E. Birgitte Lane Epithelial Biology Laboratory Institute of Medical Biology, A*STAR Biography Publications Institution JoVE Articles E. Birgitte Lane has not added a biography. If you are E. Birgitte Lane and would like to personalize this page please email our Author Liaison for assistance. Publications Direct Organelle Thermometry with Fluorescence Lifetime Imaging Microscopy in Single Myotubes Chemical Communications (Cambridge, England). Mar, 2016 | Pubmed ID: 26977478 Assays to Study Consequences of Cytoplasmic Intermediate Filament Mutations: The Case of Epidermal Keratins Methods in Enzymology. 2016 | Pubmed ID: 26795473 Making More Matrix: Enhancing the Deposition of Dermal-epidermal Junction Components in Vitro and Accelerating Organotypic Skin Culture Development, Using Macromolecular Crowding Tissue Engineering. Part A. Jan, 2015 | Pubmed ID: 25058150 Characterization of Fetal Keratinocytes, Showing Enhanced Stem Cell-like Properties: a Potential Source of Cells for Skin Reconstruction Stem Cell Reports. Aug, 2014 | Pubmed ID: 25254345 Generation and Characterisation of Keratin 7 (K7) Knockout Mice PloS One. 2013 | Pubmed ID: 23741325 Lamin B1 Fluctuations Have Differential Effects on Cellular Proliferation and Senescence The Journal of Cell Biology. Mar, 2013 | Pubmed ID: 23439683 'See-saw' Expression of MicroRNA-198 and FSTL1 from a Single Transcript in Wound Healing Nature. Mar, 2013 | Pubmed ID: 23395958 Keratins and Disease at a Glance Journal of Cell Science. Sep, 2012 | Pubmed ID: 23104737 The Mechanical Behavior of Mutant K14-R125P Keratin Bundles and Networks in NEB-1 Keratinocytes PloS One. 2012 | Pubmed ID: 22363617 Validation of GWAS Loci for Atopic Dermatitis in a Singapore Chinese Population The Journal of Investigative Dermatology. May, 2012 | Pubmed ID: 22318392 Developmental Expression of the Fermitin/kindlin Gene Family in Xenopus Laevis Embryos Developmental Dynamics : an Official Publication of the American Association of Anatomists. Aug, 2011 | Pubmed ID: 21761481 Multiple Self-healing Squamous Epithelioma is Caused by a Disease-specific Spectrum of Mutations in TGFBR1 Nature Genetics. Apr, 2011 | Pubmed ID: 21358634 Keratin 14-null Cells As a Model to Test the Efficacy of Gene Therapy Approaches in Epithelial Cells The Journal of Investigative Dermatology. Jul, 2011 | Pubmed ID: 21326298 Filaggrin Null Mutations Are Not a Protective Factor for Acne Vulgaris The Journal of Investigative Dermatology. Jun, 2011 | Pubmed ID: 21326297 Immunohistochemical Localization of Cytokeratins in the Junctional Region of Ectoderm and Endoderm Anatomical Record (Hoboken, N.J. : 2007). Nov, 2010 | Pubmed ID: 20818615 A Novel Mutation in the Kinase Domain of KIT in an Indian Family with a Mild Piebaldism Phenotype Journal of Dermatological Science. Sep, 2010 | Pubmed ID: 20688482 ERK Involvement in Resistance to Apoptosis in Keratinocytes with Mutant Keratin The Journal of Investigative Dermatology. Mar, 2010 | Pubmed ID: 19847192 Keratin K6c Mutations Cause Focal Palmoplantar Keratoderma The Journal of Investigative Dermatology. Feb, 2010 | Pubmed ID: 19609311 Severe Keratin 5 and 14 Mutations Induce Down-regulation of Junction Proteins in Keratinocytes Experimental Cell Research. Oct, 2009 | Pubmed ID: 19616543 Association of Skin Barrier Genes Within the PSORS4 Locus is Enriched in Singaporean Chinese with Early-onset Psoriasis The Journal of Investigative Dermatology. Mar, 2009 | Pubmed ID: 18787534 The Intermediate Filament Network in Cultured Human Keratinocytes is Remarkably Extensible and Resilient PloS One. 2008 | Pubmed ID: 18523546 Therapeutic SiRNAs for Dominant Genetic Skin Disorders Including Pachyonychia Congenita Journal of Dermatological Science. Sep, 2008 | Pubmed ID: 18495438 Dual-specificity Phosphatases in the Hypo-osmotic Stress Response of Keratin-defective Epithelial Cell Lines Experimental Cell Research. Jun, 2008 | Pubmed ID: 18410923 Unique and Recurrent Mutations in the Filaggrin Gene in Singaporean Chinese Patients with Ichthyosis Vulgaris The Journal of Investigative Dermatology. Jul, 2008 | Pubmed ID: 18239616 The Human Intermediate Filament Database: Comprehensive Information on a Gene Family Involved in Many Human Diseases Human Mutation. Mar, 2008 | Pubmed ID: 18033728 Molecular Force Spectroscopy of Homophilic Nectin-1 Interactions Biochemical and Biophysical Research Communications. Nov, 2007 | Pubmed ID: 17822670 A Spectrum of Mutations in Keratins K6a, K16 and K17 Causing Pachyonychia Congenita Journal of Dermatological Science. Dec, 2007 | Pubmed ID: 17719747 Ninein is Released from the Centrosome and Moves Bi-directionally Along Microtubules Journal of Cell Science. Sep, 2007 | Pubmed ID: 17698918 Multiple Self-healing Squamous Epithelioma in Different Ethnic Groups: More Than a Founder Mutation Disorder? The Journal of Investigative Dermatology. Oct, 2007 | Pubmed ID: 17554363 Intermediate Filaments and Stress Experimental Cell Research. Jun, 2007 | Pubmed ID: 17524394 Epidermolysis Bullosa Simplex in Scotland Caused by a Spectrum of Keratin Mutations The Journal of Investigative Dermatology. Mar, 2007 | Pubmed ID: 17039244 New Consensus Nomenclature for Mammalian Keratins The Journal of Cell Biology. Jul, 2006 | Pubmed ID: 16831889 Association of Shh and Ptc with Keratin Localization in the Initiation of the Formation of Circumvallate Papilla and Von Ebner's Gland Cell and Tissue Research. Aug, 2006 | Pubmed ID: 16552524 Mutation S233L in the 1B Domain of Keratin 1 Causes Epidermolytic Palmoplantar Keratoderma with "tonotubular" Keratin The Journal of Investigative Dermatology. Mar, 2006 | Pubmed ID: 16439967 Clinical and Pathological Features of Pachyonychia Congenita The Journal of Investigative Dermatology. Symposium Proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research. Oct, 2005 | Pubmed ID: 16250204 Two Families with Greither's Syndrome Caused by a Keratin 1 Mutation Journal of the American Academy of Dermatology. Nov, 2005 | Pubmed ID: 16227096 Stress Models for the Study of Intermediate Filament Function Methods in Cell Biology. 2004 | Pubmed ID: 15646621 Mechanical Stress Induces Profound Remodelling of Keratin Filaments and Cell Junctions in Epidermolysis Bullosa Simplex Keratinocytes Journal of Cell Science. Oct, 2004 | Pubmed ID: 15454576 Keratin 8/18 Breakdown and Reorganization During Apoptosis Experimental Cell Research. Jul, 2004 | Pubmed ID: 15194421 Conformational Changes in the Rod Domain of Human Keratin 8 Following Heterotypic Association with Keratin 18 and Its Implication for Filament Stability Biochemistry. Feb, 2004 | Pubmed ID: 14756564 The Quest for the Function of Simple Epithelial Keratins BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Aug, 2003 | Pubmed ID: 12879445 Phenotypes, Genotypes and Their Contribution to Understanding Keratin Function Trends in Genetics : TIG. May, 2003 | Pubmed ID: 12711220 Observation of Keratin Particles Showing Fast Bidirectional Movement Colocalized with Microtubules Journal of Cell Science. Apr, 2003 | Pubmed ID: 12640027 Long-range Polymerase Chain Reaction for Specific Full-length Amplification of the Human Keratin 14 Gene and Novel Keratin 14 Mutations in Epidermolysis Bullosa Simplex Patients The Journal of Investigative Dermatology. Mar, 2003 | Pubmed ID: 12603865 Keratin Mutations of Epidermolysis Bullosa Simplex Alter the Kinetics of Stress Response to Osmotic Shock Journal of Cell Science. Nov, 2002 | Pubmed ID: 12376565 Cloning of Human, Murine, and Marsupial Keratin 7 and a Survey of K7 Expression in the Mouse Biochemical and Biophysical Research Communications. Oct, 2002 | Pubmed ID: 12359226 Defolliculated (dfl): a Dominant Mouse Mutation Leading to Poor Sebaceous Gland Differentiation and Total Elimination of Pelage Follicles The Journal of Investigative Dermatology. Jul, 2002 | Pubmed ID: 12164921 Characterization of Early Assembly Intermediates of Recombinant Human Keratins Journal of Structural Biology. Jan-Feb, 2002 | Pubmed ID: 12064936 Deletion of the Cytoplasmatic Domain of BP180/collagen XVII Causes a Phenotype with Predominant Features of Epidermolysis Bullosa Simplex The Journal of Investigative Dermatology. Jan, 2002 | Pubmed ID: 11851893 Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding Paula Benny1,2, Cedric Badowski2, E. Birgitte Lane2, Michael Raghunath1,2,3 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 2Epithelial Biology Laboratory, Institute of Medical Biology, A*STAR, 3Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore JoVE 53642 Bioengineering
Improving 2D and 3D Skin In Vitro Models Using Macromolecular Crowding Paula Benny1,2, Cedric Badowski2, E. Birgitte Lane2, Michael Raghunath1,2,3 1Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 2Epithelial Biology Laboratory, Institute of Medical Biology, A*STAR, 3Department of Biomedical Engineering, Faculty of Engineering, National University of Singapore JoVE 53642 Bioengineering