In JoVE (1)
Other Publications (1)
Articles by E. Scott Colvin in JoVE
Assessing Replication and Beta Cell Function in Adenovirally-transduced Isolated Rodent Islets Patrick T. Fueger1,2, Angelina M. Hernandez2, Yi-Chun Chen2, E. Scott Colvin1,2 1Department of Pediatrics, Indiana University School of Medicine, 2Department of Cellular & Integrative Physiology, Indiana University School of Medicine This protocol allows one to identify factors that modulate functional beta cell mass to find potential therapeutic targets for the treatment of diabetes. The protocol consists of a streamlined method to assess islet replication and beta cell function in isolated rat islets following manipulation of gene expression with adenoviruses.