Articles by Darren Bryan in JoVE

• Cancer Research

  
  Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones Go Oshima*^1,2, Melinda E. Stack*¹, Sean C. Wightman¹, Darren Bryan¹, Elizabeth Poli¹, Lai Xue¹, Kinga B. Skowron¹, Abhineet Uppal¹, Sean P. Pitroda², Xiaona Huang², Mitchell C. Posner¹, Samuel Hellman², Ralph R. Weichselbaum², Nikolai N. Khodarev^{2 1}Department of Surgery, The University of Chicago, ²Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research, The University of Chicago The ability of metastatic clones to colonize distant sites depends on their proliferation capacity and/or their ability to survive in the host microenvironment without significant proliferation. Here, we present an animal model that allows quantitative visualization of both types of liver colonization by metastatic clones.