Douglas A. Melton

Publications

• Impracticality of Egg Donor Recruitment in the Absence of Compensation
  Cell Stem Cell. Oct, 2011  |   Pubmed ID: 21982228
• Reprogramming Within Hours Following Nuclear Transfer into Mouse but Not Human Zygotes
  Nature Communications. 2011  |   Pubmed ID: 21971503
• Wnt Signaling Specifies and Patterns Intestinal Endoderm
  Mechanisms of Development. Sep, 2011  |   Pubmed ID: 21854845
• Sox17 Promotes Differentiation in Mouse Embryonic Stem Cells by Directly Regulating Extraembryonic Gene Expression and Indirectly Antagonizing Self-renewal
  Genes & Development. Feb, 2010  |   Pubmed ID: 20123909
• How to Make Beta Cells?
  Current Opinion in Cell Biology. Dec, 2009  |   Pubmed ID: 19781928
• Generation of Pluripotent Stem Cells from Patients with Type 1 Diabetes
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009  |   Pubmed ID: 19720998
• Notch Signaling Promotes Airway Mucous Metaplasia and Inhibits Alveolar Development
  Development (Cambridge, England). May, 2009  |   Pubmed ID: 19369400
• Small Molecules Efficiently Direct Endodermal Differentiation of Mouse and Human Embryonic Stem Cells
  Cell Stem Cell. Apr, 2009  |   Pubmed ID: 19341624
• Optimal Timing of Inner Cell Mass Isolation Increases the Efficiency of Human Embryonic Stem Cell Derivation and Allows Generation of Sibling Cell Lines
  Cell Stem Cell. Feb, 2009  |   Pubmed ID: 19200798
• Transcriptional Dynamics of Endodermal Organ Formation
  Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jan, 2009  |   Pubmed ID: 19097184
• Extreme Makeover: Converting One Cell into Another
  Cell Stem Cell. Oct, 2008  |   Pubmed ID: 18940730
• Induction of Pluripotent Stem Cells from Primary Human Fibroblasts with Only Oct4 and Sox2
  Nature Biotechnology. Nov, 2008  |   Pubmed ID: 18849973
• In Vivo Reprogramming of Adult Pancreatic Exocrine Cells to Beta-cells
  Nature. Oct, 2008  |   Pubmed ID: 18754011
• Induction of Pluripotent Stem Cells by Defined Factors is Greatly Improved by Small-molecule Compounds
  Nature Biotechnology. Jul, 2008  |   Pubmed ID: 18568017
• Wnt7b Stimulates Embryonic Lung Growth by Coordinately Increasing the Replication of Epithelium and Mesenchyme
  Development (Cambridge, England). May, 2008  |   Pubmed ID: 18367557
• Marked Differences in Differentiation Propensity Among Human Embryonic Stem Cell Lines
  Nature Biotechnology. Mar, 2008  |   Pubmed ID: 18278034
• Facultative Endocrine Progenitor Cells in the Adult Pancreas
  Cell. Jan, 2008  |   Pubmed ID: 18243094
• Genetic Targeting of the Endoderm with Claudin-6CreER
  Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2008  |   Pubmed ID: 18213590
• A Gene Regulatory Network in Mouse Embryonic Stem Cells
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007  |   Pubmed ID: 17940043
• Recovery from Diabetes in Mice by Beta Cell Regeneration
  The Journal of Clinical Investigation. Sep, 2007  |   Pubmed ID: 17786244
• A Multipotent Progenitor Domain Guides Pancreatic Organogenesis
  Developmental Cell. Jul, 2007  |   Pubmed ID: 17609113
• Prospective Isolation and Global Gene Expression Analysis of Definitive and Visceral Endoderm
  Developmental Biology. Apr, 2007  |   Pubmed ID: 17328885
• Organ Size is Limited by the Number of Embryonic Progenitor Cells in the Pancreas but Not the Liver
  Nature. Feb, 2007  |   Pubmed ID: 17259975
• Notch Signaling Reveals Developmental Plasticity of Pax4(+) Pancreatic Endocrine Progenitors and Shunts Them to a Duct Fate
  Mechanisms of Development. Feb, 2007  |   Pubmed ID: 17196797
• Reversal of Type 1 Diabetes in Mice
  The New England Journal of Medicine. Jul, 2006  |   Pubmed ID: 16823003
• Control of Developmental Regulators by Polycomb in Human Embryonic Stem Cells
  Cell. Apr, 2006  |   Pubmed ID: 16630818
• The Vascular Basement Membrane: a Niche for Insulin Gene Expression and Beta Cell Proliferation
  Developmental Cell. Mar, 2006  |   Pubmed ID: 16516842
• Beta-catenin is Essential for Pancreatic Acinar but Not Islet Development
  Development (Cambridge, England). Nov, 2005  |   Pubmed ID: 16192304
• Pten Constrains Centroacinar Cell Expansion and Malignant Transformation in the Pancreas
  Cancer Cell. Sep, 2005  |   Pubmed ID: 16169464
• Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
  Cell. Sep, 2005  |   Pubmed ID: 16153702
• Nuclear Reprogramming of Somatic Cells After Fusion with Human Embryonic Stem Cells
  Science (New York, N.Y.). Aug, 2005  |   Pubmed ID: 16123299
• Direct Regulation of Intestinal Fate by Notch
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005  |   Pubmed ID: 16107537
• The Molecular Biography of the Cell
  Cell. Mar, 2005  |   Pubmed ID: 15797372
• Altered Nuclear Transfer in Stem-cell Research - a Flawed Proposal
  The New England Journal of Medicine. Dec, 2004  |   Pubmed ID: 15625329
• How Important Are Adult Stem Cells for Tissue Maintenance?
  Cell Cycle (Georgetown, Tex.). Sep, 2004  |   Pubmed ID: 15326371
• The Src Family of Tyrosine Kinases is Important for Embryonic Stem Cell Self-renewal
  The Journal of Biological Chemistry. Jul, 2004  |   Pubmed ID: 15148312
• Adult Pancreatic Beta-cells Are Formed by Self-duplication Rather Than Stem-cell Differentiation
  Nature. May, 2004  |   Pubmed ID: 15129273
• Derivation of Embryonic Stem-cell Lines from Human Blastocysts
  The New England Journal of Medicine. Mar, 2004  |   Pubmed ID: 14999088
• Global Expression Analysis of Gene Regulatory Pathways During Endocrine Pancreatic Development
  Development (Cambridge, England). Jan, 2004  |   Pubmed ID: 14660441
• Notch Signaling Controls Multiple Steps of Pancreatic Differentiation
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2003  |   Pubmed ID: 14657333
• Genes, Signals, and Lineages in Pancreas Development
  Annual Review of Cell and Developmental Biology. 2003  |   Pubmed ID: 14570564
• Role of VEGF-A in Vascularization of Pancreatic Islets
  Current Biology : CB. Jun, 2003  |   Pubmed ID: 12814555
• Endothelial Signaling During Development
  Nature Medicine. Jun, 2003  |   Pubmed ID: 12778164
• Single-cell Transcript Analysis of Pancreas Development
  Developmental Cell. Mar, 2003  |   Pubmed ID: 12636919
• Insulin Staining of ES Cell Progeny from Insulin Uptake
  Science (New York, N.Y.). Jan, 2003  |   Pubmed ID: 12532008
• Direct Lineage Tracing Reveals the Ontogeny of Pancreatic Cell Fates During Mouse Embryogenesis
  Mechanisms of Development. Jan, 2003  |   Pubmed ID: 12490294
• "Stemness": Transcriptional Profiling of Embryonic and Adult Stem Cells
  Science (New York, N.Y.). Oct, 2002  |   Pubmed ID: 12228720
• Functional Genomics of the Endocrine Pancreas: the Pancreas Clone Set and PancChip, New Resources for Diabetes Research
  Diabetes. Jul, 2002  |   Pubmed ID: 12086925
• Direct Evidence for the Pancreatic Lineage: NGN3+ Cells Are Islet Progenitors and Are Distinct from Duct Progenitors
  Development (Cambridge, England). May, 2002  |   Pubmed ID: 11973276
• Pancreatic Lineage Analysis Using a Retroviral Vector in Embryonic Mice Demonstrates a Common Progenitor for Endocrine and Exocrine Cells
  The International Journal of Developmental Biology. Mar, 2002  |   Pubmed ID: 11934148