David G. Nicholls Biography Publications JoVE Articles David G. Nicholls has not added a biography. If you are David G. Nicholls and would like to personalize this page please email our Author Liaison for assistance. Publications Fluorescence Measurement of Mitochondrial Membrane Potential Changes in Cultured Cells Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22057564 Assessing Mitochondrial Dysfunction in Cells The Biochemical Journal. Apr, 2011 | Pubmed ID: 21726199 Intrinsic Bioenergetic Properties and Stress Sensitivity of Dopaminergic Synaptosomes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2011 | Pubmed ID: 21430153 Mitochondrial Ion Circuits Essays in Biochemistry. 2010 | Pubmed ID: 20533898 Stochastic Aspects of Transmitter Release and Bioenergetic Dysfunction in Isolated Nerve Terminals Biochemical Society Transactions. Apr, 2010 | Pubmed ID: 20298202 Spare Respiratory Capacity, Oxidative Stress and Excitotoxicity Biochemical Society Transactions. Dec, 2009 | Pubmed ID: 19909281 Tight Coupling Between Glucose and Mitochondrial Metabolism in Clonal Beta-cells is Required for Robust Insulin Secretion The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19797055 Quantitative Microplate-based Respirometry with Correction for Oxygen Diffusion Analytical Chemistry. Aug, 2009 | Pubmed ID: 19555051 Metabolic Control Analysis in a Cellular Model of Elevated MAO-B: Relevance to Parkinson's Disease Neurotoxicity Research. Oct, 2009 | Pubmed ID: 19526285 Bioenergetic Analysis of Isolated Cerebrocortical Nerve Terminals on a Microgram Scale: Spare Respiratory Capacity and Stochastic Mitochondrial Failure Journal of Neurochemistry. May, 2009 | Pubmed ID: 19519782 Real-time Visualization of Cytoplasmic Calpain Activation and Calcium Deregulation in Acute Glutamate Excitotoxicity Journal of Neurochemistry. Aug, 2009 | Pubmed ID: 19493161 Mitochondrial Calcium Function and Dysfunction in the Central Nervous System Biochimica Et Biophysica Acta. Nov, 2009 | Pubmed ID: 19298790 Reactive Oxygen Species Regulation by AIF- and Complex I-depleted Brain Mitochondria Free Radical Biology & Medicine. Apr, 2009 | Pubmed ID: 19280713 Effects of Neuroglobin Overexpression on Mitochondrial Function and Oxidative Stress Following Hypoxia/reoxygenation in Cultured Neurons Journal of Neuroscience Research. Jan, 2009 | Pubmed ID: 18711728 Oxidative Stress and Energy Crises in Neuronal Dysfunction Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19076430 UCPs--unlikely Calcium Porters Nature Cell Biology. Nov, 2008 | Pubmed ID: 18978830 Measurement of Instantaneous Velocity Vectors of Organelle Transport: Mitochondrial Transport and Bioenergetics in Hippocampal Neurons Biophysical Journal. Sep, 2008 | Pubmed ID: 18757564 Forty Years of Mitchell's Proton Circuit: From Little Grey Books to Little Grey Cells Biochimica Et Biophysica Acta. Jul-Aug, 2008 | Pubmed ID: 18423395 MAO-B Elevation in Mouse Brain Astrocytes Results in Parkinson's Pathology PloS One. 2008 | Pubmed ID: 18286173 Experimental Assessment of Bioenergetic Differences Caused by the Common European Mitochondrial DNA Haplogroups H and T Gene. Mar, 2008 | Pubmed ID: 18280061 Inducible Alterations of Glutathione Levels in Adult Dopaminergic Midbrain Neurons Result in Nigrostriatal Degeneration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2007 | Pubmed ID: 18094238 Mitochondrial and Plasma Membrane Potential of Cultured Cerebellar Neurons During Glutamate-induced Necrosis, Apoptosis, and Tolerance The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2007 | Pubmed ID: 17670970 Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity After Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2007 | Pubmed ID: 17611283 Bioenergetics of Mitochondria in Cultured Neurons and Their Role in Glutamate Excitotoxicity Journal of Neuroscience Research. Nov, 2007 | Pubmed ID: 17455297 Mitochondrial Dysfunction in Huntington's Disease: the Bioenergetics of Isolated and in Situ Mitochondria from Transgenic Mice Journal of Neurochemistry. Apr, 2007 | Pubmed ID: 17394466 Mitochondrial-dependent Ca2+ Handling in Huntington's Disease Striatal Cells: Effect of Histone Deacetylase Inhibitors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2006 | Pubmed ID: 17065457 The Physiological Regulation of Uncoupling Proteins Biochimica Et Biophysica Acta. May-Jun, 2006 | Pubmed ID: 16725104 Simultaneous Monitoring of Ionophore- and Inhibitor-mediated Plasma and Mitochondrial Membrane Potential Changes in Cultured Neurons The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16551630 Commentary On: 'old and New Data, New Issues: the Mitochondrial Deltapsi' by H. Tedeschi Biochimica Et Biophysica Acta. Dec, 2005 | Pubmed ID: 16242663 Acute Glutathione Depletion Restricts Mitochondrial ATP Export in Cerebellar Granule Neurons The Journal of Biological Chemistry. Nov, 2005 | Pubmed ID: 16172117 Mitochondria and Calcium Signaling Cell Calcium. Sep-Oct, 2005 | Pubmed ID: 16087232 Calpain I Induces Cleavage and Release of Apoptosis-inducing Factor from Isolated Mitochondria The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15590628 The Integration of Mitochondrial Calcium Transport and Storage Journal of Bioenergetics and Biomembranes. Aug, 2004 | Pubmed ID: 15377857 Relationships Between Superoxide Levels and Delayed Calcium Deregulation in Cultured Cerebellar Granule Cells Exposed Continuously to Glutamate Journal of Neurochemistry. Aug, 2004 | Pubmed ID: 15255947 In Situ Respiration and Bioenergetic Status of Mitochondria in Primary Cerebellar Granule Neuronal Cultures Exposed Continuously to Glutamate The Journal of Biological Chemistry. Jul, 2004 | Pubmed ID: 15166243 Mitochondrial Membrane Potential and Aging Aging Cell. Feb, 2004 | Pubmed ID: 14965354 Bioenergetics and Transmitter Release in the Isolated Nerve Terminal Neurochemical Research. Oct, 2003 | Pubmed ID: 14570388 Oxidative Alpha-ketoglutarate Dehydrogenase Inhibition Via Subtle Elevations in Monoamine Oxidase B Levels Results in Loss of Spare Respiratory Capacity: Implications for Parkinson's Disease The Journal of Biological Chemistry. Nov, 2003 | Pubmed ID: 12963742 Interactions Between Mitochondrial Bioenergetics and Cytoplasmic Calcium in Cultured Cerebellar Granule Cells Cell Calcium. Oct-Nov, 2003 | Pubmed ID: 12909085 The Relationship Between Free and Total Calcium Concentrations in the Matrix of Liver and Brain Mitochondria The Journal of Biological Chemistry. May, 2003 | Pubmed ID: 12660243 Barbiturates Induce Mitochondrial Depolarization and Potentiate Excitotoxic Neuronal Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2002 | Pubmed ID: 12417645 Mitochondrial Function and Dysfunction in the Cell: Its Relevance to Aging and Aging-related Disease The International Journal of Biochemistry & Cell Biology. Nov, 2002 | Pubmed ID: 12200032 Bioenergetic Profile Experiment using C2C12 Myoblast Cells JoVE 2511 Biology
