David P. Speert Department of Pediatrics, Centre for Understanding and Preventing Infection in Children University of British Columbia Biography Publications Institution JoVE Articles David P. Speert has not added a biography. If you are David P. Speert and would like to personalize this page please email our Author Liaison for assistance. Publications Recurrent Subacute Post-viral Onset of Ataxia Associated with a PRF1 Mutation European Journal of Human Genetics : EJHG. Feb, 2013 | Pubmed ID: 23443029 Antibody Responses to Vaccination Among South African HIV-exposed and Unexposed Uninfected Infants During the First 2 Years of Life Clinical and Vaccine Immunology : CVI. Jan, 2013 | Pubmed ID: 23114697 Ontogeny of Toll-like Receptor Mediated Cytokine Responses of South African Infants Throughout the First Year of Life PloS One. 2012 | Pubmed ID: 23028609 Serum Susceptibility in Clinical Isolates of Burkholderia Cepacia Complex Bacteria: Development of a Growth-based Assay for High Throughput Determination Frontiers in Cellular and Infection Microbiology. 2012 | Pubmed ID: 22919658 Influence of Common Non-synonymous Toll-like Receptor 4 Polymorphisms on Bronchopulmonary Dysplasia and Prematurity in Human Infants PloS One. 2012 | Pubmed ID: 22348075 Identification of Differentially Expressed Proteins from Burkholderia Pseudomallei Isolated During Primary and Relapsing Melioidosis Microbes and Infection / Institut Pasteur. Apr, 2012 | Pubmed ID: 22172334 Identification of Hopanoid Biosynthesis Genes Involved in Polymyxin Resistance in Burkholderia Multivorans Antimicrobial Agents and Chemotherapy. Jan, 2012 | Pubmed ID: 22006009 Mucoid Morphotype Variation of Burkholderia Multivorans During Chronic Cystic Fibrosis Lung Infection is Correlated with Changes in Metabolism, Motility, Biofilm Formation and Virulence Microbiology (Reading, England). Nov, 2011 | Pubmed ID: 21835880 In Vivo-transmigrated Human Neutrophils Are Resistant to Antiapoptotic Stimulation Journal of Leukocyte Biology. Dec, 2011 | Pubmed ID: 21697259 In Vitro Susceptibility of Burkholderia Vietnamiensis to Aminoglycosides Antimicrobial Agents and Chemotherapy. May, 2011 | Pubmed ID: 21321142 Mucoid and Nonmucoid Burkholderia Cepacia Complex Bacteria in Cystic Fibrosis Infections American Journal of Respiratory and Critical Care Medicine. Jan, 2011 | Pubmed ID: 20709823 Clinical Features and Outcome of Patients with IRAK-4 and MyD88 Deficiency Medicine. Nov, 2010 | Pubmed ID: 21057262 Profound Lack of Interleukin (IL)-12/IL-23p40 in Neonates Born Early in Gestation is Associated with an Increased Risk of Sepsis The Journal of Infectious Diseases. Dec, 2010 | Pubmed ID: 20977341 Parallel Evolution in Pseudomonas Aeruginosa over 39,000 Generations in Vivo MBio. 2010 | Pubmed ID: 20856824 Toll-like Receptor Gene Polymorphisms and Preeclampsia Risk: a Case-control Study and Data Synthesis Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy. 2010 | Pubmed ID: 20818954 The Role of Mucoidy in Virulence of Bacteria from the Burkholderia Cepacia Complex: a Systematic Proteomic and Transcriptomic Analysis The Journal of Infectious Diseases. Sep, 2010 | Pubmed ID: 20670172 Mycobacterium Tuberculosis Employs Cpn60.2 As an Adhesin That Binds CD43 on the Macrophage Surface Cellular Microbiology. Nov, 2010 | Pubmed ID: 20633027 Robust TLR4-induced Gene Expression Patterns Are Not an Accurate Indicator of Human Immunity Journal of Translational Medicine. 2010 | Pubmed ID: 20105294 Mycobacterium Tuberculosis Cpn60.2 and DnaK Are Located on the Bacterial Surface, Where Cpn60.2 Facilitates Efficient Bacterial Association with Macrophages Infection and Immunity. Aug, 2009 | Pubmed ID: 19470749 Taxon K, a Complex Within the Burkholderia Cepacia Complex, Comprises at Least Two Novel Species, Burkholderia Contaminans Sp. Nov. and Burkholderia Lata Sp. Nov International Journal of Systematic and Evolutionary Microbiology. Jan, 2009 | Pubmed ID: 19126732 ROS-deficient Monocytes Have Aberrant Gene Expression That Correlates with Inflammatory Disorders of Chronic Granulomatous Disease Clinical Immunology (Orlando, Fla.). Oct, 2008 | Pubmed ID: 18676204 Differential Modulation of Innate Immune Cell Functions by the Burkholderia Cepacia Complex: Burkholderia Cenocepacia but Not Burkholderia Multivorans Disrupts Maturation and Induces Necrosis in Human Dendritic Cells Cellular Microbiology. Oct, 2008 | Pubmed ID: 18624797 Differential Mucoid Exopolysaccharide Production by Members of the Burkholderia Cepacia Complex Journal of Clinical Microbiology. Apr, 2008 | Pubmed ID: 18256220 Elucidating Global Epidemiology of Burkholderia Multivorans in Cases of Cystic Fibrosis by Multilocus Sequence Typing Journal of Clinical Microbiology. Jan, 2008 | Pubmed ID: 18032622 Recurrent Systemic Pneumococcal Disease and IRAK4 Deficiency The Pediatric Infectious Disease Journal. Nov, 2007 | Pubmed ID: 17984826 Unique Lipid a Modifications in Pseudomonas Aeruginosa Isolated from the Airways of Patients with Cystic Fibrosis The Journal of Infectious Diseases. Oct, 2007 | Pubmed ID: 17763333 Environmental Burkholderia Cepacia Complex Isolates in Human Infections Emerging Infectious Diseases. Mar, 2007 | Pubmed ID: 17552100 Enhanced Inflammatory Responses of Chronic Granulomatous Disease Leukocytes Involve ROS-independent Activation of NF-kappa B European Journal of Immunology. Apr, 2007 | Pubmed ID: 17330823 Proteomic Identification and Characterization of Bacterial Factors Associated with Burkholderia Cenocepacia Survival in a Murine Host Microbiology (Reading, England). Jan, 2007 | Pubmed ID: 17185549 Reliability of Multilocus Sequence Typing of the Burkholderia Cepacia Complex in Cystic Fibrosis Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. May, 2007 | Pubmed ID: 17141579 Bacterial Infections of the Lung in Normal and Immunodeficient Patients Novartis Foundation Symposium. 2006 | Pubmed ID: 17278384 IRAK-4 Mutation (Q293X): Rapid Detection and Characterization of Defective Post-transcriptional TLR/IL-1R Responses in Human Myeloid and Non-myeloid Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006 | Pubmed ID: 17114497 Genetic Adaptation by Pseudomonas Aeruginosa to the Airways of Cystic Fibrosis Patients Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16687478 Persistent Bacteremia and Severe Thrombocytopenia Caused by Coagulase-negative Staphylococcus in a Neonatal Intensive Care Unit Pediatrics. Feb, 2006 | Pubmed ID: 16452352 Exopolysaccharides from Burkholderia Cenocepacia Inhibit Neutrophil Chemotaxis and Scavenge Reactive Oxygen Species The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16316987 Multilocus Sequence Typing Scheme That Provides Both Species and Strain Differentiation for the Burkholderia Cepacia Complex Journal of Clinical Microbiology. Sep, 2005 | Pubmed ID: 16145124 Primary Immune Deficiencies Presenting in Adults: Seven Years of Experience from Iran Journal of Clinical Immunology. Jul, 2005 | Pubmed ID: 16133995 Chronic Granulomatous Disease: from Genetic Defect to Clinical Presentation Advances in Experimental Medicine and Biology. 2005 | Pubmed ID: 16107066 Viridans Streptococci Bacteremia in Children with Malignancy: Relevance of Species Identification and Penicillin Susceptibility The Pediatric Infectious Disease Journal. Jun, 2005 | Pubmed ID: 15933573 Identification of DNA Markers for a Transmissible Pseudomonas Aeruginosa Cystic Fibrosis Strain American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15834046 Burkholderia Cenocepacia Induces Neutrophil Necrosis in Chronic Granulomatous Disease Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15749893 Burkholderia Phenoliruptrix Sp. Nov., to Accommodate the 2,4,5-trichlorophenoxyacetic Acid and Halophenol-degrading Strain AC1100 Systematic and Applied Microbiology. Nov, 2004 | Pubmed ID: 15612618 Persistence of Burkholderia Multivorans Within the Pulmonary Macrophage in the Murine Lung Infection and Immunity. Oct, 2004 | Pubmed ID: 15385520 Production of Exopolysaccharide by Burkholderia Cenocepacia Results in Altered Cell-surface Interactions and Altered Bacterial Clearance in Mice The Journal of Infectious Diseases. Sep, 2004 | Pubmed ID: 15295701 Burkholderia Cepacia Complex and Cystic Fibrosis: in Search of the Smoking Gun American Journal of Respiratory and Critical Care Medicine. Jul, 2004 | Pubmed ID: 15220120 Differential Post-transcriptional Activation of Human Phagocytes by Different Pseudomonas Aeruginosa Isolates Cellular Microbiology. Jul, 2004 | Pubmed ID: 15186400 Detection and Genotyping of Varicella-zoster Virus by TaqMan Allelic Discrimination Real-time PCR Journal of Clinical Microbiology. Apr, 2004 | Pubmed ID: 15070981 Primary Immunodeficiency to Pneumococcal Infection Due to a Defect in Toll-like Receptor Signaling The Journal of Pediatrics. Apr, 2004 | Pubmed ID: 15069402 The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-regulated Kinase and P38 Kinase Pathways in Primary Human Monocytes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2004 | Pubmed ID: 15004180 The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-induced T Cell Polarization Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004 | Pubmed ID: 14707090 Pseudomonas Aeruginosa: Role in the Pathogenesis of the CF Lung Lesion Seminars in Respiratory and Critical Care Medicine. Dec, 2003 | Pubmed ID: 16088583 Colonial Morphology of Burkholderia Cepacia Complex Genomovar III: Implications in Exopolysaccharide Production, Pilus Expression, and Persistence in the Mouse Infection and Immunity. Feb, 2003 | Pubmed ID: 12540572 Epidemiology of Pseudomonas Aeruginosa in Cystic Fibrosis in British Columbia, Canada American Journal of Respiratory and Critical Care Medicine. Oct, 2002 | Pubmed ID: 12359659 Evaluation of a Diagnostic Polymerase Chain Reaction Assay for Neisseria Meningitidis in North America and Field Experience During an Outbreak Archives of Pathology & Laboratory Medicine. Oct, 2002 | Pubmed ID: 12296761 Biofilm Formation and Acyl Homoserine Lactone Production in the Burkholderia Cepacia Complex Journal of Bacteriology. Oct, 2002 | Pubmed ID: 12270826 Molecular Epidemiology of Pseudomonas Aeruginosa Frontiers in Bioscience : a Journal and Virtual Library. Oct, 2002 | Pubmed ID: 12165481 Effect of Burkholderia Cepacia Infection in the Clinical Course of Patients with Cystic Fibrosis: a Pilot Study in a Sydney Clinic Respirology (Carlton, Vic.). Sep, 2002 | Pubmed ID: 12153690 Multidrug Efflux Systems Play an Important Role in the Invasiveness of Pseudomonas Aeruginosa The Journal of Experimental Medicine. Jul, 2002 | Pubmed ID: 12093875 Burkholderia Anthina Sp. Nov. and Burkholderia Pyrrocinia, Two Additional Burkholderia Cepacia Complex Bacteria, May Confound Results of New Molecular Diagnostic Tools FEMS Immunology and Medical Microbiology. Jun, 2002 | Pubmed ID: 12052570 Differential Persistence Among Genomovars of the Burkholderia Cepacia Complex in a Murine Model of Pulmonary Infection Infection and Immunity. May, 2002 | Pubmed ID: 11953418 Epidemiology of Burkholderia Cepacia Complex in Patients with Cystic Fibrosis, Canada Emerging Infectious Diseases. Feb, 2002 | Pubmed ID: 11897071 Antibiotic Resistance in Pseudomonas Aeruginosa: Mechanisms and Impact on Treatment Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. Aug, 2000 | Pubmed ID: 11498392 Extração de proteínas e 2-D métodos Eletroforese em Gel de Billie Velapatiño1, James E. A. Zlosnik1, Trevor J. Hird1, David P. Speert1 1Department of Pediatrics, Centre for Understanding and Preventing Infection in Children, University of British Columbia JoVE 50730 Immunology and Infection
Extração de proteínas e 2-D métodos Eletroforese em Gel de Billie Velapatiño1, James E. A. Zlosnik1, Trevor J. Hird1, David P. Speert1 1Department of Pediatrics, Centre for Understanding and Preventing Infection in Children, University of British Columbia JoVE 50730 Immunology and Infection
