David G. Harrison

Publications

• What Fans the Fire: Insights into Mechanisms of Inflammation in Atherosclerosis and Diabetes Mellitus
  Circulation. Dec, 2011  |   Pubmed ID: 22184043
• Requirement of Argininosuccinate Lyase for Systemic Nitric Oxide Production
  Nature Medicine. Dec, 2011  |   Pubmed ID: 22081021
• Role of Vascular Extracellular Superoxide Dismutase in Hypertension
  Hypertension. Aug, 2011  |   Pubmed ID: 21730294
• A Novel High-throughput Screening Assay for Discovery of Molecules That Increase Cellular Tetrahydrobiopterin
  Journal of Biomolecular Screening. Sep, 2011  |   Pubmed ID: 21693765
• Tetrahydrobiopterin Deficiency and Nitric Oxide Synthase Uncoupling Contribute to Atherosclerosis Induced by Disturbed Flow
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011  |   Pubmed ID: 21512164
• Role of Interleukin 17 in Inflammation, Atherosclerosis, and Vascular Function in Apolipoprotein E-deficient Mice
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2011  |   Pubmed ID: 21474820
• Just Not Himself These Days: an Invitation to Submit Papers on the Topic of Inflammation and Immunity in Organ Systems Physiology and Pathophysiology
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jun, 2011  |   Pubmed ID: 21474428
• Localization of Culprit Lesions in Coronary Arteries of Patients with ST-segment Elevation Myocardial Infarctions: Relation to Bifurcations and Curvatures
  American Heart Journal. Mar, 2011  |   Pubmed ID: 21392605
• Role of Increased Guanosine Triphosphate Cyclohydrolase-1 Expression and Tetrahydrobiopterin Levels Upon T Cell Activation
  The Journal of Biological Chemistry. Apr, 2011  |   Pubmed ID: 21343293
• The Central Nervous System and Inflammation in Hypertension
  Current Opinion in Pharmacology. Apr, 2011  |   Pubmed ID: 21196131
• Inflammation, Immunity, and Hypertension
  Hypertension. Feb, 2011  |   Pubmed ID: 21149826
• Inhibition and Genetic Ablation of the B7/CD28 T-cell Costimulation Axis Prevents Experimental Hypertension
  Circulation. Dec, 2010  |   Pubmed ID: 21126972
• Regulation of Endothelial Cell Tetrahydrobiopterin Pathophysiological and Therapeutic Implications
  Advances in Pharmacology (San Diego, Calif.). 2010  |   Pubmed ID: 21081217
• Upregulation of Nox1 in Vascular Smooth Muscle Leads to Impaired Endothelium-dependent Relaxation Via ENOS Uncoupling
  American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2010  |   Pubmed ID: 20639222
• Central and Peripheral Mechanisms of T-lymphocyte Activation and Vascular Inflammation Produced by Angiotensin II-induced Hypertension
  Circulation Research. Jul, 2010  |   Pubmed ID: 20558826
• Protective Role of Extracellular Superoxide Dismutase in Renal Ischemia/reperfusion Injury
  Kidney International. Aug, 2010  |   Pubmed ID: 20505656
• Therapeutic Targeting of Mitochondrial Superoxide in Hypertension
  Circulation Research. Jul, 2010  |   Pubmed ID: 20448215
• Inflammatory Markers and Incident Heart Failure Risk in Older Adults: the Health ABC (Health, Aging, and Body Composition) Study
  Journal of the American College of Cardiology. May, 2010  |   Pubmed ID: 20447537
• Role of the Adaptive Immune System in Hypertension
  Current Opinion in Pharmacology. Apr, 2010  |   Pubmed ID: 20167535
• NO Solution for a Radical Problem: a TAL Story
  American Journal of Physiology. Renal Physiology. Apr, 2010  |   Pubmed ID: 20130124
• Uncoupled Cardiac Nitric Oxide Synthase Mediates Diastolic Dysfunction
  Circulation. Feb, 2010  |   Pubmed ID: 20083682
• Interleukin 17 Promotes Angiotensin II-induced Hypertension and Vascular Dysfunction
  Hypertension. Feb, 2010  |   Pubmed ID: 20038749
• Induction of Hypertension and Peripheral Inflammation by Reduction of Extracellular Superoxide Dismutase in the Central Nervous System
  Hypertension. Feb, 2010  |   Pubmed ID: 20008675
• GTP Cyclohydrolase I Phosphorylation and Interaction with GTP Cyclohydrolase Feedback Regulatory Protein Provide Novel Regulation of Endothelial Tetrahydrobiopterin and Nitric Oxide
  Circulation Research. Feb, 2010  |   Pubmed ID: 19926872
• Targeted Detoxification of Selected Reactive Oxygen Species in the Vascular Endothelium
  The Journal of Pharmacology and Experimental Therapeutics. Nov, 2009  |   Pubmed ID: 19692634
• Oxidative Stress and Hypertension
  The Medical Clinics of North America. May, 2009  |   Pubmed ID: 19427495
• Blood Pressure Control: Salt Gets Under Your Skin
  Nature Medicine. May, 2009  |   Pubmed ID: 19424204
• Age-accelerated Atherosclerosis Correlates with Failure to Upregulate Antioxidant Genes
  Circulation Research. Mar, 2009  |   Pubmed ID: 19265038
• Molecular Beacons Can Assess Changes in Expression and 3'-polyadenylation of Human ENOS MRNA
  American Journal of Physiology. Cell Physiology. Mar, 2009  |   Pubmed ID: 19109525
• Regulation of T-cell Function by Endogenously Produced Angiotensin II
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Feb, 2009  |   Pubmed ID: 19073907
• Calcium-dependent NOX5 Nicotinamide Adenine Dinucleotide Phosphate Oxidase Contributes to Vascular Oxidative Stress in Human Coronary Artery Disease
  Journal of the American College of Cardiology. Nov, 2008  |   Pubmed ID: 19022160
• Doubt About an Essential Role for Constitutive Nitric Oxide Synthase in Nitroglycerin-mediated Vasodilation
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2008  |   Pubmed ID: 19020103
• Is Hypertension an Immunologic Disease?
  Current Cardiology Reports. Nov, 2008  |   Pubmed ID: 18950555
• Loss of Extracellular Superoxide Dismutase Leads to Acute Lung Damage in the Presence of Ambient Air: a Potential Mechanism Underlying Adult Respiratory Distress Syndrome
  The American Journal of Pathology. Oct, 2008  |   Pubmed ID: 18787098
• Role of Menkes ATPase in Angiotensin II-induced Hypertension: a Key Modulator for Extracellular Superoxide Dismutase Function
  Hypertension. Nov, 2008  |   Pubmed ID: 18768397
• Distinct Roles of Nox1 and Nox4 in Basal and Angiotensin II-stimulated Superoxide and Hydrogen Peroxide Production
  Free Radical Biology & Medicine. Nov, 2008  |   Pubmed ID: 18760347
• Enhanced Hype
  The American Journal of Cardiology. Aug, 2008  |   Pubmed ID: 18638604
• Endothelial Function and Aminothiol Biomarkers of Oxidative Stress in Healthy Adults
  Hypertension. Jul, 2008  |   Pubmed ID: 18504327
• Activation of P300 Histone Acetyltransferase Activity is an Early Endothelial Response to Laminar Shear Stress and is Essential for Stimulation of Endothelial Nitric-oxide Synthase MRNA Transcription
  The Journal of Biological Chemistry. Jun, 2008  |   Pubmed ID: 18397880
• Molecular Mechanisms of Angiotensin II-mediated Mitochondrial Dysfunction: Linking Mitochondrial Oxidative Damage and Vascular Endothelial Dysfunction
  Circulation Research. Feb, 2008  |   Pubmed ID: 18096818
• Sad Heart from No SOD
  Hypertension. Jan, 2008  |   Pubmed ID: 18025292
• Oxidative Stress and Hypertension
  Journal of the American Society of Hypertension : JASH. Jan-Feb, 2007  |   Pubmed ID: 20409831
• Detection of Reactive Oxygen Species and Nitric Oxide in Vascular Cells and Tissues: Comparison of Sensitivity and Specificity
  Methods in Molecular Medicine. 2007  |   Pubmed ID: 18287681
• Role of the T Cell in the Genesis of Angiotensin II Induced Hypertension and Vascular Dysfunction
  The Journal of Experimental Medicine. Oct, 2007  |   Pubmed ID: 17875676
• Regulation of Tetrahydrobiopterin Biosynthesis by Shear Stress
  Circulation Research. Oct, 2007  |   Pubmed ID: 17704208
• Endothelial NF-kappaB As a Mediator of Kidney Damage: the Missing Link Between Systemic Vascular and Renal Disease?
  Circulation Research. Aug, 2007  |   Pubmed ID: 17673681
• Measurement of Reactive Oxygen Species in Cardiovascular Studies
  Hypertension. Apr, 2007  |   Pubmed ID: 17296874
• Role of the Multidrug Resistance Protein-1 in Hypertension and Vascular Dysfunction Caused by Angiotensin II
  Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2007  |   Pubmed ID: 17272743
• Reactive Oxygen Species-selective Regulation of Aortic Inflammatory Gene Expression in Type 2 Diabetes
  American Journal of Physiology. Heart and Circulatory Physiology. May, 2007  |   Pubmed ID: 17237245
• Angiotensinergic Stimulation of Vascular Endothelium in Mice Causes Hypotension, Bradycardia, and Attenuated Angiotensin Response
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006  |   Pubmed ID: 17148616
• Early Determinants of H2O2-induced Endothelial Dysfunction
  Free Radical Biology & Medicine. Sep, 2006  |   Pubmed ID: 16895801
• Role of Extracellular Superoxide Dismutase in Hypertension
  Hypertension. Sep, 2006  |   Pubmed ID: 16864745
• Bone Morphogenic Protein-4 Induces Hypertension in Mice: Role of Noggin, Vascular NADPH Oxidases, and Impaired Vasorelaxation
  Circulation. Jun, 2006  |   Pubmed ID: 16769910
• Vascular NADPH Oxidases As Drug Targets for Novel Antioxidant Strategies
  Drug Discovery Today. Jun, 2006  |   Pubmed ID: 16713904
• The Relationship Between Plasma Levels of Oxidized and Reduced Thiols and Early Atherosclerosis in Healthy Adults
  Journal of the American College of Cardiology. Mar, 2006  |   Pubmed ID: 16516085
• RNA Silencing in Vivo Reveals Role of P22phox in Rat Angiotensin Slow Pressor Response
  Hypertension. Feb, 2006  |   Pubmed ID: 16391171
• Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease
  Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2006  |   Pubmed ID: 16293794
• Can Vitamin E Prevent Cardiovascular Events and Cancer?
  Nature Clinical Practice. Cardiovascular Medicine. Oct, 2005  |   Pubmed ID: 16186847
• Atrial Fibrillation Increases Production of Superoxide by the Left Atrium and Left Atrial Appendage: Role of the NADPH and Xanthine Oxidases
  Circulation. Aug, 2005  |   Pubmed ID: 16129811
• The Role of the Multidrug Resistance Protein-1 in Modulation of Endothelial Cell Oxidative Stress
  Circulation Research. Sep, 2005  |   Pubmed ID: 16123331
• A Negative Feedback Mechanism Involving Nitric Oxide and Nuclear Factor Kappa-B Modulates Endothelial Nitric Oxide Synthase Transcription
  Journal of Molecular and Cellular Cardiology. Oct, 2005  |   Pubmed ID: 16099468
• Interactions of Peroxynitrite with Uric Acid in the Presence of Ascorbate and Thiols: Implications for Uncoupling Endothelial Nitric Oxide Synthase
  Biochemical Pharmacology. Aug, 2005  |   Pubmed ID: 15963955
• Regulation of Xanthine Oxidoreductase Protein Expression by Hydrogen Peroxide and Calcium
  Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2005  |   Pubmed ID: 15905466
• Laminar Shear Stress and 3' Polyadenylation of ENOS MRNA
  Circulation Research. Jun, 2005  |   Pubmed ID: 15905462
• The Shear Stress of Keeping Arteries Clear
  Nature Medicine. Apr, 2005  |   Pubmed ID: 15812513
• Role of Antioxidant-1 in Extracellular Superoxide Dismutase Function and Expression
  Circulation Research. Apr, 2005  |   Pubmed ID: 15761197
• Critical Involvement of Hydrogen Peroxide in Exercise-induced Up-regulation of Endothelial NO Synthase
  Cardiovascular Research. Jan, 2005  |   Pubmed ID: 15621054
• Association Between Novel Oxidative Stress Markers and C-reactive Protein Among Adults Without Clinical Coronary Heart Disease
  Atherosclerosis. Jan, 2005  |   Pubmed ID: 15585208
• ATVB in Focus: Redox Mechanisms in Blood Vessels
  Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2005  |   Pubmed ID: 15514203
• Hemodynamic and Biochemical Adaptations to Vascular Smooth Muscle Overexpression of P22phox in Mice
  American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2005  |   Pubmed ID: 15471976
• Angiotensin II-induced Hypertrophy is Potentiated in Mice Overexpressing P22phox in Vascular Smooth Muscle
  American Journal of Physiology. Heart and Circulatory Physiology. Jan, 2005  |   Pubmed ID: 15345488
• Detection of Intracellular Superoxide Formation in Endothelial Cells and Intact Tissues Using Dihydroethidium and an HPLC-based Assay
  American Journal of Physiology. Cell Physiology. Oct, 2004  |   Pubmed ID: 15306539
• Oxidative Stress and Diabetic Vascular Complications
  Current Diabetes Reports. Aug, 2004  |   Pubmed ID: 15265465
• Oscillatory Shear Stress Upregulation of Endothelial Nitric Oxide Synthase Requires Intracellular Hydrogen Peroxide and CaMKII
  Journal of Molecular and Cellular Cardiology. Jul, 2004  |   Pubmed ID: 15242742
• Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events
  Circulation. Jun, 2004  |   Pubmed ID: 15226246
• C242T CYBA Polymorphism of the NADPH Oxidase is Associated with Reduced Respiratory Burst in Human Neutrophils
  Hypertension. Jun, 2004  |   Pubmed ID: 15078863
• Vascular Oxidant Stress Enhances Progression and Angiogenesis of Experimental Atheroma
  Circulation. Feb, 2004  |   Pubmed ID: 14744973
• Shear Stress Regulates Endothelial Nitric-oxide Synthase Promoter Activity Through Nuclear Factor KappaB Binding
  The Journal of Biological Chemistry. Jan, 2004  |   Pubmed ID: 14570928
• Endothelial Control of Vasomotion and Nitric Oxide Production
  Cardiology Clinics. Aug, 2003  |   Pubmed ID: 14621446
• Endothelial NO Synthase Phosphorylated at SER635 Produces NO Without Requiring Intracellular Calcium Increase
  Free Radical Biology & Medicine. Oct, 2003  |   Pubmed ID: 14583337
• The Vascular NAD(P)H Oxidases As Therapeutic Targets in Cardiovascular Diseases
  Trends in Pharmacological Sciences. Sep, 2003  |   Pubmed ID: 12967772
• Oscillatory Shear Stress Stimulates Endothelial Production of O2- from P47phox-dependent NAD(P)H Oxidases, Leading to Monocyte Adhesion
  The Journal of Biological Chemistry. Nov, 2003  |   Pubmed ID: 12958309
• Role of Xanthine Oxidoreductase and NAD(P)H Oxidase in Endothelial Superoxide Production in Response to Oscillatory Shear Stress
  American Journal of Physiology. Heart and Circulatory Physiology. Dec, 2003  |   Pubmed ID: 12958034
• Interactions of Angiotensin II with NAD(P)H Oxidase, Oxidant Stress and Cardiovascular Disease
  Journal of the Renin-angiotensin-aldosterone System : JRAAS. Jun, 2003  |   Pubmed ID: 12806586
• Oxidation of Tetrahydrobiopterin Leads to Uncoupling of Endothelial Cell Nitric Oxide Synthase in Hypertension
  The Journal of Clinical Investigation. Apr, 2003  |   Pubmed ID: 12697739
• Interactions of Peroxynitrite, Tetrahydrobiopterin, Ascorbic Acid, and Thiols: Implications for Uncoupling Endothelial Nitric-oxide Synthase
  The Journal of Biological Chemistry. Jun, 2003  |   Pubmed ID: 12692136
• Electron Spin Resonance Characterization of Vascular Xanthine and NAD(P)H Oxidase Activity in Patients with Coronary Artery Disease: Relation to Endothelium-dependent Vasodilation
  Circulation. Mar, 2003  |   Pubmed ID: 12642358
• Role of C-Src in Regulation of Endothelial Nitric Oxide Synthase Expression During Exercise Training
  American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2003  |   Pubmed ID: 12595302
• Akt-dependent Phosphorylation of Serine 1179 and Mitogen-activated Protein Kinase Kinase/extracellular Signal-regulated Kinase 1/2 Cooperatively Mediate Activation of the Endothelial Nitric-oxide Synthase by Hydrogen Peroxide
  Molecular Pharmacology. Feb, 2003  |   Pubmed ID: 12527803
• Vascular Oxidative Stress and Endothelial Dysfunction in Patients with Chronic Heart Failure: Role of Xanthine-oxidase and Extracellular Superoxide Dismutase
  Circulation. Dec, 2002  |   Pubmed ID: 12473554
• Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation: Potential Mechanisms for Atrial Thrombosis and Stroke
  Circulation. Nov, 2002  |   Pubmed ID: 12451014
• Detection of Superoxide in Vascular Tissue
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2002  |   Pubmed ID: 12426202
• NAD(P)H Oxidase-derived Hydrogen Peroxide Mediates Endothelial Nitric Oxide Production in Response to Angiotensin II
  The Journal of Biological Chemistry. Dec, 2002  |   Pubmed ID: 12377764
• Role of P47(phox) in Vascular Oxidative Stress and Hypertension Caused by Angiotensin II
  Hypertension. Oct, 2002  |   Pubmed ID: 12364355
• Peroxidase Properties of Extracellular Superoxide Dismutase: Role of Uric Acid in Modulating in Vivo Activity
  Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2002  |   Pubmed ID: 12231557
• Maintenance of a Functional Endothelial Cell Monolayer on a Fibroblast/polymer Substrate Under Physiologically Relevant Shear Stress Conditions
  Tissue Engineering. Aug, 2002  |   Pubmed ID: 12202008
• Extracellular Superoxide Dismutase and Cardiovascular Disease
  Cardiovascular Research. Aug, 2002  |   Pubmed ID: 12123763
• Free Radicals in Heart Failure: Therapeutic Targets for Old and New Drugs
  Congestive Heart Failure (Greenwich, Conn.). May-Jun, 2002  |   Pubmed ID: 12045380
• Geldanamycin Leads to Superoxide Formation by Enzymatic and Non-enzymatic Redox Cycling. Implications for Studies of Hsp90 and Endothelial Cell Nitric-oxide Synthase
  The Journal of Biological Chemistry. Jul, 2002  |   Pubmed ID: 11983711
• The AT(1)-type Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part II: AT(1) Receptor Regulation
  Circulation. Jan, 2002  |   Pubmed ID: 11815439
• The AT(1)-type Angiotensin Receptor in Oxidative Stress and Atherogenesis: Part I: Oxidative Stress and Atherogenesis
  Circulation. Jan, 2002  |   Pubmed ID: 11804998