David L. Sacks Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases National Institutes of Health Biography Publications Institution JoVE Articles David L. Sacks has not added a biography. If you are David L. Sacks and would like to personalize this page please email our Author Liaison for assistance. Publications The Null Hypothesis of IFN-γ and Monocyte Function in Leishmaniasis Cell Host & Microbe. 05, 2020 | Pubmed ID: 32407702 M2-like, Dermal Macrophages Are Maintained Via IL-4/CCL24-mediated Cooperative Interaction with Eosinophils in Cutaneous Leishmaniasis Science Immunology. 04, 2020 | Pubmed ID: 32276966 CRISPR/Cas9 Mutagenesis in Phlebotomus Papatasi: the Immune Deficiency Pathway Impacts Vector Competence for Leishmania Major MBio. 08, 2019 | Pubmed ID: 31455654 Inflammasomes and Leishmania: in Good Times or Bad, in Sickness or in Health Current Opinion in Microbiology. 12, 2019 | Pubmed ID: 31229882 Mannose Receptor High, M2 Dermal Macrophages Mediate Nonhealing Infection in a Th1 Immune Environment The Journal of Experimental Medicine. 01, 2018 | Pubmed ID: 29247046 NOX2-Derived Reactive Oxygen Species Control Inflammation During Infection by Mediating Infection-Induced Neutrophil Apoptosis Journal of Immunology (Baltimore, Md. : 1950). 01, 2018 | Pubmed ID: 29158417 Gene Expression in Is Regulated Predominantly by Gene Dosage MBio. 09, 2017 | Pubmed ID: 28900023 Divergent Roles for Ly6C+CCR2+CX3CR1+ Inflammatory Monocytes During Primary or Secondary Infection of the Skin with the Intra-phagosomal Pathogen Leishmania Major PLoS Pathogens. Jun, 2017 | Pubmed ID: 28666021 The Transcriptome of Developmental Stages in Their Natural Sand Fly Vector MBio. 04, 2017 | Pubmed ID: 28377524 The Nlrp3 Inflammasome, IL-1β, and Neutrophil Recruitment Are Required for Susceptibility to a Nonhealing Strain of Leishmania Major in C57BL/6 Mice European Journal of Immunology. Apr, 2016 | Pubmed ID: 26689285 Cutaneous Infection with Leishmania Major Mediates Heterologous Protection Against Visceral Infection with Leishmania Infantum Journal of Immunology (Baltimore, Md. : 1950). Oct, 2015 | Pubmed ID: 26371247 Chronic Parasitic Infection Maintains High Frequencies of Short-lived Ly6C+CD4+ Effector T Cells That Are Required for Protection Against Re-infection PLoS Pathogens. Dec, 2014 | Pubmed ID: 25473946 Cross-species Genetic Exchange Between Visceral and Cutaneous Strains of Leishmania in the Sand Fly Vector Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014 | Pubmed ID: 25385616 Vaccines Against Tropical Parasitic Diseases: a Persisting Answer to a Persisting Problem Nature Immunology. May, 2014 | Pubmed ID: 24747701 Site-dependent Recruitment of Inflammatory Cells Determines the Effective Dose of Leishmania Major Infection and Immunity. Jul, 2014 | Pubmed ID: 24733090 Tracking Antigen-specific CD4+ T Cells Throughout the Course of Chronic Leishmania Major Infection in Resistant Mice European Journal of Immunology. Feb, 2013 | Pubmed ID: 23109292 Evaluation of Recombinant Leishmania Polyprotein Plus Glucopyranosyl Lipid A Stable Emulsion Vaccines Against Sand Fly-transmitted Leishmania Major in C57BL/6 Mice Journal of Immunology (Baltimore, Md. : 1950). Nov, 2012 | Pubmed ID: 23045616 Infection Parameters in the Sand Fly Vector That Predict Transmission of Leishmania Major PLoS Neglected Tropical Diseases. Aug, 2011 | Pubmed ID: 21886852 Leishmania Major Survival in Selective Phlebotomus Papatasi Sand Fly Vector Requires a Specific SCG-encoded Lipophosphoglycan Galactosylation Pattern PLoS Pathogens. 2010 | Pubmed ID: 21085609 The Impact of Vector-mediated Neutrophil Recruitment on Cutaneous Leishmaniasis Cellular Microbiology. Sep, 2009 | Pubmed ID: 19545276 Vector Transmission of Leishmania Abrogates Vaccine-induced Protective Immunity PLoS Pathogens. Jun, 2009 | Pubmed ID: 19543375 Uninfected Mosquito Bites Confer Protection Against Infection with Malaria Parasites Infection and Immunity. May, 2007 | Pubmed ID: 17339356 A Leishmania Amazonensis ZIP Family Iron Transporter is Essential for Parasite Replication Within Macrophage Phagolysosomes The Journal of Experimental Medicine. Oct, 2006 | Pubmed ID: 17000865 Antigen Requirements for Efficient Priming of CD8+ T Cells by Leishmania Major-infected Dendritic Cells Infection and Immunity. Oct, 2005 | Pubmed ID: 16177338 Prevention and Treatment of Cutaneous Leishmaniasis in Primates by Using Synthetic Type D/A Oligodeoxynucleotides Expressing CpG Motifs Infection and Immunity. Aug, 2005 | Pubmed ID: 16041009 Conditions Influencing the Efficacy of Vaccination with Live Organisms Against Leishmania Major Infection Infection and Immunity. Aug, 2005 | Pubmed ID: 16040984 Nonhealing Infection Despite Th1 Polarization Produced by a Strain of Leishmania Major in C57BL/6 Mice Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15728505 Coinjection with CpG-containing Immunostimulatory Oligodeoxynucleotides Reduces the Pathogenicity of a Live Vaccine Against Cutaneous Leishmaniasis but Maintains Its Potency and Durability Infection and Immunity. Sep, 2003 | Pubmed ID: 12933855 Immunological and Pathological Evaluation of Rhesus Macaques Infected with Leishmania Major Experimental Parasitology. Mar-Apr, 2003 | Pubmed ID: 12880593 CD4+CD25+ Regulatory T Cells Control Leishmania Major Persistence and Immunity Nature. Dec, 2002 | Pubmed ID: 12466842 Vaccination with Heat-killed Leishmania Antigen or Recombinant Leishmanial Protein and CpG Oligodeoxynucleotides Induces Long-term Memory CD4+ and CD8+ T Cell Responses and Protection Against Leishmania Major Infection The Journal of Experimental Medicine. Jun, 2002 | Pubmed ID: 12070284 The Role of Interleukin (IL)-10 in the Persistence of Leishmania Major in the Skin After Healing and the Therapeutic Potential of Anti-IL-10 Receptor Antibody for Sterile Cure The Journal of Experimental Medicine. Nov, 2001 | Pubmed ID: 11714756 Toward a Defined Anti-Leishmania Vaccine Targeting Vector Antigens: Characterization of a Protective Salivary Protein The Journal of Experimental Medicine. Aug, 2001 | Pubmed ID: 11489952 The Role of Antigen and IL-12 in Sustaining Th1 Memory Cells in Vivo: IL-12 is Required to Maintain Memory/effector Th1 Cells Sufficient to Mediate Protection to an Infectious Parasite Challenge Proceedings of the National Academy of Sciences of the United States of America. Jul, 2000 | Pubmed ID: 10890924 Development of a Natural Model of Cutaneous Leishmaniasis: Powerful Effects of Vector Saliva and Saliva Preexposure on the Long-term Outcome of Leishmania Major Infection in the Mouse Ear Dermis The Journal of Experimental Medicine. Nov, 1998 | Pubmed ID: 9815271 Uptake of Leishmania Major Amastigotes Results in Activation and Interleukin 12 Release from Murine Skin-derived Dendritic Cells: Implications for the Initiation of Anti-Leishmania Immunity The Journal of Experimental Medicine. Oct, 1998 | Pubmed ID: 9782133 Vaccination with DNA Encoding the Immunodominant LACK Parasite Antigen Confers Protective Immunity to Mice Infected with Leishmania Major The Journal of Experimental Medicine. Oct, 1997 | Pubmed ID: 9314562 Sand Fly (Phlebotomus papatasi) Embryo Microinjection for CRISPR/Cas9 Mutagenesis Isabelle Louradour1, Kashinath Ghosh1, Ehud Inbar1, David L. Sacks1, Channa Aluvihare2, Robert A. Harrell II2 1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2University of Maryland Insect Transformation Facility, The Institute for Bioscience and Biotechnology Research JoVE 61924 Genetics
Sand Fly (Phlebotomus papatasi) Embryo Microinjection for CRISPR/Cas9 Mutagenesis Isabelle Louradour1, Kashinath Ghosh1, Ehud Inbar1, David L. Sacks1, Channa Aluvihare2, Robert A. Harrell II2 1Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 2University of Maryland Insect Transformation Facility, The Institute for Bioscience and Biotechnology Research JoVE 61924 Genetics
