David J. Baylink

Publications

• Unique Anabolic Action of Stem Cell Gene Therapy Overexpressing PDGFB-DSS6 Fusion Protein in OVX Osteoporosis Mouse Model
  Bone Reports. Jun, 2020  |   Pubmed ID: 31886323
• Mechanistic Study of the Cause of Decreased Blood 1,25-Dihydroxyvitamin D in Sepsis
  BMC Infectious Diseases. Dec, 2019  |   Pubmed ID: 31791247
• Towards Clinical Translation of CD8 Regulatory T Cells Restricted by Non-Classical Major Histocompatibility Complex Ib Molecules
  International Journal of Molecular Sciences. Sep, 2019  |   Pubmed ID: 31569411
• Cyclooxygenase 2 Augments Osteoblastic but Suppresses Chondrocytic Differentiation of CD90 Skeletal Stem Cells in Fracture Sites
  Science Advances. 07, 2019  |   Pubmed ID: 31392271
• In Vivo Generation of Gut-Homing Regulatory T Cells for the Suppression of Colitis
  Journal of Immunology (Baltimore, Md. : 1950). Jun, 2019  |   Pubmed ID: 31053627
• 1,25-Dihydroxyvitamin D Suppresses M1 Macrophages and Promotes M2 Differentiation at Bone Injury Sites
  JCI Insight. 09, 2018  |   Pubmed ID: 30185660
• Detection of Dinitrosyl Iron Complexes by Ozone-based Chemiluminescence
  Nitric Oxide : Biology and Chemistry. 09, 2018  |   Pubmed ID: 30059767
• Deficient Arginase II Expression Without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice
  Immunology. 09, 2018  |   Pubmed ID: 29574762
• Dendritic Cells, Engineered to Overexpress 25-hydroxyvitamin D 1α-hydroxylase and Pulsed with a Myelin Antigen, Provide Myelin-specific Suppression of Ongoing Experimental Allergic Encephalomyelitis
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jul, 2017  |   Pubmed ID: 28363955
• Unique Regenerative Mechanism to Replace Bone Lost During Dietary Bone Depletion in Weanling Mice
  Endocrinology. 04, 2017  |   Pubmed ID: 28324039
• Effect of Aging on Stem Cells
  World Journal of Experimental Medicine. Feb, 2017  |   Pubmed ID: 28261550
• Application of Vitamin D and Vitamin D Analogs in Acute Myelogenous Leukemia
  Experimental Hematology. Feb, 2017  |   Pubmed ID: 28174131
• Targeting Non-classical Myelin Epitopes to Treat Experimental Autoimmune Encephalomyelitis
  Scientific Reports. Oct, 2016  |   Pubmed ID: 27796368
• Conditional Deletion of IGF-I in Osteocytes Unexpectedly Accelerates Bony Union of the Fracture Gap in Mice
  Bone. Nov, 2016  |   Pubmed ID: 27519969
• Vitamin D Status and Metabolism in an Ovine Pregnancy Model: Effect of Long-term, High-altitude Hypoxia
  American Journal of Physiology. Endocrinology and Metabolism. Jun, 2016  |   Pubmed ID: 27143557
• MicroRNA223 Promotes Pathogenic T-cell Development and Autoimmune Inflammation in Central Nervous System in Mice
  Immunology. Aug, 2016  |   Pubmed ID: 27083389
• Generation of Mesenchymal Stem Cells by Blood Cell Reprogramming
  Current Stem Cell Research & Therapy. 2016  |   Pubmed ID: 26027679
• Patient-specific Cardiovascular Progenitor Cells Derived from Integration-free Induced Pluripotent Stem Cells for Vascular Tissue Regeneration
  Biomaterials. Dec, 2015  |   Pubmed ID: 26398309
• PDGFB-based Stem Cell Gene Therapy Increases Bone Strength in the Mouse
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015  |   Pubmed ID: 26150503
• Osteocyte-derived Insulin-like Growth Factor I is Not Essential for the Bone Repletion Response in Mice
  PloS One. 2015  |   Pubmed ID: 25635763
• Targeted 25-hydroxyvitamin D3 1α-hydroxylase Adoptive Gene Therapy Ameliorates Dss-induced Colitis Without Causing Hypercalcemia in Mice
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2015  |   Pubmed ID: 25327179
• Role of Osteocyte-derived Insulin-Like Growth Factor I in Developmental Growth, Modeling, Remodeling, and Regeneration of the Bone
  Journal of Bone Metabolism. Feb, 2014  |   Pubmed ID: 24707466
• ENU Mutation Mapped to a Distal Region of Chromosome 11 is a Major Determinant of Bone Size
  Physiological Genomics. Dec, 2013  |   Pubmed ID: 24151243
• Osteocyte-derived Insulin-like Growth Factor I is Essential for Determining Bone Mechanosensitivity
  American Journal of Physiology. Endocrinology and Metabolism. Jul, 2013  |   Pubmed ID: 23715728
• Efficient Generation of Integration-free Ips Cells from Human Adult Peripheral Blood Using BCL-XL Together with Yamanaka Factors
  PloS One. 2013  |   Pubmed ID: 23704989
• 1,25-Dihydroxyvitamin D3 Suppresses TLR8 Expression and TLR8-mediated Inflammatory Responses in Monocytes in Vitro and Experimental Autoimmune Encephalomyelitis in Vivo
  PloS One. 2013  |   Pubmed ID: 23516559
• Rapid and Efficient Reprogramming of Human Fetal and Adult Blood CD34+ Cells into Mesenchymal Stem Cells with a Single Factor
  Cell Research. May, 2013  |   Pubmed ID: 23478301
• Les Mécanismes Cellulaires Et Moléculaires De La Guérison Des Fractures Accélérée Par Thérapie Génique COX2 : études Dans Un Modèle Murin De Fractures Multiples
  Bone. Jan, 2013  |   Pubmed ID: 23314071
• Disruption of the Insulin-like Growth Factor-1 Gene in Osteocytes Impairs Developmental Bone Growth in Mice
  Bone. Jan, 2013  |   Pubmed ID: 23032105
• Transgenic Overexpression of Pregnancy-associated Plasma Protein-A in Skeletal Muscle of Mice Increases Myofiber Size and Central Nucleation in Sedentary Muscle and Promotes Muscle Regeneration in the Injured Muscle
  Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society. Oct, 2012  |   Pubmed ID: 22709655
• Erythroid Promoter Confines FGF2 Expression to the Marrow After Hematopoietic Stem Cell Gene Therapy and Leads to Enhanced Endosteal Bone Formation
  PloS One. 2012  |   Pubmed ID: 22629419
• Targeted Overexpression of Osteoactivin in Cells of Osteoclastic Lineage Promotes Osteoclastic Resorption and Bone Loss in Mice
  PloS One. 2012  |   Pubmed ID: 22536365
• Efficace Reprogrammation De Cellules CD34(+) De Sang De Cordon Humain Dans Les Cellules Des Souches Pluripotentes Induites Et OCT4, SOX2 Seul
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2012  |   Pubmed ID: 22108860
• Leptin Receptor (Lepr) is a Negative Modulator of Bone Mechanosensitivity and Genetic Variations in Lepr May Contribute to the Differential Osteogenic Response to Mechanical Stimulation in the C57BL/6J and C3H/HeJ Pair of Mouse Strains
  The Journal of Biological Chemistry. Nov, 2010  |   Pubmed ID: 20851886
• Prevention of Colorectal Cancer with Vitamin D
  Scandinavian Journal of Gastroenterology. Aug, 2010  |   Pubmed ID: 20367197
• Retroviral-based Gene Therapy with Cyclooxygenase-2 Promotes the Union of Bony Callus Tissues and Accelerates Fracture Healing in the Rat
  The Journal of Gene Medicine. Mar, 2008  |   Pubmed ID: 18088065
• Conditional Deletion of Insulin-like Growth Factor-I in Collagen Type 1alpha2-expressing Cells Results in Postnatal Lethality and a Dramatic Reduction in Bone Accretion
  Endocrinology. Dec, 2007  |   Pubmed ID: 17717052
• Disruption of Insulin-like Growth Factor-I Expression in Type IIalphaI Collagen-expressing Cells Reduces Bone Length and Width in Mice
  Physiological Genomics. Aug, 2007  |   Pubmed ID: 17519362
• Identification of Mouse Duffy Antigen Receptor for Chemokines (Darc) As a BMD QTL Gene
  Genome Research. May, 2007  |   Pubmed ID: 17416748
• Pregnancy-associated Plasma Protein-A Increases Osteoblast Proliferation in Vitro and Bone Formation in Vivo
  Endocrinology. Dec, 2006  |   Pubmed ID: 16946002
• Whole Genome Microarray Analysis of Growth Hormone-induced Gene Expression in Bone: T-box3, a Novel Transcription Factor, Regulates Osteoblast Proliferation
  American Journal of Physiology. Endocrinology and Metabolism. Jul, 2006  |   Pubmed ID: 16464905
• Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts As Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear
  The Journal of Biological Chemistry. Apr, 2006  |   Pubmed ID: 16461770
• Identification and Characterization of Novel IGFBP5 Interacting Protein: Evidence IGFBP5-IP is a Potential Regulator of Osteoblast Cell Proliferation
  American Journal of Physiology. Cell Physiology. Mar, 2006  |   Pubmed ID: 16269403
• Pregnancy-associated Plasma Protein-A Regulates Myoblast Proliferation and Differentiation Through an Insulin-like Growth Factor-dependent Mechanism
  The Journal of Biological Chemistry. Nov, 2005  |   Pubmed ID: 16115888
• Ras-association Domain Family 1 Protein, RASSF1C, is an IGFBP-5 Binding Partner and a Potential Regulator of Osteoblast Cell Proliferation
  Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Aug, 2005  |   Pubmed ID: 16007340
• Clinical Use of Serum and Urine Bone Markers in the Management of Osteoporosis
  Current Medical Research and Opinion. Jul, 2005  |   Pubmed ID: 16004668
• Bayesian Shrinkage Estimation of Quantitative Trait Loci Parameters
  Genetics. May, 2005  |   Pubmed ID: 15781696
• Genetic Variation in Femur Extrinsic Strength in 29 Different Inbred Strains of Mice is Dependent on Variations in Femur Cross-sectional Geometry and Bone Density
  Bone. Jan, 2005  |   Pubmed ID: 15664009
• Insulin-like Growth Factor-binding Protein-5 Induces a Gender-related Decrease in Bone Mineral Density in Transgenic Mice
  Endocrinology. Feb, 2005  |   Pubmed ID: 15550514
• The Multi-functional Role of Insulin-like Growth Factor Binding Proteins in Bone
  Pediatric Nephrology (Berlin, Germany). Mar, 2005  |   Pubmed ID: 15549410
• Extracellular Signal-regulated Kinase-1 and -2 Are Both Essential for the Shear Stress-induced Human Osteoblast Proliferation
  Bone. Aug, 2004  |   Pubmed ID: 15268905
• Progress Toward Skeletal Gene Therapy
  Critical Reviews in Eukaryotic Gene Expression. 2004  |   Pubmed ID: 15104530
• Local Ex Vivo Gene Therapy with Bone Marrow Stromal Cells Expressing Human BMP4 Promotes Endosteal Bone Formation in Mice
  The Journal of Gene Medicine. Jan, 2004  |   Pubmed ID: 14716672
• Patients with Van Buchem Disease, an Osteosclerotic Genetic Disease, Have Elevated Bone Formation Markers, Higher Bone Density, and Greater Derived Polar Moment of Inertia Than Normal
  The Journal of Clinical Endocrinology and Metabolism. Dec, 2003  |   Pubmed ID: 14671168
• Expression of a Structurally Unique Osteoclastic Protein-tyrosine Phosphatase is Driven by an Alternative Intronic, Cell Type-specific Promoter
  The Journal of Biological Chemistry. Nov, 2003  |   Pubmed ID: 12949066
• Evidence That Sensitivity to Growth Hormone (GH) is Growth Period and Tissue Type Dependent: Studies in GH-deficient Lit/lit Mice
  Endocrinology. Sep, 2003  |   Pubmed ID: 12933669
• Mapping Quantitative Trait Loci That Influence Serum Insulin-like Growth Factor Binding Protein-5 Levels in F2 Mice (MRL/MpJ X SJL/J)
  Endocrinology. Aug, 2003  |   Pubmed ID: 12865330
• In Vivo Bone Formation in Fracture Repair Induced by Direct Retroviral-based Gene Therapy with Bone Morphogenetic Protein-4
  Bone. Jun, 2003  |   Pubmed ID: 12810166
• Analytical and Clinical Evaluation of the Bio-Rad HPLC Kit for Measurement of Type I Collagen Cross Links
  Journal of Bone and Mineral Metabolism. 2003  |   Pubmed ID: 12720047
• Fluid Flow Shear Stress Stimulates Human Osteoblast Proliferation and Differentiation Through Multiple Interacting and Competing Signal Transduction Pathways
  Bone. Mar, 2003  |   Pubmed ID: 12667551
• Insulin-like Growth Factor Regulates Peak Bone Mineral Density in Mice by Both Growth Hormone-dependent and -independent Mechanisms
  Endocrinology. Mar, 2003  |   Pubmed ID: 12586770
• Quantitative Trait Loci That Harbor Genes Regulating Muscle Size in (MRL/MPJ X SJL/J) F(2) Mice
  Functional & Integrative Genomics. Aug, 2002  |   Pubmed ID: 12185459
• Quantitative Trait Loci (QTL) for Lean Body Mass and Body Length in MRL/MPJ and SJL/J F(2) Mice
  Functional & Integrative Genomics. Aug, 2002  |   Pubmed ID: 12185457
• Genetic Dissection of Femur Breaking Strength in a Large Population (MRL/MpJ X SJL/J) of F2 Mice: Single QTL Effects, Epistasis, and Pleiotropy
  Genomics. May, 2002  |   Pubmed ID: 11991724
• DNA Microarrays: Their Use and Misuse
  Microcirculation (New York, N.Y. : 1994). Jan, 2002  |   Pubmed ID: 11896556
• Development of a Synthetic Peptide-based Tartrate-resistant Acid Phosphatase Radioimmunoassay for the Measurement of Bone Resorption in Rat Serum
  Journal of Bone and Mineral Metabolism. 2002  |   Pubmed ID: 11862527
• Identification of Wound Healing/regeneration Quantitative Trait Loci (QTL) at Multiple Time Points That Explain Seventy Percent of Variance in (MRL/MpJ and SJL/J) Mice F2 Population
  Genome Research. Dec, 2001  |   Pubmed ID: 11731492
• Evidence That IGF-binding Protein-5 Functions As a Growth Factor
  The Journal of Clinical Investigation. Jan, 2001  |   Pubmed ID: 11134182
• Estrogen Receptor Specificity in the Regulation of Skeletal Growth and Maturation in Male Mice
  Proceedings of the National Academy of Sciences of the United States of America. May, 2000  |   Pubmed ID: 10805804