Debra Saunders Oklahoma Medical Research Foundation Biography Publications Institution JoVE Articles Debra Saunders has not added a biography. If you are Debra Saunders and would like to personalize this page please email our Author Liaison for assistance. Publications XRN2 Is Required for Cell Motility and Invasion in Glioblastomas Cells. 04, 2022 | Pubmed ID: 35563787 OKN-007 Alters Protein Expression Profiles in High-Grade Gliomas: Mass Spectral Analysis of Blood Sera Brain Sciences. Jan, 2022 | Pubmed ID: 35053843 A Tale of Two Multi-focal Therapies for Glioblastoma: An Antibody Targeting ELTD1 and Nitrone-based OKN-007 Journal of Cellular and Molecular Medicine. 01, 2022 | Pubmed ID: 34910361 MRI As a Tool to Assess Interstitial Cystitis Associated Bladder and Brain Pathologies Diagnostics (Basel, Switzerland). Dec, 2021 | Pubmed ID: 34943535 Temporary Opening of the Blood-brain Barrier with the Nitrone Compound OKN-007 American Journal of Nuclear Medicine and Molecular Imaging. 2021 | Pubmed ID: 34754607 ELTD1 As a Multi-focal Target for Malignant Gliomas: Preclinical Studies Neuro-oncology Advances. Jan-Dec, 2021 | Pubmed ID: 34704036 Rapamycin Restores Brain Vasculature, Metabolism, and Blood-brain Barrier in an Inflammaging Model GeroScience. 04, 2021 | Pubmed ID: 33846885 SuperGAG Biopolymers for Treatment of Excessive Bladder Permeability Pharmacology Research & Perspectives. 02, 2021 | Pubmed ID: 33540486 ELTD1 As a Biomarker for Multiple Sclerosis: Pre-clinical Molecular-targeted Studies in a Mouse Experimental Autoimmune Encephalomyelitis Model Multiple Sclerosis and Related Disorders. Apr, 2021 | Pubmed ID: 33517175 Age-related Alterations in the Cerebrovasculature Affect Neurovascular Coupling and BOLD FMRI Responses: Insights from Animal Models of Aging Psychophysiology. 07, 2021 | Pubmed ID: 33141436 Novel Approaches to Combat Chemoresistance Against Glioblastomas Cancer Drug Resistance (Alhambra, Calif.). 2020 | Pubmed ID: 35582224 OKlahoma Nitrone-007: Novel Treatment for Diffuse Intrinsic Pontine Glioma Journal of Translational Medicine. 11, 2020 | Pubmed ID: 33168005 In Vivo and Ex Vivo Assessment of Bladder Hyper-permeability and Using Molecular Targeted Magnetic Resonance Imaging to Detect Claudin-2 in a Mouse Model for Interstitial Cystitis PloS One. 2020 | Pubmed ID: 33095778 Biodegradable PH-responsive Amorphous Calcium Carbonate Nanoparticles As Immunoadjuvants for Multimodal Imaging and Enhanced Photoimmunotherapy Journal of Materials Chemistry. B. 09, 2020 | Pubmed ID: 32812632 Immunologically Modified MnFeO Nanoparticles to Synergize Photothermal Therapy and Immunotherapy for Cancer Treatment Chemical Engineering Journal (Lausanne, Switzerland : 1996). Sep, 2020 | Pubmed ID: 32523422 Assessing Bladder Hyper-permeability Biomarkers Using Molecularly-targeted MRI American Journal of Nuclear Medicine and Molecular Imaging. 2020 | Pubmed ID: 32211219 Assessment of an ScFv Antibody Fragment Against ELTD1 in a G55 Glioblastoma Xenograft Model Translational Oncology. Mar, 2020 | Pubmed ID: 32208341 Molecular Changes Associated with Spinal Cord Aging GeroScience. 04, 2020 | Pubmed ID: 32144690 Optimized Monoclonal Antibody Treatment Against ELTD1 for GBM in a G55 Xenograft Mouse Model Journal of Cellular and Molecular Medicine. 01, 2020 | Pubmed ID: 31863639 PEGylated Reduced-graphene Oxide Hybridized with FeO Nanoparticles for Cancer Photothermal-immunotherapy Journal of Materials Chemistry. B. 12, 2019 | Pubmed ID: 31710067 Association of Decreased Levels of Lipopolysaccharide-binding Protein with OKN-007-induced Regression of Tumor Growth in an F98 Rat Glioma Model Journal of Neurosurgery. Oct, 2019 | Pubmed ID: 31628293 Anti-inflammatory Agent, OKN-007, Reverses Long-term Neuroinflammatory Responses in a Rat Encephalopathy Model As Assessed by Multi-parametric MRI: Implications for Aging-associated Neuroinflammation GeroScience. 08, 2019 | Pubmed ID: 31478121 Using MRI to Measure in Vivo Free Radical Production and Perfusion Dynamics in a Mouse Model of Elevated Oxidative Stress and Neurogenic Atrophy Redox Biology. 09, 2019 | Pubmed ID: 31470261 Targeting ELTD1, an Angiogenesis Marker for Glioblastoma (GBM), Also Affects VEGFR2: Molecular-targeted MRI Assessment American Journal of Nuclear Medicine and Molecular Imaging. 2019 | Pubmed ID: 30911439 Immunomodulatory Response of Layered Small Intestinal Submucosa in a Rat Bladder Regeneration Model Journal of Biomedical Materials Research. Part B, Applied Biomaterials. Aug, 2019 | Pubmed ID: 30521124 OKN-007 Increases Temozolomide (TMZ) Sensitivity and Suppresses TMZ-Resistant Glioblastoma (GBM) Tumor Growth Translational Oncology. Feb, 2019 | Pubmed ID: 30468988 Preclinical Animal Studies of Intravesical Recombinant Human Proteoglycan 4 As a Novel Potential Therapy for Diseases Resulting From Increased Bladder Permeability Urology. Jun, 2018 | Pubmed ID: 29545038 Therapeutic Efficacy of a Synthetic Epsin Mimetic Peptide in Glioma Tumor Model: Uncovering Multiple Mechanisms Beyond the VEGF-associated Tumor Angiogenesis Journal of Neuro-oncology. May, 2018 | Pubmed ID: 29357089 Reduced Urothelial Regeneration in Rat Bladders Augmented with Permeable Porcine Small Intestinal Submucosa Assessed by Magnetic Resonance Imaging Journal of Biomedical Materials Research. Part B, Applied Biomaterials. 07, 2018 | Pubmed ID: 28901710 AG488 As a Therapy Against Gliomas Oncotarget. Sep, 2017 | Pubmed ID: 29069750 Gestational Hypoxia Disrupts the Neonatal Leptin Surge and Programs Hyperphagia and Obesity in Male Offspring in the Sprague-Dawley Rat PloS One. 2017 | Pubmed ID: 28957383 ELTD1, an Effective Anti-angiogenic Target for Gliomas: Preclinical Assessment in Mouse GL261 and Human G55 Xenograft Glioma Models Neuro-oncology. 02, 2017 | Pubmed ID: 27416955 Ameliorative Effects of Antioxidants on the Hippocampal Accumulation of Pathologic Tau in a Rat Model of Blast-Induced Traumatic Brain Injury Oxidative Medicine and Cellular Longevity. 2016 | Pubmed ID: 27034735 Safe Oral Triiodo-L-Thyronine Therapy Protects from Post-Infarct Cardiac Dysfunction and Arrhythmias Without Cardiovascular Adverse Effects PloS One. 2016 | Pubmed ID: 26981865 Motif Mimetic of Epsin Perturbs Tumor Growth and Metastasis The Journal of Clinical Investigation. Dec, 2015 | Pubmed ID: 26571402 Assessment of Colon and Bladder Crosstalk in an Experimental Colitis Model Using Contrast-enhanced Magnetic Resonance Imaging Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. Nov, 2015 | Pubmed ID: 26303228 OKN-007 Decreases VEGFR-2 Levels in a Preclinical GL261 Mouse Glioma Model American Journal of Nuclear Medicine and Molecular Imaging. 2015 | Pubmed ID: 26269774 Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts PloS One. 2015 | Pubmed ID: 26248280 A New Anti-glioma Therapy, AG119: Pre-clinical Assessment in a Mouse GL261 Glioma Model BMC Cancer. Jul, 2015 | Pubmed ID: 26177924 OKN-007 Decreases Free Radical Levels in a Preclinical F98 Rat Glioma Model Free Radical Biology & Medicine. Oct, 2015 | Pubmed ID: 26119786 In Vivo Targeted Molecular Magnetic Resonance Imaging of Free Radicals in Diabetic Cardiomyopathy Within Mice Free Radical Research. 2015 | Pubmed ID: 25968951 OKN-007 Decreases Tumor Necrosis and Tumor Cell Proliferation and Increases Apoptosis in a Preclinical F98 Rat Glioma Model Journal of Magnetic Resonance Imaging : JMRI. Dec, 2015 | Pubmed ID: 25920494 Contrast Enhanced Magnetic Resonance Imaging As a Diagnostic Tool to Assess Bladder Permeability and Associated Colon Cross Talk: Preclinical Studies in a Rat Model The Journal of Urology. Apr, 2015 | Pubmed ID: 25463988 Experimental Validation of 5 In-silico Predicted Glioma Biomarkers Neuro-oncology. Dec, 2013 | Pubmed ID: 24158112 In Vivo Detection of Free Radicals in Mouse Septic Encephalopathy Using Molecular MRI and Immuno-spin Trapping Free Radical Biology & Medicine. 12, 2013 | Pubmed ID: 23978375 Molecular MRI Differentiation of VEGF Receptor-2 Levels in C6 and RG2 Glioma Models American Journal of Nuclear Medicine and Molecular Imaging. 2013 | Pubmed ID: 23901356 In Vivo Detection of Free Radicals Using Molecular MRI and Immuno-spin Trapping in a Mouse Model for Amyotrophic Lateral Sclerosis Free Radical Biology & Medicine. Oct, 2013 | Pubmed ID: 23722162 Regression of Glioma Tumor Growth in F98 and U87 Rat Glioma Models by the Nitrone OKN-007 Neuro-oncology. Mar, 2013 | Pubmed ID: 23328810 ELTD1, a Potential New Biomarker for Gliomas Neurosurgery. Jan, 2013 | Pubmed ID: 23096411 Endothelial Epsin Deficiency Decreases Tumor Growth by Enhancing VEGF Signaling The Journal of Clinical Investigation. Dec, 2012 | Pubmed ID: 23187125 In Vivo Imaging of Immuno-spin Trapped Radicals with Molecular Magnetic Resonance Imaging in a Diabetic Mouse Model Diabetes. Oct, 2012 | Pubmed ID: 22698922 In Vivo Characterization of Several Rodent Glioma Models by 1H MRS NMR in Biomedicine. Apr, 2012 | Pubmed ID: 21954105 Assessment of Thermal Effects of Interstitial Laser Phototherapy on Mammary Tumors Using Proton Resonance Frequency Method Journal of Biomedical Optics. Dec, 2011 | Pubmed ID: 22191937 Effects of PBN and OKN007 in Rodent Glioma Models Assessed by 1H MR Spectroscopy Free Radical Biology & Medicine. Jul, 2011 | Pubmed ID: 21600283 Molecular MRI Assessment of Vascular Endothelial Growth Factor Receptor-2 in Rat C6 Gliomas Journal of Cellular and Molecular Medicine. Apr, 2011 | Pubmed ID: 20497492 In Vivo Detection of Inducible Nitric Oxide Synthase in Rodent Gliomas Free Radical Biology & Medicine. Mar, 2010 | Pubmed ID: 20034558 Molecular Magnetic Resonance Imaging Approaches Used to Aid in the Understanding of the Tissue Regeneration Marker Met in Vivo: Implications for Tissue Engineering Tissue Engineering. Part A. Feb, 2010 | Pubmed ID: 19905873 Sepsis-associated Encephalopathy: a Magnetic Resonance Imaging and Spectroscopy Study Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Feb, 2010 | Pubmed ID: 19844239 Molecular Magnetic Resonance Imaging Approaches Used to Aid in the Understanding of Angiogenesis in Vivo: Implications for Tissue Engineering Tissue Engineering. Part A. Feb, 2010 | Pubmed ID: 19663584 Diffusion Tensor Imaging and Fiber Tractography of C6 Rat Glioma Journal of Magnetic Resonance Imaging : JMRI. Sep, 2008 | Pubmed ID: 18777530 Visualization of the Protective Ability of a Free Radical Trapping Compound Against Rat C6 and F98 Gliomas with Diffusion Tensor Fiber Tractography Journal of Magnetic Resonance Imaging : JMRI. Sep, 2008 | Pubmed ID: 18777527 Chemical Speciation by Selective Heteronuclear Single-quantum Coherence Spectroscopy: Determination of Double-bond Quantity in Unsaturated Fatty Acid Compounds NMR in Biomedicine. May, 2008 | Pubmed ID: 17854108 Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy Michael G. Melek1, Rheal Towner2,3, Johannes Kung1, Debra Saunders4, Michelle Zales3,4, Faizah Bhatti1,3 1Department of Pediatrics, University of Oklahoma Health Sciences Center, 2Department of Chemistry, University of Prince Edward Island, 3Center for Neuroscience, University of Oklahoma Health Sciences Center, 4Oklahoma Medical Research Foundation JoVE 64183 Medicine
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy Michael G. Melek1, Rheal Towner2,3, Johannes Kung1, Debra Saunders4, Michelle Zales3,4, Faizah Bhatti1,3 1Department of Pediatrics, University of Oklahoma Health Sciences Center, 2Department of Chemistry, University of Prince Edward Island, 3Center for Neuroscience, University of Oklahoma Health Sciences Center, 4Oklahoma Medical Research Foundation JoVE 64183 Medicine
