David Warburton Saban Research Institute Childrens Hospital Los Angeles Biography Publications Institution JoVE Articles David Warburton has not added a biography. If you are David Warburton and would like to personalize this page please email our Author Liaison for assistance. Publications Injection of Amniotic Fluid Stem Cells Delays Progression of Renal Fibrosis Journal of the American Society of Nephrology : JASN. Feb, 2012 | Pubmed ID: 22302195 MIR-99a and MIR-99b Modulate TGF-β Induced Epithelial to Mesenchymal Plasticity in Normal Murine Mammary Gland Cells PloS One. 2012 | Pubmed ID: 22299047 Cell-based Therapies for Lung Disease British Medical Bulletin. Jan, 2012 | Pubmed ID: 22279079 Mesenchymal-specific Inhibition of Vascular Endothelial Growth Factor (VEGF) Attenuates Growth in Neonatal Mice The Journal of Surgical Research. Jan, 2012 | Pubmed ID: 21696760 Embryonic Epithelial Pten Deletion Through Nkx2.1-cre Leads to Thyroid Tumorigenesis in a Strain Dependent Manner Endocrine-related Cancer. Dec, 2011 | Pubmed ID: 22167068 VEGF Optimizes the Formation of Tissue-engineered Small Intestine Regenerative Medicine. Sep, 2011 | Pubmed ID: 21916592 Contrasting Expression of Canonical Wnt Signaling Reporters TOPGAL, BATGAL and Axin2(LacZ) During Murine Lung Development and Repair PloS One. 2011 | Pubmed ID: 21858009 Cigarette Smoke Exposure Aggravates Air Space Enlargement and Alveolar Cell Apoptosis in Smad3 Knockout Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2011 | Pubmed ID: 21743024 The Milieu of Damaged Alveolar Epithelial Type 2 Cells Stimulates Alveolar Wound Repair by Endogenous and Exogenous Progenitors American Journal of Respiratory Cell and Molecular Biology. Dec, 2011 | Pubmed ID: 21700959 Stem Cells and Cell Therapies in Lung Biology and Lung Diseases Proceedings of the American Thoracic Society. Jun, 2011 | Pubmed ID: 21653527 A Perfusion-independent Role of Blood Vessels in Determining Branching Stereotypy of Lung Airways Development (Cambridge, England). Jun, 2011 | Pubmed ID: 21558382 Partial Pneumonectomy of Telomerase Null Mice Carrying Shortened Telomeres Initiates Cell Growth Arrest Resulting in a Limited Compensatory Growth Response American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2011 | Pubmed ID: 21460122 Eya1 Controls Cell Polarity, Spindle Orientation, Cell Fate and Notch Signaling in Distal Embryonic Lung Epithelium Development (Cambridge, England). Apr, 2011 | Pubmed ID: 21385765 Six1 Transcription Factor is Critical for Coordination of Epithelial, Mesenchymal and Vascular Morphogenesis in the Mammalian Lung Developmental Biology. May, 2011 | Pubmed ID: 21385574 Carbon Monoxide Pollution and Lung Function in Urban Compared with Rural Mongolian Children Respirology (Carlton, Vic.). May, 2011 | Pubmed ID: 21362106 A Modified Technique for Partial Pneumonectomy in the Mouse Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research. 2011 | Pubmed ID: 21345008 Cell Polarity and Spindle Orientation in the Distal Epithelium of Embryonic Lung Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2011 | Pubmed ID: 21246661 FGF10 Controls the Patterning of the Tracheal Cartilage Rings Via Shh Development (Cambridge, England). Jan, 2011 | Pubmed ID: 21148187 Eyes Absent 1 (Eya1) is a Critical Coordinator of Epithelial, Mesenchymal and Vascular Morphogenesis in the Mammalian Lung Developmental Biology. Feb, 2011 | Pubmed ID: 21129374 Sprouty Keeps Bowel Kinases Regular in Colon Cancer, While MiR-21 Targets Sprouty Cancer Biology & Therapy. Jan, 2011 | Pubmed ID: 21124074 Transient Overexpression of Gremlin Results in Epithelial Activation and Reversible Fibrosis in Rat Lungs American Journal of Respiratory Cell and Molecular Biology. Jun, 2011 | Pubmed ID: 20705941 Entrained Pulmonary Clocks: Epithelium and Vasculature Keeping Pace American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2010 | Pubmed ID: 20693313 Lung Organogenesis Current Topics in Developmental Biology. 2010 | Pubmed ID: 20691848 On the Derivation and Clinical Implications of "driver" Mutations in Lung Cancer American Journal of Respiratory and Critical Care Medicine. Jul, 2010 | Pubmed ID: 20463175 Explant Culture of Mouse Embryonic Whole Lung, Isolated Epithelium, or Mesenchyme Under Chemically Defined Conditions As a System to Evaluate the Molecular Mechanism of Branching Morphogenesis and Cellular Differentiation Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20204620 Protective Effect of Human Amniotic Fluid Stem Cells in an Immunodeficient Mouse Model of Acute Tubular Necrosis PloS One. 2010 | Pubmed ID: 20195358 Human Amniotic Fluid As a Potential New Source of Organ Specific Precursor Cells for Future Regenerative Medicine Applications The Journal of Urology. Mar, 2010 | Pubmed ID: 20096867 A Role for Wnt Signaling Genes in the Pathogenesis of Impaired Lung Function in Asthma American Journal of Respiratory and Critical Care Medicine. Feb, 2010 | Pubmed ID: 19926868 O-GlcNAc Mediated Glycosylation Down-regulation in Mice with Cyclophosphamide Induced Cystitis The Journal of Urology. Jan, 2010 | Pubmed ID: 19914650 Genes and Signals Regulating Murine Trophoblast Cell Development Mechanisms of Development. Jan-Feb, 2010 | Pubmed ID: 19755154 Can Increased Understanding of the Role of Lung Development and Aging Drive New Advances in Chronic Obstructive Pulmonary Disease? Proceedings of the American Thoracic Society. Dec, 2009 | Pubmed ID: 19934358 Introduction: Ninth Lund COPD Symposium Proceedings of the American Thoracic Society. Dec, 2009 | Pubmed ID: 19934348 Bcr and Abr Cooperate in Negatively Regulating Acute Inflammatory Responses Molecular and Cellular Biology. Nov, 2009 | Pubmed ID: 19703997 Development, Repair and Fibrosis: What is Common and Why It Matters Respirology (Carlton, Vic.). Jul, 2009 | Pubmed ID: 19659647 Fibroblast Growth Factor 10 Plays a Causative Role in the Tracheal Cartilage Defects in a Mouse Model of Apert Syndrome Pediatric Research. Oct, 2009 | Pubmed ID: 19581825 MiR-17 Family of MicroRNAs Controls FGF10-mediated Embryonic Lung Epithelial Branching Morphogenesis Through MAPK14 and STAT3 Regulation of E-Cadherin Distribution Developmental Biology. Sep, 2009 | Pubmed ID: 19559694 Overexpression of Fibroblast Growth Factor-10 During Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice American Journal of Respiratory and Critical Care Medicine. Sep, 2009 | Pubmed ID: 19498056 Mechanical Stretch Promotes Fetal Type II Epithelial Cell Differentiation Via Shedding of HB-EGF and TGF-alpha The Journal of Physiology. Apr, 2009 | Pubmed ID: 19237431 The 2nd International Collaborative Symposium on Stem Cell Research Regenerative Medicine. Jan, 2009 | Pubmed ID: 19105622 Regulation of Mouse Lung Development by the Extracellular Calcium-sensing Receptor, CaR The Journal of Physiology. Dec, 2008 | Pubmed ID: 18955379 Human Amniotic Fluid Stem Cells Can Integrate and Differentiate into Epithelial Lung Lineages Stem Cells (Dayton, Ohio). Nov, 2008 | Pubmed ID: 18719226 Down-regulation of Sprouty2 Via P38 MAPK Plays a Key Role in the Induction of Cellular Apoptosis by Tumor Necrosis Factor-alpha Biochemical and Biophysical Research Communications. Oct, 2008 | Pubmed ID: 18713620 Stem/progenitor Cells in Lung Development, Injury Repair, and Regeneration Proceedings of the American Thoracic Society. Aug, 2008 | Pubmed ID: 18684721 Developmental Biology: Order in the Lung Nature. Jun, 2008 | Pubmed ID: 18528385 The Human Gamma-glutamyltransferase Gene Family Human Genetics. May, 2008 | Pubmed ID: 18357469 Centrifugal Migration of Mesenchymal Cells in Embryonic Lung Developmental Dynamics : an Official Publication of the American Association of Anatomists. Mar, 2008 | Pubmed ID: 18297731 Prenatal Lung Epithelial Cell-specific Abrogation of Alk3-bone Morphogenetic Protein Signaling Causes Neonatal Respiratory Distress by Disrupting Distal Airway Formation The American Journal of Pathology. Mar, 2008 | Pubmed ID: 18258849 Tracheal Occlusion Increases the Rate of Epithelial Branching of Embryonic Mouse Lung Via the FGF10-FGFR2b-Sprouty2 Pathway Mechanisms of Development. Mar-Apr, 2008 | Pubmed ID: 18082381 The Bleomycin Animal Model: a Useful Tool to Investigate Treatment Options for Idiopathic Pulmonary Fibrosis? The International Journal of Biochemistry & Cell Biology. 2008 | Pubmed ID: 17936056 Progressive Pulmonary Fibrosis is Mediated by TGF-beta Isoform 1 but Not TGF-beta3 The International Journal of Biochemistry & Cell Biology. 2008 | Pubmed ID: 17931953 When the Lung is Stretched, Could It Be Thrombospondin Via TGFbeta1 Peptide Activation? The Journal of Physiology. Oct, 2007 | Pubmed ID: 17932141 Lung Development and Adult Lung Diseases Chest. Aug, 2007 | Pubmed ID: 17699136 TGF-beta Activates Erk MAP Kinase Signalling Through Direct Phosphorylation of ShcA The EMBO Journal. Sep, 2007 | Pubmed ID: 17673906 Fgf10 Dosage is Critical for the Amplification of Epithelial Cell Progenitors and for the Formation of Multiple Mesenchymal Lineages During Lung Development Developmental Biology. Jul, 2007 | Pubmed ID: 17560563 Sprouty2 Downregulation Plays a Pivotal Role in Mediating Crosstalk Between TGF-beta1 Signaling and EGF As Well As FGF Receptor Tyrosine Kinase-ERK Pathways in Mesenchymal Cells Journal of Cellular Physiology. Sep, 2007 | Pubmed ID: 17516543 Selenium and Metal Concentrations in Waterbird Eggs and Chicks at Agassiz National Wildlife Refuge, Minnesota Archives of Environmental Contamination and Toxicology. Jul, 2007 | Pubmed ID: 17464443 TNF-alpha Represses Transcription of Human Bone Morphogenetic Protein-4 in Lung Epithelial Cells Gene. May, 2007 | Pubmed ID: 17350185 Water Level Management and Contaminant Exposure to Tree Swallows Nesting on the Upper Mississippi River Environmental Monitoring and Assessment. Oct, 2007 | Pubmed ID: 17286172 Meeting Report: the First International Collaborative Symposium on Stem Cell Research, Seoul, Korea Stem Cells (Dayton, Ohio). May, 2007 | Pubmed ID: 17272495 Smad3 Signaling Involved in Pulmonary Fibrosis and Emphysema Proceedings of the American Thoracic Society. Nov, 2006 | Pubmed ID: 17065376 Lung Development and Susceptibility to Chronic Obstructive Pulmonary Disease Proceedings of the American Thoracic Society. Nov, 2006 | Pubmed ID: 17065371 Transforming Growth Factor-beta3 Affects Plasminogen Activator Inhibitor-1 Expression in Fetal Mice and Modulates Fibroblast-mediated Collagen Gel Contraction Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Sep-Oct, 2006 | Pubmed ID: 17014662 Levels of Mesenchymal FGFR2 Signaling Modulate Smooth Muscle Progenitor Cell Commitment in the Lung Developmental Biology. Nov, 2006 | Pubmed ID: 16989802 Fibroblast Growth Factor 10 is Required for Survival and Proliferation but Not Differentiation of Intestinal Epithelial Progenitor Cells During Murine Colon Development Developmental Biology. Nov, 2006 | Pubmed ID: 16956603 Trace Element Concentrations and Bioindicator Responses in Tree Swallows from Northwestern Minnesota Environmental Monitoring and Assessment. Jul, 2006 | Pubmed ID: 16897545 BMP4 Activation and Secretion Are Negatively Regulated by an Intracellular Gremlin-BMP4 Interaction The Journal of Biological Chemistry. Sep, 2006 | Pubmed ID: 16880207 Differential Role of FGF9 on Epithelium and Mesenchyme in Mouse Embryonic Lung Developmental Biology. May, 2006 | Pubmed ID: 16494859 The Fibroblast Growth Factor Pathway Serves a Regulatory Role in Proliferation and Apoptosis in the Pathogenesis of Intestinal Atresia Journal of Pediatric Surgery. Jan, 2006 | Pubmed ID: 16410122 VEGF-A Signaling Through Flk-1 is a Critical Facilitator of Early Embryonic Lung Epithelial to Endothelial Crosstalk and Branching Morphogenesis Developmental Biology. Feb, 2006 | Pubmed ID: 16375885 Lo, and the Niche is Knit: Lysyl Oxidase Activity and Maintenance of Lung, Aorta, and Skin Integrity The American Journal of Pathology. Oct, 2005 | Pubmed ID: 16192627 A Novel Function for the Protein Tyrosine Phosphatase Shp2 During Lung Branching Morphogenesis Developmental Biology. Jun, 2005 | Pubmed ID: 15950607 Molecular Mechanisms of Early Lung Specification and Branching Morphogenesis Pediatric Research. May, 2005 | Pubmed ID: 15817505 Colonic Atresia Without Mesenteric Vascular Occlusion. The Role of the Fibroblast Growth Factor 10 Signaling Pathway Journal of Pediatric Surgery. Feb, 2005 | Pubmed ID: 15750935 Fibroblast Growth Factor-10 Serves a Regulatory Role in Duodenal Development Journal of Pediatric Surgery. Feb, 2005 | Pubmed ID: 15750921 Infection-induced Kinin B1 Receptors in Human Pulmonary Fibroblasts: Role of Intact Pathogens and P38 Mitogen-activated Protein Kinase-dependent Signaling The Journal of Pharmacology and Experimental Therapeutics. Jun, 2005 | Pubmed ID: 15743925 Smad1 Expression and Function During Mouse Embryonic Lung Branching Morphogenesis American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2005 | Pubmed ID: 15681399 Dickkopf-1 (DKK1) Reveals That Fibronectin is a Major Target of Wnt Signaling in Branching Morphogenesis of the Mouse Embryonic Lung Developmental Biology. Jan, 2005 | Pubmed ID: 15617677 Abnormal Mouse Lung Alveolarization Caused by Smad3 Deficiency is a Developmental Antecedent of Centrilobular Emphysema American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2005 | Pubmed ID: 15591413 Stem/progenitor Cells in Lung Morphogenesis, Repair, and Regeneration Current Topics in Developmental Biology. 2004 | Pubmed ID: 15563941 Knock-on Effect of Anthrax Lethal Toxin on Macrophages Potentiates Cytotoxicity to Endothelial Cells Microbes and Infection / Institut Pasteur. Jul, 2004 | Pubmed ID: 15374005 Fibroblast Growth Factor Receptor 2 IIIb Invalidation--a Potential Cause of Familial Duodenal Atresia Journal of Pediatric Surgery. Jun, 2004 | Pubmed ID: 15185216 Fibroblast Growth Factor 10 (Fgf10) Invalidation Results in Anorectal Malformation in Mice Journal of Pediatric Surgery. Mar, 2004 | Pubmed ID: 15017552 The Molecular Genetics of Lung Morphogenesis and Injury Repair Paediatric Respiratory Reviews. 2004 | Pubmed ID: 14980285 Genomic Structure and Promoter Characterization of the Human Sprouty4 Gene, a Novel Regulator of Lung Morphogenesis American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2004 | Pubmed ID: 14977631 Overexpression of Smurf1 Negatively Regulates Mouse Embryonic Lung Branching Morphogenesis by Specifically Reducing Smad1 and Smad5 Proteins American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2004 | Pubmed ID: 14711801 Editorial Note: MDMA-induced Dopamine Neurotoxicity Psychopharmacology. Jan, 2004 | Pubmed ID: 14634718 Isolation of a Putative Progenitor Subpopulation of Alveolar Epithelial Type 2 Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2004 | Pubmed ID: 12922980 Functional Analysis of the Human Sprouty2 Gene Promoter Gene. Dec, 2003 | Pubmed ID: 14644509 Transfer of the Active Form of Transforming Growth Factor-beta 1 Gene to Newborn Rat Lung Induces Changes Consistent with Bronchopulmonary Dysplasia The American Journal of Pathology. Dec, 2003 | Pubmed ID: 14633629 TACE is Required for Fetal Murine Cardiac Development and Modeling Developmental Biology. Sep, 2003 | Pubmed ID: 14499647 Attribution and the Effects of Expectancy: How Beliefs Can Influence the Experiences of Smoking Cessation Addictive Behaviors. Sep, 2003 | Pubmed ID: 12915176 The Influence of Changing Nicotine to Tar Ratios on Human Puffing Behaviour and Perceived Sensory Response Psychopharmacology. Dec, 2003 | Pubmed ID: 12904967 Growth Factor Signaling in Lung Morphogenetic Centers: Automaticity, Stereotypy and Symmetry Respiratory Research. 2003 | Pubmed ID: 12818006 Burkholderia Cepacia-induced IL-8 Gene Expression in an Alveolar Epithelial Cell Line: Signaling Through CD14 and Mitogen-activated Protein Kinase Pediatric Research. Sep, 2003 | Pubmed ID: 12761358 Fibrillin Controls TGF-beta Activation Nature Genetics. Mar, 2003 | Pubmed ID: 12610545 Nongenomic Estrogen Action Regulates Tyrosine Phosphatase Activity and Tuberin Stability Molecular and Cellular Endocrinology. Jan, 2003 | Pubmed ID: 12581886 Differential Expression of Urokinase-type Plasminogen Activator and Plasminogen Activator Inhibitor-1 in Early and Late Gestational Mouse Skin and Skin Wounds Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society. Nov-Dec, 2002 | Pubmed ID: 12453143 Commentary On: "comprehensive Observational Assessment: Ia. A Systematic, Quantitative Procedure for Assessing the Behavioral and Physiologic State of the Mouse." Psychopharmacologia (1968) 13: 222-257 Psychopharmacology. Aug, 2002 | Pubmed ID: 12238442 Nitrofen Inhibition of Pulmonary Growth and Development Occurs in the Early Embryonic Mouse Journal of Pediatric Surgery. Sep, 2002 | Pubmed ID: 12194114 Commentary On: "Effects of Scopolamine and Nicotine on Human Rapid Information Processing Performance." Psychopharmacology (1984) 82:147-150. Nicotine Improves Information Processing: Saying the Unthinkable Psychopharmacology. Aug, 2002 | Pubmed ID: 12172687 Murine Nitrofen-induced Pulmonary Hypoplasia Does Not Involve Induction of TGF-beta Signaling Journal of Pediatric Surgery. Aug, 2002 | Pubmed ID: 12149686 Sound the Tocsin! Beware Adverse Effects of Lung Inflammation Early in Gestation American Journal of Respiratory and Critical Care Medicine. Mar, 2002 | Pubmed ID: 11897634 Smad3 Deficiency Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Mar, 2002 | Pubmed ID: 11839555 Fare Embriyonik Akciğer Kültür, Dallanma Moleküler Mekanizmalar değerlendirin Bir Sistem Gianni Carraro1, Pierre-Marie del Moral1, David Warburton1 1Saban Research Institute, Childrens Hospital Los Angeles JoVE 2035 Biology
Fare Embriyonik Akciğer Kültür, Dallanma Moleküler Mekanizmalar değerlendirin Bir Sistem Gianni Carraro1, Pierre-Marie del Moral1, David Warburton1 1Saban Research Institute, Childrens Hospital Los Angeles JoVE 2035 Biology