Darrell Kotton Pulmonary Center Boston University School of Medicine Biography Publications Institution JoVE Articles Darrell Kotton has not added a biography. If you are Darrell Kotton and would like to personalize this page please email our Author Liaison for assistance. Publications Air-liquid Interface Culture Promotes Maturation and Allows Environmental Exposure of Pluripotent Stem Cell-derived Alveolar Epithelium JCI Insight. 03, 2022 | Pubmed ID: 35315362 Specific Mesoderm Subset Derived from Human Pluripotent Stem Cells Ameliorates Microvascular Pathology in Type 2 Diabetic Mice Science Advances. 03, 2022 | Pubmed ID: 35245116 Editorial: Progenitors and Stem Cells in Thyroid Development, Disease, and Regeneration Frontiers in Endocrinology. 2022 | Pubmed ID: 35211095 CoSpar Identifies Early Cell Fate Biases from Single-cell Transcriptomic and Lineage Information Nature Biotechnology. Feb, 2022 | Pubmed ID: 35190690 Epithelial LIF Signaling Limits Apoptosis and Lung Injury During Bacterial Pneumonia American Journal of Physiology. Lung Cellular and Molecular Physiology. 04, 2022 | Pubmed ID: 35137631 Recombinant Lloviu Virus As a Tool to Study Viral Replication and Host Responses PLoS Pathogens. 02, 2022 | Pubmed ID: 35120176 Human Airway Lineages Derived from Pluripotent Stem Cells Reveal the Epithelial Responses to SARS-CoV-2 Infection American Journal of Physiology. Lung Cellular and Molecular Physiology. 03, 2022 | Pubmed ID: 35020534 Human Alveolar Type 2 Epithelium Transdifferentiates into Metaplastic KRT5 Basal Cells Nature Cell Biology. 01, 2022 | Pubmed ID: 34969962 Gaining Insight into Mitochondrial Genetic Variation and Downstream Pathophysiology: What Can I(PSCs) Do? Genes. 10, 2021 | Pubmed ID: 34828274 Sequence Logic at Enhancers Governs a Dual Mechanism of Endodermal Organ Fate Induction by FOXA Pioneer Factors Nature Communications. 11, 2021 | Pubmed ID: 34789735 Patient-specific IPSCs Carrying an SFTPC Mutation Reveal the Intrinsic Alveolar Epithelial Dysfunction at the Inception of Interstitial Lung Disease Cell Reports. Aug, 2021 | Pubmed ID: 34469722 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 Proceedings of the National Academy of Sciences of the United States of America. 09, 2021 | Pubmed ID: 34413211 Heterogeneity in Human Induced Pluripotent Stem Cell-derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters American Journal of Respiratory Cell and Molecular Biology. 10, 2021 | Pubmed ID: 34101541 Derivation of Thyroid Follicular Cells From Pluripotent Stem Cells: Insights From Development and Implications for Regenerative Medicine Frontiers in Endocrinology. 2021 | Pubmed ID: 33959101 SARS-CoV-2 Drives JAK1/2-dependent Local Complement Hyperactivation Science Immunology. 04, 2021 | Pubmed ID: 33827897 SARS-CoV-2 Induces Double-stranded RNA-mediated Innate Immune Responses in Respiratory Epithelial-derived Cells and Cardiomyocytes Proceedings of the National Academy of Sciences of the United States of America. 04, 2021 | Pubmed ID: 33811184 Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection Stem Cell Reports. 03, 2021 | Pubmed ID: 33636110 Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells Cell Stem Cell. 01, 2021 | Pubmed ID: 33098807 Reconstructed Signaling and Regulatory Networks Identify Potential Drugs for SARS-CoV-2 Infection BioRxiv : the Preprint Server for Biology. Dec, 2021 | Pubmed ID: 33083801 Epithelial Stem and Progenitor Cells in Lung Repair and Regeneration Annual Review of Physiology. 02, 2021 | Pubmed ID: 33074772 Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2 Molecular Cell. 12, 2020 | Pubmed ID: 33259812 Common Genetic Variation in Humans Impacts Susceptibility to SARS-CoV-2 Infection BioRxiv : the Preprint Server for Biology. Sep, 2020 | Pubmed ID: 32995783 SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response Cell Stem Cell. 12, 2020 | Pubmed ID: 32979316 Organoids Model Transcriptional Hallmarks of Oncogenic KRAS Activation in Lung Epithelial Progenitor Cells Cell Stem Cell. 10, 2020 | Pubmed ID: 32891189 Expression of Amyloidogenic Transthyretin Drives Hepatic Proteostasis Remodeling in an Induced Pluripotent Stem Cell Model of Systemic Amyloid Disease Stem Cell Reports. 08, 2020 | Pubmed ID: 32735824 A Highly Phenotyped Open Access Repository of Alpha-1 Antitrypsin Deficiency Pluripotent Stem Cells Stem Cell Reports. 07, 2020 | Pubmed ID: 32619491 Differentiation of Human Airway-organoids from Induced Pluripotent Stem Cells (iPSCs) Methods in Cell Biology. 2020 | Pubmed ID: 32586451 Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19 BioRxiv : the Preprint Server for Biology. Dec, 2020 | Pubmed ID: 32577649 Human IPSC-derived Alveolar and Airway Epithelial Cells Can Be Cultured at Air-liquid Interface and Express SARS-CoV-2 Host Factors BioRxiv : the Preprint Server for Biology. Jun, 2020 | Pubmed ID: 32577635 Hidden Neural States Underlie Canary Song Syntax Nature. 06, 2020 | Pubmed ID: 32555461 The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future Cell Stem Cell. 04, 2020 | Pubmed ID: 32243808 The in Vivo Genetic Program of Murine Primordial Lung Epithelial Progenitors Nature Communications. 01, 2020 | Pubmed ID: 32005814 Reconstructed Single-Cell Fate Trajectories Define Lineage Plasticity Windows During Differentiation of Human PSC-Derived Distal Lung Progenitors Cell Stem Cell. 04, 2020 | Pubmed ID: 32004478 Generation of Mesenchyme Free Intestinal Organoids from Human Induced Pluripotent Stem Cells Nature Communications. 01, 2020 | Pubmed ID: 31924806 Derivation of Self-renewing Lung Alveolar Epithelial Type II Cells from Human Pluripotent Stem Cells Nature Protocols. 12, 2019 | Pubmed ID: 31732721 Generation of a Purified IPSC-Derived Smooth Muscle-like Population For Cell Sheet Engineering Stem Cell Reports. 09, 2019 | Pubmed ID: 31422908 Pulmonary Ionocytes Challenge the Paradigm in Cystic Fibrosis Trends in Pharmacological Sciences. 10, 2018 | Pubmed ID: 30213439 Derivation of Epithelial-Only Airway Organoids from Human Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 05, 2018 | Pubmed ID: 30040246 Single-Cell Transcriptomic Profiling of Pluripotent Stem Cell-Derived SCGB3A2+ Airway Epithelium Stem Cell Reports. 05, 2018 | Pubmed ID: 29657097 Claudin-18: Unexpected Regulator of Lung Alveolar Epithelial Cell Proliferation The Journal of Clinical Investigation. 03, 2018 | Pubmed ID: 29400691 Differentiation of Human Pluripotent Stem Cells into Functional Lung Alveolar Epithelial Cells Cell Stem Cell. 10, 2017 | Pubmed ID: 28965766 Pluripotent Stem Cell Differentiation Reveals Distinct Developmental Pathways Regulating Lung- Versus Thyroid-lineage Specification Development (Cambridge, England). 11, 2017 | Pubmed ID: 28947536 Interview with Darrell Kotton Regenerative Medicine. 04, 2017 | Pubmed ID: 28621167 Prospective Isolation of NKX2-1-expressing Human Lung Progenitors Derived from Pluripotent Stem Cells The Journal of Clinical Investigation. Jun, 2017 | Pubmed ID: 28463226 Capacity of Pneumococci to Activate Macrophage Nuclear Factor κB: Influence on Necroptosis and Pneumonia Severity The Journal of Infectious Diseases. 08, 2017 | Pubmed ID: 28368460 Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells Via Temporal Regulation of Wnt Signaling Cell Stem Cell. 06, 2017 | Pubmed ID: 28366587 Thyroid Progenitors Are Robustly Derived from Embryonic Stem Cells Through Transient, Developmental Stage-Specific Overexpression of Nkx2-1 Stem Cell Reports. 02, 2017 | Pubmed ID: 28162994 Unstable Neurons Underlie a Stable Learned Behavior Nature Neuroscience. 12, 2016 | Pubmed ID: 27723744 Regeneration of Thyroid Function by Transplantation of Differentiated Pluripotent Stem Cells Cell Stem Cell. Nov, 2015 | Pubmed ID: 26593959 Emergence of a Stage-dependent Human Liver Disease Signature with Directed Differentiation of Alpha-1 Antitrypsin-deficient IPS Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25843048 Induced Pluripotent Stem Cells Model Personalized Variations in Liver Disease Resulting from α1-antitrypsin Deficiency Hepatology (Baltimore, Md.). Jul, 2015 | Pubmed ID: 25690322 Derivation of Endodermal Progenitors From Pluripotent Stem Cells Journal of Cellular Physiology. Feb, 2015 | Pubmed ID: 25160562 Modeling Pulmonary Alveolar Proteinosis with Induced Pluripotent Stem Cells American Journal of Respiratory and Critical Care Medicine. Jan, 2014 | Pubmed ID: 24428646 Diffuse Lung Disease in Children: Summary of a Scientific Conference Pediatric Pulmonology. Apr, 2014 | Pubmed ID: 23798474 Induced Pluripotent Stem Cell Modeling of Multisystemic, Hereditary Transthyretin Amyloidosis Stem Cell Reports. 2013 | Pubmed ID: 24286032 Clonal Genetic and Hematopoietic Heterogeneity Among Human-induced Pluripotent Stem Cell Lines Blood. Sep, 2013 | Pubmed ID: 23940280 Diminished Memory T-Cell Expansion Due to Delayed Kinetics of Antigen Expression by Lentivectors PloS One. 2013 | Pubmed ID: 23824049 The Aryl Hydrocarbon Receptor Directs Hematopoietic Progenitor Cell Expansion and Differentiation Blood. Jul, 2013 | Pubmed ID: 23723449 Lectin-dependent Enhancement of Ebola Virus Infection Via Soluble and Transmembrane C-type Lectin Receptors PloS One. 2013 | Pubmed ID: 23573288 Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium Tuberculosis in Vivo PLoS Pathogens. Feb, 2013 | Pubmed ID: 23436998 Lentiviral Delivery of RNAi for in Vivo Lineage-specific Modulation of Gene Expression in Mouse Lung Macrophages Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2013 | Pubmed ID: 23403494 Residual Expression of Reprogramming Factors Affects the Transcriptional Program and Epigenetic Signatures of Induced Pluripotent Stem Cells PloS One. 2012 | Pubmed ID: 23272148 The 2012 Nobel Prize in Physiology or Medicine: Democratizing Pluripotency for Lung Researchers American Journal of Respiratory and Critical Care Medicine. Dec, 2012 | Pubmed ID: 23204376 The Transcription Factors Grainyhead-like 2 and NK2-Homeobox 1 Form a Regulatory Loop That Coordinates Lung Epithelial Cell Morphogenesis and Differentiation The Journal of Biological Chemistry. Oct, 2012 | Pubmed ID: 22955271 Next-generation Regeneration: the Hope and Hype of Lung Stem Cell Research American Journal of Respiratory and Critical Care Medicine. Jun, 2012 | Pubmed ID: 22517787 Efficient Derivation of Purified Lung and Thyroid Progenitors from Embryonic Stem Cells Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482505 Self-renewing Endodermal Progenitor Lines Generated from Human Pluripotent Stem Cells Cell Stem Cell. Apr, 2012 | Pubmed ID: 22482503 Maintenance and Repair of the Lung Endothelium Does Not Involve Contributions from Marrow-derived Endothelial Precursor Cells American Journal of Respiratory Cell and Molecular Biology. Jul, 2012 | Pubmed ID: 22323363 Role of Nanog in the Maintenance of Marrow Stromal Stem Cells During Post Natal Bone Regeneration Biochemical and Biophysical Research Communications. Jan, 2012 | Pubmed ID: 22142851 Programmatic Change: Lung Disease Research in the Era of Induced Pluripotency American Journal of Physiology. Lung Cellular and Molecular Physiology. Dec, 2011 | Pubmed ID: 21984571 A Shift from Cell Cultures to Creatures: in Vivo Imaging of Small Animals in Experimental Regenerative Medicine Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011 | Pubmed ID: 21952170 Mouse ES and IPS Cells Can Form Similar Definitive Endoderm Despite Differences in Imprinted Genes The Journal of Clinical Investigation. Jun, 2011 | Pubmed ID: 21537085 Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise Nature. Feb, 2011 | Pubmed ID: 21307849 FOXO1 Modulates Osteoblast Differentiation Bone. May, 2011 | Pubmed ID: 21281751 MiR-129 Regulates Cell Proliferation by Downregulating Cdk6 Expression Cell Cycle (Georgetown, Tex.). May, 2010 | Pubmed ID: 20404570 Amelioration of Emphysema in Mice Through Lentiviral Transduction of Long-lived Pulmonary Alveolar Macrophages The Journal of Clinical Investigation. Jan, 2010 | Pubmed ID: 20038801 Epigenetic Mechanisms Modulate Thyroid Transcription Factor 1-mediated Transcription of the Surfactant Protein B Gene The Journal of Biological Chemistry. Jan, 2010 | Pubmed ID: 19906647 Excision of Reprogramming Transgenes Improves the Differentiation Potential of IPS Cells Generated with a Single Excisable Vector Stem Cells (Dayton, Ohio). Jan, 2010 | Pubmed ID: 19904830 Pulmonary Alveolar Proteinosis: a Bench-to-bedside Story of Granulocyte-macrophage Colony-stimulating Factor Dysfunction Chest. Aug, 2009 | Pubmed ID: 19666756 Transcriptional Analysis of Fracture Healing and the Induction of Embryonic Stem Cell-related Genes PloS One. 2009 | Pubmed ID: 19415118 Induced Pluripotent Stem Cell Generation Using a Single Lentiviral Stem Cell Cassette Stem Cells (Dayton, Ohio). Mar, 2009 | Pubmed ID: 19096035 Sustained Expression of Alpha1-antitrypsin After Transplantation of Manipulated Hematopoietic Stem Cells American Journal of Respiratory Cell and Molecular Biology. Aug, 2008 | Pubmed ID: 18323534 Another Notch in Stem Cell Biology: Drosophila Intestinal Stem Cells and the Specification of Cell Fates BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2008 | Pubmed ID: 18200564 The Prolonged Life-span of Alveolar Macrophages American Journal of Respiratory Cell and Molecular Biology. Apr, 2008 | Pubmed ID: 18192503 Lung Stem Cells Cell and Tissue Research. Jan, 2008 | Pubmed ID: 17805578 Failure of Bone Marrow to Reconstitute Lung Epithelium American Journal of Respiratory Cell and Molecular Biology. Oct, 2005 | Pubmed ID: 15961722 A Novel Stem-cell Population in Adult Liver with Potent Hematopoietic-reconstitution Activity Blood. Sep, 2005 | Pubmed ID: 15870171 Embryonic Lung Side Population Cells Are Hematopoietic and Vascular Precursors American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15802552 Lung Stem Cells: New Paradigms Experimental Hematology. Apr, 2004 | Pubmed ID: 15050743 Side Population Cells and Bcrp1 Expression in Lung American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2003 | Pubmed ID: 12626330 Stem Cell Antigen-1 Expression in the Pulmonary Vascular Endothelium American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2003 | Pubmed ID: 12611818 Generering av Airway Epitelial Cell Air-Liquid Interface Kulturer fra Human Pluripotent Stamceller Andrew Berical1,2, Mary Lou Beermann2, Shingo Suzuki3, Jake LeSuer2, Taylor Matte2, Brian Davis3, Darrell Kotton1,2, Finn Hawkins1,2 1Pulmonary Center, Boston University School of Medicine, 2Center for Regenerative Medicine, Boston University and Boston Medical Center, 3Center for Stem Cell and Regenerative Medicine, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center JoVE 63882 Developmental Biology
Generering av Airway Epitelial Cell Air-Liquid Interface Kulturer fra Human Pluripotent Stamceller Andrew Berical1,2, Mary Lou Beermann2, Shingo Suzuki3, Jake LeSuer2, Taylor Matte2, Brian Davis3, Darrell Kotton1,2, Finn Hawkins1,2 1Pulmonary Center, Boston University School of Medicine, 2Center for Regenerative Medicine, Boston University and Boston Medical Center, 3Center for Stem Cell and Regenerative Medicine, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center JoVE 63882 Developmental Biology
