In JoVE (1)
Articles by Diederik E. van der Feen in JoVE
Shunt Surgery, Right Heart Catheterization, and Vascular Morphometry in a Rat Model for Flow-induced Pulmonary Arterial Hypertension Diederik E. van der Feen1, Michel Weij2, Annemieke Smit-van Oosten2, Lysanne M. Jorna1, Quint A.J. Hagdorn1, Beatrijs Bartelds1, Rolf M.F. Berger1 1Center for Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, 2Research and Development Facility, University Medical Center Groningen, University of Groningen This protocol describes a surgical procedure to create a model for flow-induced pulmonary arterial hypertension (PAH) in rats and the procedures to analyze the principle hemodynamic and histological end-points in this model.
Other articles by Diederik E. van der Feen on PubMed
[A Neonate with Anaemia of Prematurity: Zinc Protoporphyrin Identifies Iron Deficiency Anaemia Without Iron Deficiency] Nederlands Tijdschrift Voor Geneeskunde. 2015 | Pubmed ID: 25740188 Anaemia is a common problem in premature infants and is generally easy to treat with iron supplementation. If the anaemia persists despite appropriate correction of deficiencies, more extensive evaluation is required. We describe a case of a premature male infant with a production-deficient anaemia without metabolic deficiencies, eventually identified as anaemia of prematurity. This type of anaemia is commonly diagnosed but its highly variable and complex aetiology and phenotype are often poorly understood. A probable explanation for the anaemia of prematurity in this case was a transient iron incorporation defect, identifiable by high levels of zinc protoporphyrin.
Egr-1 Identifies Neointimal Remodeling and Relates to Progression in Human Pulmonary Arterial Hypertension The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation. Apr, 2016 | Pubmed ID: 26774383 Pulmonary arterial hypertension (PAH) is hallmarked by the development of neointimal lesions. The transcription factor Egr-1 seems to play a critical role in neointimal formation in experimental PAH and was identified as a putative target for intervention. In this study we investigated whether Egr-1 is also associated with neointimal-type vascular remodeling in different forms of human PAH or pulmonary hypertension.