Donald M. Kuhn

Publications

• Ventilatory Long-term Facilitation is Evident After Initial and Repeated Exposure to Intermittent Hypoxia in Mice Genetically Depleted of Brain Serotonin
  Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2013  |   Pubmed ID: 24336886
• Effects of Combined Treatment with Mephedrone and Methamphetamine or 3,4-methylenedioxymethamphetamine on Serotonin Nerve Endings of the Hippocampus
  Life Sciences. Jul, 2013  |   Pubmed ID: 23892197
• Mephedrone Does Not Damage Dopamine Nerve Endings of the Striatum, but Enhances the Neurotoxicity of Methamphetamine, Amphetamine, and MDMA
  Journal of Neurochemistry. Apr, 2013  |   Pubmed ID: 23205838
• Mice Genetically Depleted of Brain Serotonin Display Social Impairments, Communication Deficits and Repetitive Behaviors: Possible Relevance to Autism
  PloS One. 2012  |   Pubmed ID: 23139830
• Evidence of 5-HT Components in Human Sperm: Implications for Protein Tyrosine Phosphorylation and the Physiology of Motility
  Reproduction (Cambridge, England). Dec, 2012  |   Pubmed ID: 23028123
• Altered Gene Expression in Cultured Microglia in Response to Simulated Blast Overpressure: Possible Role of Pulse Duration
  Neuroscience Letters. Jul, 2012  |   Pubmed ID: 22698585
• Genetic Depletion of Brain 5HT Reveals a Common Molecular Pathway Mediating Compulsivity and Impulsivity
  Journal of Neurochemistry. Jun, 2012  |   Pubmed ID: 22443164
• Mephedrone, an Abused Psychoactive Component of 'bath Salts' and Methamphetamine Congener, Does Not Cause Neurotoxicity to Dopamine Nerve Endings of the Striatum
  Journal of Neurochemistry. Mar, 2012  |   Pubmed ID: 22191803
• A Mouse Model of Human Repetitive Mild Traumatic Brain Injury
  Journal of Neuroscience Methods. Jan, 2012  |   Pubmed ID: 21930157
• Nucleus Accumbens Invulnerability to Methamphetamine Neurotoxicity
  ILAR Journal / National Research Council, Institute of Laboratory Animal Resources. 2011  |   Pubmed ID: 23382149
• Tryptophan Hydroxylase 2 Aggregates Through Disulfide Cross-linking Upon Oxidation: Possible Link to Serotonin Deficits and Non-motor Symptoms in Parkinson's Disease
  Journal of Neurochemistry. Feb, 2011  |   Pubmed ID: 21105877
• Potential Mechanisms Underlying Anxiety and Depression in Parkinson's Disease: Consequences of L-DOPA Treatment
  Neuroscience and Biobehavioral Reviews. Jan, 2011  |   Pubmed ID: 20615430
• MDMA Administration Decreases Serotonin but Not N-acetylaspartate in the Rat Brain
  Neurotoxicology. Dec, 2010  |   Pubmed ID: 20800616
• The Role of Endogenous Serotonin in Methamphetamine-induced Neurotoxicity to Dopamine Nerve Endings of the Striatum
  Journal of Neurochemistry. Nov, 2010  |   Pubmed ID: 20722968
• Soman Increases Neuronal COX-2 Levels: Possible Link Between Seizures and Protracted Neuronal Damage
  Neurotoxicology. Dec, 2010  |   Pubmed ID: 20600289
• Increases in Cytoplasmic Dopamine Compromise the Normal Resistance of the Nucleus Accumbens to Methamphetamine Neurotoxicity
  Journal of Neurochemistry. Jun, 2009  |   Pubmed ID: 19457119
• Dopamine Disposition in the Presynaptic Process Regulates the Severity of Methamphetamine-induced Neurotoxicity
  Annals of the New York Academy of Sciences. Oct, 2008  |   Pubmed ID: 18991856
• Methamphetamine-induced Neurotoxicity and Microglial Activation Are Not Mediated by Fractalkine Receptor Signaling
  Journal of Neurochemistry. Jul, 2008  |   Pubmed ID: 18410508
• A Serotonergic System in Veins: Serotonin Transporter-independent Uptake
  The Journal of Pharmacology and Experimental Therapeutics. Jun, 2008  |   Pubmed ID: 18322152
• The Newly Synthesized Pool of Dopamine Determines the Severity of Methamphetamine-induced Neurotoxicity
  Journal of Neurochemistry. May, 2008  |   Pubmed ID: 18088364
• Phosphorylation and Activation of Tryptophan Hydroxylase 2: Identification of Serine-19 As the Substrate Site for Calcium, Calmodulin-dependent Protein Kinase II
  Journal of Neurochemistry. Nov, 2007  |   Pubmed ID: 17727633
• Dopamine Quinones Activate Microglia and Induce a Neurotoxic Gene Expression Profile: Relationship to Methamphetamine-induced Nerve Ending Damage
  Annals of the New York Academy of Sciences. Aug, 2006  |   Pubmed ID: 17105901
• MDMA and Fenfluramine Reduce L-DOPA-induced Dyskinesia Via Indirect 5-HT1A Receptor Stimulation
  The European Journal of Neuroscience. May, 2006  |   Pubmed ID: 16817869
• Differential Tissue Distribution of Tryptophan Hydroxylase Isoforms 1 and 2 As Revealed with Monospecific Antibodies
  Brain Research. Apr, 2006  |   Pubmed ID: 16581041
• Mouse Tryptophan Hydroxylase Isoform 2 and the Role of Proline 447 in Enzyme Function
  Journal of Neurochemistry. Feb, 2006  |   Pubmed ID: 16405505
• Gene Expression Profile of Activated Microglia Under Conditions Associated with Dopamine Neuronal Damage
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2006  |   Pubmed ID: 16384912
• S-thiolation of Tyrosine Hydroxylase by Reactive Nitrogen Species in the Presence of Cysteine or Glutathione
  Antioxidants & Redox Signaling. Jul-Aug, 2005  |   Pubmed ID: 15998241
• MK-801 and Dextromethorphan Block Microglial Activation and Protect Against Methamphetamine-induced Neurotoxicity
  Brain Research. Jul, 2005  |   Pubmed ID: 15987631
• Cyclooxygenase-2 is an Obligatory Factor in Methamphetamine-induced Neurotoxicity
  The Journal of Pharmacology and Experimental Therapeutics. May, 2005  |   Pubmed ID: 15718289
• Attenuated Microglial Activation Mediates Tolerance to the Neurotoxic Effects of Methamphetamine
  Journal of Neurochemistry. Feb, 2005  |   Pubmed ID: 15686480
• Microglial Activation is a Pharmacologically Specific Marker for the Neurotoxic Amphetamines
  Neuroscience Letters. Sep, 2004  |   Pubmed ID: 15337264
• Methamphetamine Neurotoxicity in Dopamine Nerve Endings of the Striatum is Associated with Microglial Activation
  The Journal of Pharmacology and Experimental Therapeutics. Oct, 2004  |   Pubmed ID: 15163680
• Nitrotyrosine As a Marker for Peroxynitrite-induced Neurotoxicity: the Beginning or the End of the End of Dopamine Neurons?
  Journal of Neurochemistry. May, 2004  |   Pubmed ID: 15086510
• Gene Expression Profile of the Nucleus Accumbens of Human Cocaine Abusers: Evidence for Dysregulation of Myelin
  Journal of Neurochemistry. Mar, 2004  |   Pubmed ID: 15009677
• Identification of Differentially Regulated Transcripts in Mouse Striatum Following Methamphetamine Treatment--an Oligonucleotide Microarray Approach
  Journal of Neurochemistry. Jan, 2004  |   Pubmed ID: 14690526
• Tetrahydrobiopterin Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen Dioxide
  Molecular Pharmacology. Oct, 2003  |   Pubmed ID: 14500751
• Dopamine Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen Dioxide: is Nitrotyrosine Formation an Early Step in Dopamine Neuronal Damage?
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12771134
• Mass Mapping Sites of Nitration in Tyrosine Hydroxylase: Random Vs Selective Nitration of Three Tyrosine Residues
  Chemical Research in Toxicology. Apr, 2003  |   Pubmed ID: 12703971
• Dopamine Biosynthesis is Regulated by S-glutathionylation. Potential Mechanism of Tyrosine Hydroxylast Inhibition During Oxidative Stress
  The Journal of Biological Chemistry. Dec, 2002  |   Pubmed ID: 12376535
• Peroxynitrite Inactivates the Human Dopamine Transporter by Modification of Cysteine 342: Potential Mechanism of Neurotoxicity in Dopamine Neurons
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2002  |   Pubmed ID: 12040046
• Reduced Nicotinamide Nucleotides Prevent Nitration of Tyrosine Hydroxylase by Peroxynitrite
  Brain Research. Apr, 2002  |   Pubmed ID: 11929639
• Peroxynitrite-induced Nitration of Tyrosine Hydroxylase: Identification of Tyrosines 423, 428, and 432 As Sites of Modification by Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry and Tyrosine-scanning Mutagenesis
  The Journal of Biological Chemistry. Apr, 2002  |   Pubmed ID: 11834745