Douglas K. Graham

Publications

• UNC569, a Novel Small Molecule Mer Inhibitor with Efficacy Against Acute Lymphoblastic Leukemia in Vitro and in Vivo
  Molecular Cancer Therapeutics. Aug, 2013  |   Pubmed ID: 23997116
• MerTK Inhibition in Tumor Leukocytes Decreases Tumor Growth and Metastasis
  The Journal of Clinical Investigation. Aug, 2013  |   Pubmed ID: 23867499
• Mer Receptor Tyrosine Kinase is a Therapeutic Target in Pre-B-cell Acute Lymphoblastic Leukemia
  Blood. Aug, 2013  |   Pubmed ID: 23861246
• Molecular Pathways: MERTK Signaling in Cancer
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2013  |   Pubmed ID: 23833304
• UNC1062, a New and Potent Mer Inhibitor
  European Journal of Medicinal Chemistry. Jul, 2013  |   Pubmed ID: 23693152
• Dual ALK and MYC Rearrangements Leading to an Aggressive Variant of Anaplastic Large Cell Lymphoma
  Journal of Pediatric Hematology/oncology. Jul, 2013  |   Pubmed ID: 23619105
• MERTK Receptor Tyrosine Kinase is a Therapeutic Target in Melanoma
  The Journal of Clinical Investigation. May, 2013  |   Pubmed ID: 23585477
• Bioluminescence Imaging of Leukemia Cell Lines in Vitro and in Mouse Xenografts: Effects of Monoclonal and Polyclonal Cell Populations on Intensity and Kinetics of Photon Emission
  Journal of Hematology & Oncology. 2013  |   Pubmed ID: 23343252
• Moderate Aplastic Anemia in Children: Preliminary Outcomes for Treatment Versus Observation from a Single-institutional Experience
  Journal of Pediatric Hematology/oncology. Mar, 2013  |   Pubmed ID: 23128338
• Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia
  ACS Medicinal Chemistry Letters. Feb, 2012  |   Pubmed ID: 22662287
• Prolonged Exposure to a Mer Ligand in Leukemia: Gas6 Favors Expression of a Partial Mer Glycoform and Reveals a Novel Role for Mer in the Nucleus
  PloS One. 2012  |   Pubmed ID: 22363695
• TAM Receptors in Leukemia: Expression, Signaling, and Therapeutic Implications
  Critical Reviews in Oncogenesis. 2011  |   Pubmed ID: 22150307
• Constitutive Induction of Pro-inflammatory and Chemotactic Cytokines in Cystathionine Beta-synthase Deficient Homocystinuria
  Molecular Genetics and Metabolism. Aug, 2011  |   Pubmed ID: 21601502
• Gray Zone Lymphomas in Pediatric Patients
  Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2011  |   Pubmed ID: 20331368
• Targeting Paediatric Acute Lymphoblastic Leukaemia: Novel Therapies Currently in Development
  British Journal of Haematology. Nov, 2010  |   Pubmed ID: 20813012
• Taking Aim at Mer and Axl Receptor Tyrosine Kinases As Novel Therapeutic Targets in Solid Tumors
  Expert Opinion on Therapeutic Targets. Oct, 2010  |   Pubmed ID: 20809868
• Inhibition of Mer and Axl Receptor Tyrosine Kinases in Astrocytoma Cells Leads to Increased Apoptosis and Improved Chemosensitivity
  Molecular Cancer Therapeutics. May, 2010  |   Pubmed ID: 20423999
• Thymoma in Children: Report of 2 Cases and Review of the Literature
  Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. May-Jun, 2010  |   Pubmed ID: 20055684
• Mer Receptor Tyrosine Kinase is a Novel Therapeutic Target in Pediatric B-cell Acute Lymphoblastic Leukemia
  Blood. Sep, 2009  |   Pubmed ID: 19643988
• Mer Tyrosine Kinase (MerTK) Promotes Macrophage Survival Following Exposure to Oxidative Stress
  Journal of Leukocyte Biology. Jul, 2009  |   Pubmed ID: 19386698
• Tacrolimus As an Alternative to Cyclosporine in the Maintenance Phase of Immunosuppressive Therapy for Severe Aplastic Anemia in Children
  Pediatric Blood & Cancer. May, 2009  |   Pubmed ID: 19148946
• Pediatric Developmental Therapies: Interesting New Drugs Now in Early-stage Clinical Trials
  Current Oncology Reports. Nov, 2008  |   Pubmed ID: 18928662
• TAM Receptor Tyrosine Kinases: Biologic Functions, Signaling, and Potential Therapeutic Targeting in Human Cancer
  Advances in Cancer Research. 2008  |   Pubmed ID: 18620092
• BAC to the Future? Comparative Genomic Hybridization and Genotyping Pediatric Leukemia Cytogenetic Abnormalities
  Pediatric Blood & Cancer. Aug, 2008  |   Pubmed ID: 18300321
• Natural Killer Cell Neoplasms
  Cancer. Apr, 2008  |   Pubmed ID: 18286525
• Precursor Natural Killer Cell Leukemia
  Pediatric Blood & Cancer. Apr, 2008  |   Pubmed ID: 17417789
• A Soluble Form of the Mer Receptor Tyrosine Kinase Inhibits Macrophage Clearance of Apoptotic Cells and Platelet Aggregation
  Blood. Feb, 2007  |   Pubmed ID: 17047157
• Ectopic Expression of the Proto-oncogene Mer in Pediatric T-cell Acute Lymphoblastic Leukemia
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2006  |   Pubmed ID: 16675557
• Successful Treatment of Severe Aplastic Anemia in Children Using Standardized Immunosuppressive Therapy with Antithymocyte Globulin and Cyclosporine A
  Pediatric Blood & Cancer. Dec, 2004  |   Pubmed ID: 15390303
• Disseminated Nasopharyngeal Natural Killer Cell Lymphoblastic Lymphoma in a Child
  Medical and Pediatric Oncology. Apr, 2003  |   Pubmed ID: 12555256
• Molecular Genetic Analysis of a Small Bowel Primitive Neuroectodermal Tumor
  Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Jan-Feb, 2002  |   Pubmed ID: 11815873