Publications

• Chronic Ethanol Exposure Combined with High Fat Diet Up-regulates P2X7 Receptors That Parallels Neuroinflammation and Neuronal Loss in C57BL/6J Mice
  Journal of Neuroimmunology. Aug, 2015  |   Pubmed ID: 26198936
• Oral Delivery of Ivermectin Using a Fast Dissolving Oral Film: Implications for Repurposing Ivermectin As a Pharmacotherapy for Alcohol Use Disorder
  Alcohol (Fayetteville, N.Y.). Sep, 2015  |   Pubmed ID: 26095588
• The Importance of Animals in Advancing Research on Alcohol Use Disorders
  Alcoholism, Clinical and Experimental Research. Apr, 2015  |   Pubmed ID: 25833015
• Glycine and GABA(A) Ultra-sensitive Ethanol Receptors As Novel Tools for Alcohol and Brain Research
  Molecular Pharmacology. Dec, 2014  |   Pubmed ID: 25245406
• P2X4 Receptors (P2X4Rs) Represent a Novel Target for the Development of Drugs to Prevent And/or Treat Alcohol Use Disorders
  Frontiers in Neuroscience. 2014  |   Pubmed ID: 25009459
• Multiday Administration of Ivermectin is Effective in Reducing Alcohol Intake in Mice at Doses Shown to Be Safe in Humans
  Neuroreport. Sep, 2014  |   Pubmed ID: 25004078
• Contribution of P2X4 Receptors to Ethanol Intake in Male C57BL/6 Mice
  Neurochemical Research. Jun, 2014  |   Pubmed ID: 24671605
• Avermectins Differentially Affect Ethanol Intake and Receptor Function: Implications for Developing New Therapeutics for Alcohol Use Disorders
  The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). Jun, 2014  |   Pubmed ID: 24451653
• Structural Models of Ligand-gated Ion Channels: Sites of Action for Anesthetics and Ethanol
  Alcoholism, Clinical and Experimental Research. Mar, 2014  |   Pubmed ID: 24164436
• Sociocommunicative and Sensorimotor Impairments in Male P2X4-deficient Mice
  Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2013  |   Pubmed ID: 23604007
• Pharmacological Insights into the Role of P2X4 Receptors in Behavioural Regulation: Lessons from Ivermectin
  The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (CINP). Jun, 2013  |   Pubmed ID: 23174033
• Recent Advances in the Discovery and Preclinical Testing of Novel Compounds for the Prevention And/or Treatment of Alcohol Use Disorders
  Alcoholism, Clinical and Experimental Research. Jan, 2013  |   Pubmed ID: 22671690
• Ivermectin Reduces Alcohol Intake and Preference in Mice
  Neuropharmacology. Aug, 2012  |   Pubmed ID: 22465817
• Charge and Geometry of Residues in the Loop 2 β Hairpin Differentially Affect Agonist and Ethanol Sensitivity in Glycine Receptors
  The Journal of Pharmacology and Experimental Therapeutics. May, 2012  |   Pubmed ID: 22357974
• Alcohol-binding Sites in Distinct Brain Proteins: the Quest for Atomic Level Resolution
  Alcoholism, Clinical and Experimental Research. Sep, 2011  |   Pubmed ID: 21676006
• Implication of the Purinergic System in Alcohol Use Disorders
  Alcoholism, Clinical and Experimental Research. Apr, 2011  |   Pubmed ID: 21223299
• Ethanol is a Fast Channel Inhibitor of P2X4 Receptors
  The Journal of Pharmacology and Experimental Therapeutics. Apr, 2011  |   Pubmed ID: 21212160
• Functional Role of the Intracellular Loop Linking Transmembrane Domains 6 and 7 of the Human Dipeptide Transporter HPEPT1
  The Journal of Membrane Biology. Dec, 2010  |   Pubmed ID: 21104182
• Ivermectin Antagonizes Ethanol Inhibition in Purinergic P2X4 Receptors
  The Journal of Pharmacology and Experimental Therapeutics. Sep, 2010  |   Pubmed ID: 20543096
• Molecular Targets and Mechanisms for Ethanol Action in Glycine Receptors
  Pharmacology & Therapeutics. Jul, 2010  |   Pubmed ID: 20399807
• A Point Mutation in the Ectodomain-transmembrane 2 Interface Eliminates the Inhibitory Effects of Ethanol in P2X4 Receptors
  Journal of Neurochemistry. Jan, 2010  |   Pubmed ID: 19878433
• Mutagenesis and Cysteine Scanning of Transmembrane Domain 10 of the Human Dipeptide Transporter
  Pharmaceutical Research. Oct, 2009  |   Pubmed ID: 19685173
• Loop 2 Structure in Glycine and GABA(A) Receptors Plays a Key Role in Determining Ethanol Sensitivity
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19656948
• Roles for Loop 2 Residues of Alpha1 Glycine Receptors in Agonist Activation
  The Journal of Biological Chemistry. Oct, 2008  |   Pubmed ID: 18658152
• Roles of Ectodomain and Transmembrane Regions in Ethanol and Agonist Action in Purinergic P2X2 and P2X3 Receptors
  Neuropharmacology. Oct, 2008  |   Pubmed ID: 18639563
• Purinergic Type 2 Receptors at GABAergic Synapses on Ventral Tegmental Area Dopamine Neurons Are Targets for Ethanol Action
  The Journal of Pharmacology and Experimental Therapeutics. Oct, 2008  |   Pubmed ID: 18583548
• Targets for Ethanol Action and Antagonism in Loop 2 of the Extracellular Domain of Glycine Receptors
  Journal of Neurochemistry. Aug, 2008  |   Pubmed ID: 18485105
• Ethanol Inhibits Functional Activity of the Human Intestinal Dipeptide Transporter HPepT1 Expressed in Xenopus Oocytes
  Alcoholism, Clinical and Experimental Research. May, 2008  |   Pubmed ID: 18336632
• Evidence That Ethanol Acts on a Target in Loop 2 of the Extracellular Domain of Alpha1 Glycine Receptors
  Journal of Neurochemistry. Sep, 2007  |   Pubmed ID: 17561937
• Cysteine Scanning of Transmembrane Domain Three of the Human Dipeptide Transporter: Implications for Substrate Transport
  Journal of Drug Targeting. Apr, 2007  |   Pubmed ID: 17454359
• A Charge Pair Interaction Between Arg282 in Transmembrane Segment 7 and Asp341 in Transmembrane Segment 8 of HPepT1
  Pharmaceutical Research. Jan, 2007  |   Pubmed ID: 17009102
• Effects of Ethanol on Adenosine 5'-triphosphate-gated Purinergic and 5-hydroxytryptamine Receptors
  Alcoholism, Clinical and Experimental Research. Feb, 2006  |   Pubmed ID: 16441284
• Ethanol Differentially Affects ATP-gated P2X(3) and P2X(4) Receptor Subtypes Expressed in Xenopus Oocytes
  Neuropharmacology. Aug, 2005  |   Pubmed ID: 15993446
• Effects of the Abused Solvent Toluene on Recombinant P2X Receptors Expressed in HEK293 Cells
  Brain Research. Molecular Brain Research. Jun, 2004  |   Pubmed ID: 15193425
• Multiple Sites of Ethanol Action in Alpha1 and Alpha2 Glycine Receptors Suggested by Sensitivity to Pressure Antagonism
  Journal of Neurochemistry. Jun, 2004  |   Pubmed ID: 15147510
• Biophysical Evidence for His57 As a Proton-binding Site in the Mammalian Intestinal Transporter HPepT1
  Pharmaceutical Research. Dec, 2003  |   Pubmed ID: 14725353
• Benzodiazepine Agonist and Inverse Agonist Coupling in GABAA Receptors Antagonized by Increased Atmospheric Pressure
  European Journal of Pharmacology. May, 2003  |   Pubmed ID: 12782183
• Ethanol Potentiation of Glycine Receptors Expressed in Xenopus Oocytes Antagonized by Increased Atmospheric Pressure
  Alcoholism, Clinical and Experimental Research. May, 2003  |   Pubmed ID: 12766618
• Ethanol Sensitivity in ATP-gated P2X Receptors is Subunit Dependent
  Alcoholism, Clinical and Experimental Research. Jun, 2002  |   Pubmed ID: 12068244