Dobromir Dobrev

Publications

• Phosphodiesterase-2 is Upregulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes
  Journal of the American College of Cardiology. Jun, 2013  |   Pubmed ID: 23810893
• Safety and Efficacy of Vernakalant for Acute Cardioversion of Atrial Fibrillation: an Update
  Vascular Health and Risk Management. 2013  |   Pubmed ID: 23637539
• KCNQ1 Autoantibodies: Another Way to Regulate IKs
  Cardiovascular Research. Jun, 2013  |   Pubmed ID: 23615563
• Atrial Fibrillation Promotion by Endurance Exercise: Demonstration and Mechanistic Exploration in an Animal Model
  Journal of the American College of Cardiology. Jul, 2013  |   Pubmed ID: 23583240
• Pleiotropic Actions of Amiodarone: Still Puzzling After Half a Century
  Naunyn-Schmiedeberg's Archives of Pharmacology. Jul, 2013  |   Pubmed ID: 23568552
• Impaired Na(+)-dependent Regulation of Acetylcholine-activated Inward-rectifier K(+) Current Modulates Action Potential Rate Dependence in Patients with Chronic Atrial Fibrillation
  Journal of Molecular and Cellular Cardiology. Mar, 2013  |   Pubmed ID: 23531443
• MicroRNA29: a Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation
  Circulation. Apr, 2013  |   Pubmed ID: 23459615
• Electrical Storm: Recent Pathophysiological Insights and Therapeutic Consequences
  Basic Research in Cardiology. Mar, 2013  |   Pubmed ID: 23429935
• New Directions in Antiarrhythmic Drug Therapy for Atrial Fibrillation
  Future Cardiology. Jan, 2013  |   Pubmed ID: 23259476
• The Biology of Human Pulmonary Veins: Does It Help Us to Better Understand AF Pathophysiology in Patients?
  Heart Rhythm : the Official Journal of the Heart Rhythm Society. Mar, 2013  |   Pubmed ID: 23237913
• Cellular and Molecular Correlates of Ectopic Activity in Patients with Atrial Fibrillation
  Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Nov, 2012  |   Pubmed ID: 23104921
• Voltage-gated Na⁺ Channels: Novel Players in Fibroblast-to-myofibroblast Transition with a Potential Role in Atrial Arrhythmogenesis?
  The Journal of Physiology. Oct, 2012  |   Pubmed ID: 23082023
• Transient Receptor Potential Canonical-3 Channel-dependent Fibroblast Regulation in Atrial Fibrillation
  Circulation. Oct, 2012  |   Pubmed ID: 22992321
• Palmitoylation and Membrane Association of the Stress Axis Regulated Insert (STREX) Controls BK Channel Regulation by Protein Kinase C
  The Journal of Biological Chemistry. Sep, 2012  |   Pubmed ID: 22843729
• Is Altered Atrial MicroRNA-ome a Critical Contributor to the Pathophysiology of Atrial Fibrillation?
  Basic Research in Cardiology. Sep, 2012  |   Pubmed ID: 22802051
• Systems Approaches to Post-operative Atrial Fibrillation - Do They Help Us to Better Understand the Ionic Basis of the Arrhythmogenic Substrate?
  Journal of Molecular and Cellular Cardiology. Sep, 2012  |   Pubmed ID: 22742961
• Calcium Handling and Atrial Fibrillation
  Wiener Medizinische Wochenschrift (1946). Jul, 2012  |   Pubmed ID: 22695810
• Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression
  Circulation Research. May, 2012  |   Pubmed ID: 22511749
• The Multidimensional Role of Calcium in Atrial Fibrillation Pathophysiology: Mechanistic Insights and Therapeutic Opportunities
  European Heart Journal. Aug, 2012  |   Pubmed ID: 22507975
• Novel Molecular Targets for Atrial Fibrillation Therapy
  Nature Reviews. Drug Discovery. Apr, 2012  |   Pubmed ID: 22460122
• Enhanced Sarcoplasmic Reticulum Ca2+ Leak and Increased Na+-Ca2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients with Chronic Atrial Fibrillation
  Circulation. May, 2012  |   Pubmed ID: 22456474
• Proarrhythmic Atrial Calcium Cycling in the Diseased Heart
  Advances in Experimental Medicine and Biology. 2012  |   Pubmed ID: 22453988
• Inhibition of CaMKII Phosphorylation of RyR2 Prevents Induction of Atrial Fibrillation in FKBP12.6 Knockout Mice
  Circulation Research. Feb, 2012  |   Pubmed ID: 22158709
• Comprehensive Risk Reduction in Patients with Atrial Fibrillation: Emerging Diagnostic and Therapeutic Options--a Report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association Consensus Conference
  Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Jan, 2012  |   Pubmed ID: 21791573
• The Impact of Rapid Atrial Pacing on ADMA and Endothelial NOS
  International Journal of Cardiology. Jan, 2012  |   Pubmed ID: 20926145
• Human Atrial Action Potential and Ca2+ Model: Sinus Rhythm and Chronic Atrial Fibrillation
  Circulation Research. Oct, 2011  |   Pubmed ID: 21921263
• Differential Protein Kinase C Isoform Regulation and Increased Constitutive Activity of Acetylcholine-regulated Potassium Channels in Atrial Remodeling
  Circulation Research. Oct, 2011  |   Pubmed ID: 21903936
• Defects in Ankyrin-based Membrane Protein Targeting Pathways Underlie Atrial Fibrillation
  Circulation. Sep, 2011  |   Pubmed ID: 21859974
• Recent Advances in the Molecular Pathophysiology of Atrial Fibrillation
  The Journal of Clinical Investigation. Aug, 2011  |   Pubmed ID: 21804195
• Oxidized CaMKII Causes Cardiac Sinus Node Dysfunction in Mice
  The Journal of Clinical Investigation. Aug, 2011  |   Pubmed ID: 21785215
• Role of T-type Calcium Channel Subunits in Post-myocardial Infarction Remodelling Probed with Genetically Engineered Mice
  Cardiovascular Research. Aug, 2011  |   Pubmed ID: 21622683
• No Evidence for an Association Between the Rs2824292 Variant at Chromosome 21q21 and Ventricular Fibrillation During Acute Myocardial Infarction in a German Population
  Clinical Chemistry and Laboratory Medicine : CCLM / FESCC. Jul, 2011  |   Pubmed ID: 21574885
• Ca(2+)-related Signaling and Protein Phosphorylation Abnormalities Play Central Roles in a New Experimental Model of Electrical Storm
  Circulation. May, 2011  |   Pubmed ID: 21555709
• Prevention of Atrial Fibrillation Complications with Antiarrhythmic Drugs: Still an Unmet Need in Clinical Practice
  Expert Opinion on Pharmacotherapy. Jun, 2011  |   Pubmed ID: 21548721
• Atrial-selective Sodium Channel Block by Dronedarone: Sufficient to Terminate Atrial Fibrillation?
  Naunyn-Schmiedeberg's Archives of Pharmacology. Aug, 2011  |   Pubmed ID: 21541758
• Phosphatase-1 Inhibitor-1 in Physiological and Pathological β-adrenoceptor Signalling
  Cardiovascular Research. Aug, 2011  |   Pubmed ID: 21354993
• New Insights into the Molecular Basis of Atrial Fibrillation: Mechanistic and Therapeutic Implications
  Cardiovascular Research. Mar, 2011  |   Pubmed ID: 21296897
• Mechanisms of Atrial Tachyarrhythmias Associated with Coronary Artery Occlusion in a Chronic Canine Model
  Circulation. Jan, 2011  |   Pubmed ID: 21200008
• Enhanced Myofilament Responsiveness Upon β-adrenergic Stimulation in Post-infarct Remodeled Myocardium
  Journal of Molecular and Cellular Cardiology. Mar, 2011  |   Pubmed ID: 21156182
• The Ryanodine Receptor Channel As a Molecular Motif in Atrial Fibrillation: Pathophysiological and Therapeutic Implications
  Cardiovascular Research. Mar, 2011  |   Pubmed ID: 20943673
• Vernakalant
  Nature Reviews. Drug Discovery. Dec, 2010  |   Pubmed ID: 21119728
• Voltage-clamp-based Methods for the Detection of Constitutively Active Acetylcholine-gated I(K,ACh) Channels in the Diseased Heart
  Methods in Enzymology. 2010  |   Pubmed ID: 21036255
• Calmodulin Kinase II, Sarcoplasmic Reticulum Ca2+ Leak, and Atrial Fibrillation
  Trends in Cardiovascular Medicine. Jan, 2010  |   Pubmed ID: 20685575
• Multiple Potential Molecular Contributors to Atrial Hypocontractility Caused by Atrial Tachycardia Remodeling in Dogs
  Circulation. Arrhythmia and Electrophysiology. Oct, 2010  |   Pubmed ID: 20660541
• Left-to-right Atrial Inward Rectifier Potassium Current Gradients in Patients with Paroxysmal Versus Chronic Atrial Fibrillation
  Circulation. Arrhythmia and Electrophysiology. Oct, 2010  |   Pubmed ID: 20657029
• Aldosterone-receptor Antagonism As a Potential Therapeutic Option for Atrial Fibrillation
  British Journal of Pharmacology. Apr, 2010  |   Pubmed ID: 20388187
• New Antiarrhythmic Drugs for Treatment of Atrial Fibrillation
  Lancet. Apr, 2010  |   Pubmed ID: 20334907
• Constitutively Active Phosphatase Inhibitor-1 Improves Cardiac Contractility in Young Mice but is Deleterious After Catecholaminergic Stress and with Aging
  The Journal of Clinical Investigation. Feb, 2010  |   Pubmed ID: 20071777
• Animal Models for Atrial Fibrillation: Clinical Insights and Scientific Opportunities
  Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Feb, 2010  |   Pubmed ID: 19875395
• Atrial Ca2+ Signaling in Atrial Fibrillation As an Antiarrhythmic Drug Target
  Naunyn-Schmiedeberg's Archives of Pharmacology. Mar, 2010  |   Pubmed ID: 19784635
• Inhibition of IK,ACh Current May Contribute to Clinical Efficacy of Class I and Class III Antiarrhythmic Drugs in Patients with Atrial Fibrillation
  Naunyn-Schmiedeberg's Archives of Pharmacology. Mar, 2010  |   Pubmed ID: 19760273
• Stroke Prevention Versus Bleeding Risk of Vitamin-K Antagonists: a Double-edged Sword in Patients with Atrial Fibrillation Who Require Surgery
  Cardiovascular Therapeutics. 2009  |   Pubmed ID: 19903184
• Calmodulin Kinase II-mediated Sarcoplasmic Reticulum Ca2+ Leak Promotes Atrial Fibrillation in Mice
  The Journal of Clinical Investigation. Jul, 2009  |   Pubmed ID: 19603549
• Ion Channel Portrait of the Human Sinus Node: Useful for a Better Understanding of Sinus Node Function and Dysfunction in Humans?
  Circulation. Mar, 2009  |   Pubmed ID: 19332478
• Acute Atrial Tachyarrhythmia Induces Angiotensin II Type 1 Receptor-mediated Oxidative Stress and Microvascular Flow Abnormalities in the Ventricles
  European Heart Journal. Jun, 2009  |   Pubmed ID: 19269986
• Distinct Contractile and Molecular Differences Between Two Goat Models of Atrial Dysfunction: AV Block-induced Atrial Dilatation and Atrial Fibrillation
  Journal of Molecular and Cellular Cardiology. Mar, 2009  |   Pubmed ID: 19100271
• Remodelling of Cardiac Repolarization: How Homeostatic Responses Can Lead to Arrhythmogenesis
  Cardiovascular Research. Feb, 2009  |   Pubmed ID: 18826964
• Calcium-handling Abnormalities Underlying Atrial Arrhythmogenesis and Contractile Dysfunction in Dogs with Congestive Heart Failure
  Circulation. Arrhythmia and Electrophysiology. Jun, 2008  |   Pubmed ID: 19808399
• Atrial Remodeling and Atrial Fibrillation: Mechanisms and Implications
  Circulation. Arrhythmia and Electrophysiology. Apr, 2008  |   Pubmed ID: 19808395
• The German Competence Network on Atrial Fibrillation (AFNET)
  Herz. Dec, 2008  |   Pubmed ID: 19137244
• Calcium Handling Abnormalities in Atrial Fibrillation As a Target for Innovative Therapeutics
  Journal of Cardiovascular Pharmacology. Oct, 2008  |   Pubmed ID: 18791467
• Cellular Signaling Underlying Atrial Tachycardia Remodeling of L-type Calcium Current
  Circulation Research. Oct, 2008  |   Pubmed ID: 18723446
• Phosphatase Inhibitor-1-deficient Mice Are Protected from Catecholamine-induced Arrhythmias and Myocardial Hypertrophy
  Cardiovascular Research. Dec, 2008  |   Pubmed ID: 18689792
• Intracellular Calcium Leak Due to FKBP12.6 Deficiency in Mice Facilitates the Inducibility of Atrial Fibrillation
  Heart Rhythm : the Official Journal of the Heart Rhythm Society. Jul, 2008  |   Pubmed ID: 18598963
• Digital Lock-in Techniques for Adaptive Power-line Interference Extraction
  Physiological Measurement. Jul, 2008  |   Pubmed ID: 18560061
• Four and a Half LIM Protein 1: a Novel Chaperone for Atrium-specific Kv1.5 Channels with a Potential Role in Atrial Arrhythmogenesis
  Cardiovascular Research. Jun, 2008  |   Pubmed ID: 18390898
• New Concepts in Understanding and Modulating Atrial Repolarisation in Patients with Atrial Fibrillation
  Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing. Aug, 2008  |   Pubmed ID: 18330686
• Bootstrapped Two-electrode Biosignal Amplifier
  Medical & Biological Engineering & Computing. Jun, 2008  |   Pubmed ID: 18266016
• Changes in I K, ACh Single-channel Activity with Atrial Tachycardia Remodelling in Canine Atrial Cardiomyocytes
  Cardiovascular Research. Jan, 2008  |   Pubmed ID: 18006448
• Cardiomyocyte Ca2+ Overload in Atrial Tachycardia: is Blockade of L-type Ca2+ Channels a Promising Approach to Prevent Electrical Remodeling and Arrhythmogenesis?
  Naunyn-Schmiedeberg's Archives of Pharmacology. Dec, 2007  |   Pubmed ID: 17999053
• Vascular Large Conductance Calcium-activated Potassium Channels: Functional Role and Therapeutic Potential
  Naunyn-Schmiedeberg's Archives of Pharmacology. Nov, 2007  |   Pubmed ID: 17932654
• Pharmacological Evidence for Altered Src Kinase Regulation of I (Ca,L) in Patients with Chronic Atrial Fibrillation
  Naunyn-Schmiedeberg's Archives of Pharmacology. Aug, 2007  |   Pubmed ID: 17593353
• Decreased Phosphorylation Levels of Cardiac Myosin-binding Protein-C in Human and Experimental Heart Failure
  Journal of Molecular and Cellular Cardiology. Aug, 2007  |   Pubmed ID: 17560599
• Differential Phosphorylation-dependent Regulation of Constitutively Active and Muscarinic Receptor-activated IK,ACh Channels in Patients with Chronic Atrial Fibrillation
  Cardiovascular Research. Jun, 2007  |   Pubmed ID: 17362895
• Novel Anti-arrhythmic Agents for the Treatment of Atrial Fibrillation
  Current Opinion in Pharmacology. Apr, 2007  |   Pubmed ID: 17303472
• 5-hydroxytryptamine and Atrial Arrhythmogenesis: a "culprit Mechanism" or Bystander in Patients with Chronic Atrial Fibrillation?
  Journal of Molecular and Cellular Cardiology. Jan, 2007  |   Pubmed ID: 17064728
• Molecular Determinants of Altered Ca2+ Handling in Human Chronic Atrial Fibrillation
  Circulation. Aug, 2006  |   Pubmed ID: 16894034
• Role of Calcineurin and Protein Phosphatase-2A in the Regulation of Phosphatase Inhibitor-1 in Cardiac Myocytes
  Biochemical and Biophysical Research Communications. Aug, 2006  |   Pubmed ID: 16774736
• Do Genetics Help to Better Understand the Underlying Mechanisms of Atrial Fibrillation?
  European Heart Journal. Jul, 2006  |   Pubmed ID: 16760202
• Electrical Remodeling in Atrial Fibrillation
  Herz. Apr, 2006  |   Pubmed ID: 16738832
• Human Atrial Ion Channel and Transporter Subunit Gene-expression Remodeling Associated with Valvular Heart Disease and Atrial Fibrillation
  Circulation. Jul, 2005  |   Pubmed ID: 16027256
• Comparing the Global MRNA Expression Profile of Human Atrial and Ventricular Myocardium with High-density Oligonucleotide Arrays
  The Journal of Thoracic and Cardiovascular Surgery. Jun, 2005  |   Pubmed ID: 15942582
• Effects of Immunoglobulin G from Patients with Dilated Cardiomyopathy on Rat Cardiomyocytes
  Basic & Clinical Pharmacology & Toxicology. Jun, 2005  |   Pubmed ID: 15910408
• Quantification of G Protein Gaalphas Subunit Splice Variants in Different Human Tissues and Cells Using Pyrosequencing
  Gene Expression. 2005  |   Pubmed ID: 15892449
• Defective Cardiac Ryanodine Receptor Regulation During Atrial Fibrillation
  Circulation. Apr, 2005  |   Pubmed ID: 15851612
• Recording Atrial Monophasic Action Potentials Using Standard Pacemaker Leads: an Alternative Way to Study Electrophysiology Properties of the Human Atrium in Vivo?
  Pacing and Clinical Electrophysiology : PACE. Dec, 2004  |   Pubmed ID: 15613126
• An Aqueous Extract of the Marine Sponge Ectyoplasia Ferox Stimulates L-type Ca2+-current by Direct Interaction with the Cav1.2 Subunit
  Naunyn-Schmiedeberg's Archives of Pharmacology. Dec, 2004  |   Pubmed ID: 15599709
• Role of IKur in Controlling Action Potential Shape and Contractility in the Human Atrium: Influence of Chronic Atrial Fibrillation
  Circulation. Oct, 2004  |   Pubmed ID: 15477405
• Muscarinic Subtype-2 Receptor Autoantibodies: Actors or Bystanders in Human Atrial Fibrillation?
  European Heart Journal. Jul, 2004  |   Pubmed ID: 15231365
• Mechanisms of Beta-adrenergic Receptor-mediated Venodilation in Humans
  Clinical Pharmacology and Therapeutics. Jan, 2004  |   Pubmed ID: 14749691
• Decreased ATP-sensitive K(+) Current Density During Chronic Human Atrial Fibrillation
  Journal of Molecular and Cellular Cardiology. Dec, 2003  |   Pubmed ID: 14654366
• Transcription Factors for Ion Channels: Active or Passive Players in Cardiac Remodeling?
  Cardiovascular Research. Nov, 2003  |   Pubmed ID: 14613850
• Remodeling of Cardiomyocyte Ion Channels in Human Atrial Fibrillation
  Basic Research in Cardiology. May, 2003  |   Pubmed ID: 12883831
• Cardiac Sympathetic Innervation and Control of Potassium Channel Function
  Journal of Molecular and Cellular Cardiology. Feb, 2003  |   Pubmed ID: 12606253
• Therapeutically Relevant Concentrations of Neomycin Selectively Inhibit P-type Ca2+ Channels in Rat Striatum
  European Journal of Pharmacology. Feb, 2003  |   Pubmed ID: 12586205
• Rate-adaptive Pacing Using Intracardiac Impedance Shows No Evidence for Positive Feedback During Dobutamine Stress Test
  Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology. Jul, 2002  |   Pubmed ID: 12134978
• What is a Good Tutorial from the Student's Point of View? Evaluation of Tutorials in a Newly Established PBL Block Course "Basics of Drug Therapy"
  Naunyn-Schmiedeberg's Archives of Pharmacology. Jul, 2002  |   Pubmed ID: 12107636
• Human Inward Rectifier Potassium Channels in Chronic and Postoperative Atrial Fibrillation
  Cardiovascular Research. May, 2002  |   Pubmed ID: 12062344
• Problem-based Learning: a New Pathway to Competence?
  Trends in Pharmacological Sciences. Apr, 2002  |   Pubmed ID: 11931987