Communications. 11, 2021  |   Pubmed ID: 34789735
• Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease
  Cell Reports. Aug, 2021  |   Pubmed ID: 34469722
• Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19
  Proceedings of the National Academy of Sciences of the United States of America. 09, 2021  |   Pubmed ID: 34413211
• Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters
  American Journal of Respiratory Cell and Molecular Biology. 10, 2021  |   Pubmed ID: 34101541
• Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine
  Frontiers in Endocrinology. 2021  |   Pubmed ID: 33959101
• SARS-CoV-2 Drives JAK1/2-dependent Local Complement Hyperactivation
  Science Immunology. 04, 2021  |   Pubmed ID: 33827897
• SARS-CoV-2 Induces Double-stranded RNA-mediated Innate Immune Responses in Respiratory Epithelial-derived Cells and Cardiomyocytes
  Proceedings of the National Academy of Sciences of the United States of America. 04, 2021  |   Pubmed ID: 33811184
• Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection
  Stem Cell Reports. 03, 2021  |   Pubmed ID: 33636110
• Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells
  Cell Stem Cell. 01, 2021  |   Pubmed ID: 33098807
• Reconstructed Signaling and Regulatory Networks Identify Potential Drugs for SARS-CoV-2 Infection
  BioRxiv : the Preprint Server for Biology. Dec, 2021  |   Pubmed ID: 33083801
• Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration
  Annual Review of Physiology. 02, 2021  |   Pubmed ID: 33074772
• Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
  Molecular Cell. 12, 2020  |   Pubmed ID: 33259812
• Common Genetic Variation in Humans Impacts Susceptibility to SARS-CoV-2 Infection
  BioRxiv : the Preprint Server for Biology. Sep, 2020  |   Pubmed ID: 32995783
• SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
  Cell Stem Cell. 12, 2020  |   Pubmed ID: 32979316
• Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells
  Cell Stem Cell. 10, 2020  |   Pubmed ID: 32891189
• Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease
  Stem Cell Reports. 08, 2020  |   Pubmed ID: 32735824
• A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells
  Stem Cell Reports. 07, 2020  |   Pubmed ID: 32619491
• Differentiation of Human Airway-organoids from Induced Pluripotent Stem Cells (iPSCs)
  Methods in Cell Biology. 2020  |   Pubmed ID: 32586451
• Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19
  BioRxiv : the Preprint Server for Biology. Dec, 2020  |   Pubmed ID: 32577649
• Human IPSC-derived Alveolar and Airway Epithelial Cells Can Be Cultured at Air-liquid Interface and Express SARS-CoV-2 Host Factors
  BioRxiv : the Preprint Server for Biology. Jun, 2020  |   Pubmed ID: 32577635
• Hidden Neural States Underlie Canary Song Syntax
  Nature. 06, 2020  |   Pubmed ID: 32555461
• The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future
  Cell Stem Cell. 04, 2020  |   Pubmed ID: 32243808
• The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors
  Nature Communications. 01, 2020  |   Pubmed ID: 32005814
• Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors
  Cell Stem Cell. 04, 2020  |   Pubmed ID: 32004478
• Generation of Mesenchyme Free Intestinal Organoids from Human Induced Pluripotent Stem Cells
  Nature Communications. 01, 2020  |   Pubmed ID: 31924806
• Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells
  Nature Protocols. 12, 2019  |   Pubmed ID: 31732721
• Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering
  Stem Cell Reports. 09, 2019  |   Pubmed ID: 31422908
• Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis
  Trends in Pharmacological Sciences. 10, 2018  |   Pubmed ID: 30213439
• Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells
  Current Protocols in Stem Cell Biology. 05, 2018  |   Pubmed ID: 30040246
• Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium
  Stem Cell Reports. 05, 2018  |   Pubmed ID: 29657097
• Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation
  The Journal of Clinical Investigation. 03, 2018  |   Pubmed ID: 29400691
• Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells
  Cell Stem Cell. 10, 2017  |   Pubmed ID: 28965766
• Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification
  Development (Cambridge, England). 11, 2017  |   Pubmed ID: 28947536
• Interview with Darrell Kotton
  Regenerative Medicine. 04, 2017  |   Pubmed ID: 28621167
• Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells
  The Journal of Clinical Investigation. Jun, 2017  |   Pubmed ID: 28463226
• Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity
  The Journal of Infectious Diseases. 08, 2017  |   Pubmed ID: 28368460
• Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling
  Cell Stem Cell. 06, 2017  |   Pubmed ID: 28366587
• Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells Through Transient, Developmental Stage-Specific Overexpression of Nkx2-1
  Stem Cell Reports. 02, 2017  |   Pubmed ID: 28162994
• Unstable Neurons Underlie a Stable Learned Behavior
  Nature Neuroscience. 12, 2016  |   Pubmed ID: 27723744
• Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells
  Cell Stem Cell. Nov, 2015  |   Pubmed ID: 26593959
• Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells
  Stem Cell Reports. May, 2015  |   Pubmed ID: 25843048
• Induced Pluripotent Stem Cells Model Personalized Variations in Liver Disease Resulting from α1-antitrypsin Deficiency
  Hepatology (Baltimore, Md.). Jul, 2015  |   Pubmed ID: 25690322
• Derivation of Endodermal Progenitors From Pluripotent Stem Cells
  Journal of Cellular Physiology. Feb, 2015  |   Pubmed ID: 25160562
• Modeling Pulmonary Alveolar Proteinosis with Induced Pluripotent Stem Cells
  American Journal of Respiratory and Critical Care Medicine. Jan, 2014  |   Pubmed ID: 24428646
• Diffuse Lung Disease in Children: Summary of a Scientific Conference
  Pediatric Pulmonology. Apr, 2014  |   Pubmed ID: 23798474
• Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis
  Stem Cell Reports. 2013  |   Pubmed ID: 24286032
• Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines
  Blood. Sep, 2013  |   Pubmed ID: 23940280
• Diminished Memory T-Cell Expansion Due to Delayed Kinetics of Antigen Expression by Lentivectors
  PloS One. 2013  |   Pubmed ID: 23824049
• The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation
  Blood. Jul, 2013  |   Pubmed ID: 23723449
• Lectin-dependent Enhancement of Ebola Virus Infection Via Soluble and Transmembrane C-type Lectin Receptors
  PloS One. 2013  |   Pubmed ID: 23573288
• Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium Tuberculosis in Vivo
  PLoS Pathogens. Feb, 2013  |   Pubmed ID: 23436998
• Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013  |   Pubmed ID: 23403494
• Residual Expression of Reprogramming Factors Affects the Transcriptional Program and Epigenetic Signatures of Induced Pluripotent Stem Cells
  PloS One. 2012  |   Pubmed ID: 23272148
• The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers
  American Journal of Respiratory and Critical Care Medicine. Dec, 2012  |   Pubmed ID: 23204376
• Die Transkription Faktoren Grainyhead-wie 2 Und NK2-Homeobox 1 Bilden Eine Regulatorische Schleife, Die Lunge Epithelzellen Morphogenese Und Differenzierung Koordiniert
  The Journal of Biological Chemistry. Oct, 2012  |   Pubmed ID: 22955271
• Regenerierung Der Nächsten Generation: Die Hoffnung Und Den Hype Der Lunge Stammzellenforschung
  American Journal of Respiratory and Critical Care Medicine. Jun, 2012  |   Pubmed ID: 22517787
• Effiziente Ableitung Der Gereinigten Lunge Und Schilddrüse Vorläuferzellen Aus Embryonalen Stammzellen
  Cell Stem Cell. Apr, 2012  |   Pubmed ID: 22482505
• Erneuernde Endodermalen Vorläuferzellen Linien Aus Menschlichen Pluripotenten Stammzellen Erzeugt
  Cell Stem Cell. Apr, 2012  |   Pubmed ID: 22482503
• Instandhaltung Und Reparatur Der Lunge Endothels Darf Nicht Mit Beiträgen Von Knochenmark Abgeleitete Endothelialen Vorläuferzellen
  American Journal of Respiratory Cell and Molecular Biology. Jul, 2012  |   Pubmed ID: 22323363
• Die Rolle Der Nanog in Der Pflege Von Knochenmark Stromal Stammzellen Während Post Natal Knochenregeneration
  Biochemical and Biophysical Research Communications. Jan, 2012  |   Pubmed ID: 22142851
• Programmgesteuerte Änderung: Lunge-Krankheit-Forschung in Der Ära Der Induzierten Pluripotenz
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011  |   Pubmed ID: 21984571
• Eine Verschiebung Von Zellkulturen Zu Kreaturen: In-vivo Imaging Bei Kleintieren in Experimentelle Regenerative Medizin
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011  |   Pubmed ID: 21952170
• Maus ES Und IPS-Zellen Können ähnliche Endgültige Endodermis Trotz Unterschiedlicher Eingeprägten Gene Bilden
  The Journal of Clinical Investigation. Jun, 2011  |   Pubmed ID: 21537085
• Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise
  Nature. Feb, 2011  |   Pubmed ID: 21307849
• FOXO1 Moduliert Osteoblasten Differenzierung
  Bone. May, 2011  |   Pubmed ID: 21281751
• MiR-129 Regulates Cell Proliferation by Downregulating Cdk6 Expression
  Cell Cycle (Georgetown, Tex.). May, 2010  |   Pubmed ID: 20404570
• Verbesserung Des Emphysems Bei Mäusen Durch Lentivirale Transduktion Der Langlebigen Pulmonale Alveoläre Makrophagen
  The Journal of Clinical Investigation. Jan, 2010  |   Pubmed ID: 20038801
• Epigenetic Mechanisms Modulate Thyroid Transcription Factor 1-mediated Transcription of the Surfactant Protein B Gene
  The Journal of Biological Chemistry. Jan, 2010  |   Pubmed ID: 19906647
• Exzision Der Reprogrammierung Transgene Verbessert Das Differenzierung Potenzial Von IPS-Zellen, Die Mit Einem Einzigen Verbrauchsteuerpflichtiger Vektor Erzeugt
  Stem Cells (Dayton, Ohio). Jan, 2010  |   Pubmed ID: 19904830
• Alveolarproteinose: Eine Bank-zu-Bett-Geschichte Der Granulozyten-Makrophagen-Kolonie-stimulierende Faktor Dysfunktion
  Chest. Aug, 2009  |   Pubmed ID: 19666756
• Transkriptionelle Analyse Der Bruch Zu Heilen Und Die Induktion Von Embryonalen Stammzellen-bezogenen Gene
  PloS One. 2009  |   Pubmed ID: 19415118
• Induzierte Pluripotente Stammzellen-Generierung Mit Eine Einzigen Lentivirale Stammzell-Kassette
  Stem Cells (Dayton, Ohio). Mar, 2009  |   Pubmed ID: 19096035
• Nachhaltig Ausdruck Der Alpha1-Antitrypsin Nach Der Transplantation Von Manipulierten Hematopoietic Stammzellen
  American Journal of Respiratory Cell and Molecular Biology. Aug, 2008  |   Pubmed ID: 18323534
• Eine Weitere Kerbe in Stammzellbiologie: Drosophila Intestinale Stammzellen Und Die Spezifikation Der Zelle Schicksale
  BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008  |   Pubmed ID: 18200564
• Die Verlängerte Lebensdauer Der Alveolären Makrophagen
  American Journal of Respiratory Cell and Molecular Biology. Apr, 2008  |   Pubmed ID: 18192503
• Lung Stammzellen
  Cell and Tissue Research. Jan, 2008  |   Pubmed ID: 17805578
• Ausfall Des Knochenmark, Lunge Epithel Zu Rekonstituieren
  American Journal of Respiratory Cell and Molecular Biology. Oct, 2005  |   Pubmed ID: 15961722
• Eine Neuartige Stammzellen-Population in Erwachsenen Leber Mit Potenten Hämatopoetischen Rekonstitution Aktivität
  Blood. Sep, 2005  |   Pubmed ID: 15870171
• Embryonale Lungenzellen Seite Bevölkerung Sind Hämatopoetischen Und Vaskuläre Vorstufen
  American Journal of Respiratory Cell and Molecular Biology. Jul, 2005  |   Pubmed ID: 15802552
• Lunge-Stammzellen: Neue Paradigmen
  Experimental Hematology. Apr, 2004  |   Pubmed ID: 15050743
• Seite Bevölkerung Zellen Und Bcrp1 Ausdruck in Der Lunge
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003  |   Pubmed ID: 12626330
• Stammzellen-Antigen-1 Ausdruck in Der Pulmonalen Vaskulären Endothel
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003  |   Pubmed ID: 12611818