Dorothee Weihrauch Department of Anesthesiology Medical College of Wisconsin Biography Publications Institution JoVE Articles Dorothee Weihrauch has not added a biography. If you are Dorothee Weihrauch and would like to personalize this page please email our Author Liaison for assistance. Publications Electromagnetic Energy (670 Nm) Stimulates Vasodilation Through Activation of the Large Conductance Potassium Channel (BKCa) PloS One. 2021 | Pubmed ID: 34610026 Red Light Stimulates Vasodilation Through Extracellular Vesicle Trafficking Journal of Photochemistry and Photobiology. B, Biology. Jul, 2021 | Pubmed ID: 34049180 Intralipid Increases Nitric Oxide Release from Human Endothelial Cells During Oxidative Stress JPEN. Journal of Parenteral and Enteral Nutrition. 02, 2021 | Pubmed ID: 32291784 Adjuvant Doxycycline to Enhance Anti-amyloid Effects: Results from the Dual Phase 2 Trial EClinicalMedicine. Jun, 2020 | Pubmed ID: 32529175 Inhibition of Myeloperoxidase Increases Revascularization and Improves Blood Flow in a Diabetic Mouse Model of Hindlimb Ischaemia Diabetes & Vascular Disease Research. Mar-Apr, 2020 | Pubmed ID: 32223319 PPARγ-Independent Side Effects of Thiazolidinediones on Mitochondrial Redox State in Rat Isolated Hearts Cells. 01, 2020 | Pubmed ID: 31968546 Corrigendum to "Red/near Infrared Light Stimulates Release of an Endothelium Dependent Vasodilator and Rescues Vascular Dysfunction in a Diabetes Model" [Free Radic. Biol. Med. 113:157-164] Free Radical Biology & Medicine. 02, 2019 | Pubmed ID: 30581102 Wavelength-dependence of Vasodilation and NO Release from S-nitrosothiols and Dinitrosyl Iron Complexes by Far Red/near Infrared Light Archives of Biochemistry and Biophysics. 07, 2018 | Pubmed ID: 29752896 Rationale and Design of DUAL Study: Doxycycline to Upgrade Response in Light Chain (AL) Amyloidosis (DUAL): A Phase 2 Pilot Study of a Two-pronged Approach of Prolonged Doxycycline with Plasma Cell-directed Therapy in the Treatment of AL Amyloidosis Contemporary Clinical Trials Communications. Dec, 2017 | Pubmed ID: 29696194 Red/near Infrared Light Stimulates Release of an Endothelium Dependent Vasodilator and Rescues Vascular Dysfunction in a Diabetes Model Free Radical Biology & Medicine. 12, 2017 | Pubmed ID: 28935419 Detection of TRPV4 Channel Current-like Activity in Fawn Hooded Hypertensive (FHH) Rat Cerebral Arterial Muscle Cells PloS One. 2017 | Pubmed ID: 28472069 Lipid Emulsion Enhances Cardiac Performance After Ischemia-reperfusion in Isolated Hearts from Summer-active Arctic Ground Squirrels Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology. Jul, 2017 | Pubmed ID: 28364393 An IRF5 Decoy Peptide Reduces Myocardial Inflammation and Fibrosis and Improves Endothelial Cell Function in Tight-Skin Mice PloS One. 2016 | Pubmed ID: 27050551 Alagebrium Inhibits Neointimal Hyperplasia and Restores Distributions of Wall Shear Stress by Reducing Downstream Vascular Resistance in Obese and Diabetic Rats American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2015 | Pubmed ID: 26254329 Isoflurane Favorably Modulates Guanosine Triphosphate Cyclohydrolase-1 and Endothelial Nitric Oxide Synthase During Myocardial Ischemia and Reperfusion Injury in Rats Anesthesiology. Sep, 2015 | Pubmed ID: 26192027 A Novel Path of Improving Heart Function After Infarction Journal of Molecular and Cellular Cardiology. Jul, 2015 | Pubmed ID: 25944086 Porous Ongrowth Surfaces Alter Osteoblast Maturation and Mineralization Journal of Biomedical Materials Research. Part A. Jan, 2015 | Pubmed ID: 24677492 Sigma-1 Receptor Expression in Sensory Neurons and the Effect of Painful Peripheral Nerve Injury Molecular Pain. Sep, 2013 | Pubmed ID: 24015960 Inhibition of Myeloperoxidase Decreases Vascular Oxidative Stress and Increases Vasodilatation in Sickle Cell Disease Mice Journal of Lipid Research. Nov, 2013 | Pubmed ID: 23956444 N-acetyl Lysyltyrosylcysteine Amide Inhibits Myeloperoxidase, a Novel Tripeptide Inhibitor Journal of Lipid Research. Nov, 2013 | Pubmed ID: 23883583 Far Red/near Infrared Light Treatment Promotes Femoral Artery Collateralization in the Ischemic Hindlimb Journal of Molecular and Cellular Cardiology. Sep, 2013 | Pubmed ID: 23702287 Apolipoprotein A-1 Mimetic D-4F Enhances Isoflurane-induced ENOS Signaling and Cardioprotection During Acute Hyperglycemia American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2013 | Pubmed ID: 23666677 Metal Ions Activate Vascular Endothelial Cells and Increase Lymphocyte Chemotaxis and Binding Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Sep, 2013 | Pubmed ID: 23629852 Intraganglionic AAV6 Results in Efficient and Long-term Gene Transfer to Peripheral Sensory Nervous System in Adult Rats PloS One. 2013 | Pubmed ID: 23613824 Transient Repetitive Exposure to Low Level Light Therapy Enhances Collateral Blood Vessel Growth in the Ischemic Hindlimb of the Tight Skin Mouse Photochemistry and Photobiology. May-Jun, 2013 | Pubmed ID: 23231468 4F Decreases IRF5 Expression and Activation in Hearts of Tight Skin Mice PloS One. 2012 | Pubmed ID: 23251680 Absence of Type VI Collagen Paradoxically Improves Cardiac Function, Structure, and Remodeling After Myocardial Infarction Circulation Research. Mar, 2012 | Pubmed ID: 22343710 Hexosamine Pathway Activation and O-linked-N-acetylglucosamine: Novel Mediators of Endothelial Dysfunction in Hyperglycemia and Diabetes Vascular Pharmacology. Mar-Apr, 2012 | Pubmed ID: 22289438 Isoflurane Differentially Modulates Mitochondrial Reactive Oxygen Species Production Via Forward Versus Reverse Electron Transport Flow: Implications for Preconditioning Anesthesiology. Sep, 2011 | Pubmed ID: 21862887 Endothelial-cardiomyocyte Crosstalk Enhances Pharmacological Cardioprotection Journal of Molecular and Cellular Cardiology. Nov, 2011 | Pubmed ID: 21791217 Store-operated Ca2+ Entry in Sensory Neurons: Functional Role and the Effect of Painful Nerve Injury The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2011 | Pubmed ID: 21389210 Abnormal Fibrillin-1 Expression and Chronic Oxidative Stress Mediate Endothelial Mesenchymal Transition in a Murine Model of Systemic Sclerosis American Journal of Physiology. Cell Physiology. Mar, 2011 | Pubmed ID: 21160034 Altered Mitochondrial Membrane Potential, Mass, and Morphology in the Mononuclear Cells of Humans with Type 2 Diabetes Translational Research : the Journal of Laboratory and Clinical Medicine. Jul, 2010 | Pubmed ID: 20621033 Genetic Deletion of Apolipoprotein A-I Increases Airway Hyperresponsiveness, Inflammation, and Collagen Deposition in the Lung Journal of Lipid Research. Sep, 2010 | Pubmed ID: 20498409 Hyperglycemia Adversely Modulates Endothelial Nitric Oxide Synthase During Anesthetic Preconditioning Through Tetrahydrobiopterin- and Heat Shock Protein 90-mediated Mechanisms Anesthesiology. Mar, 2010 | Pubmed ID: 20124983 KATP Channel Subunits in Rat Dorsal Root Ganglia: Alterations by Painful Axotomy Molecular Pain. Jan, 2010 | Pubmed ID: 20102598 Myocardial Interstitial Fluid Inhibits Proliferation and Cardiomyocyte Differentiation in Pluripotent Embryonic Stem Cells American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2009 | Pubmed ID: 19633209 Depletion of Calcium Stores in Injured Sensory Neurons: Anatomic and Functional Correlates Anesthesiology. Aug, 2009 | Pubmed ID: 19602957 Mechanism of Differential Cardiovascular Response to Propofol in Dahl Salt-sensitive, Brown Norway, and Chromosome 13-substituted Consomic Rat Strains: Role of Large Conductance Ca2+ and Voltage-activated Potassium Channels The Journal of Pharmacology and Experimental Therapeutics. Sep, 2009 | Pubmed ID: 19541907 Morphine Reduces the Threshold of Helium Preconditioning Against Myocardial Infarction: the Role of Opioid Receptors in Rabbits Journal of Cardiothoracic and Vascular Anesthesia. Oct, 2009 | Pubmed ID: 19231239 Role of Heat Shock Protein 90 and Endothelial Nitric Oxide Synthase During Early Anesthetic and Ischemic Preconditioning Anesthesiology. Feb, 2009 | Pubmed ID: 19194158 Inhibition of Glycogen Synthase Kinase or the Apoptotic Protein P53 Lowers the Threshold of Helium Cardioprotection in Vivo: the Role of Mitochondrial Permeability Transition Anesthesia and Analgesia. Sep, 2008 | Pubmed ID: 18713881 The Mechanism of Helium-induced Preconditioning: a Direct Role for Nitric Oxide in Rabbits Anesthesia and Analgesia. Sep, 2008 | Pubmed ID: 18713880 Reactive Oxygen Species and Mitochondrial Adenosine Triphosphate-regulated Potassium Channels Mediate Helium-induced Preconditioning Against Myocardial Infarction in Vivo Journal of Cardiothoracic and Vascular Anesthesia. Aug, 2008 | Pubmed ID: 18662630 Histopathology of Experimentally Induced Asthma in a Murine Model of Sickle Cell Disease Blood. Sep, 2008 | Pubmed ID: 18579795 Telokin Expression and the Effect of Hypoxia on Its Phosphorylation Status in Smooth Muscle Cells from Small and Large Pulmonary Arteries American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2008 | Pubmed ID: 18375742 Diabetes Abolishes Sildenafil-induced CGMP-dependent Protein Kinase-I Expression and Cardioprotection Journal of Cardiovascular Pharmacology. Dec, 2007 | Pubmed ID: 18091584 Noble Gases Without Anesthetic Properties Protect Myocardium Against Infarction by Activating Prosurvival Signaling Kinases and Inhibiting Mitochondrial Permeability Transition in Vivo Anesthesia and Analgesia. Sep, 2007 | Pubmed ID: 17717207 Effects of D-4F on Vasodilation, Oxidative Stress, Angiostatin, Myocardial Inflammation, and Angiogenic Potential in Tight-skin Mice American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2007 | Pubmed ID: 17496220 Efficient Transgenic Rat Production by a Lentiviral Vector American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2007 | Pubmed ID: 17322424 Inhibition of Apoptotic Protein P53 Lowers the Threshold of Isoflurane-induced Cardioprotection During Early Reperfusion in Rabbits Anesthesia and Analgesia. Dec, 2006 | Pubmed ID: 17122210 Extracellular Signal-regulated Kinases Trigger Isoflurane Preconditioning Concomitant with Upregulation of Hypoxia-inducible Factor-1alpha and Vascular Endothelial Growth Factor Expression in Rats Anesthesia and Analgesia. Aug, 2006 | Pubmed ID: 16861403 Gender-specificity of Delayed Preconditioning by Isoflurane in Rabbits: Potential Role of Endothelial Nitric Oxide Synthase Anesthesia and Analgesia. Aug, 2006 | Pubmed ID: 16861402 Rosiglitazone Antagonizes Vascular Endothelial Growth Factor Signaling and Nuclear Factor of Activated T Cells Activation in Cardiac Valve Endothelium Endothelium : Journal of Endothelial Cell Research. May-Jun, 2006 | Pubmed ID: 16840174 Cardioprotection by Volatile Anesthetics: New Applications for Old Drugs? Current Opinion in Anaesthesiology. Aug, 2006 | Pubmed ID: 16829721 Endothelium-derived Microparticles Inhibit Human Cardiac Valve Endothelial Cell Function Shock (Augusta, Ga.). Jun, 2006 | Pubmed ID: 16721264 The Influence of B-cell Lymphoma 2 Protein, an Antiapoptotic Regulator of Mitochondrial Permeability Transition, on Isoflurane-induced and Ischemic Postconditioning in Rabbits Anesthesia and Analgesia. May, 2006 | Pubmed ID: 16632808 Inhibition of Glycogen Synthase Kinase Enhances Isoflurane-induced Protection Against Myocardial Infarction During Early Reperfusion in Vivo Anesthesia and Analgesia. May, 2006 | Pubmed ID: 16632807 Role of Erk1/2, P70s6K, and ENOS in Isoflurane-induced Cardioprotection During Early Reperfusion in Vivo Canadian Journal of Anaesthesia = Journal Canadien D'anesthesie. Feb, 2006 | Pubmed ID: 16434759 Inhibition of Mitochondrial Permeability Transition Enhances Isoflurane-induced Cardioprotection During Early Reperfusion: the Role of Mitochondrial KATP Channels Anesthesia and Analgesia. Dec, 2005 | Pubmed ID: 16301224 Isoflurane Inhibits Cardiac Myocyte Apoptosis During Oxidative and Inflammatory Stress by Activating Akt and Enhancing Bcl-2 Expression Anesthesiology. Nov, 2005 | Pubmed ID: 16249675 Morphine Enhances Isoflurane-induced Postconditioning Against Myocardial Infarction: the Role of Phosphatidylinositol-3-kinase and Opioid Receptors in Rabbits Anesthesia and Analgesia. Oct, 2005 | Pubmed ID: 16192500 Role of Endothelial Nitric Oxide Synthase As a Trigger and Mediator of Isoflurane-induced Delayed Preconditioning in Rabbit Myocardium Anesthesiology. Jul, 2005 | Pubmed ID: 15983459 Cardioprotection by Volatile Anesthetics Vascular Pharmacology. Apr-May, 2005 | Pubmed ID: 15922257 Haptoglobin Expression and Activity During Coronary Collateralization American Journal of Physiology. Heart and Circulatory Physiology. Mar, 2005 | Pubmed ID: 15550518 Preconditioning by Isoflurane is Mediated by Reactive Oxygen Species Generated from Mitochondrial Electron Transport Chain Complex III Anesthesia and Analgesia. Nov, 2004 | Pubmed ID: 15502022 Protein Kinase C-epsilon Primes the Cardiac Sarcolemmal Adenosine Triphosphate-sensitive Potassium Channel to Modulation by Isoflurane Anesthesiology. Aug, 2004 | Pubmed ID: 15277921 Autologous Vascular Smooth Muscle Cell-based Myocardial Gene Therapy to Induce Coronary Collateral Growth American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2004 | Pubmed ID: 15277192 Chronic Hyperglycemia Attenuates Coronary Collateral Development and Impairs Proliferative Properties of Myocardial Interstitial Fluid by Production of Angiostatin Circulation. May, 2004 | Pubmed ID: 15136506 Protein Kinase C Translocation and Src Protein Tyrosine Kinase Activation Mediate Isoflurane-induced Preconditioning in Vivo: Potential Downstream Targets of Mitochondrial Adenosine Triphosphate-sensitive Potassium Channels and Reactive Oxygen Species Anesthesiology. Mar, 2004 | Pubmed ID: 15108965 Angiostatin and Matrix Metalloprotease Expression Following Ischemic Acute Renal Failure American Journal of Physiology. Renal Physiology. May, 2004 | Pubmed ID: 15075185 Reactive Oxygen Species Are Critical Mediators of Coronary Collateral Development in a Canine Model American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2003 | Pubmed ID: 12816750 N-acetylcysteine Restores Isoflurane-induced Preconditioning Against Myocardial Infarction During Hyperglycemia Anesthesiology. Jun, 2003 | Pubmed ID: 12766647 L-4F, an Apolipoprotein A-1 Mimetic, Dramatically Improves Vasodilation in Hypercholesterolemia and Sickle Cell Disease Circulation. May, 2003 | Pubmed ID: 12732610 Mitochondrial Adenosine Triphosphate-regulated Potassium Channel Opening Acts As a Trigger for Isoflurane-induced Preconditioning by Generating Reactive Oxygen Species Anesthesiology. Apr, 2003 | Pubmed ID: 12657856 Expression of VEGF and Angiopoietins-1 and -2 During Ischemia-induced Coronary Angiogenesis American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2003 | Pubmed ID: 12649074 Reactive Oxygen Species Modulate Coronary Wall Shear Stress and Endothelial Function During Hyperglycemia American Journal of Physiology. Heart and Circulatory Physiology. May, 2003 | Pubmed ID: 12543642 Mechanism of Preconditioning by Isoflurane in Rabbits: a Direct Role for Reactive Oxygen Species Anesthesiology. Dec, 2002 | Pubmed ID: 12459675 An Intramyocardial Catheter for Repeated in Vivo Sampling of Interstitial Fluid Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2002 | Pubmed ID: 12459145 Angiostatin Inhibits Coronary Angiogenesis During Impaired Production of Nitric Oxide Circulation. May, 2002 | Pubmed ID: 11994253 Non-thermal Infrared Light Treatment of Ischemia/Reperfusion Injury and Subsequent Analysis of Macrophage Differentiation Tyler Compton1, Nicholas Poellinger2, Janine Struve3, John G. Krolikowski1, James T. Ninomiya4, Dorothee Weihrauch1 1Department of Anesthesiology, Medical College of Wisconsin, 2Department of Internal Medicine, Loyola University Medical Center, 3Department of Orthopedic Surgery, Medical College of Wisconsin, 4Department of Orthopedic Surgery, University of New Mexico JoVE 62908 Biology Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice Dorothee Weihrauch1, John G. Krolikowski1,2, Deron W. Jones3, Tahniyath Zaman3, Omoshalewa Bamkole1, Janine Struve4, Paul S. Pagel5, Nicole L. Lohr6, Kirkwood A. Pritchard, Jr.3 1Department of Anesthesiology, Medical College of Wisconsin, 2Clement J. Zablocki Veterans Affairs Medical Center, 3Department of Surgery, Division of Pediatric Surgery, Children's Research Institute, 4Department of Orthopedic Surgery, Medical College of Wisconsin, 5Deptarment of Anesthesiology, Clement J Zblocki Veteran Affairs Medical Center, 6Department of Medicine, Division of Cardiology, Medical College of Wisconsin JoVE 55036 Immunology and Infection
Non-thermal Infrared Light Treatment of Ischemia/Reperfusion Injury and Subsequent Analysis of Macrophage Differentiation Tyler Compton1, Nicholas Poellinger2, Janine Struve3, John G. Krolikowski1, James T. Ninomiya4, Dorothee Weihrauch1 1Department of Anesthesiology, Medical College of Wisconsin, 2Department of Internal Medicine, Loyola University Medical Center, 3Department of Orthopedic Surgery, Medical College of Wisconsin, 4Department of Orthopedic Surgery, University of New Mexico JoVE 62908 Biology
Vasodilation of Isolated Vessels and the Isolation of the Extracellular Matrix of Tight-skin Mice Dorothee Weihrauch1, John G. Krolikowski1,2, Deron W. Jones3, Tahniyath Zaman3, Omoshalewa Bamkole1, Janine Struve4, Paul S. Pagel5, Nicole L. Lohr6, Kirkwood A. Pritchard, Jr.3 1Department of Anesthesiology, Medical College of Wisconsin, 2Clement J. Zablocki Veterans Affairs Medical Center, 3Department of Surgery, Division of Pediatric Surgery, Children's Research Institute, 4Department of Orthopedic Surgery, Medical College of Wisconsin, 5Deptarment of Anesthesiology, Clement J Zblocki Veteran Affairs Medical Center, 6Department of Medicine, Division of Cardiology, Medical College of Wisconsin JoVE 55036 Immunology and Infection
