David G. Harrison Department of Medicine, Division of Cardiology Emory University Biography Publications Institution JoVE Articles David G. Harrison has not added a biography. If you are David G. Harrison and would like to personalize this page please email our Author Liaison for assistance. Publications What Fans the Fire: Insights into Mechanisms of Inflammation in Atherosclerosis and Diabetes Mellitus Circulation. Dec, 2011 | Pubmed ID: 22184043 Requirement of Argininosuccinate Lyase for Systemic Nitric Oxide Production Nature Medicine. Dec, 2011 | Pubmed ID: 22081021 Role of Vascular Extracellular Superoxide Dismutase in Hypertension Hypertension. Aug, 2011 | Pubmed ID: 21730294 A Novel High-throughput Screening Assay for Discovery of Molecules That Increase Cellular Tetrahydrobiopterin Journal of Biomolecular Screening. Sep, 2011 | Pubmed ID: 21693765 Tetrahydrobiopterin Deficiency and Nitric Oxide Synthase Uncoupling Contribute to Atherosclerosis Induced by Disturbed Flow Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011 | Pubmed ID: 21512164 Role of Interleukin 17 in Inflammation, Atherosclerosis, and Vascular Function in Apolipoprotein E-deficient Mice Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011 | Pubmed ID: 21474820 Just Not Himself These Days: an Invitation to Submit Papers on the Topic of Inflammation and Immunity in Organ Systems Physiology and Pathophysiology American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jun, 2011 | Pubmed ID: 21474428 Localization of Culprit Lesions in Coronary Arteries of Patients with ST-segment Elevation Myocardial Infarctions: Relation to Bifurcations and Curvatures American Heart Journal. Mar, 2011 | Pubmed ID: 21392605 Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels Upon T Cell Activation The Journal of Biological Chemistry. Apr, 2011 | Pubmed ID: 21343293 The Central Nervous System and Inflammation in Hypertension Current Opinion in Pharmacology. Apr, 2011 | Pubmed ID: 21196131 Inflammation, Immunity, and Hypertension Hypertension. Feb, 2011 | Pubmed ID: 21149826 Inhibition and Genetic Ablation of the B7/CD28 T-cell Costimulation Axis Prevents Experimental Hypertension Circulation. Dec, 2010 | Pubmed ID: 21126972 Regulation of Endothelial Cell Tetrahydrobiopterin Pathophysiological and Therapeutic Implications Advances in Pharmacology (San Diego, Calif.). 2010 | Pubmed ID: 21081217 Upregulation of Nox1 in Vascular Smooth Muscle Leads to Impaired Endothelium-dependent Relaxation Via ENOS Uncoupling American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2010 | Pubmed ID: 20639222 Central and Peripheral Mechanisms of T-lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II-induced Hypertension Circulation Research. Jul, 2010 | Pubmed ID: 20558826 Protective Role of Extracellular Superoxide Dismutase in Renal Ischemia/reperfusion Injury Kidney International. Aug, 2010 | Pubmed ID: 20505656 Therapeutic Targeting of Mitochondrial Superoxide in Hypertension Circulation Research. Jul, 2010 | Pubmed ID: 20448215 Inflammatory Markers and Incident Heart Failure Risk in Older Adults: the Health ABC (Health, Aging, and Body Composition) Study Journal of the American College of Cardiology. May, 2010 | Pubmed ID: 20447537 Role of the Adaptive Immune System in Hypertension Current Opinion in Pharmacology. Apr, 2010 | Pubmed ID: 20167535 NO Solution for a Radical Problem: a TAL Story American Journal of Physiology. Renal Physiology. Apr, 2010 | Pubmed ID: 20130124 Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction Circulation. Feb, 2010 | Pubmed ID: 20083682 Interleukin 17 Promotes Angiotensin II-induced Hypertension and Vascular Dysfunction Hypertension. Feb, 2010 | Pubmed ID: 20038749 Induction of Hypertension and Peripheral Inflammation by Reduction of Extracellular Superoxide Dismutase in the Central Nervous System Hypertension. Feb, 2010 | Pubmed ID: 20008675 GTP Cyclohydrolase I Phosphorylation and Interaction with GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide Circulation Research. Feb, 2010 | Pubmed ID: 19926872 Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium The Journal of Pharmacology and Experimental Therapeutics. Nov, 2009 | Pubmed ID: 19692634 Oxidative Stress and Hypertension The Medical Clinics of North America. May, 2009 | Pubmed ID: 19427495 Blood Pressure Control: Salt Gets Under Your Skin Nature Medicine. May, 2009 | Pubmed ID: 19424204 Age-accelerated Atherosclerosis Correlates with Failure to Upregulate Antioxidant Genes Circulation Research. Mar, 2009 | Pubmed ID: 19265038 Molecular Beacons Can Assess Changes in Expression and 3'-polyadenylation of Human ENOS MRNA American Journal of Physiology. Cell Physiology. Mar, 2009 | Pubmed ID: 19109525 Regulation of T-cell Function by Endogenously Produced Angiotensin II American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Feb, 2009 | Pubmed ID: 19073907 Calcium-dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease Journal of the American College of Cardiology. Nov, 2008 | Pubmed ID: 19022160 Doubt About an Essential Role for Constitutive Nitric Oxide Synthase in Nitroglycerin-mediated Vasodilation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008 | Pubmed ID: 19020103 Is Hypertension an Immunologic Disease? Current Cardiology Reports. Nov, 2008 | Pubmed ID: 18950555 Loss of Extracellular Superoxide Dismutase Leads to Acute Lung Damage in the Presence of Ambient Air: a Potential Mechanism Underlying Adult Respiratory Distress Syndrome The American Journal of Pathology. Oct, 2008 | Pubmed ID: 18787098 Role of Menkes ATPase in Angiotensin II-induced Hypertension: a Key Modulator for Extracellular Superoxide Dismutase Function Hypertension. Nov, 2008 | Pubmed ID: 18768397 Distinct Roles of Nox1 and Nox4 in Basal and Angiotensin II-stimulated Superoxide and Hydrogen Peroxide Production Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18760347 Enhanced Hype The American Journal of Cardiology. Aug, 2008 | Pubmed ID: 18638604 Endothelial Function and Aminothiol Biomarkers of Oxidative Stress in Healthy Adults Hypertension. Jul, 2008 | Pubmed ID: 18504327 Activation of P300 Histone Acetyltransferase Activity is an Early Endothelial Response to Laminar Shear Stress and is Essential for Stimulation of Endothelial Nitric-oxide Synthase MRNA Transcription The Journal of Biological Chemistry. Jun, 2008 | Pubmed ID: 18397880 Molecular Mechanisms of Angiotensin II-mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction Circulation Research. Feb, 2008 | Pubmed ID: 18096818 Sad Heart from No SOD Hypertension. Jan, 2008 | Pubmed ID: 18025292 Oxidative Stress and Hypertension Journal of the American Society of Hypertension : JASH. Jan-Feb, 2007 | Pubmed ID: 20409831 Detection of Reactive Oxygen Species and Nitric Oxide in Vascular Cells and Tissues: Comparison of Sensitivity and Specificity Methods in Molecular Medicine. 2007 | Pubmed ID: 18287681 Role of the T Cell in the Genesis of Angiotensin II Induced Hypertension and Vascular Dysfunction The Journal of Experimental Medicine. Oct, 2007 | Pubmed ID: 17875676 Regulation of Tetrahydrobiopterin Biosynthesis by Shear Stress Circulation Research. Oct, 2007 | Pubmed ID: 17704208 Endothelial NF-kappaB As a Mediator of Kidney Damage: the Missing Link Between Systemic Vascular and Renal Disease? Circulation Research. Aug, 2007 | Pubmed ID: 17673681 Measurement of Reactive Oxygen Species in Cardiovascular Studies Hypertension. Apr, 2007 | Pubmed ID: 17296874 Role of the Multidrug Resistance Protein-1 in Hypertension and Vascular Dysfunction Caused by Angiotensin II Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2007 | Pubmed ID: 17272743 Reactive Oxygen Species-selective Regulation of Aortic Inflammatory Gene Expression in Type 2 Diabetes American Journal of Physiology. Heart and Circulatory Physiology. May, 2007 | Pubmed ID: 17237245 Angiotensinergic Stimulation of Vascular Endothelium in Mice Causes Hypotension, Bradycardia, and Attenuated Angiotensin Response Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17148616 Early Determinants of H2O2-induced Endothelial Dysfunction Free Radical Biology & Medicine. Sep, 2006 | Pubmed ID: 16895801 Role of Extracellular Superoxide Dismutase in Hypertension Hypertension. Sep, 2006 | Pubmed ID: 16864745 Bone Morphogenic Protein-4 Induces Hypertension in Mice: Role of Noggin, Vascular NADPH Oxidases, and Impaired Vasorelaxation Circulation. Jun, 2006 | Pubmed ID: 16769910 Vascular NADPH Oxidases As Drug Targets for Novel Antioxidant Strategies Drug Discovery Today. Jun, 2006 | Pubmed ID: 16713904 The Relationship Between Plasma Levels of Oxidized and Reduced Thiols and Early Atherosclerosis in Healthy Adults Journal of the American College of Cardiology. Mar, 2006 | Pubmed ID: 16516085 RNA Silencing in Vivo Reveals Role of P22phox in Rat Angiotensin Slow Pressor Response Hypertension. Feb, 2006 | Pubmed ID: 16391171 Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2006 | Pubmed ID: 16293794 Can Vitamin E Prevent Cardiovascular Events and Cancer? Nature Clinical Practice. Cardiovascular Medicine. Oct, 2005 | Pubmed ID: 16186847 Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage: Role of the NADPH and Xanthine Oxidases Circulation. Aug, 2005 | Pubmed ID: 16129811 The Role of the Multidrug Resistance Protein-1 in Modulation of Endothelial Cell Oxidative Stress Circulation Research. Sep, 2005 | Pubmed ID: 16123331 A Negative Feedback Mechanism Involving Nitric Oxide and Nuclear Factor Kappa-B Modulates Endothelial Nitric Oxide Synthase Transcription Journal of Molecular and Cellular Cardiology. Oct, 2005 | Pubmed ID: 16099468 Interactions of Peroxynitrite with Uric Acid in the Presence of Ascorbate and Thiols: Implications for Uncoupling Endothelial Nitric Oxide Synthase Biochemical Pharmacology. Aug, 2005 | Pubmed ID: 15963955 Regulation of Xanthine Oxidoreductase Protein Expression by Hydrogen Peroxide and Calcium Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2005 | Pubmed ID: 15905466 Laminar Shear Stress and 3' Polyadenylation of ENOS MRNA Circulation Research. Jun, 2005 | Pubmed ID: 15905462 The Shear Stress of Keeping Arteries Clear Nature Medicine. Apr, 2005 | Pubmed ID: 15812513 Role of Antioxidant-1 in Extracellular Superoxide Dismutase Function and Expression Circulation Research. Apr, 2005 | Pubmed ID: 15761197 Critical Involvement of Hydrogen Peroxide in Exercise-induced Up-regulation of Endothelial NO Synthase Cardiovascular Research. Jan, 2005 | Pubmed ID: 15621054 Association Between Novel Oxidative Stress Markers and C-reactive Protein Among Adults Without Clinical Coronary Heart Disease Atherosclerosis. Jan, 2005 | Pubmed ID: 15585208 ATVB in Focus: Redox Mechanisms in Blood Vessels Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2005 | Pubmed ID: 15514203 Hemodynamic and Biochemical Adaptations to Vascular Smooth Muscle Overexpression of P22phox in Mice American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2005 | Pubmed ID: 15471976 Angiotensin II-induced Hypertrophy is Potentiated in Mice Overexpressing P22phox in Vascular Smooth Muscle American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2005 | Pubmed ID: 15345488 Detection of Intracellular Superoxide Formation in Endothelial Cells and Intact Tissues Using Dihydroethidium and an HPLC-based Assay American Journal of Physiology. Cell Physiology. Oct, 2004 | Pubmed ID: 15306539 Oxidative Stress and Diabetic Vascular Complications Current Diabetes Reports. Aug, 2004 | Pubmed ID: 15265465 Oscillatory Shear Stress Upregulation of Endothelial Nitric Oxide Synthase Requires Intracellular Hydrogen Peroxide and CaMKII Journal of Molecular and Cellular Cardiology. Jul, 2004 | Pubmed ID: 15242742 Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events Circulation. Jun, 2004 | Pubmed ID: 15226246 C242T CYBA Polymorphism of the NADPH Oxidase is Associated with Reduced Respiratory Burst in Human Neutrophils Hypertension. Jun, 2004 | Pubmed ID: 15078863 Vascular Oxidant Stress Enhances Progression and Angiogenesis of Experimental Atheroma Circulation. Feb, 2004 | Pubmed ID: 14744973 Shear Stress Regulates Endothelial Nitric-oxide Synthase Promoter Activity Through Nuclear Factor KappaB Binding The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14570928 Endothelial Control of Vasomotion and Nitric Oxide Production Cardiology Clinics. Aug, 2003 | Pubmed ID: 14621446 Endothelial NO Synthase Phosphorylated at SER635 Produces NO Without Requiring Intracellular Calcium Increase Free Radical Biology & Medicine. Oct, 2003 | Pubmed ID: 14583337 The Vascular NAD(P)H Oxidases As Therapeutic Targets in Cardiovascular Diseases Trends in Pharmacological Sciences. Sep, 2003 | Pubmed ID: 12967772 Oscillatory Shear Stress Stimulates Endothelial Production of O2- from P47phox-dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12958309 Role of Xanthine Oxidoreductase and NAD(P)H Oxidase in Endothelial Superoxide Production in Response to Oscillatory Shear Stress American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2003 | Pubmed ID: 12958034 Interactions of Angiotensin II with NAD(P)H Oxidase, Oxidant Stress and Cardiovascular Disease Journal of the Renin-angiotensin-aldosterone System : JRAAS. Jun, 2003 | Pubmed ID: 12806586 Oxidation of Tetrahydrobiopterin Leads to Uncoupling of Endothelial Cell Nitric Oxide Synthase in Hypertension The Journal of Clinical Investigation. Apr, 2003 | Pubmed ID: 12697739 Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols: Implications for Uncoupling Endothelial Nitric-oxide Synthase The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12692136 Electron Spin Resonance Characterization of Vascular Xanthine and NAD(P)H Oxidase Activity in Patients with Coronary Artery Disease: Relation to Endothelium-dependent Vasodilation Circulation. Mar, 2003 | Pubmed ID: 12642358 Role of C-Src in Regulation of Endothelial Nitric Oxide Synthase Expression During Exercise Training American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2003 | Pubmed ID: 12595302 Akt-dependent Phosphorylation of Serine 1179 and Mitogen-activated Protein Kinase Kinase/extracellular Signal-regulated Kinase 1/2 Cooperatively Mediate Activation of the Endothelial Nitric-oxide Synthase by Hydrogen Peroxide Molecular Pharmacology. Feb, 2003 | Pubmed ID: 12527803 Vascular Oxidative Stress and Endothelial Dysfunction in Patients with Chronic Heart Failure: Role of Xanthine-oxidase and Extracellular Superoxide Dismutase Circulation. Dec, 2002 | Pubmed ID: 12473554 Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation: Potential Mechanisms for Atrial Thrombosis and Stroke Circulation. Nov, 2002 | Pubmed ID: 12451014 Detection of Superoxide in Vascular Tissue Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2002 | Pubmed ID: 12426202 NAD(P)H Oxidase-derived Hydrogen Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II The Journal of Biological Chemistry. Dec, 2002 | Pubmed ID: 12377764 Role of P47(phox) in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II Hypertension. Oct, 2002 | Pubmed ID: 12364355 Peroxidase Properties of Extracellular Superoxide Dismutase: Role of Uric Acid in Modulating in Vivo Activity Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2002 | Pubmed ID: 12231557 Maintenance of a Functional Endothelial Cell Monolayer on a Fibroblast/polymer Substrate Under Physiologically Relevant Shear Stress Conditions Tissue Engineering. Aug, 2002 | Pubmed ID: 12202008 Extracellular Superoxide Dismutase and Cardiovascular Disease Cardiovascular Research. Aug, 2002 | Pubmed ID: 12123763 Free Radicals in Heart Failure: Therapeutic Targets for Old and New Drugs Congestive Heart Failure (Greenwich, Conn.). May-Jun, 2002 | Pubmed ID: 12045380 Geldanamycin Leads to Superoxide Formation by Enzymatic and Non-enzymatic Redox Cycling. Implications for Studies of Hsp90 and Endothelial Cell Nitric-oxide Synthase The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11983711 The AT(1)-type Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part II: AT(1) Receptor Regulation Circulation. Jan, 2002 | Pubmed ID: 11815439 The AT(1)-type Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part I: Oxidative Stress and Atherogenesis Circulation. Jan, 2002 | Pubmed ID: 11804998 Модель возмущенного течения индуцированного атеросклероза в сонной артерии мыши по частичному Лигирование и простой способ выделения РНК из сонной эндотелия Douglas Nam1, Chih-Wen Ni2, Amir Rezvan1, Jin Suo2, Klaudia Budzyn1, Alexander Llanos1, David G. Harrison1, Don P. Giddens2, Hanjoong Jo1,2,3 1Department of Medicine, Division of Cardiology, Emory University, 2Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, 3Department of Bioinspired Science, Ewha Womans University JoVE 1861 Medicine
Модель возмущенного течения индуцированного атеросклероза в сонной артерии мыши по частичному Лигирование и простой способ выделения РНК из сонной эндотелия Douglas Nam1, Chih-Wen Ni2, Amir Rezvan1, Jin Suo2, Klaudia Budzyn1, Alexander Llanos1, David G. Harrison1, Don P. Giddens2, Hanjoong Jo1,2,3 1Department of Medicine, Division of Cardiology, Emory University, 2Coulter Department of Biomedical Engineering, Georgia Tech and Emory University, 3Department of Bioinspired Science, Ewha Womans University JoVE 1861 Medicine