David M. Langenau Molecular Pathology, Cancer Center and Center for Regenerative Medicine Massachusetts General Hospital Biography Publications Institution JoVE Articles David M. Langenau has not added a biography. If you are David M. Langenau and would like to personalize this page please email our Author Liaison for assistance. Publications Rhabdomyosarcoma: Current Challenges and Their Implications for Developing Therapies Cold Spring Harbor Perspectives in Medicine. 2014 | Pubmed ID: 25368019 Optimized Cell Transplantation Using Adult Rag2 Mutant Zebrafish Nature Methods. Aug, 2014 | Pubmed ID: 25042784 Lineage of Origin in Rhabdomyosarcoma Informs Pharmacological Response Genes & Development. Jul, 2014 | Pubmed ID: 25030697 Zebrafish As a Model to Assess Cancer Heterogeneity, Progression and Relapse Disease Models & Mechanisms. Jul, 2014 | Pubmed ID: 24973745 Glycogen Synthase Kinase 3 Inhibitors Induce the Canonical WNT/β-catenin Pathway to Suppress Growth and Self-renewal in Embryonal Rhabdomyosarcoma Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24706870 Loss of Function Tp53 Mutations Do Not Accelerate the Onset of Myc-induced T-cell Acute Lymphoblastic Leukaemia in the Zebrafish British Journal of Haematology. Jul, 2014 | Pubmed ID: 24690081 Clonal Evolution Enhances Leukemia-propagating Cell Frequency in T Cell Acute Lymphoblastic Leukemia Through Akt/mTORC1 Pathway Activation Cancer Cell. Mar, 2014 | Pubmed ID: 24613413 Pten Regulates Zebrafish Hematopoiesis Blood. Jan, 2014 | Pubmed ID: 24408201 Cross-species Array Comparative Genomic Hybridization Identifies Novel Oncogenic Events in Zebrafish and Human Embryonal Rhabdomyosarcoma PLoS Genetics. Aug, 2013 | Pubmed ID: 24009521 Zebrafish Rhabdomyosarcoma Reflects the Developmental Stage of Oncogene Expression During Myogenesis Development (Cambridge, England). Jul, 2013 | Pubmed ID: 23821038 The Histone Methyltransferase SUV39H1 Suppresses Embryonal Rhabdomyosarcoma Formation in Zebrafish PloS One. 2013 | Pubmed ID: 23705022 A Novel Chemical Screening Strategy in Zebrafish Identifies Common Pathways in Embryogenesis and Rhabdomyosarcoma Development Development (Cambridge, England). Jun, 2013 | Pubmed ID: 23615277 Through the Looking Glass: Visualizing Leukemia Growth, Migration, and Engraftment Using Fluorescent Transgenic Zebrafish Advances in Hematology. 2012 | Pubmed ID: 22829834 Improved Somatic Mutagenesis in Zebrafish Using Transcription Activator-like Effector Nucleases (TALENs) PloS One. 2012 | Pubmed ID: 22655075 In Vivo Imaging of Tumor-propagating Cells, Regional Tumor Heterogeneity, and Dynamic Cell Movements in Embryonal Rhabdomyosarcoma Cancer Cell. May, 2012 | Pubmed ID: 22624717 Sarcomas Induced in Discrete Subsets of Prospectively Isolated Skeletal Muscle Cells Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22135462 Fluorescent Imaging of Cancer in Zebrafish Methods in Cell Biology. 2011 | Pubmed ID: 21951542 Zebrafish Models of Rhabdomyosarcoma Methods in Cell Biology. 2011 | Pubmed ID: 21951539 High-throughput Imaging of Adult Fluorescent Zebrafish with an LED Fluorescence Macroscope Nature Protocols. Feb, 2011 | Pubmed ID: 21293462 Selection-free Zinc-finger-nuclease Engineering by Context-dependent Assembly (CoDA) Nature Methods. Jan, 2011 | Pubmed ID: 21151135 T-lymphoblastic Lymphoma Cells Express High Levels of BCL2, S1P1, and ICAM1, Leading to a Blockade of Tumor Cell Intravasation Cancer Cell. Oct, 2010 | Pubmed ID: 20951945 AMAZe-ing Tools for Mosaic Analysis in Zebrafish Nature Methods. Mar, 2010 | Pubmed ID: 20195251 High-throughput Cell Transplantation Establishes That Tumor-initiating Cells Are Abundant in Zebrafish T-cell Acute Lymphoblastic Leukemia Blood. Apr, 2010 | Pubmed ID: 20056790 Zebrafish As a Model for Cancer Self-renewal Zebrafish. Dec, 2009 | Pubmed ID: 19954344 Construction and Application of a Zebrafish Array Comparative Genomic Hybridization Platform Genes, Chromosomes & Cancer. Feb, 2009 | Pubmed ID: 18973135 Generation and Characterization of Transgenic Zebrafish Lines Using Different Ubiquitous Promoters Transgenic Research. Apr, 2008 | Pubmed ID: 17968670 Heat-shock Induction of T-cell Lymphoma/leukaemia in Conditional Cre/lox-regulated Transgenic Zebrafish British Journal of Haematology. Jul, 2007 | Pubmed ID: 17593023 Heat Shock-inducible Cre/Lox Approaches to Induce Diverse Types of Tumors and Hyperplasia in Transgenic Zebrafish Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17517602 Effects of RAS on the Genesis of Embryonal Rhabdomyosarcoma Genes & Development. Jun, 2007 | Pubmed ID: 17510286 Cre/lox-regulated Transgenic Zebrafish Model with Conditional Myc-induced T Cell Acute Lymphoblastic Leukemia Proceedings of the National Academy of Sciences of the United States of America. Apr, 2005 | Pubmed ID: 15827121 The Zebrafish: a New Model of T-cell and Thymic Development Nature Reviews. Immunology. Apr, 2005 | Pubmed ID: 15803150 Suppression of Apoptosis by Bcl-2 Overexpression in Lymphoid Cells of Transgenic Zebrafish Blood. Apr, 2005 | Pubmed ID: 15618471 Effects of Lethal Irradiation in Zebrafish and Rescue by Hematopoietic Cell Transplantation Blood. Sep, 2004 | Pubmed ID: 15142873 In Vivo Tracking of T Cell Development, Ablation, and Engraftment in Transgenic Zebrafish Proceedings of the National Academy of Sciences of the United States of America. May, 2004 | Pubmed ID: 15123839 The Use of Zebrafish to Understand Immunity Immunity. Apr, 2004 | Pubmed ID: 15084267 Knockdown of Zebrafish Fancd2 Causes Developmental Abnormalities Via P53-dependent Apoptosis Developmental Cell. Dec, 2003 | Pubmed ID: 14667412 Myc-induced T Cell Leukemia in Transgenic Zebrafish Science (New York, N.Y.). Feb, 2003 | Pubmed ID: 12574629 Normale og maligne muskel celle transplantation i immunsvækkede Voksen Zebrafisk Inês M. Tenente*1,2,3, Qin Tang*1,2, John C. Moore1,2, David M. Langenau1,2 1Molecular Pathology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, 2Harvard Stem Cell Institute, 3GABBA - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto Immunology and Infection Quantifying the Frequency of Tumor-propagating Cells Using Limiting Dilution Cell Transplantation in Syngeneic Zebrafish JoVE 2790 Biology
Normale og maligne muskel celle transplantation i immunsvækkede Voksen Zebrafisk Inês M. Tenente*1,2,3, Qin Tang*1,2, John C. Moore1,2, David M. Langenau1,2 1Molecular Pathology, Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, 2Harvard Stem Cell Institute, 3GABBA - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto Immunology and Infection
Quantifying the Frequency of Tumor-propagating Cells Using Limiting Dilution Cell Transplantation in Syngeneic Zebrafish JoVE 2790 Biology