Dieter Egli Biography Publications JoVE Articles Dieter Egli has not added a biography. If you are Dieter Egli and would like to personalize this page please email our Author Liaison for assistance. Publications Permanent Neonatal Diabetes-causing Insulin Mutations Have Dominant Negative Effects on Beta Cell Identity Molecular Metabolism. Jan, 2024 | Pubmed ID: 38237895 Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells Cell Reports. Jan, 2024 | Pubmed ID: 38194345 DNA Replication in Early Mammalian Embryos is Patterned, Predisposing Lamina-associated Regions to Fragility BioRxiv : the Preprint Server for Biology. Dec, 2023 | Pubmed ID: 38234839 Permanent Neonatal Diabetes-causing Insulin Mutations Have Dominant Negative Effects on Beta Cell Identity BioRxiv : the Preprint Server for Biology. Sep, 2023 | Pubmed ID: 37745320 Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells BioRxiv : the Preprint Server for Biology. Jun, 2023 | Pubmed ID: 37398435 Replication Stress in Mammalian Embryo Development, Differentiation, and Reprogramming Trends in Cell Biology. Oct, 2023 | Pubmed ID: 37202286 ZnT8 Loss of Function Mutation Increases Resistance of Human Embryonic Stem Cell-Derived Beta Cells to Apoptosis in Low Zinc Condition Cells. Mar, 2023 | Pubmed ID: 36980244 Reduced Calcium Levels and Accumulation of Abnormal Insulin Granules in Stem Cell Models of HNF1A Deficiency Communications Biology. Aug, 2022 | Pubmed ID: 35918471 Replication Stress Impairs Chromosome Segregation and Preimplantation Development in Human Embryos Cell. Aug, 2022 | Pubmed ID: 35858625 Comprehensive Analysis of DNA Replication Timing Across 184 Cell Lines Suggests a Role for MCM10 in Replication Timing Regulation Human Molecular Genetics. Aug, 2022 | Pubmed ID: 35394024 Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes Frontiers in Endocrinology. 2021 | Pubmed ID: 34858326 Delayed DNA Replication in Haploid Human Embryonic Stem Cells Genome Research. Dec, 2021 | Pubmed ID: 34810218 The Genetic Architecture of DNA Replication Timing in Human Pluripotent Stem Cells Nature Communications. Nov, 2021 | Pubmed ID: 34799581 Heritable Human Genome Editing: Research Progress, Ethical Considerations, and Hurdles to Clinical Practice Cell. Mar, 2021 | Pubmed ID: 33740453 Bardet-Biedl Syndrome Proteins Regulate Intracellular Signaling and Neuronal Function in Patient-specific IPSC-derived Neurons The Journal of Clinical Investigation. Apr, 2021 | Pubmed ID: 33630762 Reduced Replication Fork Speed Promotes Pancreatic Endocrine Differentiation and Controls Graft Size JCI Insight. Mar, 2021 | Pubmed ID: 33529174 Allele-Specific Chromosome Removal After Cas9 Cleavage in Human Embryos Cell. Dec, 2020 | Pubmed ID: 33125898 How Safe Are Universal Pluripotent Stem Cells? Cell Stem Cell. Aug, 2020 | Pubmed ID: 32763183 Detection of Base Analogs Incorporated During DNA Replication by Nanopore Sequencing Nucleic Acids Research. Sep, 2020 | Pubmed ID: 32710620 Pluripotent Stem Cells with Low Differentiation Potential Contain Incompletely Reprogrammed DNA Replication The Journal of Cell Biology. Sep, 2020 | Pubmed ID: 32673399 Lessons Learned from Somatic Cell Nuclear Transfer International Journal of Molecular Sciences. Mar, 2020 | Pubmed ID: 32230814 Efficient SNP Editing in Haploid Human Pluripotent Stem Cells Journal of Assisted Reproduction and Genetics. Apr, 2020 | Pubmed ID: 32162131 How Safe Are Universal Pluripotent Stem Cells? Cell Stem Cell. Mar, 2020 | Pubmed ID: 32142661 GLP-1 Receptor Agonists Synergize with DYRK1A Inhibitors to Potentiate Functional Human β Cell Regeneration Science Translational Medicine. Feb, 2020 | Pubmed ID: 32051230 Physiological Consequences of Transient Hyperleptinemia During Discrete Developmental Periods on Body Weight in Mice Science Translational Medicine. Jan, 2020 | Pubmed ID: 31894105 Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell-Derived Insulin-Expressing Cells Require NEUROD1 Diabetes. Dec, 2019 | Pubmed ID: 31519700 Distinct Imprinting Signatures and Biased Differentiation of Human Androgenetic and Parthenogenetic Embryonic Stem Cells Cell Stem Cell. Sep, 2019 | Pubmed ID: 31491396 Stimulation of CRISPR-mediated Homology-directed Repair by an Engineered RAD18 Variant Nature Communications. Jul, 2019 | Pubmed ID: 31363085 Induction of α Cell-restricted Gc in Dedifferentiating β Cells Contributes to Stress-induced β-cell Dysfunction JCI Insight. May, 2019 | Pubmed ID: 31120862 Transgenic Substitution with Greater Amberjack Seriola Dumerili Fish Insulin 2 in NOD Mice Reduces Beta Cell Immunogenicity Scientific Reports. Mar, 2019 | Pubmed ID: 30899071 Ciliary Gene RPGRIP1L is Required for Hypothalamic Arcuate Neuron Development JCI Insight. Feb, 2019 | Pubmed ID: 30728336 NanoMod: a Computational Tool to Detect DNA Modifications Using Nanopore Long-read Sequencing Data BMC Genomics. Feb, 2019 | Pubmed ID: 30712508 Combined Inhibition of DYRK1A, SMAD, and Trithorax Pathways Synergizes to Induce Robust Replication in Adult Human Beta Cells Cell Metabolism. Mar, 2019 | Pubmed ID: 30581122 β Cell Replacement After Gene Editing of a Neonatal Diabetes-Causing Mutation at the Insulin Locus Stem Cell Reports. Dec, 2018 | Pubmed ID: 30503261 Pancreatic Beta Cell Differentiation From Human Pluripotent Stem Cells Current Protocols in Human Genetics. Oct, 2018 | Pubmed ID: 30192441 Inter-homologue Repair in Fertilized Human Eggs? Nature. 08, 2018 | Pubmed ID: 30089924 Identification and Analysis of Islet Antigen-Specific CD8 T Cells with T Cell Libraries Journal of Immunology (Baltimore, Md. : 1950). Sep, 2018 | Pubmed ID: 30082321 Compensating Human Subjects Providing Oocytes for Stem Cell Research: 9-year Experience and Outcomes Journal of Assisted Reproduction and Genetics. Jul, 2018 | Pubmed ID: 29872942 ILDR2 Has a Negligible Role in Hepatic Steatosis PloS One. 2018 | Pubmed ID: 29847571 Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta Cells Transplantation. Aug, 2018 | Pubmed ID: 29781950 β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells Diabetes. Jan, 2018 | Pubmed ID: 28931519 Tying Genetic Stability to Cell Identity Cell Cycle (Georgetown, Tex.). Jun, 2017 | Pubmed ID: 28548589 Genomic Instability During Reprogramming by Nuclear Transfer is DNA Replication Dependent Nature Cell Biology. Apr, 2017 | Pubmed ID: 28263958 Genome Transfer Prevents Fragmentation and Restores Developmental Potential of Developmentally Compromised Postovulatory Aged Mouse Oocytes Stem Cell Reports. Mar, 2017 | Pubmed ID: 28242217 PC1/3 Deficiency Impacts Pro-opiomelanocortin Processing in Human Embryonic Stem Cell-Derived Hypothalamic Neurons Stem Cell Reports. Feb, 2017 | Pubmed ID: 28132887 Inconsistency in 'three-parent' IVF Study Reproductive Biomedicine Online. Mar, 2017 | Pubmed ID: 28038847 Deficiency in Prohormone Convertase PC1 Impairs Prohormone Processing in Prader-Willi Syndrome The Journal of Clinical Investigation. Jan, 2017 | Pubmed ID: 27941249 Induced Pluripotent Stem Cells (iPSC) Created from Skin Fibroblasts of Patients with Prader-Willi Syndrome (PWS) Retain the Molecular Signature of PWS Stem Cell Research. Nov, 2016 | Pubmed ID: 27789403 Identification and Propagation of Haploid Human Pluripotent Stem Cells Nature Protocols. Nov, 2016 | Pubmed ID: 27763625 Analysis of Chromosomal Aberrations and Recombination by Allelic Bias in RNA-Seq Nature Communications. Jul, 2016 | Pubmed ID: 27385103 Efficient Generation of Hypothalamic Neurons from Human Pluripotent Stem Cells Current Protocols in Human Genetics. Jul, 2016 | Pubmed ID: 27367166 Genetic Drift Can Compromise Mitochondrial Replacement by Nuclear Transfer in Human Oocytes Cell Stem Cell. Jun, 2016 | Pubmed ID: 27212703 Hypomorphism of Fto and Rpgrip1l Causes Obesity in Mice The Journal of Clinical Investigation. May, 2016 | Pubmed ID: 27064284 Derivation and Differentiation of Haploid Human Embryonic Stem Cells Nature. Apr, 2016 | Pubmed ID: 26982723 Attitudes Toward Prevention of MtDNA-related Diseases Through Oocyte Mitochondrial Replacement Therapy Human Reproduction (Oxford, England). May, 2016 | Pubmed ID: 26936885 Human Embryos Commonly Form Abnormal Nuclei During Development: a Mechanism of DNA Damage, Embryonic Aneuploidy, and Developmental Arrest Human Reproduction (Oxford, England). Feb, 2016 | Pubmed ID: 26621855 From Cloned Frogs to Patient Matched Stem Cells: Induced Pluripotency or Somatic Cell Nuclear Transfer? Current Opinion in Genetics & Development. Oct, 2015 | Pubmed ID: 26282611 Toward Beta Cell Replacement for Diabetes The EMBO Journal. Apr, 2015 | Pubmed ID: 25733347 Differentiation of Hypothalamic-like Neurons from Human Pluripotent Stem Cells The Journal of Clinical Investigation. Feb, 2015 | Pubmed ID: 25555215 Stem Cell-Derived Beta Cells for Treatment of Type 1 Diabetes? EBioMedicine. Dec, 2014 | Pubmed ID: 26137512 Comparable Frequencies of Coding Mutations and Loss of Imprinting in Human Pluripotent Cells Derived by Nuclear Transfer and Defined Factors Cell Stem Cell. Nov, 2014 | Pubmed ID: 25517467 FOXO1 Inhibition Yields Functional Insulin-producing Cells in Human Gut Organoid Cultures Nature Communications. 2014 | Pubmed ID: 24979718 Gene Therapy in Patient-specific Stem Cell Lines and a Preclinical Model of Retinitis Pigmentosa with Membrane Frizzled-related Protein Defects Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2014 | Pubmed ID: 24895994 Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice Cell Metabolism. May, 2014 | Pubmed ID: 24807221 Human Oocytes Reprogram Adult Somatic Nuclei of a Type 1 Diabetic to Diploid Pluripotent Stem Cells Nature. Jun, 2014 | Pubmed ID: 24776804 Hyperphagia: Current Concepts and Future Directions Proceedings of the 2nd International Conference on Hyperphagia Obesity (Silver Spring, Md.). Feb, 2014 | Pubmed ID: 24574081 Validation of Genome-wide Association Study (GWAS)-identified Disease Risk Alleles with Patient-specific Stem Cell Lines Human Molecular Genetics. Jul, 2014 | Pubmed ID: 24497574 β-cell Dysfunction Due to Increased ER Stress in a Stem Cell Model of Wolfram Syndrome Diabetes. Mar, 2014 | Pubmed ID: 24227685 Harnessing the Stem Cell Potential: the Path to Prevent Mitochondrial Disease Nature Medicine. Dec, 2013 | Pubmed ID: 24309656 Mouse BAZ1A (ACF1) is Dispensable for Double-strand Break Repair but is Essential for Averting Improper Gene Expression During Spermatogenesis PLoS Genetics. Nov, 2013 | Pubmed ID: 24244200 Connecting the Cell Cycle with Cellular Identity Cellular Reprogramming. Oct, 2013 | Pubmed ID: 24073943 IPSC-derived β Cells Model Diabetes Due to Glucokinase Deficiency The Journal of Clinical Investigation. Jul, 2013 | Pubmed ID: 23778137 Tying Replication to Cell Identity Nature Reviews. Molecular Cell Biology. Jun, 2013 | Pubmed ID: 23698578 Improved Methods for Reprogramming Human Dermal Fibroblasts Using Fluorescence Activated Cell Sorting PloS One. 2013 | Pubmed ID: 23555815 Nuclear Genome Transfer in Human Oocytes Eliminates Mitochondrial DNA Variants Nature. Jan, 2013 | Pubmed ID: 23254936 Mouse Ooplasm Confers Context-specific Reprogramming Capacity Nature Genetics. Sep, 2012 | Pubmed ID: 22902786 Langfristige Sicherheit Und Wirksamkeit Von Menschlichen Induzierten Pluripotenten Stammzellen Zelle (iPS)-Prothesen in Einem Präklinischen Modell Der Retinitis Pigmentosa Molecular Medicine (Cambridge, Mass.). Aug, 2012 | Pubmed ID: 22895806 BRCA1 Tumor Unterdrückung Hängt BRCT Phosphoprotein Bindung, Aber Nicht Seine E3-Ligase-Aktivität Science (New York, N.Y.). Oct, 2011 | Pubmed ID: 22034435 Unmöglichkeit Der Ei Spender Einstellung Keine Entschädigung Cell Stem Cell. Oct, 2011 | Pubmed ID: 21982228 Menschliche Eizellen Umprogrammieren Somatischen Zellen in Einen Pluripotenten Zustand Nature. Oct, 2011 | Pubmed ID: 21979046 Neuprogrammierung Innerhalb Von Stunden Nach Kerntransfer in Maus Aber Nicht Menschlichen Zygoten Nature Communications. 2011 | Pubmed ID: 21971503 Die New York-Stammzell-Stiftung: Fünfte Translational Stem Cell Research Jahreskonferenz Annals of the New York Academy of Sciences. May, 2011 | Pubmed ID: 21615750 Empfänger Zelle Nukleare Faktoren Sind Für Die Neuprogrammierung Durch Kerntransfer Erforderlich Development (Cambridge, England). Jun, 2010 | Pubmed ID: 20463036 Spatenstich Für Translatorischen Stammzellforschung Annals of the New York Academy of Sciences. Mar, 2010 | Pubmed ID: 20233361 Eine Überexpression Von Metall-responsive Transkriptionsfaktor (MTF-1) in Drosophila Melanogaster Aerztlichen Lebensdauer Reduktion Oxidativer Stress Und Metall-Toxizität Zugeordnet Neurobiology of Aging. Jul, 2010 | Pubmed ID: 18775584 Ein Klein-Molekül-Inhibitor Der Tgf-Beta Signalisierung Ersetzt Sox2 in Neuprogrammierung Durch Nanog Induzieren Cell Stem Cell. Nov, 2009 | Pubmed ID: 19818703 Eine Anpassung Nach Chromosom Übertragung Ins Maus Blastomeren Current Biology : CB. Aug, 2009 | Pubmed ID: 19682906 Digitale RNA-Allelotyping Enthüllt Gewebe-spezifischen Und Allel-spezifische Genexpression in Menschlichen Nature Methods. Aug, 2009 | Pubmed ID: 19620972 Gezielte Bisulfit-Sequenzierung Zeigt Veränderungen in Der DNA-Methylierung, Die Nukleare Neuprogrammierung Zugeordnet Nature Biotechnology. Apr, 2009 | Pubmed ID: 19330000 Optimalen Zeitpunkt Der Inneren Zelle Masse Isolation Erhöht Die Effizienz Der Ableitung Der Menschlichen Embryonalen Stammzellen Und Ermöglicht Die Generierung Von Geschwister-Zelllinien Cell Stem Cell. Feb, 2009 | Pubmed ID: 19200798 Dumpy-30 Familienmitglieder Als Determinanten Der Männlichen Fruchtbarkeit Und Interaktion Partner Der Metall-responsive Transkriptionsfaktor 1 (MTF-1) in Drosophila BMC Developmental Biology. 2008 | Pubmed ID: 18588663 Mediators of Reprogramming: Transcription Factors and Transitions Through Mitosis Nature Reviews. Molecular Cell Biology. Jul, 2008 | Pubmed ID: 18568039 CAF-1 Ist Für Drosophila-Entwicklung Und Die Wartung Der Epigenetische Speicher Beteiligt Developmental Biology. Nov, 2007 | Pubmed ID: 17916346 Entwicklungsbiologie Reprogrammierung Nach Chromosom Übertragung Ins Mitotische Maus Zygoten Nature. Jun, 2007 | Pubmed ID: 17554301 Kupfer-Homöostase in Drosophila Durch Komplexes Zusammenspiel Von Import, Lagerung Und Verhalten Vermeiden The EMBO Journal. Feb, 2007 | Pubmed ID: 17290228 In-vivo-Konstruktion Von Transgenen Drosophila Genetics. Apr, 2007 | Pubmed ID: 17179096 Transkriptom Reaktion Auf Heavy-Metal-Spannung in Drosophila Enthüllt Einen Neue Zink-Transporter, Der Resistenz Gegenüber Zink Verleiht Nucleic Acids Research. 2006 | Pubmed ID: 16973896 Die Vier Mitglieder Der Familie Der Drosophila-Metallothionein Weisen Deutliche Überschneidungen Noch Rollen in Heavy-Metal-Homöostase Und Entgiftung Genes to Cells : Devoted to Molecular & Cellular Mechanisms. Jun, 2006 | Pubmed ID: 16716195 Eine Familie Ko Alle Vier Drosophila Metallothioneins Offenbart Eine Zentrale Rolle in Kupfer-Homöostase Und Entgiftung Molecular and Cellular Biology. Mar, 2006 | Pubmed ID: 16508004 Metall-responsiven Transkriptionsfaktor (MTF-1) Behandelt Beide Extreme, Kupfer Und Kupfer-Belastung Hunger, Durch Die Aktivierung Verschiedener Gene Genes & Development. Apr, 2005 | Pubmed ID: 15833915 Metall-responsiven Transkriptionsfaktor (MTF-1) Und Schwermetall-Stress-Antwort in Drosophila Und Säugetierzellen: Ein Funktioneller Vergleich Biological Chemistry. Jul, 2004 | Pubmed ID: 15318808 Eine Effiziente Methode, Um Chromosomale Rearrangements Durch Gezielte DNA-Doppelstrang-Brüche in Drosophila Melanogaster Zu Generieren Genome Research. Jul, 2004 | Pubmed ID: 15197166 Physikalische Und Funktionelle Interaktion Zwischen Den Bloom-Syndrom-Gen Und Der Größten Untereinheit Von Faktor 1 Chromatinassemblierung Molecular and Cellular Biology. Jun, 2004 | Pubmed ID: 15143166 Knockout Von "Metall-responsiven Transkriptionsfaktor" MTF-1 in Drosophila Durch Homologe Rekombination Offenbart Seine Zentrale Rolle in Der Heavy-Metal-Homöostase The EMBO Journal. Jan, 2003 | Pubmed ID: 12505988 Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells JoVE 65530 Biology Nuclear Transfer in Maus-Oozyten Dieter Egli1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 116 Biology
Optimized Protocol for Generating Functional Pancreatic Insulin-secreting Cells from Human Pluripotent Stem Cells JoVE 65530 Biology
Nuclear Transfer in Maus-Oozyten Dieter Egli1, Kevin Eggan1 1Department of Molecular and Cell Biology, Harvard JoVE 116 Biology
