Eckhard Wolf

Publications

• Standardized, Systemic Phenotypic Analysis Reveals Kidney Dysfunction As Main Alteration of Kctd1 (I27N) Mutant Mice
  Journal of Biomedical Science. Aug, 2017  |   Pubmed ID: 28818080
• Every-other-day Feeding Extends Lifespan but Fails to Delay Many Symptoms of Aging in Mice
  Nature Communications. Jul, 2017  |   Pubmed ID: 28761067
• The Munich MIDY Pig Biobank - A Unique Resource for Studying Organ Crosstalk in Diabetes
  Molecular Metabolism. Aug, 2017  |   Pubmed ID: 28752056
• Surface Modification of Pig Endothelial Cells with a Branched Heparin Conjugate Improves Their Compatibility with Human Blood
  Scientific Reports. Jun, 2017  |   Pubmed ID: 28667310
• Meis1: Effects on Motor Phenotypes and the Sensorimotor System in Mice
  Disease Models & Mechanisms. Aug, 2017  |   Pubmed ID: 28645892
• Extensive Phenotypic Characterization of a New Transgenic Mouse Reveals Pleiotropic Perturbations in Physiology Due to Mesenchymal HGH Minigene Expression
  Scientific Reports. May, 2017  |   Pubmed ID: 28546545
• Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016
  Molecular and Cellular Pediatrics. May, 2017  |   Pubmed ID: 28516419
• Retinopathy with Central Oedema in an INS (C94Y) Transgenic Pig Model of Long-term Diabetes
  Diabetologia. Aug, 2017  |   Pubmed ID: 28480495
• Chromatin-remodeling Factor SMARCD2 Regulates Transcriptional Networks Controlling Differentiation of Neutrophil Granulocytes
  Nature Genetics. May, 2017  |   Pubmed ID: 28369036
• Vessel Network Architecture of Adult Human Islets Promotes Distinct Cell-cell Interactions in Situ and is Altered After Transplantation
  Endocrinology. Jan, 2017  |   Pubmed ID: 28324008
• INS-eGFP Transgenic Pigs: a Novel Reporter System for Studying Maturation, Growth and Vascularisation of Neonatal Islet-like Cell Clusters
  Diabetologia. Jun, 2017  |   Pubmed ID: 28315950
• Bezafibrate Ameliorates Diabetes Via Reduced Steatosis and Improved Hepatic Insulin Sensitivity in Diabetic TallyHo Mice
  Molecular Metabolism. Mar, 2017  |   Pubmed ID: 28271032
• Modification of the Fatty Acid Composition of an Obesogenic Diet Improves the Maternal and Placental Metabolic Environment in Obese Pregnant Mice
  Biochimica Et Biophysica Acta. Jun, 2017  |   Pubmed ID: 28235645
• Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD)
  Scientific Reports. Feb, 2017  |   Pubmed ID: 28220896
• Diabetes Mellitus-Induced Microvascular Destabilization in the Myocardium
  Journal of the American College of Cardiology. Jan, 2017  |   Pubmed ID: 28081822
• Direct Introduction of Gene Constructs into the Pronucleus-like Structure of Cloned Embryos: a New Strategy for the Generation of Genetically Modified Pigs
  Transgenic Research. Apr, 2017  |   Pubmed ID: 27943082
• Loss of DRO1/CCDC80 Results in Obesity and Promotes Adipocyte Differentiation
  Molecular and Cellular Endocrinology. Jan, 2017  |   Pubmed ID: 27645901
• Serum Response Factor (SRF) Ablation Interferes with Acute Stress-Associated Immediate and Long-Term Coping Mechanisms
  Molecular Neurobiology. Dec, 2016  |   Pubmed ID: 27914009
• The First Scube3 Mutant Mouse Line with Pleiotropic Phenotypic Alterations
  G3 (Bethesda, Md.). Dec, 2016  |   Pubmed ID: 27815347
• Viable Ednra (Y129F) Mice Feature Human Mandibulofacial Dysostosis with Alopecia (MFDA) Syndrome Due to the Homologue Mutation
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Dec, 2016  |   Pubmed ID: 27671791
• Progressive Muscle Proteome Changes in a Clinically Relevant Pig Model of Duchenne Muscular Dystrophy
  Scientific Reports. Sep, 2016  |   Pubmed ID: 27634466
• A Mouse Model for Ulcerative Colitis Based on NOD-scid IL2R γnull Mice Reconstituted with Peripheral Blood Mononuclear Cells from Affected Individuals
  Disease Models & Mechanisms. Sep, 2016  |   Pubmed ID: 27491073
• Progress in Clinical Encapsulated Islet Xenotransplantation
  Transplantation. Nov, 2016  |   Pubmed ID: 27482959
• Clinical Chemistry Reference Intervals for C57BL/6J, C57BL/6N, and C3HeB/FeJ Mice (Mus Musculus)
  Journal of the American Association for Laboratory Animal Science : JAALAS. 2016  |   Pubmed ID: 27423143
• Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle
  PloS One. 2016  |   Pubmed ID: 27420727
• Efficient Production of Multi-modified Pigs for Xenotransplantation by 'combineering', Gene Stacking and Gene Editing
  Scientific Reports. Jun, 2016  |   Pubmed ID: 27353424
• Bezafibrate Improves Insulin Sensitivity and Metabolic Flexibility in STZ-Induced Diabetic Mice
  Diabetes. Sep, 2016  |   Pubmed ID: 27284107
• Comparative Aspects of Rodent and Nonrodent Animal Models for Mechanistic and Translational Diabetes Research
  Theriogenology. Jul, 2016  |   Pubmed ID: 27180329
• Ubiquitous LEA29Y Expression Blocks T Cell Co-Stimulation but Permits Sexual Reproduction in Genetically Modified Pigs
  PloS One. 2016  |   Pubmed ID: 27175998
• Transgenic Expression of Human Thrombomodulin Inhibits HMGB1-Induced Porcine Aortic Endothelial Cell Activation
  Transplantation. Sep, 2016  |   Pubmed ID: 27077599
• Chimeric 2C10R4 Anti-CD40 Antibody Therapy is Critical for Long-term Survival of GTKO.hCD46.hTBM Pig-to-primate Cardiac Xenograft
  Nature Communications. Apr, 2016  |   Pubmed ID: 27045379
• Generation and Standardized, Systemic Phenotypic Analysis of Pou3f3L423P Mutant Mice
  PloS One. 2016  |   Pubmed ID: 27003440
• Growth Hormone (GH)-transgenic Insulin-like Growth Factor 1 (IGF1)-deficient Mice Allow Dissociation of Excess GH and IGF1 Effects on Glomerular and Tubular Growth
  Physiological Reports. Mar, 2016  |   Pubmed ID: 26997624
• First Update of the International Xenotransplantation Association Consensus Statement on Conditions for Undertaking Clinical Trials of Porcine Islet Products in Type 1 Diabetes--Chapter 2b: Genetically Modified Source Pigs
  Xenotransplantation. Jan-Feb, 2016  |   Pubmed ID: 26926888
• Tissue Sampling Guides for Porcine Biomedical Models
  Toxicologic Pathology. Apr, 2016  |   Pubmed ID: 26883152
• Mildly Compromised Tetrahydrobiopterin Cofactor Biosynthesis Due to Pts Variants Leads to Unusual Body Fat Distribution and Abdominal Obesity in Mice
  Journal of Inherited Metabolic Disease. Mar, 2016  |   Pubmed ID: 26830550
• Exome Sequencing Identifies a Nonsense Mutation in Fam46a Associated with Bone Abnormalities in a New Mouse Model for Skeletal Dysplasia
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Apr, 2016  |   Pubmed ID: 26803617
• Inhibition of Complement Component C5 Prevents Clotting in an Ex Vivo Model of Xenogeneic Activation of Coagulation
  Xenotransplantation. Mar, 2016  |   Pubmed ID: 26773447
• Oxalate-induced Chronic Kidney Disease with Its Uremic and Cardiovascular Complications in C57BL/6 Mice
  American Journal of Physiology. Renal Physiology. Apr, 2016  |   Pubmed ID: 26764204
• Pillars Article: CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs. Cell. 1999. 99: 23-33
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2016  |   Pubmed ID: 26685313
• Developmental Endothelial Locus-1 Modulates Platelet-monocyte Interactions and Instant Blood-mediated Inflammatory Reaction in Islet Transplantation
  Thrombosis and Haemostasis. Apr, 2016  |   Pubmed ID: 26676803
• Stage-dependent Remodeling of the Nuclear Envelope and Lamina During Rabbit Early Embryonic Development
  The Journal of Reproduction and Development. Apr, 2016  |   Pubmed ID: 26640117
• MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2016  |   Pubmed ID: 26564819
• Tailored Pig Models for Preclinical Efficacy and Safety Testing of Targeted Therapies
  Toxicologic Pathology. Apr, 2016  |   Pubmed ID: 26511847
• Dissociation of Somatic Growth, Time of Sexual Maturity, and Life Expectancy by Overexpression of an RGD-deficient IGFBP-2 Variant in Female Transgenic Mice
  Aging Cell. Feb, 2016  |   Pubmed ID: 26507795
• Incretin Actions and Consequences of Incretin-based Therapies: Lessons from Complementary Animal Models
  The Journal of Pathology. Jan, 2016  |   Pubmed ID: 26455904
• Metamizol Relieves Pain Without Interfering With Cerulein-Induced Acute Pancreatitis in Mice
  Pancreas. Apr, 2016  |   Pubmed ID: 26418910
• Efavirenz Causes Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy in Endothelial Cells
  Cardiovascular Toxicology. Jan, 2016  |   Pubmed ID: 25666561
• 3D Structured Illumination Microscopy of Mammalian Embryos and Spermatozoa
  BMC Developmental Biology. Nov, 2015  |   Pubmed ID: 26610350
• Pre-clinical Heterotopic Intrathoracic Heart Xenotransplantation: a Possibly Useful Clinical Technique
  Xenotransplantation. Nov-Dec, 2015  |   Pubmed ID: 26602740
• Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets
  PloS One. 2015  |   Pubmed ID: 26600426
• Engraftment and Reversal of Diabetes After Intramuscular Transplantation of Neonatal Porcine Islet-like Clusters
  Xenotransplantation. Nov-Dec, 2015  |   Pubmed ID: 26490671
• Pigs Pave a Way to De Novo Formation of Functional Human Kidneys
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015  |   Pubmed ID: 26460047
• Phytohemagglutinin Facilitates the Aggregation of Blastomere Pairs from Day 5 Donor Embryos with Day 4 Host Embryos for Chimeric Bovine Embryo Multiplication
  Theriogenology. Dec, 2015  |   Pubmed ID: 26409823
• EIF6 Coordinates Insulin Sensitivity and Lipid Metabolism by Coupling Translation to Transcription
  Nature Communications. Sep, 2015  |   Pubmed ID: 26383020
• Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127
  Advances in Experimental Medicine and Biology. 2015  |   Pubmed ID: 26306448
• Analysis of Mammalian Gene Function Through Broad-based Phenotypic Screens Across a Consortium of Mouse Clinics
  Nature Genetics. Jul, 2015  |   Pubmed ID: 26214591
• Functional Compensation Among HMGN Variants Modulates the DNase I Hypersensitive Sites at Enhancers
  Genome Research. Sep, 2015  |   Pubmed ID: 26156321
• Dysregulated IGFBP5 Expression Causes Axon Degeneration and Motoneuron Loss in Diabetic Neuropathy
  Acta Neuropathologica. Sep, 2015  |   Pubmed ID: 26025657
• Transgenic Expression of Human CD46 on Porcine Endothelium: Effect on Coagulation and Fibrinolytic Cascades During Ex Vivo Human-to-Pig Limb Xenoperfusions
  Transplantation. Oct, 2015  |   Pubmed ID: 25965410
• Virus Safety of Islet Cell Transplantation from Transgenic Pigs to Marmosets
  Virus Research. Jun, 2015  |   Pubmed ID: 25956348
• Remodeling of the Nuclear Envelope and Lamina During Bovine Preimplantation Development and Its Functional Implications
  PloS One. 2015  |   Pubmed ID: 25932910
• Effects of the Glucagon-like Peptide-1 Receptor Agonist Liraglutide in Juvenile Transgenic Pigs Modeling a Pre-diabetic Condition
  Journal of Translational Medicine. Feb, 2015  |   Pubmed ID: 25890210
• Inactivation of Itf2 Promotes Intestinal Tumorigenesis in Apc(Min/+) Mice
  Biochemical and Biophysical Research Communications. May, 2015  |   Pubmed ID: 25869068
• Pig-to-baboon Heterotopic Heart Transplantation--exploratory Preliminary Experience with Pigs Transgenic for Human Thrombomodulin and Comparison of Three Costimulation Blockade-based Regimens
  Xenotransplantation. May-Jun, 2015  |   Pubmed ID: 25847282
• Glucose Tolerance Tests for Systematic Screening of Glucose Homeostasis in Mice
  Current Protocols in Mouse Biology. Mar, 2015  |   Pubmed ID: 25727201
• Viable Pigs with a Conditionally-activated Oncogenic KRAS Mutation
  Transgenic Research. Jun, 2015  |   Pubmed ID: 25716163
• Commentary on "Meta-analysis of the Independent and Cumulative Effects of Multiple Genetic Modifications on Pig Lung Xenograft Performance During Ex Vivo Perfusion with Human Blood" (by Harris Et Al.): Tailoring Donor Pigs for Xenotransplantation-how to Find the Right Combination of Genetic Modifications?
  Xenotransplantation. Mar-Apr, 2015  |   Pubmed ID: 25711248
• Screen for Alterations of Iron Related Parameters in N-ethyl-N-nitrosourea-treated Mice Identified Mutant Lines with Increased Plasma Ferritin Levels
  Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine. Apr, 2015  |   Pubmed ID: 25636453
• Uterine Responses to the Preattachment Embryo in Domestic Ungulates: Recognition of Pregnancy and Preparation for Implantation
  Annual Review of Animal Biosciences. 2015  |   Pubmed ID: 25387113
• Nuclear Transfer and Transgenesis in the Pig
  Methods in Molecular Biology (Clifton, N.J.). 2015  |   Pubmed ID: 25287337
• Proteome Analysis of Early Lineage Specification in Bovine Embryos
  Proteomics. Feb, 2015  |   Pubmed ID: 25143135
• Metformin Supports the Antidiabetic Effect of a Sodium Glucose Cotransporter 2 Inhibitor by Suppressing Endogenous Glucose Production in Diabetic Mice
  Diabetes. Jan, 2015  |   Pubmed ID: 25071027
• Expression Pattern of STAT5A Gene During Early Bovine Embryogenesis
  Zygote (Cambridge, England). Apr, 2015  |   Pubmed ID: 23981721
• Positional Changes of a Pluripotency Marker Gene During Structural Reorganization of Fibroblast Nuclei in Cloned Early Bovine Embryos
  Nucleus (Austin, Tex.). 2014  |   Pubmed ID: 25495180
• Reprogramming of Fibroblast Nuclei in Cloned Bovine Embryos Involves Major Structural Remodeling with Both Striking Similarities and Differences to Nuclear Phenotypes of in Vitro Fertilized Embryos
  Nucleus (Austin, Tex.). 2014  |   Pubmed ID: 25482066
• Uromodulin Retention in Thick Ascending Limb of Henle's Loop Affects SCD1 in Neighboring Proximal Tubule: Renal Transcriptome Studies in Mouse Models of Uromodulin-associated Kidney Disease
  PloS One. 2014  |   Pubmed ID: 25409434
• Calcitonin Controls Bone Formation by Inhibiting the Release of Sphingosine 1-phosphate from Osteoclasts
  Nature Communications. 2014  |   Pubmed ID: 25333900
• Pleiotropic Functions for Transcription Factor Zscan10
  PloS One. 2014  |   Pubmed ID: 25111779
• Stage-specific Proteome Signatures in Early Bovine Embryo Development
  Journal of Proteome Research. Oct, 2014  |   Pubmed ID: 25102770
• Standardized, Systemic Phenotypic Analysis of Slc12a1I299F Mutant Mice
  Journal of Biomedical Science. Aug, 2014  |   Pubmed ID: 25084970
• DRO1 Inactivation Drives Colorectal Carcinogenesis in ApcMin/+ Mice
  Molecular Cancer Research : MCR. Nov, 2014  |   Pubmed ID: 25053805
• Dual Fluorescent Reporter Pig for Cre Recombination: Transgene Placement at the ROSA26 Locus
  PloS One. 2014  |   Pubmed ID: 25025770
• Uniformity of Nucleosome Preservation Pattern in Mammalian Sperm and Its Connection to Repetitive DNA Elements
  Developmental Cell. Jul, 2014  |   Pubmed ID: 24998597
• Genome Activation in Bovine Embryos: Review of the Literature and New Insights from RNA Sequencing Experiments
  Animal Reproduction Science. Sep, 2014  |   Pubmed ID: 24975847
• Abnormal Brain Iron Metabolism in Irp2 Deficient Mice is Associated with Mild Neurological and Behavioral Impairments
  PloS One. 2014  |   Pubmed ID: 24896637
• Complement Dependent Early Immunological Responses During Ex Vivo Xenoperfusion of HCD46/HLA-E Double Transgenic Pig Forelimbs with Human Blood
  Xenotransplantation. May-Jun, 2014  |   Pubmed ID: 24635052
• Homologous Recombination Contributes to the Repair of Zinc-finger-nuclease Induced Double Strand Breaks in Pig Primary Cells and Facilitates Recombination with Exogenous DNA
  Journal of Biotechnology. May, 2014  |   Pubmed ID: 24613297
• Fine Mapping of Genome Activation in Bovine Embryos by RNA Sequencing
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2014  |   Pubmed ID: 24591639
• No Amelioration of Uromodulin Maturation and Trafficking Defect by Sodium 4-phenylbutyrate in Vivo: Studies in Mouse Models of Uromodulin-associated Kidney Disease
  The Journal of Biological Chemistry. Apr, 2014  |   Pubmed ID: 24567330
• Mitochondrial Dysfunction and Decrease in Body Weight of a Transgenic Knock-in Mouse Model for TDP-43
  The Journal of Biological Chemistry. Apr, 2014  |   Pubmed ID: 24515116
• The ABC of BTC: Structural Properties and Biological Roles of Betacellulin
  Seminars in Cell & Developmental Biology. Apr, 2014  |   Pubmed ID: 24440602
• Comparative and Retrospective Molecular Analysis of Parapoxvirus (PPV) Isolates
  Virus Research. Mar, 2014  |   Pubmed ID: 24373950
• Regulatory Sequences of the Porcine THBD Gene Facilitate Endothelial-specific Expression of Bioactive Human Thrombomodulin in Single- and Multitransgenic Pigs
  Transplantation. Jan, 2014  |   Pubmed ID: 24150517
• Genetically Engineered Pig Models for Diabetes Research
  Transgenic Research. Feb, 2014  |   Pubmed ID: 24065178
• Blood Collection from Mice and Hematological Analyses on Mouse Blood
  Current Protocols in Mouse Biology. Jun, 2013  |   Pubmed ID: 26069060
• Clinical Chemistry and Other Laboratory Tests on Mouse Plasma or Serum
  Current Protocols in Mouse Biology. Jun, 2013  |   Pubmed ID: 26069059
• Phenotypic Comparison of Common Mouse Strains Developing High-fat Diet-induced Hepatosteatosis
  Molecular Metabolism. 2013  |   Pubmed ID: 24327959
• Protein O-mannosylation is Crucial for E-cadherin-mediated Cell Adhesion
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2013  |   Pubmed ID: 24297939
• A Broad Phenotypic Screen Identifies Novel Phenotypes Driven by a Single Mutant Allele in Huntington's Disease CAG Knock-in Mice
  PloS One. 2013  |   Pubmed ID: 24278347
• Standardized, Systemic Phenotypic Analysis of Umod(C93F) and Umod(A227T) Mutant Mice
  PloS One. 2013  |   Pubmed ID: 24205203
• Ligand-independent Epidermal Growth Factor Receptor Hyperactivation Increases Sebaceous Gland Size and Sebum Secretion in Mice
  Experimental Dermatology. Oct, 2013  |   Pubmed ID: 24079739
• Activation of the Lectin Pathway of Complement in Pig-to-human Xenotransplantation Models
  Transplantation. Nov, 2013  |   Pubmed ID: 23958924
• Increased Activation of the Epidermal Growth Factor Receptor in Transgenic Mice Overexpressing Epigen Causes Peripheral Neuropathy
  Biochimica Et Biophysica Acta. Dec, 2013  |   Pubmed ID: 23899604
• Rapamycin Extends Murine Lifespan but Has Limited Effects on Aging
  The Journal of Clinical Investigation. Aug, 2013  |   Pubmed ID: 23863708
• An ENU Mutagenesis-derived Mouse Model with a Dominant Jak1 Mutation Resembling Phenotypes of Systemic Autoimmune Disease
  The American Journal of Pathology. Aug, 2013  |   Pubmed ID: 23791841
• Dystrophin-deficient Pigs Provide New Insights into the Hierarchy of Physiological Derangements of Dystrophic Muscle
  Human Molecular Genetics. Nov, 2013  |   Pubmed ID: 23784375
• Type of Uromodulin Mutation and Allelic Status Influence Onset and Severity of Uromodulin-associated Kidney Disease in Mice
  Human Molecular Genetics. Oct, 2013  |   Pubmed ID: 23748428
• Factors Influencing the Efficiency of Generating Genetically Engineered Pigs by Nuclear Transfer: Multi-factorial Analysis of a Large Data Set
  BMC Biotechnology. May, 2013  |   Pubmed ID: 23688045
• High Mobility Group N Proteins Modulate the Fidelity of the Cellular Transcriptional Profile in a Tissue- and Variant-specific Manner
  The Journal of Biological Chemistry. Jun, 2013  |   Pubmed ID: 23620591
• Cytoplasmic Mislocalization of POU3F4 Due to Novel Mutations Leads to Deafness in Humans and Mice
  Human Mutation. Aug, 2013  |   Pubmed ID: 23606368
• ITRAQ Proteome Analysis Reflects a Progressed Differentiation State of Epiblast Derived Versus Inner Cell Mass Derived Murine Embryonic Stem Cells
  Journal of Proteomics. Sep, 2013  |   Pubmed ID: 23603003
• Mouse Nuclear Myosin I Knock-out Shows Interchangeability and Redundancy of Myosin Isoforms in the Cell Nucleus
  PloS One. 2013  |   Pubmed ID: 23593477
• Tissue-specific and Minor Inter-individual Variation in Imprinting of IGF2R is a Common Feature of Bos Taurus Concepti and Not Correlated with Fetal Weight
  PloS One. 2013  |   Pubmed ID: 23593146
• Modeling Hepatic Osteodystrophy in Abcb4 Deficient Mice
  Bone. Aug, 2013  |   Pubmed ID: 23545228
• SMC6 is an Essential Gene in Mice, but a Hypomorphic Mutant in the ATPase Domain Has a Mild Phenotype with a Range of Subtle Abnormalities
  DNA Repair. May, 2013  |   Pubmed ID: 23518413
• Immune Aspects of Embryo-maternal Cross-talk in the Bovine Uterus
  Journal of Reproductive Immunology. Mar, 2013  |   Pubmed ID: 23432868
• NOD-scid IL2R γnull Mice Engrafted with Human Peripheral Blood Mononuclear Cells As a Model to Test Therapeutics Targeting Human Signaling Pathways
  Journal of Translational Medicine. Jan, 2013  |   Pubmed ID: 23294516
• Permanent Neonatal Diabetes in INS(C94Y) Transgenic Pigs
  Diabetes. May, 2013  |   Pubmed ID: 23274907
• Genetic Deletion of the EGFR Ligand Epigen Does Not Affect Mouse Embryonic Development and Tissue Homeostasis
  Experimental Cell Research. Feb, 2013  |   Pubmed ID: 23142483
• Induction of Oxazolone-mediated Features of Atopic Dermatitis in NOD-scid IL2Rγ(null) Mice Engrafted with Human Peripheral Blood Mononuclear Cells
  Disease Models & Mechanisms. Jan, 2013  |   Pubmed ID: 22822046
• Hosting the Preimplantation Embryo: Potentials and Limitations of Different Approaches for Analysing Embryo-endometrium Interactions in Cattle
  Reproduction, Fertility, and Development. 2012  |   Pubmed ID: 23244829
• The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers
  PloS One. 2012  |   Pubmed ID: 23226392
• Completion of the Swine Genome Will Simplify the Production of Swine As a Large Animal Biomedical Model
  BMC Medical Genomics. Nov, 2012  |   Pubmed ID: 23151353
• Potential of Primary Kidney Cells for Somatic Cell Nuclear Transfer Mediated Transgenesis in Pig
  BMC Biotechnology. Nov, 2012  |   Pubmed ID: 23140586
• Truncation of MIMT1 Gene in the PEG3 Domain Leads to Major Changes in Placental Gene Expression and Stillbirth in Cattle
  Biology of Reproduction. Jun, 2012  |   Pubmed ID: 23100617
• Inactivation and Inducible Oncogenic Mutation of P53 in Gene Targeted Pigs
  PloS One. 2012  |   Pubmed ID: 23071491
• The Hepatic Phosphatidylcholine Transporter ABCB4 As Modulator of Glucose Homeostasis
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2012  |   Pubmed ID: 22982378
• In-vivo Biodegradation of Extruded Lipid Implants in Rabbits
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Oct, 2012  |   Pubmed ID: 22964393
• Innovations in Phenotyping of Mouse Models in the German Mouse Clinic
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2012  |   Pubmed ID: 22926221
• Transcriptome Analyses of Bovine, Porcine and Equine Endometrium During the Pre-implantation Phase
  Animal Reproduction Science. Sep, 2012  |   Pubmed ID: 22917876
• A Porcine Model of Familial Adenomatous Polyposis
  Gastroenterology. Nov, 2012  |   Pubmed ID: 22864254
• Does Enamelin Have Pleiotropic Effects on Organs Other Than the Teeth? Lessons from a Phenotyping Screen of Two Enamelin-mutant Mouse Lines
  European Journal of Oral Sciences. Aug, 2012  |   Pubmed ID: 22813216
• Cytochrome C Oxidase Subunit 4 Isoform 2-knockout Mice Show Reduced Enzyme Activity, Airway Hyporeactivity, and Lung Pathology
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Sep, 2012  |   Pubmed ID: 22730437
• Large-scale Phenotyping of an Accurate Genetic Mouse Model of JNCL Identifies Novel Early Pathology Outside the Central Nervous System
  PloS One. 2012  |   Pubmed ID: 22701626
• Cytomegalovirus Replicon-based Regulation of Gene Expression in Vitro and in Vivo
  PLoS Pathogens. 2012  |   Pubmed ID: 22685399
• A New Mouse Model for Studying EGFR-dependent Gastric Polyps
  Biochimica Et Biophysica Acta. Aug, 2012  |   Pubmed ID: 22579588
• New Mouse Models for Metabolic Bone Diseases Generated by Genome-wide ENU Mutagenesis
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Aug, 2012  |   Pubmed ID: 22527485
• Xenografted Islet Cell Clusters from INSLEA29Y Transgenic Pigs Rescue Diabetes and Prevent Immune Rejection in Humanized Mice
  Diabetes. Jun, 2012  |   Pubmed ID: 22522620
• Changing Metabolic Signatures of Amino Acids and Lipids During the Prediabetic Period in a Pig Model with Impaired Incretin Function and Reduced β-cell Mass
  Diabetes. Aug, 2012  |   Pubmed ID: 22492530
• Neurobeachin, a Regulator of Synaptic Protein Targeting, is Associated with Body Fat Mass and Feeding Behavior in Mice and Body-mass Index in Humans
  PLoS Genetics. 2012  |   Pubmed ID: 22438821
• Human TNF-related Apoptosis-inducing Ligand-expressing Dendritic Cells from Transgenic Pigs Attenuate Human Xenogeneic T Cell Responses
  Xenotransplantation. Jan-Feb, 2012  |   Pubmed ID: 22360752
• Negative Feedback Mechanisms Surpass the Effect of Intrinsic EGFR Activation During Skin Chemical Carcinogenesis
  The American Journal of Pathology. Apr, 2012  |   Pubmed ID: 22306420
• Clinical Chemistry of Human FcRn Transgenic Mice
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Apr, 2012  |   Pubmed ID: 22193411
• First Inducible Transgene Expression in Porcine Large Animal Models
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Mar, 2012  |   Pubmed ID: 22138035
• Normal Epidermal Growth Factor Receptor Signaling is Dispensable for Bone Anabolic Effects of Parathyroid Hormone
  Bone. Jan, 2012  |   Pubmed ID: 22056328
• Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium
  Biology of Reproduction. Feb, 2012  |   Pubmed ID: 22034527
• Gene Expression Profiling of Bovine Peripartal Placentomes: Detection of Molecular Pathways Potentially Involved in the Release of Foetal Membranes
  Reproduction (Cambridge, England). Jan, 2012  |   Pubmed ID: 22031715
• Lack of Pur-alpha Alters Postnatal Brain Development and Causes Megalencephaly
  Human Molecular Genetics. Feb, 2012  |   Pubmed ID: 22010047
• A Transgenic Mouse Line Expressing Cre Recombinase in Pancreatic β-cells
  Genesis (New York, N.Y. : 2000). May, 2012  |   Pubmed ID: 21998080
• In Vivo Evidence for Epidermal Growth Factor Receptor (EGFR)-mediated Release of Prolactin from the Pituitary Gland
  The Journal of Biological Chemistry. Nov, 2011  |   Pubmed ID: 21914800
• Postnatal Development of Numbers and Mean Sizes of Pancreatic Islets and Beta-cells in Healthy Mice and GIPR(dn) Transgenic Diabetic Mice
  PloS One. 2011  |   Pubmed ID: 21818396
• Cell Arrest and Cell Death in Mammalian Preimplantation Development: Lessons from the Bovine Model
  PloS One. 2011  |   Pubmed ID: 21811561
• Reduced Amino Acids in the Bovine Uterine Lumen of Cloned Versus in Vitro Fertilized Pregnancies Prior to Implantation
  Cellular Reprogramming. Oct, 2011  |   Pubmed ID: 21774685
• Toxicity Modelling of Plk1-targeted Therapies in Genetically Engineered Mice and Cultured Primary Mammalian Cells
  Nature Communications. 2011  |   Pubmed ID: 21772266
• Generation of N-ethyl-N-nitrosourea-induced Mouse Mutants with Deviations in Hematological Parameters
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Oct, 2011  |   Pubmed ID: 21553221
• Requirement of the RNA-editing Enzyme ADAR2 for Normal Physiology in Mice
  The Journal of Biological Chemistry. May, 2011  |   Pubmed ID: 21467037
• Missing-in-metastasis MIM/MTSS1 Promotes Actin Assembly at Intercellular Junctions and is Required for Integrity of Kidney Epithelia
  Journal of Cell Science. Apr, 2011  |   Pubmed ID: 21406566
• Increase of Essential Amino Acids in the Bovine Uterine Lumen During Preimplantation Development
  Reproduction (Cambridge, England). May, 2011  |   Pubmed ID: 21383026
• Decreased Incidence of Papillomas in Mice with Impaired EGFR Function During Multi-stage Skin Carcinogenesis
  Experimental Dermatology. Mar, 2011  |   Pubmed ID: 21323750
• A Novel N-ethyl-N-nitrosourea-induced Mutation in Phospholipase Cγ2 Causes Inflammatory Arthritis, Metabolic Defects, and Male Infertility in Vitro in a Murine Model
  Arthritis and Rheumatism. May, 2011  |   Pubmed ID: 21305534
• Formation of Nucleoli in Interspecies Nuclear Transfer Embryos Derived from Bovine, Porcine, and Rabbit Oocytes and Nuclear Donor Cells of Various Species
  Reproduction (Cambridge, England). Apr, 2011  |   Pubmed ID: 21239525
• Utilization of a Mutagenesis Screen to Generate Mouse Models of Hyperaldosteronism
  Endocrinology. Jan, 2011  |   Pubmed ID: 21068155
• Bovine Endometrial Metallopeptidases MMP14 and MMP2 and the Metallopeptidase Inhibitor TIMP2 Participate in Maternal Preparation of Pregnancy
  Molecular and Cellular Endocrinology. Jan, 2011  |   Pubmed ID: 20887771
• Mouse Phenotyping
  Methods (San Diego, Calif.). Feb, 2011  |   Pubmed ID: 20708688
• Genomic Integration of Adenoviral Gene Transfer Vectors Following Transduction of Fertilized Mouse Oocytes
  Transgenic Research. Feb, 2011  |   Pubmed ID: 20464633
• A Key Role for E-cadherin in Intestinal Homeostasis and Paneth Cell Maturation
  PloS One. Dec, 2010  |   Pubmed ID: 21179475
• Actions and Interactions of Progesterone and Estrogen on Transcriptome Profiles of the Bovine Endometrium
  Physiological Genomics. Nov, 2010  |   Pubmed ID: 20876846
• FISH on 3D Preserved Bovine and Murine Preimplantation Embryos
  Methods in Molecular Biology (Clifton, N.J.). 2010  |   Pubmed ID: 20809333
• Quantification of Leukocyte Genomic 5-methylcytosine Levels Reveals Epigenetic Plasticity in Healthy Adult Cloned Cattle
  Cellular Reprogramming. Apr, 2010  |   Pubmed ID: 20677931
• Differential Endometrial Gene Expression in Pregnant and Nonpregnant Sows
  Biology of Reproduction. Aug, 2010  |   Pubmed ID: 20393170
• Transgenic Pigs As Models for Translational Biomedical Research
  Journal of Molecular Medicine (Berlin, Germany). Jul, 2010  |   Pubmed ID: 20339830
• Mutation of the Na(+)-K(+)-2Cl(-) Cotransporter NKCC2 in Mice is Associated with Severe Polyuria and a Urea-selective Concentrating Defect Without Hyperreninemia
  American Journal of Physiology. Renal Physiology. Jun, 2010  |   Pubmed ID: 20219826
• Loss of the Actin Remodeler Eps8 Causes Intestinal Defects and Improved Metabolic Status in Mice
  PloS One. Mar, 2010  |   Pubmed ID: 20209148
• Glucose Intolerance and Reduced Proliferation of Pancreatic Beta-cells in Transgenic Pigs with Impaired Glucose-dependent Insulinotropic Polypeptide Function
  Diabetes. May, 2010  |   Pubmed ID: 20185813
• Escherichia Coli Infection Induces Distinct Local and Systemic Transcriptome Responses in the Mammary Gland
  BMC Genomics. Feb, 2010  |   Pubmed ID: 20184744
• Transgenic Pigs for Xenotransplantation: Selection of Promoter Sequences for Reliable Transgene Expression
  Current Opinion in Organ Transplantation. Apr, 2010  |   Pubmed ID: 20061949
• Betacellulin Protects from Pancreatitis by Activating Stress-activated Protein Kinase
  Gastroenterology. Apr, 2010  |   Pubmed ID: 20038432
• Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3 ( 416insG ) Mice
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Feb, 2010  |   Pubmed ID: 20033184
• Genetic Modification of Pigs As Organ Donors for Xenotransplantation
  Molecular Reproduction and Development. Mar, 2010  |   Pubmed ID: 19998476
• EGFR Ligands Exert Diverging Effects on Male Reproductive Organs
  Experimental and Molecular Pathology. Feb, 2010  |   Pubmed ID: 19931240
• Germ-line Transmission of Lentiviral PGK-EGFP Integrants in Transgenic Cattle: New Perspectives for Experimental Embryology
  Transgenic Research. Aug, 2010  |   Pubmed ID: 19862638
• Epigen Transgenic Mice Develop Enlarged Sebaceous Glands
  The Journal of Investigative Dermatology. Feb, 2010  |   Pubmed ID: 19693025
• Specific Transgene Expression in Mouse Pancreatic Beta-cells Under the Control of the Porcine Insulin Promoter
  Molecular and Cellular Endocrinology. Feb, 2010  |   Pubmed ID: 19682540
• Novel Missense Mutation of Uromodulin in Mice Causes Renal Dysfunction with Alterations in Urea Handling, Energy, and Bone Metabolism
  American Journal of Physiology. Renal Physiology. Nov, 2009  |   Pubmed ID: 19692485
• Clinical Chemistry of Congenic Mice with Quantitative Trait Loci for Predicted Responses to Trypanosoma Congolense Infection
  Infection and Immunity. Sep, 2009  |   Pubmed ID: 19596769
• Dll1 Haploinsufficiency in Adult Mice Leads to a Complex Phenotype Affecting Metabolic and Immunological Processes
  PloS One. Jun, 2009  |   Pubmed ID: 19562077
• Reprogramming of Active and Repressive Histone Modifications Following Nuclear Transfer with Rabbit Mesenchymal Stem Cells and Adult Fibroblasts
  Cloning and Stem Cells. Jun, 2009  |   Pubmed ID: 19508112
• N-ethyl-N-nitrosourea Mutagenesis Produced a Small Number of Mice with Altered Plasma Electrolyte Levels
  Journal of Biomedical Science. Jun, 2009  |   Pubmed ID: 19505327
• Evidence for Estrogen-dependent Uterine Serpin (SERPINA14) Expression During Estrus in the Bovine Endometrial Glandular Epithelium and Lumen
  Biology of Reproduction. Oct, 2009  |   Pubmed ID: 19494250
• Chronic Growth Hormone Excess is Associated with Increased Aldosterone: a Study in Patients with Acromegaly and in Growth Hormone Transgenic Mice
  Experimental Biology and Medicine (Maywood, N.J.). Aug, 2009  |   Pubmed ID: 19491373
• A Humanized Version of Foxp2 Affects Cortico-basal Ganglia Circuits in Mice
  Cell. May, 2009  |   Pubmed ID: 19490899
• A New Fgf10 Mutation in the Mouse Leads to Atrophy of the Harderian Gland and Slit-eye Phenotype in Heterozygotes: a Novel Model for Dry-eye Disease?
  Investigative Ophthalmology & Visual Science. Sep, 2009  |   Pubmed ID: 19407009
• Distribution and Expression of Porcine Endogenous Retroviruses in Multi-transgenic Pigs Generated for Xenotransplantation
  Xenotransplantation. Mar-Apr, 2009  |   Pubmed ID: 19392721
• The C-terminal Cytoplasmic Domain of Human ProEGF is a Negative Modulator of Body and Organ Weights in Transgenic Mice
  FEBS Letters. Apr, 2009  |   Pubmed ID: 19328792
• Scrapie-infected Transgenic Mice Expressing a Laminin Receptor Decoy Mutant Reveal a Prolonged Incubation Time Associated with Low Levels of PrPres
  Journal of Molecular Biology. May, 2009  |   Pubmed ID: 19324055
• The Endometrium Responds Differently to Cloned Versus Fertilized Embryos
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2009  |   Pubmed ID: 19307558
• Maternal Inexperience As a Risk Factor of Innate Fear and PTSD-like Symptoms in Mice
  Journal of Psychiatric Research. Sep, 2009  |   Pubmed ID: 19304295
• Systemic First-line Phenotyping
  Methods in Molecular Biology (Clifton, N.J.). 2009  |   Pubmed ID: 19266331
• Changes of Higher Order Chromatin Arrangements During Major Genome Activation in Bovine Preimplantation Embryos
  Experimental Cell Research. Jul, 2009  |   Pubmed ID: 19254712