Derek J. Wilson

Publications

• Distinct Dynamic Modes Enable the Engagement of Dissimilar Ligands in a Promiscuous Atypical RNA Recognition Motif
  Biochemistry. Dec, 2016  |   Pubmed ID: 27959512
• Potent Inhibition of 3-Deoxy-d-arabinoheptulosonate-7-phosphate (DAHP) Synthase by DAHP Oxime, a Phosphate Group Mimic
  Biochemistry. Dec, 2016  |   Pubmed ID: 27933795
• Hydrogen Deuterium Exchange Mass Spectrometry in Biopharmaceutical Discovery and Development - A Review
  Analytica Chimica Acta. Oct, 2016  |   Pubmed ID: 27662755
• Differential Mobility Spectrometry-Hydrogen Deuterium Exchange (DMS-HDX) As a Probe of Protein Conformation in Solution
  Journal of the American Society for Mass Spectrometry. Jun, 2016  |   Pubmed ID: 26965162
• Signal Transducer and Activator of Transcription 3 (STAT3) Inhibitor, S3I-201, Acts As a Potent and Non-selective Alkylating Agent
  Oncotarget. Apr, 2016  |   Pubmed ID: 26942696
• Conformational Dynamics and Allostery in Pyruvate Kinase
  The Journal of Biological Chemistry. Apr, 2016  |   Pubmed ID: 26879751
• Dimerization of the Type IV Pilin from Pseudomonas Aeruginosa Strain K122-4 Results in Increased Helix Stability As Measured by Time-resolved Hydrogen-deuterium Exchange
  Structural Dynamics (Melville, N.Y.). Jan, 2016  |   Pubmed ID: 26798830
• Comparing Equilibrium and Kinetic Protein Unfolding Using Time-resolved Electrospray-coupled Ion Mobility Mass Spectrometry
  The Analyst. Oct, 2015  |   Pubmed ID: 26115375
• Hyperphosphorylation of Intrinsically Disordered Tau Protein Induces an Amyloidogenic Shift in Its Conformational Ensemble
  PloS One. 2015  |   Pubmed ID: 25767879
• Pre-equilibration Kinetic Size-exclusion Chromatography with Mass Spectrometry Detection (peKSEC-MS) for Label-free Solution-based Kinetic Analysis of Protein-small Molecule Interactions
  The Analyst. Feb, 2015  |   Pubmed ID: 25611307
• Unambiguous Characterization of Analytical Markers in Complex, Seized Opiate Samples Using an Enhanced Ion Mobility Trace Detector-mass Spectrometer
  Analytical Chemistry. Nov, 2014  |   Pubmed ID: 25302672
• Changes in Signal Transducer and Activator of Transcription 3 (STAT3) Dynamics Induced by Complexation with Pharmacological Inhibitors of Src Homology 2 (SH2) Domain Dimerization
  The Journal of Biological Chemistry. Nov, 2014  |   Pubmed ID: 25288792
• Kinetic Size-exclusion Chromatography with Mass Spectrometry Detection: an Approach for Solution-based Label-free Kinetic Analysis of Protein-small Molecule Interactions
  Analytical Chemistry. Oct, 2014  |   Pubmed ID: 25275785
• An Improved Rapid Mixing Device for Time-resolved Electrospray Mass Spectrometry Measurements
  ChemistryOpen. Jun, 2014  |   Pubmed ID: 25050229
• Oxidative Protein Labeling with Analysis by Mass Spectrometry for the Study of Structure, Folding, and Dynamics
  Antioxidants & Redox Signaling. Jul, 2014  |   Pubmed ID: 24512178
• Characterizing Rapid, Activity-linked Conformational Transitions in Proteins Via Sub-second Hydrogen Deuterium Exchange Mass Spectrometry
  The FEBS Journal. Nov, 2013  |   Pubmed ID: 23663649
• Measuring Kinetic Isotope Effects in Enzyme Reactions Using Time-resolved Electrospray Mass Spectrometry
  Analytical Chemistry. Apr, 2013  |   Pubmed ID: 23461634
• An Electrospray Ms-coupled Microfluidic Device for Sub-second Hydrogen/deuterium Exchange Pulse-labelling Reveals Allosteric Effects in Enzyme Inhibition
  Lab on a Chip. Jul, 2013  |   Pubmed ID: 23426018
• Conformer Selection and Intensified Dynamics During Catalytic Turnover in Chymotrypsin
  Angewandte Chemie (International Ed. in English). Sep, 2012  |   Pubmed ID: 22936643
• Time-resolved Mass Spectrometry for Monitoring Millisecond Time-scale Solution-phase Processes
  European Journal of Mass Spectrometry (Chichester, England). 2012  |   Pubmed ID: 22641726
• Specific Disruption of Transthyretin(105-115) Fibrilization Using "stabilizing" Inhibitors of Transthyretin Amyloidogenesis
  Biochemistry. Apr, 2012  |   Pubmed ID: 22482799
• Measuring Dynamics in Weakly Structured Regions of Proteins Using Microfluidics-enabled Subsecond H/D Exchange Mass Spectrometry
  Analytical Chemistry. Apr, 2012  |   Pubmed ID: 22458633
• Kinetic Capillary Electrophoresis with Mass-spectrometry Detection (KCE-MS) Facilitates Label-free Solution-based Kinetic Analysis of Protein-small Molecule Binding
  Chembiochem : a European Journal of Chemical Biology. Nov, 2011  |   Pubmed ID: 22012742
• Understanding and Optimizing Electrospray Ionization Techniques for Proteomic Analysis
  Expert Review of Proteomics. Apr, 2011  |   Pubmed ID: 21501013
• Rational Manipulation of Amyloidogenesis Using an Atomic Level Map of Peptide-fibril Interactions
  Biochemistry. Jul, 2010  |   Pubmed ID: 20560641
• A Microfluidic Reactor for Rapid, Low-pressure Proteolysis with On-chip Electrospray Ionization
  Rapid Communications in Mass Spectrometry : RCM. Feb, 2010  |   Pubmed ID: 20049884
• Binding Interactions in Early- and Late-stage Amyloid Aggregates of TTR(105-115)
  Biophysical Chemistry. Sep, 2009  |   Pubmed ID: 19501449
• A Versatile Microfluidic Chip for Millisecond Time-scale Kinetic Studies by Electrospray Mass Spectrometry
  Journal of the American Society for Mass Spectrometry. Jan, 2009  |   Pubmed ID: 18845447
• Hydrogen/deuterium Scrambling During Quadrupole Time-of-flight MS/MS Analysis of a Zinc-binding Protein Domain
  Analytical Chemistry. Jan, 2007  |   Pubmed ID: 17194133
• Protein Folding Mechanisms Studied by Time-resolved Electrospray Mass Spectrometry
  BioTechniques. Feb, 2006  |   Pubmed ID: 16526400
• Ultrarapid Desalting of Protein Solutions for Electrospray Mass Spectrometry in a Microchannel Laminar Flow Device
  Analytical Chemistry. Nov, 2005  |   Pubmed ID: 16255586
• Pulsed Hydrogen Exchange and Electrospray Charge-state Distribution As Complementary Probes of Protein Structure in Kinetic Experiments: Implications for Ubiquitin Folding
  Biochemistry. Jun, 2005  |   Pubmed ID: 15952769
• Kinetic Unfolding Mechanism of the Inducible Nitric Oxide Synthase Oxygenase Domain Determined by Time-resolved Electrospray Mass Spectrometry
  Biochemistry. Feb, 2005  |   Pubmed ID: 15709740
• Subunit Disassembly and Unfolding Kinetics of Hemoglobin Studied by Time-resolved Electrospray Mass Spectrometry
  Biochemistry. Nov, 2004  |   Pubmed ID: 15544350
• Mechanistic Studies on Enzymatic Reactions by Electrospray Ionization MS Using a Capillary Mixer with Adjustable Reaction Chamber Volume for Time-resolved Measurements
  Analytical Chemistry. May, 2004  |   Pubmed ID: 15117195
• A Capillary Mixer with Adjustable Reaction Chamber Volume for Millisecond Time-resolved Studies by Electrospray Mass Spectrometry
  Analytical Chemistry. Dec, 2003  |   Pubmed ID: 16465695