In JoVE (1)
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Articles by Douglas H. Pike in JoVE
Assaying Locomotor Activity to Study Circadian Rhythms and Sleep Parameters in Drosophila Joanna C. Chiu1,2, Kwang Huei Low1,3, Douglas H. Pike1, Evrim Yildirim1,3, Isaac Edery1,3 1Center for Advanced Biotechnology and Medicine, Rutgers University, 2Current Address: Department of Entomology, College of Agricultural and Environmental Sciences, University of California, Davis, 3Department of Molecular Biology and Biochemistry, Rutgers University We describe procedures for recording daily locomotor activity rhythms of Drosophila and subsequent data analysis. Locomotor activity rhythms are a reliable behavioral output of animal circadian clocks and are used as the standard readout of clock function when studying circadian mutants or examining how the environment regulates the circadian system.
Other articles by Douglas H. Pike on PubMed
Sleep Triggered by an Immune Response in Drosophila is Regulated by the Circadian Clock and Requires the NFkappaB Relish BMC Neuroscience. 2010 | Pubmed ID: 20144235 Immune challenge impacts behavior in many species. In mammals, this adaptive behavior is often manifested as an increase in sleep. Sleep has therefore been proposed to benefit the host by enhancing immune function and thereby overcome the challenge. To facilitate genetic studies on the relationship between sleep and immune function, we characterized the effect of the immune response on sleep in Drosophila melanogaster. Behavioral features of sleep as well as the innate immune response signaling pathways are well characterized in flies and are highly conserved in mammals.