Diogo O. Souza Graduate Program in Biochemistry Universidade Federal do Rio Grande do Sul Biography Publications Institution JoVE Articles Diogo O. Souza has not added a biography. If you are Diogo O. Souza and would like to personalize this page please email our Author Liaison for assistance. Publications JM-20 Treatment Prevents Neuronal Damage and Memory Impairment Induced by Aluminum Chloride in Rats Neurotoxicology. Sep, 2021 | Pubmed ID: 34481871 Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model Frontiers in Psychiatry. 2021 | Pubmed ID: 34421682 Allopurinol Attenuates Postoperative Pain and Modulates the Purinergic System in Patients Undergoing Abdominal Hysterectomy: a Randomized Controlled Trial Journal of Anesthesia. Aug, 2021 | Pubmed ID: 34390392 Zika Virus Infection Associated with Autism Spectrum Disorder: A Case Report Neuroimmunomodulation. Jun, 2021 | Pubmed ID: 34082423 Allopurinol for Fibromyalgia Pain in Adults: A Randomized Controlled Trial Pain Practice : the Official Journal of World Institute of Pain. Apr, 2021 | Pubmed ID: 33864725 Effects of Intranasal Guanosine Administration on Brain Function in a Rat Model of Ischemic Stroke Purinergic Signalling. 06, 2021 | Pubmed ID: 33834349 About the Source and Consequences of F-FDG Brain PET Hypometabolism in Short and Long COVID-19 European Journal of Nuclear Medicine and Molecular Imaging. 08, 2021 | Pubmed ID: 33813593 Novel Arylidene Malonate Derivative, KM-34, Showed Neuroprotective Effects on in Vitro and in Vivo Models of Ischemia/reperfusion European Journal of Pharmacology. May, 2021 | Pubmed ID: 33722590 PET Imaging As a Tool for Assessing COVID-19 Brain Changes Trends in Neurosciences. 12, 2020 | Pubmed ID: 33131922 Dietary Omega-3 Fatty Acids Prevent Neonatal Seizure-induced Early Alterations in the Hippocampal Glutamatergic System and Memory Deficits in Adulthood Nutritional Neuroscience. Oct, 2020 | Pubmed ID: 33107813 Guanosine Enhances Glutamate Uptake and Oxidation, Preventing Oxidative Stress in Mouse Hippocampal Slices Submitted to High Glutamate Levels Brain Research. 12, 2020 | Pubmed ID: 32866546 S100B Protein and Neuron-specific Enolase As Predictors of Postoperative Cognitive Dysfunction in Aged Dogs: a Case-control Study Veterinary Anaesthesia and Analgesia. Nov, 2020 | Pubmed ID: 32800537 Guanosine Fast Onset Antidepressant-like Effects in the Olfactory Bulbectomy Mice Model Scientific Reports. 05, 2020 | Pubmed ID: 32439951 Amyloid-β Oligomers in Cellular Models of Alzheimer's Disease Journal of Neurochemistry. 11, 2020 | Pubmed ID: 32320074 Modified Expression of Antioxidant Genes in Lobster Cockroach, Nauphoeta Cinerea Exposed to Methylmercury and Monosodium Glutamate Chemico-biological Interactions. Feb, 2020 | Pubmed ID: 32007422 Association Between Zika Virus and Future Neurological Diseases Journal of the Neurological Sciences. 02, 2020 | Pubmed ID: 31835212 ZIKAVID-Zika Virus Infection Database: a New Platform to Analyze the Molecular Impact of Zika Virus Infection Journal of Neurovirology. 02, 2020 | Pubmed ID: 31512145 Acute Liver Failure Induces Glial Reactivity, Oxidative Stress and Impairs Brain Energy Metabolism in Rats Frontiers in Molecular Neuroscience. 2019 | Pubmed ID: 31998076 The Astrocyte Biochemistry Seminars in Cell & Developmental Biology. 11, 2019 | Pubmed ID: 30951895 Caffeine and Cannabinoid Receptors Modulate Impulsive Behavior in an Animal Model of Attentional Deficit and Hyperactivity Disorder The European Journal of Neuroscience. 06, 2019 | Pubmed ID: 30667546 Behavioral, Neurochemical and Brain Oscillation Abnormalities in an Experimental Model of Acute Liver Failure Neuroscience. 03, 2019 | Pubmed ID: 30654003 Memantine Mediates Astrocytic Activity in Response to Excitotoxicity Induced by PP2A Inhibition Neuroscience Letters. 03, 2019 | Pubmed ID: 30586637 Zika Virus Infection of Human Mesenchymal Stem Cells Promotes Differential Expression of Proteins Linked to Several Neurological Diseases Molecular Neurobiology. Jul, 2019 | Pubmed ID: 30377986 JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain Molecular Neurobiology. Jan, 2019 | Pubmed ID: 29725905 Dietary Co-exposure to Methylmercury and Monosodium Glutamate Disrupts Cellular and Behavioral Responses in the Lobster Cockroach, Nauphoeta Cinerea Model Environmental Toxicology and Pharmacology. Dec, 2018 | Pubmed ID: 30300794 Multi-targeting Effects of a New Synthetic Molecule (JM-20) in Experimental Models of Cerebral Ischemia Pharmacological Reports : PR. Aug, 2018 | Pubmed ID: 29933207 Antioxidant and Neuroprotective Effects of KM-34, A Novel Synthetic Catechol, Against Oxidative Stress-Induced Neurotoxicity Drug Research. May, 2018 | Pubmed ID: 29100263 Cortical Bilateral Adaptations in Rats Submitted to Focal Cerebral Ischemia: Emphasis on Glial Metabolism Molecular Neurobiology. 03, 2018 | Pubmed ID: 28271402 ZIKA Virus and Neuroscience: the Need for a Translational Collaboration Molecular Neurobiology. 02, 2018 | Pubmed ID: 28185126 Mitochondrial Involvement in Memory Impairment Induced by Scopolamine in Rats Neurological Research. Jul, 2017 | Pubmed ID: 28398193 Olfactory Bulbectomy in Mice Triggers Transient and Long-lasting Behavioral Impairments and Biochemical Hippocampal Disturbances Progress in Neuro-psychopharmacology & Biological Psychiatry. 06, 2017 | Pubmed ID: 28223107 Guanosine Exerts Neuroprotective Effect in an Experimental Model of Acute Ammonia Intoxication Molecular Neurobiology. 07, 2017 | Pubmed ID: 27052954 Guanosine Anxiolytic-Like Effect Involves Adenosinergic and Glutamatergic Neurotransmitter Systems Molecular Neurobiology. 01, 2017 | Pubmed ID: 26742520 How Does Zebrafish Support New Strategies for Neuroprotection and Neuroregeneration in Hypoxia-related Diseases? Neural Regeneration Research. Jul, 2016 | Pubmed ID: 27630683 Scientific Performance of Brazilian Researchers in Pharmacology with Grants from CNPq: A Comparative Study Within the Brazilian Categories Anais Da Academia Brasileira De Ciencias. 2016 | Pubmed ID: 27556222 Antimicrobial Activity and Modulatory Effect of Essential Oil from the Leaf of Rhaphiodon Echinus (Nees & Mart) Schauer on Some Antimicrobial Drugs Molecules (Basel, Switzerland). Jun, 2016 | Pubmed ID: 27338314 Neurobehavioral and Biochemical Changes in Nauphoeta Cinerea Following Dietary Exposure to Chlorpyrifos Pesticide Biochemistry and Physiology. Jun, 2016 | Pubmed ID: 27155480 Corrigendum: Long-term NMDAR Antagonism Correlates Reduced Astrocytic Glutamate Uptake with Anxiety-like Phenotype Frontiers in Cellular Neuroscience. 2016 | Pubmed ID: 27147966 Neuroprotection of Luteolin Against Methylmercury-induced Toxicity in Lobster Cockroach Nauphoeta Cinerea Environmental Toxicology and Pharmacology. Mar, 2016 | Pubmed ID: 26905302 Brain Zinc Chelation by Diethyldithiocarbamate Increased the Behavioral and Mitochondrial Damages in Zebrafish Subjected to Hypoxia Scientific Reports. Feb, 2016 | Pubmed ID: 26854133 Intranasal Guanosine Administration Presents a Wide Therapeutic Time Window to Reduce Brain Damage Induced by Permanent Ischemia in Rats Purinergic Signalling. Mar, 2016 | Pubmed ID: 26695181 Evaluation of Zinc Effect on Cadmium Action in Lipid Peroxidation and Metallothionein Levels in the Brain Toxicology Reports. 2015 | Pubmed ID: 28962421 Neuroprotection by JM-20 Against Oxygen-glucose Deprivation in Rat Hippocampal Slices: Involvement of the Akt/GSK-3β Pathway Neurochemistry International. Nov, 2015 | Pubmed ID: 26361722 Influence of Diphenyl Diselenide on Chlorpyrifos-induced Toxicity in Drosophila Melanogaster Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS). Oct, 2015 | Pubmed ID: 26302912 Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene Diepoxide Disrupt Redox Status and Modify Different Electrophile Sensitive Target Enzymes and Genes in Drosophila Melanogaster Redox Biology. Aug, 2015 | Pubmed ID: 26117601 Long-term NMDAR Antagonism Correlates Reduced Astrocytic Glutamate Uptake with Anxiety-like Phenotype Frontiers in Cellular Neuroscience. 2015 | Pubmed ID: 26089779 High Phosphate Serum Levels Correlate with the Severity of Experimental Severe Acute Pancreatitis: Insight into the Purinergic System Pancreas. May, 2015 | Pubmed ID: 25815645 Original Mechanisms of Antipsychotic Action by the Indole Alkaloid Alstonine (Picralima Nitida) Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. Jan, 2015 | Pubmed ID: 25636871 The Effects of JM-20 on the Glutamatergic System in Synaptic Vesicles, Synaptosomes and Neural Cells Cultured from Rat Brain Neurochemistry International. Feb, 2015 | Pubmed ID: 25617730 Antioxidant Effects of JM-20 on Rat Brain Mitochondria and Synaptosomes: Mitoprotection Against Ca²⁺-induced Mitochondrial Impairment Brain Research Bulletin. Oct, 2014 | Pubmed ID: 25305343 Anxiolytic Effects of Diphenyl Diselenide on Adult Zebrafish in a Novelty Paradigm Progress in Neuro-psychopharmacology & Biological Psychiatry. Oct, 2014 | Pubmed ID: 24936773 Evaluation of Spontaneous Recovery of Behavioral and Brain Injury Profiles in Zebrafish After Hypoxia Behavioural Brain Research. Sep, 2013 | Pubmed ID: 23867150 Topographical Analysis of Reactive Zinc in the Central Nervous System of Adult Zebrafish (Danio Rerio) Zebrafish. Sep, 2013 | Pubmed ID: 23829199 Riluzole Increases Glutamate Uptake by Cultured C6 Astroglial Cells International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience. Nov, 2013 | Pubmed ID: 23777615 AgRP Neurons Regulate Development of Dopamine Neuronal Plasticity and Nonfood-associated Behaviors Nature Neuroscience. Jun, 2012 | Pubmed ID: 22729177 Behavioral Effects of Taurine Pretreatment in Zebrafish Acutely Exposed to Ethanol Neuropharmacology. Sep, 2012 | Pubmed ID: 22634362 Ω3-Polyunsaturated Fatty Acids Prevent Lipoperoxidation, Modulate Antioxidant Enzymes, and Reduce Lipid Content but Do Not Alter Glycogen Metabolism in the Livers of Diabetic Rats Fed on a High Fat Thermolyzed Diet Molecular and Cellular Biochemistry. Feb, 2012 | Pubmed ID: 21989716 Evidence That Hyperprolinemia Alters Glutamatergic Homeostasis in Rat Brain: Neuroprotector Effect of Guanosine Neurochemical Research. Jan, 2012 | Pubmed ID: 21935728 37 Years of Scientific Activity in a Biochemistry Department in Brazil: Patterns of Growth and Factors Leading to Increased Productivity Anais Da Academia Brasileira De Ciencias. Sep, 2011 | Pubmed ID: 21739081 Differences in Spatio-temporal Behavior of Zebrafish in the Open Tank Paradigm After a Short-period Confinement into Dark and Bright Environments PloS One. May, 2011 | Pubmed ID: 21559304 Enriched Environment Effects on Behavior, Memory and BDNF in Low and High Exploratory Mice Physiology & Behavior. Mar, 2011 | Pubmed ID: 21236277 Structure-activity Relationship of Flavonoids Derived from Medicinal Plants in Preventing Methylmercury-induced Mitochondrial Dysfunction Environmental Toxicology and Pharmacology. Nov, 2010 | Pubmed ID: 21127717 Agrp Neurons Mediate Sirt1's Action on the Melanocortin System and Energy Balance: Roles for Sirt1 in Neuronal Firing and Synaptic Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2010 | Pubmed ID: 20810901 Algorithms to Predict Cerebral Malaria in Murine Models Using the SHIRPA Protocol Malaria Journal. Mar, 2010 | Pubmed ID: 20334682 Gestational and Postnatal Low Protein Diet Alters Insulin Sensitivity in Female Rats Experimental Biology and Medicine (Maywood, N.J.). Dec, 2009 | Pubmed ID: 19934364 Morphological Changes in Hippocampal Astrocytes Induced by Environmental Enrichment in Mice Brain Research. Jun, 2009 | Pubmed ID: 19374889 Effects of Undernutrition on Glutamatergic Parameters in the Cerebral Cortex of Young Rats Physiology & Behavior. Jul, 2008 | Pubmed ID: 18485424 Profile of Glutamate Uptake and Cellular Viability in Hippocampal Slices Exposed to Oxygen and Glucose Deprivation: Developmental Aspects and Protection by Guanosine Brain Research. Jan, 2008 | Pubmed ID: 18053975 Prenatal Methylmercury Exposure Hampers Glutathione Antioxidant System Ontogenesis and Causes Long-lasting Oxidative Stress in the Mouse Brain Toxicology and Applied Pharmacology. Feb, 2008 | Pubmed ID: 18023834 Duration of Environmental Enrichment Influences the Magnitude and Persistence of Its Behavioral Effects on Mice Physiology & Behavior. Jan, 2008 | Pubmed ID: 17949760 Western Style Diet Impairs Entrance of Blood-borne Insulin-like Growth Factor-1 into the Brain Neuromolecular Medicine. 2007 | Pubmed ID: 17999206 Evidence That Glutaric Acid Reduces Glutamate Uptake by Cerebral Cortex of Infant Rats Life Sciences. Dec, 2007 | Pubmed ID: 17963786 Proposal of a Guanine-based Purinergic System in the Mammalian Central Nervous System Pharmacology & Therapeutics. Dec, 2007 | Pubmed ID: 17884172 Age and Brain Structural Related Effects of Glutaric and 3-hydroxyglutaric Acids on Glutamate Binding to Plasma Membranes During Rat Brain Development Cellular and Molecular Neurobiology. Sep, 2007 | Pubmed ID: 17786551 Naturally Occurring Compounds Affect Glutamatergic Neurotransmission in Rat Brain Neurochemical Research. Nov, 2007 | Pubmed ID: 17577666 Methylmercury Induces Oxidative Injury, Alterations in Permeability and Glutamine Transport in Cultured Astrocytes Brain Research. Feb, 2007 | Pubmed ID: 17182013 The Sesquiterpenes Polygodial and Drimanial in Vitro Affect Glutamatergic Transport in Rat Brain Neurochemical Research. Mar, 2006 | Pubmed ID: 16733820 Effect of 2-deoxy-D-glucose on Aminoacids Metabolism in Rats' Cerebral Cortex Slices Neurochemical Research. Mar, 2006 | Pubmed ID: 16733818 A Simple Webcam-based Approach for the Measurement of Rodent Locomotion and Other Behavioural Parameters Journal of Neuroscience Methods. Oct, 2006 | Pubmed ID: 16701901 Glutamate Uptake is Stimulated by Extracellular S100B in Hippocampal Astrocytes Cellular and Molecular Neurobiology. Feb, 2006 | Pubmed ID: 16633903 Acute and Chronic Electroconvulsive Shock in Rats: Effects on Peripheral Markers of Neuronal Injury and Glial Activity Life Sciences. May, 2006 | Pubmed ID: 16413036 Serum S100B Levels in Patients with Neural Tube Defects Clinica Chimica Acta; International Journal of Clinical Chemistry. Feb, 2006 | Pubmed ID: 16143320 Motor Impairment Induced by Oral Exposure to Methylmercury in Adult Mice Environmental Toxicology and Pharmacology. Jan, 2005 | Pubmed ID: 21783473 Exercise Affects Glutamate Receptors in Postsynaptic Densities from Cortical Mice Brain Brain Research. Dec, 2005 | Pubmed ID: 16298350 Effects of Glutamate Transporter and Receptor Ligands on Neuronal Glutamate Uptake Neuroscience Research. Sep, 2005 | Pubmed ID: 16011854 Cinnarizine Has an Atypical Antipsychotic Profile in Animal Models of Psychosis Journal of Psychopharmacology (Oxford, England). Jul, 2005 | Pubmed ID: 15982988 The Ischemic Rat Heart Releases S100B Life Sciences. Jul, 2005 | Pubmed ID: 15921704 Gestational and Postnatal Malnutrition Affects Sensitivity of Young Rats to Picrotoxin and Quinolinic Acid and Uptake of GABA by Cortical and Hippocampal Slices Brain Research. Developmental Brain Research. Feb, 2005 | Pubmed ID: 15707671 Beta-amyloid Treatment Sensitizes Mice to Amphetamine-induced Locomotion but Reduces Response to Caffeine Neuro-degenerative Diseases. 2004 | Pubmed ID: 16908972 Changes in S100B Cerebrospinal Fluid Levels of Rats Subjected to Predator Stress Brain Research. Dec, 2004 | Pubmed ID: 15527746 Increased Locomotor Response to Amphetamine, but Not Other Psychostimulants, in Adult Mice Submitted to a Low-protein Diet Physiology & Behavior. Oct, 2004 | Pubmed ID: 15501499 The Effects of Ebselen on [3H]glutamate Uptake by Synaptic Vesicles from Rat Brain Brain Research. Nov, 2004 | Pubmed ID: 15494171 Biochemical Brain Markers and Purinergic Parameters in Rat CSF After Seizure Induced by Pentylenetetrazol Brain Research Bulletin. Sep, 2004 | Pubmed ID: 15464860 Glutaric Acid Stimulates Glutamate Binding and Astrocytic Uptake and Inhibits Vesicular Glutamate Uptake in Forebrain from Young Rats Neurochemistry International. Dec, 2004 | Pubmed ID: 15337307 High Extracellular K+ Levels Stimulate Acetate Oxidation in Brain Slices from Well and Malnourished Rats Neurochemical Research. Aug, 2004 | Pubmed ID: 15260133 Ontogenetic Profile of Glutamate Uptake in Brain Structures Slices from Rats: Sensitivity to Guanosine Mechanisms of Ageing and Development. Jul, 2004 | Pubmed ID: 15246742 Characterization of Imido [8-(3)H] Guanosine 5'-triphosphate Binding Sites to Rat Brain Membranes Neurochemical Research. Apr, 2004 | Pubmed ID: 15098945 Anticonvulsant Effect of GMP Depends on Its Conversion to Guanosine Brain Research. Apr, 2004 | Pubmed ID: 15044076 Effect of DHEA Glutamate Release from Synaptosomes of Rats at Different Ages Neurochemical Research. Feb, 2004 | Pubmed ID: 15002728 Caffeine As a Neuroprotective Adenosine Receptor Antagonist The Annals of Pharmacotherapy. Apr, 2004 | Pubmed ID: 14982979 In Vitro Effects of D-2-hydroxyglutaric Acid on Glutamate Binding, Uptake and Release in Cerebral Cortex of Rats Journal of the Neurological Sciences. Feb, 2004 | Pubmed ID: 14706223 Increase in Serum S100B Protein Level After a Swimming Race Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquee. Oct, 2003 | Pubmed ID: 14710522 Effects of L-2-hydroxyglutaric Acid on Various Parameters of the Glutamatergic System in Cerebral Cortex of Rats Metabolic Brain Disease. Sep, 2003 | Pubmed ID: 14567473 Diphenyl Diselenide Protects Rat Hippocampal Slices Submitted to Oxygen-glucose Deprivation and Diminishes Inducible Nitric Oxide Synthase Immunocontent Brain Research. Oct, 2003 | Pubmed ID: 12965245 Ebselen Protects Against Methylmercury-induced Inhibition of Glutamate Uptake by Cortical Slices from Adult Mice Toxicology Letters. Oct, 2003 | Pubmed ID: 12927352 Neuroprotective Effect of Ebselen on Rat Hippocampal Slices Submitted to Oxygen-glucose Deprivation: Correlation with Immunocontent of Inducible Nitric Oxide Synthase Neuroscience Letters. Jul, 2003 | Pubmed ID: 12850558 Effects of Undernutrition on Glutamatergic Parameters in Rat Brain Neurochemical Research. Aug, 2003 | Pubmed ID: 12834257 Methylmercury Inhibits Glutamate Uptake by Synaptic Vesicles from Rat Brain Neuroreport. Mar, 2003 | Pubmed ID: 12657889 Effect of Undernutrition on GMP-PNP Binding and Adenylate Cyclase Activity from Rat Brain Cellular and Molecular Neurobiology. Jun, 2002 | Pubmed ID: 12469877 The Adenosine Antagonist Theophylline Impairs P50 Auditory Sensory Gating in Normal Subjects Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2002 | Pubmed ID: 12377399 Intrahippocampal Infusion of Ebselen Impairs Retention of an Inhibitory Avoidance Task in Rats European Journal of Pharmacology. Sep, 2002 | Pubmed ID: 12231387 Utilization of Energy Nutrients by Cerebellar Slices Neurochemical Research. Mar, 2002 | Pubmed ID: 11958517 Quinolinic Acid Stimulates Synaptosomal Glutamate Release and Inhibits Glutamate Uptake into Astrocytes Neurochemistry International. Jun, 2002 | Pubmed ID: 11900857 Serum S100B Levels in Patients with Lupus Erythematosus: Preliminary Observation Clinical and Diagnostic Laboratory Immunology. Jan, 2002 | Pubmed ID: 11777848 Measurement of Glutamate Uptake using Radiolabeled L-[3H]-Glutamate in Acute Transverse Slices Obtained from Rodent Resected Hippocampus Débora G. Souza1, Yasmine Nonose1, Diogo O. Souza1,2, Roberto F. Almeida3,4 1Graduate Program in Biochemistry, Universidade Federal do Rio Grande do Sul, 2Department of Biochemistry, Universidade Federal do Rio Grande do Sul, 3Department of Biological Sciences, Universidade Federal de Ouro Preto, 4Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto JoVE 62292 Biochemistry
Measurement of Glutamate Uptake using Radiolabeled L-[3H]-Glutamate in Acute Transverse Slices Obtained from Rodent Resected Hippocampus Débora G. Souza1, Yasmine Nonose1, Diogo O. Souza1,2, Roberto F. Almeida3,4 1Graduate Program in Biochemistry, Universidade Federal do Rio Grande do Sul, 2Department of Biochemistry, Universidade Federal do Rio Grande do Sul, 3Department of Biological Sciences, Universidade Federal de Ouro Preto, 4Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Ouro Preto JoVE 62292 Biochemistry
