Douglas R. Seals

Publications

• 2013 APS Edward F. Adolph Distinguished Lecture The Remarkable Anti-Aging Effects of Aerobic Exercise on Systemic Arteries
  Journal of Applied Physiology (Bethesda, Md. : 1985). May, 2014  |   Pubmed ID: 24855137
• Mitochondria-targeted Antioxidant (MitoQ) Ameliorates Age-related Arterial Endothelial Dysfunction in Mice
  The Journal of Physiology. Apr, 2014  |   Pubmed ID: 24665093
• Inorganic Nitrite Supplementation for Healthy Arterial Aging
  Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2014  |   Pubmed ID: 24408999
• Superoxide Signaling in Perivascular Adipose Tissue Promotes Age-related Artery Stiffness
  Aging Cell. Jun, 2014  |   Pubmed ID: 24341314
• Vascular Endothelial Function and Oxidative Stress Are Related to Dietary Niacin Intake Among Healthy Middle-aged and Older Adults
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2014  |   Pubmed ID: 24311750
• Battery of Behavioral Tests in Mice That Models Age-associated Changes in Human Motor Function
  Age (Dordrecht, Netherlands). Apr, 2014  |   Pubmed ID: 24122289
• Essential Role of Estrogen for Improvements in Vascular Endothelial Function with Endurance Exercise in Postmenopausal Women
  The Journal of Clinical Endocrinology and Metabolism. Nov, 2013  |   Pubmed ID: 24092827
• Aging Compounds Western Diet-associated Large Artery Endothelial Dysfunction in Mice: Prevention by Voluntary Aerobic Exercise
  Experimental Gerontology. Nov, 2013  |   Pubmed ID: 23954368
• Dietary Sodium Restriction and Association with Urinary Marinobufagenin, Blood Pressure, and Aortic Stiffness
  Clinical Journal of the American Society of Nephrology : CJASN. Nov, 2013  |   Pubmed ID: 23929930
• Activation of the Unfolded Protein Response in Vascular Endothelial Cells of Nondiabetic Obese Adults
  The Journal of Clinical Endocrinology and Metabolism. Sep, 2013  |   Pubmed ID: 23913943
• Response to Effect of Fenofibrate on Vascular Endothelial Function: Statistical Appraisal and Its Validity
  Hypertension. Jun, 2013  |   Pubmed ID: 23819148
• Translational Physiology: from Molecules to Public Health
  The Journal of Physiology. Jul, 2013  |   Pubmed ID: 23732641
• Life-long Caloric Restriction Reduces Oxidative Stress and Preserves Nitric Oxide Bioavailability and Function in Arteries of Old Mice
  Aging Cell. Oct, 2013  |   Pubmed ID: 23714110
• Aortic Pulse Wave Velocity and Reflecting Distance Estimation from Peripheral Waveforms in Humans: Detection of Age- and Exercise Training-Related Differences
  American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2013  |   Pubmed ID: 23624628
• The Autophagy Enhancer Spermidine Reverses Arterial Aging
  Mechanisms of Ageing and Development. Jul-Aug, 2013  |   Pubmed ID: 23612189
• The Dependence of FMD% on Baseline Diameter: a Problem Solved by Allometric Scaling - No Problem in This Case
  Clinical Science (London, England : 1979). Jul, 2013  |   Pubmed ID: 23368887
• Curcumin Ameliorates Arterial Dysfunction and Oxidative Stress with Aging
  Experimental Gerontology. Feb, 2013  |   Pubmed ID: 23142245
• Dietary Sodium Restriction Reverses Vascular Endothelial Dysfunction in Middle-aged/older Adults with Moderately Elevated Systolic Blood Pressure
  Journal of the American College of Cardiology. Jan, 2013  |   Pubmed ID: 23141486
• Regular Aerobic Exercise Protects Against Impaired Fasting Plasma Glucose-associated Vascular Endothelial Dysfunction with Aging
  Clinical Science (London, England : 1979). Mar, 2013  |   Pubmed ID: 23025811
• Fenofibrate Improves Vascular Endothelial Function by Reducing Oxidative Stress While Increasing Endothelial Nitric Oxide Synthase in Healthy Normolipidemic Older Adults
  Hypertension. Dec, 2012  |   Pubmed ID: 23108655
• Vascular Smooth Muscle Responsiveness to Nitric Oxide is Reduced in Healthy Adults with Increased Adiposity
  American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2012  |   Pubmed ID: 22821988
• Hysterectomy is Associated with Large Artery Stiffening in Estrogen-deficient Postmenopausal Women
  Menopause (New York, N.Y.). Sep, 2012  |   Pubmed ID: 22692329
• Tetrahydrobiopterin Supplementation Enhances Carotid Artery Compliance in Healthy Older Men: a Pilot Study
  American Journal of Hypertension. Oct, 2012  |   Pubmed ID: 22673017
• Sodium Nitrite De-stiffening of Large Elastic Arteries with Aging: Role of Normalization of Advanced Glycation End-products
  Experimental Gerontology. Aug, 2012  |   Pubmed ID: 22588062
• Translational Evidence That Impaired Autophagy Contributes to Arterial Ageing
  The Journal of Physiology. Jul, 2012  |   Pubmed ID: 22570377
• Sustained Activation of AMPK Ameliorates Age-associated Vascular Endothelial Dysfunction Via a Nitric Oxide-independent Mechanism
  Mechanisms of Ageing and Development. May, 2012  |   Pubmed ID: 22484146
• Vascular Health in the Ageing Athlete
  Experimental Physiology. Mar, 2012  |   Pubmed ID: 22266948
• Vascular Endothelial Function Is Not Related to Serum Uric Acid in Healthy Adults
  American Journal of Hypertension. Jan, 2012  |   Pubmed ID: 22237152
• Superoxide-lowering Therapy with TEMPOL Reverses Arterial Dysfunction with Aging in Mice
  Aging Cell. Apr, 2012  |   Pubmed ID: 22168264
• MicroRNA Changes in Human Arterial Endothelial Cells with Senescence: Relation to Apoptosis, ENOS and Inflammation
  Experimental Gerontology. Jan, 2012  |   Pubmed ID: 22037549
• Replicative Aging Induces Endothelial to Mesenchymal Transition in Human Aortic Endothelial Cells: Potential Role of Inflammation
  Journal of Vascular Research. 2012  |   Pubmed ID: 21985896
• Habitually Exercising Older Men Do Not Demonstrate Age-associated Vascular Endothelial Oxidative Stress
  Aging Cell. Dec, 2011  |   Pubmed ID: 21943306
• Plasma Norepinephrine is an Independent Predictor of Vascular Endothelial Function with Aging in Healthy Women
  Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2011  |   Pubmed ID: 21903879
• SIRT-1 and Vascular Endothelial Dysfunction with Ageing in Mice and Humans
  The Journal of Physiology. Sep, 2011  |   Pubmed ID: 21746786
• Aerobic Exercise Reverses Arterial Inflammation with Aging in Mice
  American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2011  |   Pubmed ID: 21622824
• Increased Proinflammatory and Oxidant Gene Expression in Circulating Mononuclear Cells in Older Adults: Amelioration by Habitual Exercise
  Physiological Genomics. Jul, 2011  |   Pubmed ID: 21610086
• Exercise Protects Against Myocardial Ischemia-reperfusion Injury Via Stimulation of β(3)-adrenergic Receptors and Increased Nitric Oxide Signaling: Role of Nitrite and Nitrosothiols
  Circulation Research. Jun, 2011  |   Pubmed ID: 21527738
• Salicylate Treatment Improves Age-associated Vascular Endothelial Dysfunction: Potential Role of Nuclear Factor KappaB and Forkhead Box O Phosphorylation
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Apr, 2011  |   Pubmed ID: 21303813
• Nitrite Supplementation Reverses Vascular Endothelial Dysfunction and Large Elastic Artery Stiffness with Aging
  Aging Cell. Jun, 2011  |   Pubmed ID: 21276184
• Aging and Vascular Endothelial Function in Humans
  Clinical Science (London, England : 1979). May, 2011  |   Pubmed ID: 21244363
• The Importance of Population-wide Sodium Reduction As a Means to Prevent Cardiovascular Disease and Stroke: a Call to Action from the American Heart Association
  Circulation. Mar, 2011  |   Pubmed ID: 21233236
• 25-Hydroxyvitamin D Deficiency is Associated with Inflammation-linked Vascular Endothelial Dysfunction in Middle-aged and Older Adults
  Hypertension. Jan, 2011  |   Pubmed ID: 21115878
• Sex-specific Effects of Habitual Aerobic Exercise on Brachial Artery Flow-mediated Dilation in Middle-aged and Older Adults
  Clinical Science (London, England : 1979). Jan, 2011  |   Pubmed ID: 20642454
• Life-long Caloric Restriction Elicits Pronounced Protection of the Aged Myocardium: a Role for AMPK
  Mechanisms of Ageing and Development. Nov-Dec, 2010  |   Pubmed ID: 20934448
• Arterial Stiffening with Ageing is Associated with Transforming Growth Factor-β1-related Changes in Adventitial Collagen: Reversal by Aerobic Exercise
  The Journal of Physiology. Oct, 2010  |   Pubmed ID: 20807791
• Leukocyte Telomere Length is Preserved with Aging in Endurance Exercise-trained Adults and Related to Maximal Aerobic Capacity
  Mechanisms of Ageing and Development. Feb, 2010  |   Pubmed ID: 20064545
• Vascular Endothelial Function is Related to White Blood Cell Count and Myeloperoxidase Among Healthy Middle-aged and Older Adults
  Hypertension. Feb, 2010  |   Pubmed ID: 20048194
• Protein Expression in Vascular Endothelial Cells Obtained from Human Peripheral Arteries and Veins
  Journal of Vascular Research. 2010  |   Pubmed ID: 19672102
• Role of NFkappaB in Age-related Vascular Endothelial Dysfunction in Humans
  Aging. Aug, 2009  |   Pubmed ID: 20157550
• Low Dietary Sodium Intake is Associated with Enhanced Vascular Endothelial Function in Middle-aged and Older Adults with Elevated Systolic Blood Pressure
  Therapeutic Advances in Cardiovascular Disease. Oct, 2009  |   Pubmed ID: 19723834
• Habitual Exercise and Vascular Ageing
  The Journal of Physiology. Dec, 2009  |   Pubmed ID: 19723776
• Vascular Endothelial Estrogen Receptor Alpha is Modulated by Estrogen Status and Related to Endothelial Function and Endothelial Nitric Oxide Synthase in Healthy Women
  The Journal of Clinical Endocrinology and Metabolism. Sep, 2009  |   Pubmed ID: 19509105
• Vascular Endothelial Dysfunction with Aging: Endothelin-1 and Endothelial Nitric Oxide Synthase
  American Journal of Physiology. Heart and Circulatory Physiology. Jul, 2009  |   Pubmed ID: 19465546
• Voluntary Wheel Running Restores Endothelial Function in Conduit Arteries of Old Mice: Direct Evidence for Reduced Oxidative Stress, Increased Superoxide Dismutase Activity and Down-regulation of NADPH Oxidase
  The Journal of Physiology. Jul, 2009  |   Pubmed ID: 19417091
• Nuclear Factor-{kappa}B Activation Contributes to Vascular Endothelial Dysfunction Via Oxidative Stress in Overweight/obese Middle-aged and Older Humans
  Circulation. Mar, 2009  |   Pubmed ID: 19237660
• B6D2F1 Mice Are a Suitable Model of Oxidative Stress-mediated Impaired Endothelium-dependent Dilation with Aging
  The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. Jan, 2009  |   Pubmed ID: 19211548
• Modulation of Vascular Endothelial Function by Low-density Lipoprotein Cholesterol with Aging: Influence of Habitual Exercise
  American Journal of Hypertension. Mar, 2009  |   Pubmed ID: 19114985
• Aging is Associated with Greater Nuclear NF Kappa B, Reduced I Kappa B Alpha, and Increased Expression of Proinflammatory Cytokines in Vascular Endothelial Cells of Healthy Humans
  Aging Cell. Dec, 2008  |   Pubmed ID: 18782346
• Cytochrome P-450 2C9 Signaling Does Not Contribute to Age-associated Vascular Endothelial Dysfunction in Humans
  Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2008  |   Pubmed ID: 18669935
• Habitual Exercise and Arterial Aging
  Journal of Applied Physiology (Bethesda, Md. : 1985). Oct, 2008  |   Pubmed ID: 18583377
• Weight Loss Alone Improves Conduit and Resistance Artery Endothelial Function in Young and Older Overweight/obese Adults
  Hypertension. Jul, 2008  |   Pubmed ID: 18504322
• Decreased Maximal Heart Rate with Aging is Related to Reduced {beta}-adrenergic Responsiveness but is Largely Explained by a Reduction in Intrinsic Heart Rate
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jul, 2008  |   Pubmed ID: 18483165
• Endurance Exercise Performance in Masters Athletes: Age-associated Changes and Underlying Physiological Mechanisms
  The Journal of Physiology. Jan, 2008  |   Pubmed ID: 17717011
• High-dose Ascorbic Acid Infusion Abolishes Chronic Vasoconstriction and Restores Resting Leg Blood Flow in Healthy Older Men
  Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2007  |   Pubmed ID: 17965239
• Increased Thermogenic Responsiveness to Intravenous Beta-adrenergic Stimulation in Habitually Exercising Humans is Not Related to Skeletal Muscle Beta2-adrenergic Receptor Density
  Experimental Physiology. Sep, 2007  |   Pubmed ID: 17573413
• Direct Evidence of Endothelial Oxidative Stress with Aging in Humans: Relation to Impaired Endothelium-dependent Dilation and Upregulation of Nuclear Factor-kappaB
  Circulation Research. Jun, 2007  |   Pubmed ID: 17478731
• Thermic Effect of Food and Beta-adrenergic Thermogenic Responsiveness in Habitually Exercising and Sedentary Healthy Adult Humans
  Journal of Applied Physiology (Bethesda, Md. : 1985). Aug, 2007  |   Pubmed ID: 17463294
• Commentary on Viewpoint "Human Experimentation: No Accurate, Quantitative Data?"
  Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2007  |   Pubmed ID: 17341743
• Overweight and Obese Humans Demonstrate Increased Vascular Endothelial NAD(P)H Oxidase-p47(phox) Expression and Evidence of Endothelial Oxidative Stress
  Circulation. Feb, 2007  |   Pubmed ID: 17242275
• A Transdisciplinary Model Integrating Genetic, Physiological, and Psychological Correlates of Voluntary Exercise
  Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association. Jan, 2007  |   Pubmed ID: 17209695
• Oxidative Stress Contributes to Chronic Leg Vasoconstriction in Estrogen-deficient Postmenopausal Women
  Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2007  |   Pubmed ID: 17110511
• Impaired Flow-mediated Dilation with Age is Not Explained by L-arginine Bioavailability or Endothelial Asymmetric Dimethylarginine Protein Expression
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2007  |   Pubmed ID: 16946027
• Habitual Aerobic Exercise is Associated with Smaller Femoral Artery Intima-media Thickness with Age in Healthy Men and Women
  European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology. Oct, 2006  |   Pubmed ID: 17001222
• Oxidative Stress Explains Differences in Large Elastic Artery Compliance Between Sedentary and Habitually Exercising Postmenopausal Women
  Menopause (New York, N.Y.). Nov-Dec, 2006  |   Pubmed ID: 16977254
• Modulatory Influences on Ageing of the Vasculature in Healthy Humans
  Experimental Gerontology. May, 2006  |   Pubmed ID: 16537099
• Xanthine Oxidase Does Not Contribute to Impaired Peripheral Conduit Artery Endothelium-dependent Dilatation with Ageing
  The Journal of Physiology. Mar, 2006  |   Pubmed ID: 16439428
• Cardiac Vagal Modulation of Heart Rate During Prolonged Submaximal Exercise in Animals with Healed Myocardial Infarctions: Effects of Training
  American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2006  |   Pubmed ID: 16339826
• Thermogenic Responsiveness to Beta-adrenergic Stimulation is Augmented in Exercising Versus Sedentary Adults: Role of Oxidative Stress
  The Journal of Physiology. Feb, 2006  |   Pubmed ID: 16308351
• Thermogenic Responsiveness to Nonspecific Beta-adrenergic Stimulation is Not Related to Genetic Variation in Codon 16 of the Beta2-adrenergic Receptor
  American Journal of Physiology. Endocrinology and Metabolism. Apr, 2006  |   Pubmed ID: 16278251
• Tetrahydrobiopterin Augments Endothelium-dependent Dilatation in Sedentary but Not in Habitually Exercising Older Adults
  The Journal of Physiology. Nov, 2005  |   Pubmed ID: 16141271
• Aortic Input Impedance Increases with Age in Healthy Men and Women
  Hypertension. Jun, 2005  |   Pubmed ID: 15867143
• Ascorbic Acid Selectively Improves Large Elastic Artery Compliance in Postmenopausal Women
  Hypertension. Jun, 2005  |   Pubmed ID: 15867135
• Fatness is a Better Predictor of Cardiovascular Disease Risk Factor Profile Than Aerobic Fitness in Healthy Men
  Circulation. Apr, 2005  |   Pubmed ID: 15837943
• Women Have Lower Tonic Autonomic Support of Arterial Blood Pressure and Less Effective Baroreflex Buffering Than Men
  Circulation. Feb, 2005  |   Pubmed ID: 15687139
• Stiffening Our Resolve Against Adult Weight Gain
  Hypertension. Feb, 2005  |   Pubmed ID: 15623541
• Ascorbic Acid Does Not Affect the Age-associated Reduction in Maximal Cardiac Output and Oxygen Consumption in Healthy Adults
  Journal of Applied Physiology (Bethesda, Md. : 1985). Mar, 2005  |   Pubmed ID: 15501926
• Collateral Damage: Cardiovascular Consequences of Chronic Sympathetic Activation with Human Aging
  American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2004  |   Pubmed ID: 15475526
• Role of Sympathetic Neural Activation in Age- and Habitual Exercise-related Differences in the Thermic Effect of Food
  The Journal of Clinical Endocrinology and Metabolism. Oct, 2004  |   Pubmed ID: 15472218
• High Energy Flux Mediates the Tonically Augmented Beta-adrenergic Support of Resting Metabolic Rate in Habitually Exercising Older Adults
  The Journal of Clinical Endocrinology and Metabolism. Jul, 2004  |   Pubmed ID: 15240648
• Increased Abdominal-to-peripheral Fat Distribution Contributes to Altered Autonomic-circulatory Control with Human Aging
  American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2004  |   Pubmed ID: 15178547
• Dietary Sodium Restriction Rapidly Improves Large Elastic Artery Compliance in Older Adults with Systolic Hypertension
  Hypertension. Jul, 2004  |   Pubmed ID: 15173128
• Ascorbic Acid Does Not Affect Large Elastic Artery Compliance or Central Blood Pressure in Young and Older Men
  American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2004  |   Pubmed ID: 15020306
• Ascorbic Acid Increases Cardiovagal Baroreflex Sensitivity in Healthy Older Men
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2004  |   Pubmed ID: 14962830
• Effect of Acute and Chronic Ascorbic Acid on Flow-mediated Dilatation with Sedentary and Physically Active Human Ageing
  The Journal of Physiology. Apr, 2004  |   Pubmed ID: 14754992
• Chronic Sympathetic Activation: Consequence and Cause of Age-associated Obesity?
  Diabetes. Feb, 2004  |   Pubmed ID: 14747276
• Left Ventricular Structure and Diastolic Function with Human Ageing. Relation to Habitual Exercise and Arterial Stiffness
  European Heart Journal. Dec, 2003  |   Pubmed ID: 14659773
• Oxidative Stress Does Not Modulate Metabolic Rate or Skeletal Muscle Sympathetic Activity with Primary Aging in Adult Humans
  The Journal of Clinical Endocrinology and Metabolism. Oct, 2003  |   Pubmed ID: 14557479
• Adiposity Contributes to Differences in Left Ventricular Structure and Diastolic Function with Age in Healthy Men
  The Journal of Clinical Endocrinology and Metabolism. Oct, 2003  |   Pubmed ID: 14557469
• Invited Review: Dynamic Exercise Performance in Masters Athletes: Insight into the Effects of Primary Human Aging on Physiological Functional Capacity
  Journal of Applied Physiology (Bethesda, Md. : 1985). Nov, 2003  |   Pubmed ID: 14555676
• Baroreflex Buffering in Sedentary and Endurance Exercise-trained Healthy Men
  Hypertension. Jun, 2003  |   Pubmed ID: 12732585
• Habitual Exercise and the Age-associated Decline in Large Artery Compliance
  Exercise and Sport Sciences Reviews. Apr, 2003  |   Pubmed ID: 12715969
• Baroreflex Buffering is Reduced with Age in Healthy Men
  Circulation. Apr, 2003  |   Pubmed ID: 12665501
• Regular Exercise, Hormone Replacement Therapy and the Age-related Decline in Carotid Arterial Compliance in Healthy Women
  Cardiovascular Research. Mar, 2003  |   Pubmed ID: 12618248
• Basal Leg Blood Flow in Healthy Women is Related to Age and Hormone Replacement Therapy Status
  The Journal of Physiology. Feb, 2003  |   Pubmed ID: 12562958
• Use of Acetylene Breathing to Determine Cardiac Output in Young and Older Adults
  Medicine and Science in Sports and Exercise. Jan, 2003  |   Pubmed ID: 12544636
• Greater Rate of Decline in Maximal Aerobic Capacity with Age in Endurance-trained Than in Sedentary Men
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2003  |   Pubmed ID: 12533496
• Declines in Physiological Functional Capacity with Age: a Longitudinal Study in Peak Swimming Performance
  Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2003  |   Pubmed ID: 12391125
• Decline in Insulin Action with Age in Endurance-trained Humans
  Journal of Applied Physiology (Bethesda, Md. : 1985). Dec, 2002  |   Pubmed ID: 12391128
• Arterial Intima-media Thickness: Site-specific Associations with HRT and Habitual Exercise
  American Journal of Physiology. Heart and Circulatory Physiology. Oct, 2002  |   Pubmed ID: 12234791
• Changes in Maximal Aerobic Capacity with Age in Endurance-trained Women: 7-yr Follow-up
  Journal of Applied Physiology (Bethesda, Md. : 1985). Jun, 2002  |   Pubmed ID: 12015340
• Influence of Ageing on the Sympathetic Nervous System and Adrenal Medulla at Rest and During Stress
  Biogerontology. 2002  |   Pubmed ID: 12014841
• Is Autonomic Support of Arterial Blood Pressure Related to Habitual Exercise Status in Healthy Men?
  The Journal of Physiology. Apr, 2002  |   Pubmed ID: 11956356
• Regular Aerobic Exercise and the Age-related Increase in Carotid Artery Intima-media Thickness in Healthy Men
  Journal of Applied Physiology (Bethesda, Md. : 1985). Apr, 2002  |   Pubmed ID: 11896010
• The Influence of Aging on the Human Sympathetic Nervous System and Brain Norepinephrine Turnover
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2002  |   Pubmed ID: 11832414