Dorien Ward-van Oostwaard

Publications

• Subtype-specific Promoter-driven Action Potential Imaging for Precise Disease Modelling and Drug Testing in HiPSC-derived Cardiomyocytes
  European Heart Journal. Jan, 2017  |   Pubmed ID: 28182242
• A New HERG Allosteric Modulator Rescues Genetic and Drug-induced Long-QT Syndrome Phenotypes in Cardiomyocytes from Isogenic Pairs of Patient Induced Pluripotent Stem Cells
  EMBO Molecular Medicine. 09, 2016  |   Pubmed ID: 27470144
• Subtype-specific Promoter-driven Action Potential Imaging for Precise Disease Modelling and Drug Testing in HiPSC-derived Cardiomyocytes
  European Heart Journal. Jun, 2016  |   Pubmed ID: 27311732
• Altered Calcium Handling and Increased Contraction Force in Human Embryonic Stem Cell Derived Cardiomyocytes Following Short Term Dexamethasone Exposure
  Biochemical and Biophysical Research Communications. Nov, 2015  |   Pubmed ID: 26456652
• Recessive Cardiac Phenotypes in Induced Pluripotent Stem Cell Models of Jervell and Lange-Nielsen Syndrome: Disease Mechanisms and Pharmacological Rescue
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014  |   Pubmed ID: 25453094
• BMP4 Promotes EMT and Mesodermal Commitment in Human Embryonic Stem Cells Via SLUG and MSX2
  Stem Cells (Dayton, Ohio). Mar, 2014  |   Pubmed ID: 24549638
• Isogenic Human Pluripotent Stem Cell Pairs Reveal the Role of a KCNH2 Mutation in Long-QT Syndrome
  The EMBO Journal. Dec, 2013  |   Pubmed ID: 24213244
• Cardiomyocytes Derived from Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease
  Circulation. Jun, 2012  |   Pubmed ID: 22647976
• Screening Ethnically Diverse Human Embryonic Stem Cells Identifies a Chromosome 20 Minimal Amplicon Conferring Growth Advantage
  Nature Biotechnology. Dec, 2011  |   Pubmed ID: 22119741
• NKX2-5(eGFP/w) HESCs for Isolation of Human Cardiac Progenitors and Cardiomyocytes
  Nature Methods. Dec, 2011  |   Pubmed ID: 22020065
• Inhibition of ROCK Improves Survival of Human Embryonic Stem Cell-derived Cardiomyocytes After Dissociation
  Annals of the New York Academy of Sciences. Feb, 2010  |   Pubmed ID: 20201886
• Identification of Cell Surface Proteins for Antibody-based Selection of Human Embryonic Stem Cell-derived Cardiomyocytes
  Journal of Proteome Research. Mar, 2010  |   Pubmed ID: 20088484
• Improvement of Mouse Cardiac Function by HESC-derived Cardiomyocytes Correlates with Vascularity but Not Graft Size
  Stem Cell Research. Sep-Nov, 2009  |   Pubmed ID: 19560991
• Feeder-free Monolayer Cultures of Human Embryonic Stem Cells Express an Epithelial Plasma Membrane Protein Profile
  Stem Cells (Dayton, Ohio). Nov, 2008  |   Pubmed ID: 18703662
• Recombinant Vitronectin is a Functionally Defined Substrate That Supports Human Embryonic Stem Cell Self-renewal Via Alphavbeta5 Integrin
  Stem Cells (Dayton, Ohio). Sep, 2008  |   Pubmed ID: 18599809
• Insulin Redirects Differentiation from Cardiogenic Mesoderm and Endoderm to Neuroectoderm in Differentiating Human Embryonic Stem Cells
  Stem Cells (Dayton, Ohio). Mar, 2008  |   Pubmed ID: 18096723
• Human Embryonic Stem Cell-derived Cardiomyocytes Survive and Mature in the Mouse Heart and Transiently Improve Function After Myocardial Infarction
  Stem Cell Research. Oct, 2007  |   Pubmed ID: 19383383
• Gene-specific Vulnerability to Imprinting Variability in Human Embryonic Stem Cell Lines
  Genome Research. Dec, 2007  |   Pubmed ID: 17989250
• Monitoring of Cell Therapy and Assessment of Cardiac Function Using Magnetic Resonance Imaging in a Mouse Model of Myocardial Infarction
  Nature Protocols. 2007  |   Pubmed ID: 17947998
• An Experimental Correction for Arginine-to-proline Conversion Artifacts in SILAC-based Quantitative Proteomics
  Nature Methods. Sep, 2007  |   Pubmed ID: 17762871
• Restriction Landmark Genome Scanning Identifies Culture-induced DNA Methylation Instability in the Human Embryonic Stem Cell Epigenome
  Human Molecular Genetics. May, 2007  |   Pubmed ID: 17409196
• Genome-wide Transcriptional Profiling of Human Embryonic Stem Cells Differentiating to Cardiomyocytes
  Stem Cells (Dayton, Ohio). Aug, 2006  |   Pubmed ID: 16675594
• A Quest for Human and Mouse Embryonic Stem Cell-specific Proteins
  Molecular & Cellular Proteomics : MCP. Jul, 2006  |   Pubmed ID: 16600995
• Human Embryonic Stem Cells: Towards Therapies for Cardiac Disease. Derivation of a Dutch Human Embryonic Stem Cell Line
  Reproductive Biomedicine Online. Oct, 2005  |   Pubmed ID: 16274613
• Increased Cardiomyocyte Differentiation from Human Embryonic Stem Cells in Serum-free Cultures
  Stem Cells (Dayton, Ohio). Jun-Jul, 2005  |   Pubmed ID: 15917473
• Regulation of Human Embryonic Stem Cell Differentiation by BMP-2 and Its Antagonist Noggin
  Journal of Cell Science. Mar, 2004  |   Pubmed ID: 14996946
• Differentiation of Human Embryonic Stem Cells to Cardiomyocytes: Role of Coculture with Visceral Endoderm-like Cells
  Circulation. Jun, 2003  |   Pubmed ID: 12742992