David C. Hay MRC Centre for Regenerative Medicine University of Edinburgh Biography Publications Institution JoVE Articles David C. Hay has not added a biography. If you are David C. Hay and would like to personalize this page please email our Author Liaison for assistance. Publications Inflammation-associated Suppression of Metabolic Gene Networks in Acute and Chronic Liver Disease Archives of Toxicology. Jan, 2020 | Pubmed ID: 31919559 Metabolic Control of Gene Transcription in Non-alcoholic Fatty Liver Disease: the Role of the Epigenome Clinical Epigenetics. 07, 2019 | Pubmed ID: 31319896 Combining Stem Cell-derived Hepatocytes with Impedance Sensing to Better Predict Human Drug Toxicity Expert Opinion on Drug Metabolism & Toxicology. Jan, 2019 | Pubmed ID: 30572740 Science-based Assessment of Source Materials for Cell-based Medicines: Report of a Stakeholders Workshop Regenerative Medicine. 12, 2018 | Pubmed ID: 30488776 3D Human Liver Tissue from Pluripotent Stem Cells Displays Stable Phenotype in Vitro and Supports Compromised Liver Function in Vivo Archives of Toxicology. 10, 2018 | Pubmed ID: 30155720 Modelling Non-alcoholic Fatty Liver Disease in Human Hepatocyte-like Cells Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2018 | Pubmed ID: 29786565 Developing Defined Substrates for Stem Cell Culture and Differentiation Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2018 | Pubmed ID: 29786564 Innate Immunity in Stem Cell-derived Hepatocytes Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2018 | Pubmed ID: 29786555 A Human IPSC Line Capable of Differentiating into Functional Macrophages Expressing ZsGreen: a Tool for the Study and Tracking of Therapeutic Cells Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2018 | Pubmed ID: 29786554 Designer Human Tissue: Coming to a Lab Near You Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Jul, 2018 | Pubmed ID: 29786548 Correction To: Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety The AAPS Journal. Feb, 2018 | Pubmed ID: 29435689 Liver Cell Therapy: is This the End of the Beginning? Cellular and Molecular Life Sciences : CMLS. Apr, 2018 | Pubmed ID: 29181772 Pluripotent Stem Cell-Derived Human Tissue: Platforms to Evaluate Drug Metabolism and Safety The AAPS Journal. Dec, 2017 | Pubmed ID: 29270863 Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor Stem Cell Reports. Dec, 2017 | Pubmed ID: 29173899 Erratum To: Modelling Foetal Exposure to Maternal Smoking Using Hepatoblasts from Pluripotent Stem Cells Archives of Toxicology. 11, 2017 | Pubmed ID: 28980015 Erratum To: Modelling Foetal Exposure to Maternal Smoking Using Hepatoblasts from Pluripotent Stem Cells Archives of Toxicology. Jul, 2017 | Pubmed ID: 28733887 Modelling Foetal Exposure to Maternal Smoking Using Hepatoblasts from Pluripotent Stem Cells Archives of Toxicology. Nov, 2017 | Pubmed ID: 28510779 A Drug-Induced Hybrid Electrospun Poly-Capro-Lactone: Cell-Derived Extracellular Matrix Scaffold for Liver Tissue Engineering Tissue Engineering. Part A. 07, 2017 | Pubmed ID: 28437180 Stem Cell-derived Models to Improve Mechanistic Understanding and Prediction of Human Drug-induced Liver Injury Hepatology (Baltimore, Md.). Feb, 2017 | Pubmed ID: 27775817 Corrigendum to "Gene Networks and Transcription Factor Motifs Defining the Differentiation of Human Stem Cells into Hepatocyte-like Cells" [J Hepatol 2015;63:934-942] Journal of Hepatology. Feb, 2016 | Pubmed ID: 28743474 Pluripotent Stem Cell Derived Hepatocytes: Using Materials to Define Cellular Differentiation and Tissue Engineering Journal of Materials Chemistry. B. May, 2016 | Pubmed ID: 27746914 Mass Production of Stem Cell Derived Human Hepatocytes for Experimental Medicine Expert Review of Gastroenterology & Hepatology. Jul, 2016 | Pubmed ID: 27145120 Reducing Hepatocyte Injury and Necrosis in Response to Paracetamol Using Noncoding RNAs Stem Cells Translational Medicine. Jun, 2016 | Pubmed ID: 27057006 Concise Review: Advances in Generating Hepatocytes from Pluripotent Stem Cells for Translational Medicine Stem Cells (Dayton, Ohio). Jun, 2016 | Pubmed ID: 27015786 Fluid Shear Stress Modulation of Hepatocyte-like Cell Function Archives of Toxicology. Jul, 2016 | Pubmed ID: 26979076 Low-Density Lipoprotein Uptake Demonstrates a Hepatocyte Phenotype in the Dog, but Is Nonspecific Stem Cells and Development. Jan, 2016 | Pubmed ID: 26423241 Recombinant Laminins Drive the Differentiation and Self-Organization of HESC-Derived Hepatocytes Stem Cell Reports. Dec, 2015 | Pubmed ID: 26626180 Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015) Advanced Healthcare Materials. Aug, 2015 | Pubmed ID: 26308957 Serum-Free Directed Differentiation of Human Embryonic Stem Cells to Hepatocytes Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 26272137 Hepatic Progenitor Cells of Biliary Origin with Liver Repopulation Capacity Nature Cell Biology. Aug, 2015 | Pubmed ID: 26192438 Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance Advanced Healthcare Materials. Aug, 2015 | Pubmed ID: 26109270 Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation Advanced Materials (Deerfield Beach, Fla.). Jul, 2015 | Pubmed ID: 26033422 Gene Networks and Transcription Factor Motifs Defining the Differentiation of Stem Cells into Hepatocyte-like Cells Journal of Hepatology. Oct, 2015 | Pubmed ID: 26022688 Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner The Journal of Clinical Endocrinology and Metabolism. Jun, 2015 | Pubmed ID: 25803269 Concise Review: Workshop Review: Understanding and Assessing the Risks of Stem Cell-based Therapies Stem Cells Translational Medicine. Apr, 2015 | Pubmed ID: 25722427 Deriving Functional Hepatocytes from Pluripotent Stem Cells Current Protocols in Stem Cell Biology. 2014 | Pubmed ID: 25081564 Modulating Innate Immunity Improves Hepatitis C Virus Infection and Replication in Stem Cell-derived Hepatocytes Stem Cell Reports. Jul, 2014 | Pubmed ID: 25068132 Galectin-3 Regulates Hepatic Progenitor Cell Expansion During Liver Injury Gut. May, 2014 | Pubmed ID: 24837171 Accurate Prediction of Drug-induced Liver Injury Using Stem Cell-derived Populations Stem Cells Translational Medicine. Feb, 2014 | Pubmed ID: 24375539 Modeling Human Liver Biology Using Stem Cell-derived Hepatocytes International Journal of Molecular Sciences. Nov, 2013 | Pubmed ID: 24201130 Rapid and Scalable Human Stem Cell Differentiation: Now in 3D Stem Cells and Development. Oct, 2013 | Pubmed ID: 23879796 Developing High-fidelity Hepatotoxicity Models from Pluripotent Stem Cells Stem Cells Translational Medicine. Jul, 2013 | Pubmed ID: 23757504 Liver Tissue Engineering and Cell Sources: Issues and Challenges Liver International : Official Journal of the International Association for the Study of the Liver. May, 2013 | Pubmed ID: 23490085 Development of an Embryoid Body-based Screening Strategy for Assessing the Hepatocyte Differentiation Potential of Human Embryonic Stem Cells Following Single-cell Dissociation Cellular Reprogramming. Feb, 2013 | Pubmed ID: 23379579 Pluripotent Stem Cell-derived Hepatocytes: Potential and Challenges in Pharmacology Annual Review of Pharmacology and Toxicology. 2013 | Pubmed ID: 23294308 Maintaining Hepatic Stem Cell Gene Expression on Biological and Synthetic Substrata BioResearch Open Access. Jan, 2012 | Pubmed ID: 23515003 Novel Biopolymers to Enhance Endothelialisation of Intra-vascular Devices Advanced Healthcare Materials. Sep, 2012 | Pubmed ID: 23184801 A Genome-wide Screen in Human Embryonic Stem Cells Reveals Novel Sites of Allele-specific Histone Modification Associated with Known Disease Loci Epigenetics & Chromatin. May, 2012 | Pubmed ID: 22607690 Stem Cell Differentiation and Human Liver Disease World Journal of Gastroenterology. May, 2012 | Pubmed ID: 22563188 SUMOylation of HNF4α Regulates Protein Stability and Hepatocyte Function Journal of Cell Science. Aug, 2012 | Pubmed ID: 22505616 Lineage-specific Distribution of High Levels of Genomic 5-hydroxymethylcytosine in Mammalian Development Cell Research. Sep, 2011 | Pubmed ID: 21747414 Unbiased Screening of Polymer Libraries to Define Novel Substrates for Functional Hepatocytes with Inducible Drug Metabolism Stem Cell Research. Mar, 2011 | Pubmed ID: 21277274 Persistence of Functional Hepatocyte-like Cells in Immune-compromised Mice Liver International : Official Journal of the International Association for the Study of the Liver. Feb, 2011 | Pubmed ID: 21143581 The Complexities of Engineering Human Stem Cell-derived Therapeutics Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 21490704 The Comparison Between Conditioned Media and Serum-free Media in Human Embryonic Stem Cell Culture and Differentiation Cellular Reprogramming. Apr, 2010 | Pubmed ID: 20677928 Post-translational Modification by SUMO Toxicology. Dec, 2010 | Pubmed ID: 20674646 Pluripotent Stem Cell Derived Hepatocyte Like Cells and Their Potential in Toxicity Screening Toxicology. Dec, 2010 | Pubmed ID: 20674645 Cadaveric Hepatocytes Repopulate Diseased Livers: Life After Death Gastroenterology. Sep, 2010 | Pubmed ID: 20659459 Role of Stem-cell-derived Hepatic Endoderm in Human Drug Discovery Biochemical Society Transactions. Aug, 2010 | Pubmed ID: 20658999 Hepatic Endoderm Differentiation from Human Embryonic Stem Cells Current Stem Cell Research & Therapy. Sep, 2010 | Pubmed ID: 20214561 Portal Venous Endothelium in Developing Human Liver Contains Haematopoietic and Epithelial Progenitor Cells Experimental Cell Research. May, 2010 | Pubmed ID: 20211168 Three-dimensional Culture of Human Embryonic Stem Cell Derived Hepatic Endoderm and Its Role in Bioartificial Liver Construction Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 20169088 Generation of Functional Human Hepatic Endoderm from Human Induced Pluripotent Stem Cells Hepatology (Baltimore, Md.). Jan, 2010 | Pubmed ID: 19877180 Third-degree Heart Block Associated with Bupivacaine Infusion Following Total Knee Arthroplasty. A Case Report The Journal of Bone and Joint Surgery. American Volume. Sep, 2009 | Pubmed ID: 19724003 Progress and Future Challenges in Stem Cell-derived Liver Technologies American Journal of Physiology. Gastrointestinal and Liver Physiology. Aug, 2009 | Pubmed ID: 19520740 Side Population Cells in Developing Human Liver Are Primarily Haematopoietic Progenitor Cells Experimental Cell Research. Aug, 2009 | Pubmed ID: 19233167 Highly Efficient Differentiation of HESCs to Functional Hepatic Endoderm Requires ActivinA and Wnt3a Signaling Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18719101 The Inhibitory Role of Stromal Cell Mesenchyme on Human Embryonic Stem Cell Hepatocyte Differentiation is Overcome by Wnt3a Treatment Cloning and Stem Cells. Sep, 2008 | Pubmed ID: 18479212 Efficient Differentiation of Hepatocytes from Human Embryonic Stem Cells Exhibiting Markers Recapitulating Liver Development in Vivo Stem Cells (Dayton, Ohio). Apr, 2008 | Pubmed ID: 18238852 Progenitor Cell Characterization and Location in the Developing Human Liver Stem Cells and Development. Oct, 2007 | Pubmed ID: 17999598 Direct Differentiation of Human Embryonic Stem Cells to Hepatocyte-like Cells Exhibiting Functional Activities Cloning and Stem Cells. 2007 | Pubmed ID: 17386014 Oct-4 Knockdown Induces Similar Patterns of Endoderm and Trophoblast Differentiation Markers in Human and Mouse Embryonic Stem Cells Stem Cells (Dayton, Ohio). 2004 | Pubmed ID: 14990861 Activation of NF-kappaB Nuclear Transcription Factor by Flow in Human Endothelial Cells Biochimica Et Biophysica Acta. Sep, 2003 | Pubmed ID: 12972291 Multiomics Analyses of HNF4α Protein Domain Function During Human Pluripotent Stem Cell Differentiation IScience. | Pubmed ID: 31185456 The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response Via Caveolae Current Biology : CB. | Pubmed ID: 30595521 Спецификация печеночного прародителя из плюрипотентных стволовых клеток с использованием определенной системы дифференцировки Jose Meseguer-Ripolles1, Yu Wang1, Agnes Sorteberg1, Aishwariya Sharma2, Nan-Linda Ding2, Baltasar Lucendo-Villarin1, Philipp Kramer2, Charis-Patricia Segeritz2, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh, 2Research & Development, STEMCELL Technologies Inc JoVE 61256 Biology Введение точечных мутаций в плюрипотентные стволовые клетки человека с помощью бесшовного редактирования генома Yu Wang1, Andrew J. H. Smith1, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh JoVE 61152 Genetics Сыворотка Бесплатное производство трехмерных человеческих гепатосфер из плюрипотентных стволовых клеток Balta Lucendo-Villarin1, Hassan Rashidi1,2, Sharmin Alhaque1,3, Lena Fischer1,4, Jose Meseguer-Ripolles1, Yu Wang1, Cliona O'Farrelly4, Michael Themis3, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh, 2UCL Great Ormond Street Institute of Child Health, University College London, 3Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, 4School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin JoVE 59965 Developmental Biology
Спецификация печеночного прародителя из плюрипотентных стволовых клеток с использованием определенной системы дифференцировки Jose Meseguer-Ripolles1, Yu Wang1, Agnes Sorteberg1, Aishwariya Sharma2, Nan-Linda Ding2, Baltasar Lucendo-Villarin1, Philipp Kramer2, Charis-Patricia Segeritz2, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh, 2Research & Development, STEMCELL Technologies Inc JoVE 61256 Biology
Введение точечных мутаций в плюрипотентные стволовые клетки человека с помощью бесшовного редактирования генома Yu Wang1, Andrew J. H. Smith1, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh JoVE 61152 Genetics
Сыворотка Бесплатное производство трехмерных человеческих гепатосфер из плюрипотентных стволовых клеток Balta Lucendo-Villarin1, Hassan Rashidi1,2, Sharmin Alhaque1,3, Lena Fischer1,4, Jose Meseguer-Ripolles1, Yu Wang1, Cliona O'Farrelly4, Michael Themis3, David C. Hay1 1MRC Centre for Regenerative Medicine, University of Edinburgh, 2UCL Great Ormond Street Institute of Child Health, University College London, 3Division of Biosciences, Department of Life Sciences, College of Health and Life Sciences, Brunel University London, 4School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin JoVE 59965 Developmental Biology
