David Shima Ocular Biology and Therapeutics University College London Institute of Ophthalmology Biography Publications Institution JoVE Articles David Shima has not added a biography. If you are David Shima and would like to personalize this page please email our Author Liaison for assistance. Publications Differential Apicobasal VEGF Signaling at Vascular Blood-neural Barriers Developmental Cell. Sep, 2014 | Pubmed ID: 25175707 Spontaneous CNV in a Novel Mutant Mouse is Associated with Early VEGF-A-driven Angiogenesis and Late-stage Focal Edema, Neural Cell Loss, and Dysfunction Investigative Ophthalmology & Visual Science. Jun, 2014 | Pubmed ID: 24845632 A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells Via the NLRP3 Inflammasome PloS One. 2013 | Pubmed ID: 23840644 VEGF-A is Necessary and Sufficient for Retinal Neuroprotection in Models of Experimental Glaucoma The American Journal of Pathology. Apr, 2013 | Pubmed ID: 23416159 Assessing a Novel Depot Delivery Strategy for Noninvasive Administration of VEGF/PDGF RTK Inhibitors for Ocular Neovascular Disease Investigative Ophthalmology & Visual Science. Feb, 2013 | Pubmed ID: 23385800 Do Anti-angiogenic VEGF (VEGFxxxb) Isoforms Exist? A Cautionary Tale PloS One. 2012 | Pubmed ID: 22567098 フォークヘッドボックスN4(Foxn4)は、初期網膜前駆細胞の視細胞の運命を抑制するシグナリングDLL4ノッチをアクティブにします Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22323600 Delivery of Anti-angiogenic Molecular Therapies for Retinal Disease Drug Discovery Today. Apr, 2010 | Pubmed ID: 20184967 The Heparin-binding Domain Confers Diverse Functions of VEGF-A in Development and Disease: a Structure-function Study Biochemical Society Transactions. Dec, 2009 | Pubmed ID: 19909247 Delta-like 4 is Indispensable in Thymic Environment Specific for T Cell Development The Journal of Experimental Medicine. Oct, 2008 | Pubmed ID: 18824583 Blood Vessel Maturation and Response to Vascular-disrupting Therapy in Single Vascular Endothelial Growth Factor-A Isoform-producing Tumors Cancer Research. Apr, 2008 | Pubmed ID: 18381437 Simultaneous but Not Prior Inhibition of VEGF165 Enhances the Efficacy of Photodynamic Therapy in Multiple Models of Ocular Neovascularization Investigative Ophthalmology & Visual Science. Feb, 2008 | Pubmed ID: 18235012 RGS5 Expression is a Quantitative Measure of Pericyte Coverage of Blood Vessels Angiogenesis. 2008 | Pubmed ID: 18038251 Molecular Mapping and Functional Characterization of the VEGF164 Heparin-binding Domain The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17626017 Vascular Endothelial Growth Factor-A is a Survival Factor for Retinal Neurons and a Critical Neuroprotectant During the Adaptive Response to Ischemic Injury The American Journal of Pathology. Jul, 2007 | Pubmed ID: 17591953 Synergies of VEGF Inhibition and Photodynamic Therapy in the Treatment of Age-related Macular Degeneration Investigative Ophthalmology & Visual Science. Apr, 2007 | Pubmed ID: 17389510 Erythropoietin Promotes Survival of Retinal Ganglion Cells in DBA/2J Glaucoma Mice Investigative Ophthalmology & Visual Science. Mar, 2007 | Pubmed ID: 17325165 Inhibitory Effect of an Antibody to Cryptic Collagen Type IV Epitopes on Choroidal Neovascularization Molecular Vision. 2006 | Pubmed ID: 17110907 An in Vitro Assay Reveals a Role for the Diaphragm Protein PV-1 in Endothelial Fenestra Morphogenesis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17075074 Proceedings of the Third International Symposium on Retinopathy of Prematurity: an Update on ROP from the Lab to the Nursery (November 2003, Anaheim, California) Molecular Vision. 2006 | Pubmed ID: 16735995 Inhibition of Platelet-derived Growth Factor B Signaling Enhances the Efficacy of Anti-vascular Endothelial Growth Factor Therapy in Multiple Models of Ocular Neovascularization The American Journal of Pathology. Jun, 2006 | Pubmed ID: 16723717 Pegaptanib, a Targeted Anti-VEGF Aptamer for Ocular Vascular Disease Nature Reviews. Drug Discovery. Feb, 2006 | Pubmed ID: 16518379 VEGF Function in Vascular Pathogenesis Experimental Cell Research. Mar, 2006 | Pubmed ID: 16330026 A Therapeutic Aptamer Inhibits Angiogenesis by Specifically Targeting the Heparin Binding Domain of VEGF165 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16357200 The Role of Vascular Endothelial Growth Factor in Ocular Health and Disease Retina (Philadelphia, Pa.). Feb-Mar, 2005 | Pubmed ID: 15689799 Vascular Endothelial Growth Factor Controls Neuronal Migration and Cooperates with Sema3A to Pattern Distinct Compartments of the Facial Nerve Genes & Development. Nov, 2004 | Pubmed ID: 15545635 Neuropilin-1 is Required for Endothelial Tip Cell Guidance in the Developing Central Nervous System Developmental Dynamics : an Official Publication of the American Association of Anatomists. Nov, 2004 | Pubmed ID: 15376331 VEGF164(165) As the Pathological Isoform: Differential Leukocyte and Endothelial Responses Through VEGFR1 and VEGFR2 Investigative Ophthalmology & Visual Science. Feb, 2004 | Pubmed ID: 14744874 VEGF164-mediated Inflammation is Required for Pathological, but Not Physiological, Ischemia-induced Retinal Neovascularization The Journal of Experimental Medicine. Aug, 2003 | Pubmed ID: 12900522 VEGF Guides Angiogenic Sprouting Utilizing Endothelial Tip Cell Filopodia The Journal of Cell Biology. Jun, 2003 | Pubmed ID: 12810700 Mutations in Dynein Link Motor Neuron Degeneration to Defects in Retrograde Transport Science (New York, N.Y.). May, 2003 | Pubmed ID: 12730604 Spatially Restricted Patterning Cues Provided by Heparin-binding VEGF-A Control Blood Vessel Branching Morphogenesis Genes & Development. Oct, 2002 | Pubmed ID: 12381667 VE-PTP and VE-cadherin Ectodomains Interact to Facilitate Regulation of Phosphorylation and Cell Contacts The EMBO Journal. Sep, 2002 | Pubmed ID: 12234928 個別のNSFの活動によって媒介されるシーケンシャルSNARE分解とGATE-16-GOS-28複雑なアセンブリでは、ゴルジ膜融合をドライブ The Journal of Cell Biology. Jun, 2002 | Pubmed ID: 12070132 磁気マイクロスフェアの眼注射によって誘発実験緑内障 Shannon Bunker1, Joanna Holeniewska1, Sauparnika Vijay2, Annegret Dahlmann-Noor2,3, Peng Khaw2,4, Yin-Shan Ng5, David Shima1,6, Richard Foxton1 1Ocular Biology and Therapeutics, University College London Institute of Ophthalmology, 2University College London Institue of Ophthalmology, 3Moorfields Eye Hospital, 4NIHR Biomedical Research Centre, Moorfields Eye Hospital, 5Schepens Eye Research Institute, Harvard Medical School, 6Hoffman-La Roche Medicine
磁気マイクロスフェアの眼注射によって誘発実験緑内障 Shannon Bunker1, Joanna Holeniewska1, Sauparnika Vijay2, Annegret Dahlmann-Noor2,3, Peng Khaw2,4, Yin-Shan Ng5, David Shima1,6, Richard Foxton1 1Ocular Biology and Therapeutics, University College London Institute of Ophthalmology, 2University College London Institue of Ophthalmology, 3Moorfields Eye Hospital, 4NIHR Biomedical Research Centre, Moorfields Eye Hospital, 5Schepens Eye Research Institute, Harvard Medical School, 6Hoffman-La Roche Medicine