David Sulzer Departments of Psychiatry, Neurology, & Pharmacology Columbia University Medical Campus Biography Publications Institution JoVE Articles David Sulzer has not added a biography. If you are David Sulzer and would like to personalize this page please email our Author Liaison for assistance. Publications Dopamine's Effects on Corticostriatal Synapses During Reward-Based Behaviors Neuron. Feb, 2018 | Pubmed ID: 29420932 Voluntary Adolescent Drinking Enhances Excitation by Low Levels of Alcohol in a Subset of Dopaminergic Neurons in the Ventral Tegmental Area Neuropharmacology. Nov, 2016 | Pubmed ID: 27475082 Loss of MTOR-dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits Neuron. Sep, 2014 | Pubmed ID: 25155956 Calcium Currents Regulate Dopamine Autoreceptors Brain : a Journal of Neurology. Aug, 2014 | Pubmed ID: 25057130 Neuronal Vulnerability, Pathogenesis, and Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Jan, 2013 | Pubmed ID: 22791686 Regulation of Presynaptic Neurotransmission by Macroautophagy Neuron. Apr, 2012 | Pubmed ID: 22542182 Constitutive Upregulation of Chaperone-mediated Autophagy in Huntington's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Dec, 2011 | Pubmed ID: 22171050 4-Component Relativistic Magnetically Induced Current Density Using London Atomic Orbitals Physical Chemistry Chemical Physics : PCCP. Dec, 2011 | Pubmed ID: 22080205 Imaging Presynaptic Exocytosis in Corticostriatal Slices Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21913113 Multiple Personalities in the Ventral Tegmental Area Neuron. Jun, 2011 | Pubmed ID: 21658574 How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission Neuron. Feb, 2011 | Pubmed ID: 21338876 Neuromelanin Activates Microglia and Induces Degeneration of Dopaminergic Neurons: Implications for Progression of Parkinson's Disease Neurotoxicity Research. Jan, 2011 | Pubmed ID: 19957214 Presynaptic Regulation of Dopamine Transmission in Schizophrenia Schizophrenia Bulletin. Jan, 2011 | Pubmed ID: 19525353 AGAP1/AP-3-dependent Endocytic Recycling of M5 Muscarinic Receptors Promotes Dopamine Release The EMBO Journal. Aug, 2010 | Pubmed ID: 20664521 Development of PH-responsive Fluorescent False Neurotransmitters Journal of the American Chemical Society. Jul, 2010 | Pubmed ID: 20540519 Cargo Recognition Failure is Responsible for Inefficient Autophagy in Huntington's Disease Nature Neuroscience. May, 2010 | Pubmed ID: 20383138 Vesicular Glutamate Transport Promotes Dopamine Storage and Glutamate Corelease in Vivo Neuron. Mar, 2010 | Pubmed ID: 20223200 Clues to How Alpha-synuclein Damages Neurons in Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. 2010 | Pubmed ID: 20187229 Glutamate Controls Growth Rate and Branching of Dopaminergic Axons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2009 | Pubmed ID: 19776283 Fluorescent False Neurotransmitters Visualize Dopamine Release from Individual Presynaptic Terminals Science (New York, N.Y.). Jun, 2009 | Pubmed ID: 19423778 Interplay Between Cytosolic Dopamine, Calcium, and Alpha-synuclein Causes Selective Death of Substantia Nigra Neurons Neuron. Apr, 2009 | Pubmed ID: 19409267 Bacterial Artificial Chromosome Transgenic Mice Expressing a Truncated Mutant Parkin Exhibit Age-dependent Hypokinetic Motor Deficits, Dopaminergic Neuron Degeneration, and Accumulation of Proteinase K-resistant Alpha-synuclein The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2009 | Pubmed ID: 19228951 Secretory Vesicle Rebound Hyperacidification and Increased Quantal Size Resulting from Prolonged Methamphetamine Exposure Journal of Neurochemistry. Dec, 2008 | Pubmed ID: 19014382 Repeated Exposure to Methamphetamine Causes Long-lasting Presynaptic Corticostriatal Depression That is Renormalized with Drug Readministration Neuron. Apr, 2008 | Pubmed ID: 18400166 Neuronal Pigmented Autophagic Vacuoles: Lipofuscin, Neuromelanin, and Ceroid As Macroautophagic Responses During Aging and Disease Journal of Neurochemistry. Jul, 2008 | Pubmed ID: 18384642 Methamphetamine Inhibits Antigen Processing, Presentation, and Phagocytosis PLoS Pathogens. Feb, 2008 | Pubmed ID: 18282092 Autophagy Induced by Alexander Disease-mutant GFAP Accumulation is Regulated by P38/MAPK and MTOR Signaling Pathways Human Molecular Genetics. Jun, 2008 | Pubmed ID: 18276609 PKC Theta Activity Maintains Normal Quantal Size in Chromaffin Cells Journal of Neurochemistry. Jun, 2008 | Pubmed ID: 18248621 Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes Autophagy. Feb, 2008 | Pubmed ID: 18188003 Dopamine-modified Alpha-synuclein Blocks Chaperone-mediated Autophagy The Journal of Clinical Investigation. Feb, 2008 | Pubmed ID: 18172548 Parkinson's Disease: Return of an Old Prime Suspect Neuron. Jul, 2007 | Pubmed ID: 17610813 Multiple Hit Hypotheses for Dopamine Neuron Loss in Parkinson's Disease Trends in Neurosciences. May, 2007 | Pubmed ID: 17418429 Alpha-synuclein Overexpression in PC12 and Chromaffin Cells Impairs Catecholamine Release by Interfering with a Late Step in Exocytosis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2006 | Pubmed ID: 17108165 A Glial Cell Line-derived Neurotrophic Factor (GDNF):tetanus Toxin Fragment C Protein Conjugate Improves Delivery of GDNF to Spinal Cord Motor Neurons in Mice Brain Research. Nov, 2006 | Pubmed ID: 17020749 Alpha-synuclein Overexpression Increases Cytosolic Catecholamine Concentration The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2006 | Pubmed ID: 16957086 Sorting of Vesicular Monoamine Transporter 2 to the Regulated Secretory Pathway Confers the Somatodendritic Exocytosis of Monoamines Neuron. Nov, 2005 | Pubmed ID: 16301178 Transcriptional and Behavioral Interaction Between 22q11.2 Orthologs Modulates Schizophrenia-related Phenotypes in Mice Nature Neuroscience. Nov, 2005 | Pubmed ID: 16234811 Analysis of Exocytotic Events Recorded by Amperometry Nature Methods. Sep, 2005 | Pubmed ID: 16118635 Neurotoxicity and Behavioral Deficits Associated with Septin 5 Accumulation in Dopaminergic Neurons Journal of Neurochemistry. Aug, 2005 | Pubmed ID: 16092945 SNAREs Can Promote Complete Fusion and Hemifusion As Alternative Outcomes The Journal of Cell Biology. Jul, 2005 | Pubmed ID: 16027221 Mechanisms of Neurotransmitter Release by Amphetamines: a Review Progress in Neurobiology. Apr, 2005 | Pubmed ID: 15955613 Antidepressants and the Monoamine Masquerade Neuron. Apr, 2005 | Pubmed ID: 15820686 Neurodegeneration and Neuroprotection in Parkinson Disease NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2004 | Pubmed ID: 15717014 The Neuromelanin of Human Substantia Nigra: Physiological and Pathogenic Aspects Pigment Cell Research / Sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society. Dec, 2004 | Pubmed ID: 15541018 Impaired Degradation of Mutant Alpha-synuclein by Chaperone-mediated Autophagy Science (New York, N.Y.). Aug, 2004 | Pubmed ID: 15333840 Heterosynaptic Dopamine Neurotransmission Selects Sets of Corticostriatal Terminals Neuron. May, 2004 | Pubmed ID: 15157425 Frequency-dependent Modulation of Dopamine Release by Nicotine Nature Neuroscience. Jun, 2004 | Pubmed ID: 15146187 Regulation of the Development of Mesencephalic Dopaminergic Systems by the Selective Expression of Glial Cell Line-derived Neurotrophic Factor in Their Targets The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2004 | Pubmed ID: 15044553 Dopamine Neurons Release Transmitter Via a Flickering Fusion Pore Nature Neuroscience. Apr, 2004 | Pubmed ID: 14990933 Dopamine Neurons Mediate a Fast Excitatory Signal Via Their Glutamatergic Synapses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2004 | Pubmed ID: 14749442 Glutamate Spillover in the Striatum Depresses Dopaminergic Transmission by Activating Group I Metabotropic Glutamate Receptors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2003 | Pubmed ID: 14627643 Real-time Decoding of Dopamine Concentration Changes in the Caudate-putamen During Tonic and Phasic Firing Journal of Neurochemistry. Dec, 2003 | Pubmed ID: 14622108 Neuromelanin of the Substantia Nigra: a Neuronal Black Hole with Protective and Toxic Characteristics Trends in Neurosciences. Nov, 2003 | Pubmed ID: 14585596 Presynaptic Regulation of Dopaminergic Neurotransmission Journal of Neurochemistry. Oct, 2003 | Pubmed ID: 14511105 Intracellular Patch Electrochemistry: Regulation of Cytosolic Catecholamines in Chromaffin Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2003 | Pubmed ID: 12843288 D3 Dopamine Autoreceptors Do Not Activate G-protein-gated Inwardly Rectifying Potassium Channel Currents in Substantia Nigra Dopamine Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2003 | Pubmed ID: 12843272 Dopamine Transport Currents Are Promoted from Curiosity to Physiology Trends in Neurosciences. Apr, 2003 | Pubmed ID: 12689764 The Identification of Vesicular Glutamate Transporter 3 Suggests Novel Modes of Signaling by Glutamate Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12388773 Methamphetamine-induced Degeneration of Dopaminergic Neurons Involves Autophagy and Upregulation of Dopamine Synthesis The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Oct, 2002 | Pubmed ID: 12388602 Resistance of Alpha -synuclein Null Mice to the Parkinsonian Neurotoxin MPTP Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12376616 Altered Dopamine Release and Uptake Kinetics in Mice Lacking D2 Receptors The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2002 | Pubmed ID: 12223553 Stimulation-dependent Regulation of the PH, Volume and Quantal Size of Bovine and Rodent Secretory Vesicles The Journal of Physiology. Jul, 2002 | Pubmed ID: 12122145 Transgenic Superoxide Dismutase Overproducer: Murine Methods in Enzymology. 2002 | Pubmed ID: 11912908 The Absolute Concentration of Nigral Neuromelanin, Assayed by a New Sensitive Method, Increases Throughout the Life and is Dramatically Decreased in Parkinson's Disease FEBS Letters. Jan, 2002 | Pubmed ID: 11801257 Intraneuronal Dopamine-quinone Synthesis: a Review Neurotoxicity Research. Feb, 2000 | Pubmed ID: 12835101 Neuromelanin Biosynthesis is Driven by Excess Cytosolic Catecholamines Not Accumulated by Synaptic Vesicles Proceedings of the National Academy of Sciences of the United States of America. Oct, 2000 | Pubmed ID: 11050221 Dale's Principle and Glutamate Corelease from Ventral Midbrain Dopamine Neurons Amino Acids. 2000 | Pubmed ID: 11026472 Regulation of Quantal Size by Presynaptic Mechanisms Reviews in the Neurosciences. 2000 | Pubmed ID: 10718152 Piezo yüksek doğruluk cerrahi Osteal kaldırma (FAZÖR): Farelerde geliştirilmiş kafatası pencere ameliyat için bir teknik Samuel D. Clark1, Rachel Mikofsky*1, Jacqueline Lawson*1, David Sulzer1 1Departments of Psychiatry, Neurology, & Pharmacology, Columbia University Medical Campus JoVE 56172 Neuroscience Bireysel Presinaptik Terminalleri Dopamin Yayın FFNs ile görüntülendi Hui Zhang1,2, Niko G. Gubernator3,4, Minerva Yue1, Roland G. W. Staal1, Eugene V. Mosharov1, Daniela Pereira1, Vojtech Balsanek3, Paul A. Vadola3, Bipasha Mukherjee5, Robert H. Edwards5, David Sulzer1,2,6, Dalibor Sames3 1Departments of Neurology, Columbia University, 2Departments of Psychiatry and Pharmacology, Columbia University, 3Department of Chemistry, Columbia University, 4eMolecules, Inc., 5Departments of Neurology and Physiology, University of California School of Medicine, San Francisco, 6Division of Molecular Therapeutics, New York Psychiatric Institute JoVE 1562 Biology
Piezo yüksek doğruluk cerrahi Osteal kaldırma (FAZÖR): Farelerde geliştirilmiş kafatası pencere ameliyat için bir teknik Samuel D. Clark1, Rachel Mikofsky*1, Jacqueline Lawson*1, David Sulzer1 1Departments of Psychiatry, Neurology, & Pharmacology, Columbia University Medical Campus JoVE 56172 Neuroscience
Bireysel Presinaptik Terminalleri Dopamin Yayın FFNs ile görüntülendi Hui Zhang1,2, Niko G. Gubernator3,4, Minerva Yue1, Roland G. W. Staal1, Eugene V. Mosharov1, Daniela Pereira1, Vojtech Balsanek3, Paul A. Vadola3, Bipasha Mukherjee5, Robert H. Edwards5, David Sulzer1,2,6, Dalibor Sames3 1Departments of Neurology, Columbia University, 2Departments of Psychiatry and Pharmacology, Columbia University, 3Department of Chemistry, Columbia University, 4eMolecules, Inc., 5Departments of Neurology and Physiology, University of California School of Medicine, San Francisco, 6Division of Molecular Therapeutics, New York Psychiatric Institute JoVE 1562 Biology
