Dominique Schols Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy KU Leuven Biography Publications Institution JoVE Articles Dominique Schols has not added a biography. If you are Dominique Schols and would like to personalize this page please email our Author Liaison for assistance. Publications Optimization of Triazolo[4,5-d]pyrimidines Towards Human CC Chemokine Receptor 7 (CCR7) Antagonists European Journal of Medicinal Chemistry. Mar, 2023 | Pubmed ID: 36924670 A Regioselective Step-by-step CCl Functionalization Approach Affords a Novel Family of CArTh'Th''H Fullerene Derivatives with Promising Antiviral Properties Chemical Communications (Cambridge, England). Mar, 2023 | Pubmed ID: 36916636 Exploration of Pyrido[3,4-]pyrimidines As Antagonists of the Human Chemokine Receptor CXCR2 Molecules (Basel, Switzerland). Feb, 2023 | Pubmed ID: 36903345 Visible-Light-Promoted Tandem Thiol-Ene Click Reaction/Transannular Cyclization and Regioselective Cyclopropane Ring-Opening to Construct Sulfur-Containing Diterpenes Organic Letters. Feb, 2023 | Pubmed ID: 36662155 FLUIDOT: A Modular Microfluidic Platform for Single-Cell Study and Retrieval, with Applications in Drug Tolerance Screening and Antibody Mining Small Methods. Mar, 2023 | Pubmed ID: 36642827 Design and Synthesis of a New Series of Hybrids of Functionalised N-[(1H-1,2,3-triazol-4-yl)methyl]quinazoline-2,4-dione with Antiviral Activity Against Respiratory Syncytial Virus Antiviral Research. Jan, 2023 | Pubmed ID: 36587900 Development of a Live Biotherapeutic Throat Spray with Lactobacilli Targeting Respiratory Viral Infections Microbial Biotechnology. Jan, 2023 | Pubmed ID: 36468246 Identification of Polyphenol Derivatives As Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors Molecules (Basel, Switzerland). Dec, 2022 | Pubmed ID: 36615354 Systemic Cytokines and GlycA Discriminate Disease Status and Predict Corticosteroid Response in HTLV-1-associated Neuroinflammation Journal of Neuroinflammation. Dec, 2022 | Pubmed ID: 36482436 Synthesis and Evaluation of 3-alkynyl-5-aryl-7-aza-indoles As Broad-spectrum Antiviral Agents Frontiers in Chemistry. 2022 | Pubmed ID: 36385995 A Stabilized CXCL9(74-103)-derived Peptide Selectively Inhibits Proliferation, Adhesion and Metastasis of Tumor Cells That Express High Levels of Heparan Sulfate International Journal of Biological Macromolecules. Dec, 2022 | Pubmed ID: 36272565 Design, Synthesis, Anti-Varicella-Zoster and Antimicrobial Activity of (Isoxazolidin-3-yl)Phosphonate Conjugates of N1-Functionalised Quinazoline-2,4-Diones Molecules (Basel, Switzerland). Oct, 2022 | Pubmed ID: 36235061 Can We Attenuate Ischaemia-reperfusion Injury of Allografts in a Porcine Left Lung Transplant Models by Adsorption of Cytokines? European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Dec, 2022 | Pubmed ID: 36214633 Corrigendum: Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model Frontiers in Immunology. 2022 | Pubmed ID: 36211405 Carbohydrate-binding Protein from Stinging Nettle As Fusion Inhibitor for SARS-CoV-2 Variants of Concern Frontiers in Cellular and Infection Microbiology. 2022 | Pubmed ID: 36111239 Triphosphate Prodrugs of the Anti-HIV-Active Compound 3'-Deoxy-3'-fluorothymidine (FLT) Journal of Medicinal Chemistry. Sep, 2022 | Pubmed ID: 36099330 Cellular Electrical Impedance As a Method to Decipher CCR7 Signalling and Biased Agonism International Journal of Molecular Sciences. Aug, 2022 | Pubmed ID: 36012168 Cryo-EM Structures of Wild-type and E138K/M184I Mutant HIV-1 RT/DNA Complexed with Inhibitors Doravirine and Rilpivirine Proceedings of the National Academy of Sciences of the United States of America. Jul, 2022 | Pubmed ID: 35858448 Potent Neutralizing Anti-SARS-CoV-2 Human Antibodies Cure Infection with SARS-CoV-2 Variants in Hamster Model IScience. Aug, 2022 | Pubmed ID: 35813873 SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells Viruses. May, 2022 | Pubmed ID: 35632693 The Discovery of Zika Virus NS2B-NS3 Inhibitors with Antiviral Activity Via an Integrated Virtual Screening Approach European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Aug, 2022 | Pubmed ID: 35618201 Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity ACS Medicinal Chemistry Letters. May, 2022 | Pubmed ID: 35571875 Stimulation of the Atypical Chemokine Receptor 3 (ACKR3) by a Small-molecule Agonist Attenuates Fibrosis in a Preclinical Liver but Not Lung Injury Model Cellular and Molecular Life Sciences : CMLS. May, 2022 | Pubmed ID: 35562519 Effect of Particle Carriers for Intraperitoneal Drug Delivery on the Course of Ovarian Cancer and Its Immune Microenvironment in a Mouse Model Pharmaceutics. Mar, 2022 | Pubmed ID: 35456521 In Silico Design, Synthesis and Anti-HIV Activity of Quinoline Derivatives As Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Computational Biology and Chemistry. Jun, 2022 | Pubmed ID: 35395595 Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model Frontiers in Immunology. 2022 | Pubmed ID: 35371094 A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening Frontiers in Pharmacology. 2022 | Pubmed ID: 35370691 Identification of Novel Chemotypes As CXCR2 Antagonists Via a Scaffold Hopping Approach from a Thiazolo[4,5-d]pyrimidine European Journal of Medicinal Chemistry. May, 2022 | Pubmed ID: 35313168 Circulating Donor-Specific Anti-HLA Antibodies Associate With Immune Activation Independent of Kidney Transplant Histopathological Findings Frontiers in Immunology. 2022 | Pubmed ID: 35281018 Targeting Chemokine Receptors from the Inside-out: Discovery and Development of Small-molecule Intracellular Antagonists Chemical Communications (Cambridge, England). Mar, 2022 | Pubmed ID: 35274633 Synthesis, in Vitro Cytotoxicity, molecular Docking and ADME Study of Some Indolin-2-one Linked 1,2,3-triazole Derivatives Computational Biology and Chemistry. Apr, 2022 | Pubmed ID: 35168158 Anthranilamides with Quinoline and β-carboline Scaffolds: Design, Synthesis, and Biological Activity Molecular Diversity. Oct, 2022 | Pubmed ID: 34997441 Atypical Response to Bacterial Coinfection and Persistent Neutrophilic Bronchoalveolar Inflammation Distinguish Critical COVID-19 from Influenza JCI Insight. Jan, 2022 | Pubmed ID: 34793331 Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis American Journal of Respiratory and Critical Care Medicine. Jan, 2022 | Pubmed ID: 34724391 Discovery of ( ±)-3-(1H-pyrazol-1-yl)-6,7-dihydro-5H-[1,2,4]triazolo[3,4-b][1,3,4] Thiadiazine Derivatives with Promising in Vitro Anticoronavirus and Antitumoral Activity Molecular Diversity. Jun, 2022 | Pubmed ID: 34165689 Itaconic Acid Hybrids As Potential Anticancer Agents Molecular Diversity. Feb, 2022 | Pubmed ID: 33043404 Deciphering the Role of Extracellular Vesicles Derived from ZIKV-Infected HcMEC/D3 Cells on the Blood-Brain Barrier System Viruses. Nov, 2021 | Pubmed ID: 34960632 Sliding of HIV-1 Reverse Transcriptase over DNA Creates a Transient P Pocket - Targeting P-pocket by Fragment Screening Nature Communications. Dec, 2021 | Pubmed ID: 34880240 Skeleton Binding Protein-1-mediated Parasite Sequestration Inhibits Spontaneous Resolution of Malaria-associated Acute Respiratory Distress Syndrome PLoS Pathogens. Nov, 2021 | Pubmed ID: 34843584 Peripherally-driven Myeloid NFkB and IFN/ISG Responses Predict Malignancy Risk, Survival, and Immunotherapy Regime in Ovarian Cancer Journal for Immunotherapy of Cancer. Nov, 2021 | Pubmed ID: 34795003 Synthesis and Anti-HIV Activity of a Novel Series of Isoquinoline-Based CXCR4 Antagonists Molecules (Basel, Switzerland). Oct, 2021 | Pubmed ID: 34684878 D-Peptide-Based Probe for CXCR4-Targeted Molecular Imaging and Radionuclide Therapy Pharmaceutics. Oct, 2021 | Pubmed ID: 34683912 A Proteomic Study on the Membrane Protein Fraction of T Cells Confirms High Substrate Selectivity for the ER Translocation Inhibitor Cyclotriazadisulfonamide Molecular & Cellular Proteomics : MCP. 2021 | Pubmed ID: 34481949 Water-Promoted Reaction of CArCl Compounds with Thiophenes Delivers a Family of Multifunctional Fullerene Derivatives with Selective Antiviral Properties Organic Letters. Sep, 2021 | Pubmed ID: 34468156 Exploring the DNTP -binding Site of HIV-1 Reverse Transcriptase for Inhibitor Design European Journal of Medicinal Chemistry. Dec, 2021 | Pubmed ID: 34425311 Novel N-Substituted 3-Aryl-4-(diethoxyphosphoryl)azetidin-2-ones As Antibiotic Enhancers and Antiviral Agents in Search for a Successful Treatment of Complex Infections International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34360797 Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases Frontiers in Immunology. 2021 | Pubmed ID: 34276694 Labyrinthopeptin A1 Inhibits Dengue and Zika Virus Infection by Interfering with the Viral Phospholipid Membrane Virology. Oct, 2021 | Pubmed ID: 34274562 Broad Spectrum Anti-coronavirus Activity of a Series of Anti-malaria Quinoline Analogues Antiviral Research. Sep, 2021 | Pubmed ID: 34217752 Active Components from Prevent HIV-1 Entry by Distinct Mechanisms of Action International Journal of Molecular Sciences. May, 2021 | Pubmed ID: 34068829 A Novel Series of Indole Alkaloid Derivatives Inhibit Dengue and Zika Virus Infection by Interference with the Viral Replication Complex Antimicrobial Agents and Chemotherapy. Jul, 2021 | Pubmed ID: 34001508 Small Molecule Cyclotriazadisulfonamide Abrogates the Upregulation of the Human Receptors CD4 and 4-1BB and Suppresses In Vitro Activation and Proliferation of T Lymphocytes Frontiers in Immunology. 2021 | Pubmed ID: 33968048 Biological Characterization of Ligands Targeting the Human CC Chemokine Receptor 8 (CCR8) Reveals the Biased Signaling Properties of Small Molecule Agonists Biochemical Pharmacology. Jun, 2021 | Pubmed ID: 33872569 Corrigendum to 'Discovery of HIV Entry Inhibitors Via a Hybrid CXCR4 and CCR5 Receptor Pharmacophore-based Virtual Screening Approach' [European Journal of Pharmaceutical Sciences 155 (2020) 105537] European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2021 | Pubmed ID: 33814256 FO-SPR Biosensor Calibrated with Recombinant Extracellular Vesicles Enables Specific and Sensitive Detection Directly in Complex Matrices Journal of Extracellular Vesicles. Feb, 2021 | Pubmed ID: 33664936 Synthesis, in Silico ADME, Molecular Docking and in Vitro Cytotoxicity Evaluation of Stilbene Linked 1,2,3-triazoles Heliyon. Jan, 2021 | Pubmed ID: 33553718 A Novel Experimental Porcine Model to Assess the Impact of Differential Pulmonary Blood Flow on Ischemia-reperfusion Injury After Unilateral Lung Transplantation Intensive Care Medicine Experimental. Feb, 2021 | Pubmed ID: 33543363 Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b]pyridines As Highly Potent Inhibitors of Cyclin G-associated Kinase European Journal of Medicinal Chemistry. Mar, 2021 | Pubmed ID: 33497888 Palladium-catalyzed Cross-coupling Reactions on a Bromo-naphthalene Scaffold in the Search for Novel Human CC Chemokine Receptor 8 (CCR8) Antagonists Bioorganic Chemistry. Feb, 2021 | Pubmed ID: 33383325 Characterization of the Carbohydrate-Binding Agents HHA, GNA, and UDA As Inhibitors of Influenza A and B Virus Replication Antimicrobial Agents and Chemotherapy. Feb, 2021 | Pubmed ID: 33288640 Synthesis, Molecular Docking and Preliminary Antileukemic Activity of 4-Methoxybenzyl Derivatives Bearing Imidazo[2,1-b][1,3,4]thiadiazole Chemistry & Biodiversity. Feb, 2021 | Pubmed ID: 33274824 A Single-dose Live-attenuated YF17D-vectored SARS-CoV-2 Vaccine Candidate Nature. 02, 2021 | Pubmed ID: 33260195 γ-Non-Symmetrically Dimasked TriPPPro Prodrugs As Potential Antiviral Agents Against HIV ChemMedChem. Feb, 2021 | Pubmed ID: 33089929 STAT2 Signaling Restricts Viral Dissemination but Drives Severe Pneumonia in SARS-CoV-2 Infected Hamsters Nature Communications. 11, 2020 | Pubmed ID: 33203860 γ-Ketobenzyl-Modified Nucleoside Triphosphate Prodrugs As Potential Antivirals Journal of Medicinal Chemistry. Nov, 2020 | Pubmed ID: 33186038 Development of a Novel SPR Assay to Study CXCR4-Ligand Interactions Biosensors. Oct, 2020 | Pubmed ID: 33096938 Thiophene-based Water-soluble Fullerene Derivatives As Highly Potent Antiherpetic Pharmaceuticals Organic & Biomolecular Chemistry. Nov, 2020 | Pubmed ID: 33084716 Alkylated Benzimidazoles: Design, Synthesis, Docking, DFT Analysis, ADMET Property, Molecular Dynamics and Activity Against HIV and YFV Computational Biology and Chemistry. Dec, 2020 | Pubmed ID: 33068917 Membrane Permeable, Bioreversibly Modified Prodrugs of Nucleoside Diphosphate-γ-Phosphonates Journal of Medicinal Chemistry. Oct, 2020 | Pubmed ID: 32991174 Synthesis of New Riboflavin Modified ODNs: Effect of Riboflavin Moiety on the G-quadruplex Arrangement and Stability Bioorganic Chemistry. Nov, 2020 | Pubmed ID: 32919132 Discovery of HIV Entry Inhibitors Via a Hybrid CXCR4 and CCR5 Receptor Pharmacophore-based Virtual Screening Approach European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Dec, 2020 | Pubmed ID: 32890663 Water-soluble Fullerene-based Nanostructures with Promising Antiviral and Myogenic Activity Chemical Communications (Cambridge, England). Sep, 2020 | Pubmed ID: 32748905 Lipophilic Triphosphate Prodrugs of Various Nucleoside Analogues Journal of Medicinal Chemistry. Jul, 2020 | Pubmed ID: 32515595 Anti-HIV-Active Nucleoside Triphosphate Prodrugs Journal of Medicinal Chemistry. Jun, 2020 | Pubmed ID: 32421343 Prodrugs of γ-Alkyl-Modified Nucleoside Triphosphates: Improved Inhibition of HIV Reverse Transcriptase Angewandte Chemie (International Ed. in English). Dec, 2020 | Pubmed ID: 32379948 Early Protein Expression Profile in Bronchoalveolar Lavage Fluid and Clinical Outcomes in Primary Graft Dysfunction After Lung Transplantation European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery. Aug, 2020 | Pubmed ID: 32267918 A Chimeric Yellow Fever-Zika Virus Vaccine Candidate Fully Protects Against Yellow Fever Virus Infection in Mice Emerging Microbes & Infections. 2020 | Pubmed ID: 32116148 Design, Synthesis and Biological Evaluation of 2-alkoxycarbonyl-3-anilinoindoles As a New Class of Potent Inhibitors of Tubulin Polymerization Bioorganic Chemistry. Apr, 2020 | Pubmed ID: 32086053 Tryptophan Trimers and Tetramers Inhibit Dengue and Zika Virus Replication by Interfering with Viral Attachment Processes Antimicrobial Agents and Chemotherapy. Feb, 2020 | Pubmed ID: 31932383 Preprotein Signature for Full Susceptibility to the Co-translational Translocation Inhibitor Cyclotriazadisulfonamide Traffic (Copenhagen, Denmark). Feb, 2020 | Pubmed ID: 31675144 Design, Synthesis and Antiviral Evaluation of Novel Acyclic Phosphonate Nucleotide Analogs with Triazolo[4,5-]pyridine, Imidazo[4,5-]pyridine and Imidazo[4,5-]pyridin-2(3)-one Systems Nucleosides, Nucleotides & Nucleic Acids. 2020 | Pubmed ID: 31550993 Cu PET Imaging of the CXCR4 Chemokine Receptor Using a Cross-Bridged Cyclam Bis-Tetraazamacrocyclic Antagonist Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2020 | Pubmed ID: 31201250 Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides As Potential Antitumor Or/and Antiviral Agents Medicinal Chemistry (Shariqah (United Arab Emirates)). 2020 | Pubmed ID: 30799795 Acyclic Nucleoside Phosphonates Containing the Amide Bond: Hydroxy Derivatives Monatshefte Fur Chemie. 2019 | Pubmed ID: 32214483 Novel Isoxazolidine and γ-Lactam Analogues of Homonucleosides Molecules (Basel, Switzerland). Nov, 2019 | Pubmed ID: 31698778 A Unique Class of Lignin Derivatives Displays Broad Anti-HIV Activity by Interacting with the Viral Envelope Virus Research. Dec, 2019 | Pubmed ID: 31618614 Antitumor and Antiviral Activities of 4-substituted 1,2,3-triazolyl-2,3-dibenzyl-L-ascorbic Acid Derivatives European Journal of Medicinal Chemistry. Dec, 2019 | Pubmed ID: 31586832 Modifications in the Branched Arms of a Class of Dual Inhibitors of HIV and EV71 Replication Expand Their Antiviral Spectrum Antiviral Research. Aug, 2019 | Pubmed ID: 31228490 Diversion of the Arbuzov Reaction: Alkylation of C-Cl Instead of Phosphonic Ester Formation on the Fullerene Cage Organic & Biomolecular Chemistry. Aug, 2019 | Pubmed ID: 31169856 Advantages and Shortcomings of Cell-based Electrical Impedance Measurements As a GPCR Drug Discovery Tool Biosensors & Bioelectronics. Jul, 2019 | Pubmed ID: 31077988 Highly Stable Hexitol Based XNA Aptamers Targeting the Vascular Endothelial Growth Factor Nucleic Acids Research. Jun, 2019 | Pubmed ID: 30968117 Acetate As a Model for Aspartate-based CXCR4 Chemokine Receptor Binding of Cobalt and Nickel Complexes of Cross-bridged Tetraazamacrocycles Dalton Transactions (Cambridge, England : 2003). Feb, 2019 | Pubmed ID: 30729243 Synthesis and Anti-HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives Chemistry & Biodiversity. Feb, 2019 | Pubmed ID: 30431702 Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles Medicinal Chemistry (Shariqah (United Arab Emirates)). 2019 | Pubmed ID: 30411688 A Yellow Fever-Zika Chimeric Virus Vaccine Candidate Protects Against Zika Infection and Congenital Malformations in Mice NPJ Vaccines. 2018 | Pubmed ID: 30564463 CXCR4-targeting Nanobodies Differentially Inhibit CXCR4 Function and HIV Entry Biochemical Pharmacology. Dec, 2018 | Pubmed ID: 30342024 Nanobody-Fc Constructs Targeting Chemokine Receptor CXCR4 Potently Inhibit Signaling and CXCR4-mediated HIV-entry and Induce Antibody Effector Functions Biochemical Pharmacology. Dec, 2018 | Pubmed ID: 30342023 Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation and Anti-HIV-1 Activity Frontiers in Immunology. 2018 | Pubmed ID: 30233568 Design, Synthesis, in Vitro Antiproliferative Activity and Apoptosis-inducing Studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one Derivatives Obtained by a Molecular Hybridisation Approach Journal of Enzyme Inhibition and Medicinal Chemistry. Dec, 2018 | Pubmed ID: 30141353 Synthesis of a 3'-C-ethynyl-β-d-ribofuranose Purine Nucleoside Library: Discovery of C7-deazapurine Analogs As Potent Antiproliferative Nucleosides European Journal of Medicinal Chemistry. Sep, 2018 | Pubmed ID: 30098481 Isoxazolidine Conjugates of N3-Substituted 6-Bromoquinazolinones-Synthesis, Anti-Varizella-Zoster Virus, and Anti-Cytomegalovirus Activity Molecules (Basel, Switzerland). Jul, 2018 | Pubmed ID: 30060562 Engineering Lactobacillus Rhamnosus GG and GR-1 to Express HIV-inhibiting Griffithsin International Journal of Antimicrobial Agents. Nov, 2018 | Pubmed ID: 30040991 Asymmetric Primaquine and Halogenaniline Fumardiamides As Novel Biologically Active Michael Acceptors Molecules (Basel, Switzerland). Jul, 2018 | Pubmed ID: 30011922 Iterative Chemical Engineering of Vancomycin Leads to Novel Vancomycin Analogs With a High Therapeutic Index Frontiers in Microbiology. 2018 | Pubmed ID: 29930540 CXCR7/ACKR3-targeting Ligands Interfere with X7 HIV-1 and HIV-2 Entry and Replication in Human Host Cells Heliyon. Mar, 2018 | Pubmed ID: 29560468 Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity Molecules (Basel, Switzerland). Jan, 2018 | Pubmed ID: 29385738 Aminomethylation of Heliomycin: Preparation and Anticancer Characterization of the First Series of Semi-synthetic Derivatives European Journal of Medicinal Chemistry. Jan, 2018 | Pubmed ID: 29137865 Signaling Properties of the Human Chemokine Receptors CXCR4 and CXCR7 by Cellular Electric Impedance Measurements PloS One. 2017 | Pubmed ID: 28945785 Design, Synthesis, and the Biological Evaluation of a New Series of Acyclic 1,2,3-Triazole Nucleosides Archiv Der Pharmazie. Sep, 2017 | Pubmed ID: 28763115 Expanding the Antiviral Spectrum of 3-Fluoro-2-(phosphonomethoxy)propyl Acyclic Nucleoside Phosphonates: Diamyl Aspartate Amidate Prodrugs Journal of Medicinal Chemistry. Jul, 2017 | Pubmed ID: 28682067 Immunoregulatory Effects of Multipotent Adult Progenitor Cells in a Porcine Ex Vivo Lung Perfusion Model Stem Cell Research & Therapy. Jul, 2017 | Pubmed ID: 28676074 Comparison of Cell-based Assays for the Identification and Evaluation of Competitive CXCR4 Inhibitors PloS One. 2017 | Pubmed ID: 28410420 Synthesis and Ativiral Activity of 5-(Benzylthio)-4-carbamyl-1,2,3-triazoles Against Human Cytomegalovirus (CMV) and Varicella-zoster Virus (VZV) Medicinal Chemistry (Shariqah (United Arab Emirates)). 2017 | Pubmed ID: 28290250 Structure-activity Relationship Studies on a Trp Dendrimer with Dual Activities Against HIV and Enterovirus A71. Modifications on the Amino Acid Antiviral Research. Mar, 2017 | Pubmed ID: 28017762 A Proteomic Survey Indicates Sortilin As a Secondary Substrate of the ER Translocation Inhibitor Cyclotriazadisulfonamide (CADA) Molecular & Cellular Proteomics : MCP. Feb, 2017 | Pubmed ID: 27998951 Synthesis of Different Types of Alkoxy Fullerene Derivatives from Chlorofullerene CCl Organic & Biomolecular Chemistry. Jan, 2017 | Pubmed ID: 27830866 Synthesis, Anti-varicella-zoster Virus and Anti-cytomegalovirus Activity of Quinazoline-2,4-diones Containing Isoxazolidine and Phosphonate Substructures European Journal of Medicinal Chemistry. Jan, 2017 | Pubmed ID: 27750154 Novel Isoxazolidine Analogues of Homonucleosides and Homonucleotides Tetrahedron. Dec, 2016 | Pubmed ID: 32287430 Synthesis of Novel -acyl--d-glucopyranosylamines and Ureas As Potential Lead Cytostatic Agents Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents. 2016 | Pubmed ID: 32214768 Synthesis, Antiviral, Cytotoxic and Cytostatic Evaluation of -(phosphonoalkyl)uracil Derivatives Monatshefte Fur Chemie. 2016 | Pubmed ID: 32214481 Acyclic Nucleoside Phosphonates Containing the Amide Bond Monatshefte Fur Chemie. 2016 | Pubmed ID: 27881885 The Lectin-like Protein 1 in Lactobacillus Rhamnosus GR-1 Mediates Tissue-specific Adherence to Vaginal Epithelium and Inhibits Urogenital Pathogens Scientific Reports. Nov, 2016 | Pubmed ID: 27869151 High Mannose-specific Lectin Msl Mediates Key Interactions of the Vaginal Lactobacillus Plantarum Isolate CMPG5300 Scientific Reports. Nov, 2016 | Pubmed ID: 27853317 Synthesis and the Biological Activity of Phosphonylated 1,2,3-Triazolenaphthalimide Conjugates Molecules (Basel, Switzerland). Oct, 2016 | Pubmed ID: 27792200 Lectin-Like Molecules of Lactobacillus Rhamnosus GG Inhibit Pathogenic Escherichia Coli and Salmonella Biofilm Formation PloS One. 2016 | Pubmed ID: 27537843 Aspartate-Based CXCR4 Chemokine Receptor Binding of Cross-Bridged Tetraazamacrocyclic Copper(II) and Zinc(II) Complexes Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2016 | Pubmed ID: 27458983 New Isoxazolidine-Conjugates of Quinazolinones-Synthesis, Antiviral and Cytostatic Activity Molecules (Basel, Switzerland). Jul, 2016 | Pubmed ID: 27455228 Lectin-Glycan Interaction Network-Based Identification of Host Receptors of Microbial Pathogenic Adhesins MBio. 07, 2016 | Pubmed ID: 27406561 Synthesis of Novel Chiral Sulfonamide-Bearing 1,2,4-Triazole-3-thione Analogs Derived from D- and L-Phenylalanine Esters As Potential Anti-Influenza Agents Chirality. 06, 2016 | Pubmed ID: 27225330 The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model PLoS Neglected Tropical Diseases. 05, 2016 | Pubmed ID: 27163257 Membrane-permeable Triphosphate Prodrugs of Nucleoside Analogues Angewandte Chemie (International Ed. in English). Apr, 2016 | Pubmed ID: 27008042 Tuning Side Arm Electronics in Unsymmetrical Cyclotriazadisulfonamide (CADA) Endoplasmic Reticulum (ER) Translocation Inhibitors to Improve Their Human Cluster of Differentiation 4 (CD4) Receptor Down-Modulating Potencies Journal of Medicinal Chemistry. Mar, 2016 | Pubmed ID: 26974263 Exploring the Purine Core of 3'-C-ethynyladenosine (EAdo) in Search of Novel Nucleoside Therapeutics Bioorganic & Medicinal Chemistry Letters. Apr, 2016 | Pubmed ID: 26965865 Discovery of Antitumor Anthra[2,3-b]furan-3-carboxamides: Optimization of Synthesis and Evaluation of Antitumor Properties European Journal of Medicinal Chemistry. Apr, 2016 | Pubmed ID: 26890118 Synthesis and Bioactivity of Novel Trisubstituted Triazole Nucleosides Nucleosides, Nucleotides & Nucleic Acids. 2016 | Pubmed ID: 26854981 Vascular Endothelial Growth Factor Pathway in Endometriosis: Genetic Variants and Plasma Biomarkers Fertility and Sterility. Apr, 2016 | Pubmed ID: 26773192 Design, Synthesis, and Antiviral Activity of Novel Ribonucleosides of 1,2,3-Triazolylbenzyl-aminophosphonates Archiv Der Pharmazie. Jan, 2016 | Pubmed ID: 26575425 Lipophilic Prodrugs of Nucleoside Triphosphates As Biochemical Probes and Potential Antivirals Nature Communications. Oct, 2015 | Pubmed ID: 26503889 Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker Molecules (Basel, Switzerland). Oct, 2015 | Pubmed ID: 26501246 BAL Neutrophilia in Azithromycin-treated Lung Transplant Recipients: Clinical Significance Transplant Immunology. Sep, 2015 | Pubmed ID: 26168736 Design, Antiviral and Cytostatic Properties of Isoxazolidine-containing Amonafide Analogues Bioorganic & Medicinal Chemistry. Jul, 2015 | Pubmed ID: 26001344 An Easy Microwave-assisted Synthesis of C8-alkynyl Adenine Pyranonucleosides As Novel Cytotoxic Antitumor Agents Frontiers in Chemistry. 2015 | Pubmed ID: 25853123 Branched-chain Sugar Nucleosides: Stereocontrolled Synthesis and Bioevaluation of Novel 3'-C-trifluoromethyl and 3'-C-methyl Pyranonucleosides Carbohydrate Research. Apr, 2015 | Pubmed ID: 25812993 NICTABA and UDA, Two GlcNAc-binding Lectins with Unique Antiviral Activity Profiles The Journal of Antimicrobial Chemotherapy. 2015 | Pubmed ID: 25700718 Differential Cytokine, Chemokine and Growth Factor Expression in Phenotypes of Chronic Lung Allograft Dysfunction Transplantation. Jan, 2015 | Pubmed ID: 25050473 Signal Peptide-binding Drug As a Selective Inhibitor of Co-translational Protein Translocation PLoS Biology. Dec, 2014 | Pubmed ID: 25460167 2-(4-Chlorobenzyl)-6-arylimidazo[2,1-b][1,3,4]thiadiazoles: Synthesis, Cytotoxic Activity and Mechanism of Action European Journal of Medicinal Chemistry. Sep, 2014 | Pubmed ID: 25064346 Design, Synthesis, Antiviral and Cytostatic Activity of ω-(1H-1,2,3-triazol-1-yl)(polyhydroxy)alkylphosphonates As Acyclic Nucleotide Analogues Bioorganic & Medicinal Chemistry. Jul, 2014 | Pubmed ID: 24906510 Sulfated Escherichia Coli K5 Polysaccharide Derivatives Inhibit Dengue Virus Infection of Human Microvascular Endothelial Cells by Interacting with the Viral Envelope Protein E Domain III PloS One. 2013 | Pubmed ID: 24015314 A Multi-targeted Drug Candidate with Dual Anti-HIV and Anti-HSV Activity PLoS Pathogens. 2013 | Pubmed ID: 23935482 Algal Lectins As Potential HIV Microbicide Candidates Marine Drugs. Jul, 2012 | Pubmed ID: 22851920 Carbohydrate-binding Agents Efficiently Prevent Dendritic Cell-specific Intercellular Adhesion Molecule-3-grabbing Nonintegrin (DC-SIGN)-directed HIV-1 Transmission to T Lymphocytes Molecular Pharmacology. Jan, 2007 | Pubmed ID: 17056872 Mutational Pathways, Resistance Profile, and Side Effects of Cyanovirin Relative to Human Immunodeficiency Virus Type 1 Strains with N-glycan Deletions in Their Gp120 Envelopes Journal of Virology. Sep, 2006 | Pubmed ID: 16912292 Клеточная электроимпедансная платформа для оценки ингибиторов вируса Зика в режиме реального времени Merel Oeyen1, Eef Meyen1, Dominique Schols1 1Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven JoVE 65149 Immunology and Infection Потока на основе цитометрии проба для выявления соединений, которые нарушают Связывание лиганда дневно меченых КЭС хемокиновых 12 КЭС хемокиновых рецепторов 4 Geert Schoofs1, Anneleen Van Hout1, Thomas D'huys1, Dominique Schols1, Tom Van Loy1 1Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven JoVE 57271 Biology Кинетическая на основе флуоресценции Ca2 + мобилизации Assay для определения G белка в сочетании рецепторов агонистов, антагонисты и аллостерический модуляторы Sandra Claes1, Thomas D'huys1, Anneleen Van Hout1, Dominique Schols1, Tom Van Loy1 1Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven JoVE 56780 Medicine
Клеточная электроимпедансная платформа для оценки ингибиторов вируса Зика в режиме реального времени Merel Oeyen1, Eef Meyen1, Dominique Schols1 1Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, KU Leuven JoVE 65149 Immunology and Infection
Потока на основе цитометрии проба для выявления соединений, которые нарушают Связывание лиганда дневно меченых КЭС хемокиновых 12 КЭС хемокиновых рецепторов 4 Geert Schoofs1, Anneleen Van Hout1, Thomas D'huys1, Dominique Schols1, Tom Van Loy1 1Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven JoVE 57271 Biology
Кинетическая на основе флуоресценции Ca2 + мобилизации Assay для определения G белка в сочетании рецепторов агонистов, антагонисты и аллостерический модуляторы Sandra Claes1, Thomas D'huys1, Anneleen Van Hout1, Dominique Schols1, Tom Van Loy1 1Laboratory of Virology and Chemotherapy, Department of Microbiology and Immunology, Rega Institute for Medical Research, KU Leuven JoVE 56780 Medicine
