Dean A. Lee Center for Childhood Cancer and Blood Disease Nationwide Children's Hospital Biography Publications Institution JoVE Articles Dean A. Lee has not added a biography. If you are Dean A. Lee and would like to personalize this page please email our Author Liaison for assistance. Publications Aggressive Natural Killer-cell Leukemia mutational Landscape and Drug Profiling Highlight JAK-STAT Signaling As Therapeutic Target Nature Communications. Apr, 2018 | Pubmed ID: 29674644 Inhibiting TGF-beta Signaling Preserves the Function of Highly Activated, in Vitro Expanded Natural Killer Cells in AML and Colon Cancer Models PloS One. 2018 | Pubmed ID: 29342200 Ex Vivo-expanded NK Cells from Blood and Ascites of Ovarian Cancer Patients Are Cytotoxic Against Autologous Primary Ovarian Cancer Cells Cancer Immunology, Immunotherapy : CII. Apr, 2018 | Pubmed ID: 29299659 Ex Vivo-expanded Natural Killer Cells Derived From Long-term Cryopreserved Cord Blood Are Cytotoxic Against Primary Breast Cancer Cells Journal of Immunotherapy (Hagerstown, Md. : 1997). Feb/Mar, 2018 | Pubmed ID: 29189387 Venous Thromboembolism in Pediatric Hematopoietic Cell Transplant: A Multicenter Cohort Study Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. Feb, 2018 | Pubmed ID: 29128552 Radiotherapy Enhances Natural Killer Cell Cytotoxicity and Localization in Pre-clinical Canine Sarcomas and First-in-dog Clinical Trial Journal for Immunotherapy of Cancer. Dec, 2017 | Pubmed ID: 29254507 Phase 1 Clinical Trial Using MbIL21 Ex Vivo-expanded Donor-derived NK Cells After Haploidentical Transplantation Blood. 10, 2017 | Pubmed ID: 28835441 Ex Vivo Expanded Natural Killer Cells from Breast Cancer Patients and Healthy Donors Are Highly Cytotoxic Against Breast Cancer Cell Lines and Patient-derived Tumours Breast Cancer Research : BCR. Jul, 2017 | Pubmed ID: 28668076 IL-18/IL-15/IL-12 Synergy Induces Elevated and Prolonged IFN-γ Production by Ex Vivo Expanded NK Cells Which is Not Due to Enhanced STAT4 Activation Molecular Immunology. Aug, 2017 | Pubmed ID: 28644973 Interferon Gamma Induces Changes in Natural Killer (NK) Cell Ligand Expression and Alters NK Cell-Mediated Lysis of Pediatric Cancer Cell Lines Frontiers in Immunology. 2017 | Pubmed ID: 28428785 The Histone Deacetylase Inhibitor Valproic Acid Inhibits NKG2D Expression in Natural Killer Cells Through Suppression of STAT3 and HDAC3 Scientific Reports. Mar, 2017 | Pubmed ID: 28338101 Natural Killer Cells in Malignant Hematology: A Primer for the Non-immunologist Blood Reviews. Mar, 2017 | Pubmed ID: 27665023 La Terapia Della Cellula NK: Targeting Ricaduta Di Malattia Dopo Trapianto Di Cellule Staminali Ematopoietiche Immunotherapy. Feb, 2012 | Pubmed ID: 22329587 Membrana-limiti IL-21 Promuove Sostenuta Proliferazione Ex Vivo Di Cellule Natural Killer PloS One. 2012 | Pubmed ID: 22279576 Infusione Di CD19-regia Di Cellule T Per Aumentare Il Controllo Della Malattia Nei Pazienti Sottoposti a Autologo Trapianto Cellule Staminali Ematopoietiche Per Neoplasie Avanzate B-linfoidi Human Gene Therapy. Jan, 2012 | Pubmed ID: 22107246 Riprogrammazione Di Cellule CD19-specifiche T Con IL 21 Di Segnalazione Può Migliorare Adoptive Immunoterapia Dei Tumori Maligni B-lineage Cancer Research. May, 2011 | Pubmed ID: 21558388 Acquisizione, Preparazione E Valutazione Funzionale Delle Cellule NK Umane Per Adoptive Immunoterapia Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20686960 Un Dispositivo Di Microelectroporation Ad Alto Rendimento Per Introdurre Un Recettore Chimerico Antigene Per Reindirizzare La Specificità Delle Cellule T Umane Biomedical Microdevices. Oct, 2010 | Pubmed ID: 20574820 Combinando CD19 Redirezione E Alloanergization Per Generare Cellule T Umane Di Tumore-specifici Per La Terapia Dei Tumori Maligni Delle Cellule B Cellule Allogeniche Cancer Research. May, 2010 | Pubmed ID: 20424114 PiggyBac Sistema Trasposone/permettono Di Generare Le Cellule T CD19-specifici Per Il Trattamento Di Neoplasie B-lineage Human Gene Therapy. Apr, 2010 | Pubmed ID: 19905893 EBV + Malattia Linfoproliferativa Dopo Chemioterapia Prolungata Per Refrattario LCH Pediatric Blood & Cancer. Mar, 2008 | Pubmed ID: 17243127 C/EBPbeta Soppressione Dall'interruzione Della CUGBP1 Risultante Da Un Complesso Riarrangiamento Di MLL Cancer Genetics and Cytogenetics. Sep, 2007 | Pubmed ID: 17854664 Vaccini Rotavirus The New England Journal of Medicine. Apr, 2006 | Pubmed ID: 16625014 Sarcoma Granulocytic Presentando Come Polmonite in Un Bambino Con Leucemia Mieloide Acuta T: Diagnosi Mediante Ibridazione in Situ Fluorescente Journal of Pediatric Hematology/oncology. Jul, 2004 | Pubmed ID: 15218417 Tumore-specifico Umane CD4 + Cellule T Regolatorie E Loro Ligandi: Implicazioni Per L'immunoterapia Immunity. Jan, 2004 | Pubmed ID: 14738769 Attivati Linfociti T Periferici Apoptosi Quando Coltivate Con Monociti Attivati Tramite La Legatura Di II Classe HLA Cellular Immunology. Oct, 2003 | Pubmed ID: 14698144 Generazione di cellule Knock-out NK umano primario ed espansa utilizzando Cas9 ribonucleoproteine Meisam Naeimi Kararoudi1, Hamid Dolatshad2, Prashant Trikha1, Syed-Rehan A. Hussain3, Ezgi Elmas1, Jennifer A. Foltz1, Jena E. Moseman1, Aarohi Thakkar1, Robin J. Nakkula1, Margaret Lamb1, Nitin Chakravarti1, K. John McLaughlin3, Dean A. Lee1 1Center for Childhood Cancer and Blood Disease, Nationwide Children's Hospital, 2Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, 3Center for Clinical and Translational Research, Nationwide Children's Hospital Research Institute JoVE 58237 Immunology and Infection Espansione, di purificazione, e la valutazione funzionale delle cellule del sangue umano periferico NK Srinivas S. Somanchi1, Vladimir V. Senyukov1, Cecele J. Denman1, Dean A. Lee1 1Division of Pediatrics, MD Anderson Cancer Center - University of Texas JoVE 2540 Immunology and Infection
Generazione di cellule Knock-out NK umano primario ed espansa utilizzando Cas9 ribonucleoproteine Meisam Naeimi Kararoudi1, Hamid Dolatshad2, Prashant Trikha1, Syed-Rehan A. Hussain3, Ezgi Elmas1, Jennifer A. Foltz1, Jena E. Moseman1, Aarohi Thakkar1, Robin J. Nakkula1, Margaret Lamb1, Nitin Chakravarti1, K. John McLaughlin3, Dean A. Lee1 1Center for Childhood Cancer and Blood Disease, Nationwide Children's Hospital, 2Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, 3Center for Clinical and Translational Research, Nationwide Children's Hospital Research Institute JoVE 58237 Immunology and Infection
Espansione, di purificazione, e la valutazione funzionale delle cellule del sangue umano periferico NK Srinivas S. Somanchi1, Vladimir V. Senyukov1, Cecele J. Denman1, Dean A. Lee1 1Division of Pediatrics, MD Anderson Cancer Center - University of Texas JoVE 2540 Immunology and Infection