Davide Trotti

Publications

• Proteostatic Imbalance and Protein Spreading in Amyotrophic Lateral Sclerosis
  The EMBO Journal. May, 2021  |   Pubmed ID: 33792056
• Synaptic Dysfunction Induced by Glycine-alanine Dipeptides in C9orf72-ALS/FTD is Rescued by SV2 Replenishment
  EMBO Molecular Medicine. 05, 2020  |   Pubmed ID: 32347002
• Excess Glutamate Secreted from Astrocytes Drives Upregulation of P-glycoprotein in Endothelial Cells in Amyotrophic Lateral Sclerosis
  Experimental Neurology. 06, 2019  |   Pubmed ID: 30974102
• Repeat-associated Non-AUG Translation in C9orf72-ALS/FTD is Driven by Neuronal Excitation and Stress
  EMBO Molecular Medicine. 02, 2019  |   Pubmed ID: 30617154
• MiR126-5p Downregulation Facilitates Axon Degeneration and NMJ Disruption Via a Non-Cell-Autonomous Mechanism in ALS
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 06, 2018  |   Pubmed ID: 29773756
• Haploinsufficiency Leads to Neurodegeneration in C9ORF72 ALS/FTD Human Induced Motor Neurons
  Nature Medicine. 03, 2018  |   Pubmed ID: 29400714
• EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis
  Advances in Neurobiology. 2017  |   Pubmed ID: 28828608
• Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies
  The AAPS Journal. 11, 2017  |   Pubmed ID: 28779378
• Mutation of the Caspase-3 Cleavage Site in the Astroglial Glutamate Transporter EAAT2 Delays Disease Progression and Extends Lifespan in the SOD1-G93A Mouse Model of ALS
  Experimental Neurology. 06, 2017  |   Pubmed ID: 28342750
• Pathogenic Determinants and Mechanisms of ALS/FTD Linked to Hexanucleotide Repeat Expansions in the C9orf72 Gene
  Neuroscience Letters. 01, 2017  |   Pubmed ID: 27619540
• Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD
  Cell Reports. 10, 2016  |   Pubmed ID: 27732842
• Astrocytes Drive Upregulation of the Multidrug Resistance Transporter ABCB1 (P-Glycoprotein) in Endothelial Cells of the Blood-brain Barrier in Mutant Superoxide Dismutase 1-linked Amyotrophic Lateral Sclerosis
  Glia. 08, 2016  |   Pubmed ID: 27158936
• Regulation of ABC Efflux Transporters at Blood-brain Barrier in Health and Neurological Disorders
  Brain Research. Dec, 2015  |   Pubmed ID: 26187753
• ABC Transporter-driven Pharmacoresistance in Amyotrophic Lateral Sclerosis
  Brain Research. May, 2015  |   Pubmed ID: 25175835
• Inhibiting Drug Efflux Transporters Improves Efficacy of ALS Therapeutics
  Annals of Clinical and Translational Neurology. Dec, 2014  |   Pubmed ID: 25574474
• Role of Mitochondria in Mutant SOD1 Linked Amyotrophic Lateral Sclerosis
  Biochimica Et Biophysica Acta. Aug, 2014  |   Pubmed ID: 24568860
• Sumoylation of Critical Proteins in Amyotrophic Lateral Sclerosis: Emerging Pathways of Pathogenesis
  Neuromolecular Medicine. Dec, 2013  |   Pubmed ID: 24062161
• Small Peptides Against the Mutant SOD1/Bcl-2 Toxic Mitochondrial Complex Restore Mitochondrial Function and Cell Viability in Mutant SOD1-mediated ALS
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2013  |   Pubmed ID: 23843527
• Selective Increase of Two ABC Drug Efflux Transporters at the Blood-spinal Cord Barrier Suggests Induced Pharmacoresistance in ALS
  Neurobiology of Disease. Aug, 2012  |   Pubmed ID: 22521463
• An Over-oxidized Form of Superoxide Dismutase Found in Sporadic Amyotrophic Lateral Sclerosis with Bulbar Onset Shares a Toxic Mechanism with Mutant SOD1
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2012  |   Pubmed ID: 22416121
• Motor Neuron Impairment Mediated by a Sumoylated Fragment of the Glial Glutamate Transporter EAAT2
  Glia. Nov, 2011  |   Pubmed ID: 21769946
• Voltage-dependent Inwardly Rectifying Potassium Conductance in the Outer Membrane of Neuronal Mitochondria
  The Journal of Biological Chemistry. Aug, 2010  |   Pubmed ID: 20551319
• ALS-linked Mutant SOD1 Damages Mitochondria by Promoting Conformational Changes in Bcl-2
  Human Molecular Genetics. Aug, 2010  |   Pubmed ID: 20460269
• Glutamate Transporters and the Excitotoxic Path to Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis
  Antioxidants & Redox Signaling. Jul, 2009  |   Pubmed ID: 19413484
• Nordihydroguaiaretic Acid Increases Glutamate Uptake in Vitro and in Vivo: Therapeutic Implications for Amyotrophic Lateral Sclerosis
  Experimental Neurology. Sep, 2008  |   Pubmed ID: 18625223
• A Caspase-3-cleaved Fragment of the Glial Glutamate Transporter EAAT2 is Sumoylated and Targeted to Promyelocytic Leukemia Nuclear Bodies in Mutant SOD1-linked Amyotrophic Lateral Sclerosis
  The Journal of Biological Chemistry. Nov, 2007  |   Pubmed ID: 17823119
• Astrocytes Expressing ALS-linked Mutant FUS Induce Motor Neuron Death Through Release of Tumor Necrosis Factor-alpha
  Glia.   |   Pubmed ID: 29380416
• Antisense Proline-arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates That Initiate in Vitro and in Vivo Neuronal Death
  Neuron.   |   Pubmed ID: 25521377