Edith Heard

Publications

• XIST Loss Impairs Mammary Stem Cell Differentiation and Increases Tumorigenicity Through Mediator Hyperactivation
  Cell. 06, 2022  |   Pubmed ID: 35597241
• Molecular Biology for Green Recovery-A Call for Action
  PLoS Biology. 04, 2022  |   Pubmed ID: 35452449
• Gene Regulation in Time and Space During X-chromosome Inactivation
  Nature Reviews. Molecular Cell Biology. 04, 2022  |   Pubmed ID: 35013589
• The X Chromosome from Telomere to Telomere: Key Achievements and Future Opportunities
  Faculty Reviews. 2021  |   Pubmed ID: 35088059
• Noncoding RNAs: Biology and Applications-a Keystone Symposia Report
  Annals of the New York Academy of Sciences. 12, 2021  |   Pubmed ID: 34791665
• Locus Specific Epigenetic Modalities of Random Allelic Expression Imbalance
  Nature Communications. 09, 2021  |   Pubmed ID: 34504093
• Parental-to-embryo Switch of Chromosome Organization in Early Embryogenesis
  Nature. 04, 2020  |   Pubmed ID: 32238933
• SPEN Integrates Transcriptional and Epigenetic Control of X-inactivation
  Nature. 02, 2020  |   Pubmed ID: 32025035
• A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression Across a Topological Boundary
  Molecular Cell. 01, 2020  |   Pubmed ID: 31759823
• Xist RNA in Action: Past, Present, and Future
  PLoS Genetics. 09, 2019  |   Pubmed ID: 31537017
• Advances in Epigenetics Link Genetics to the Environment and Disease
  Nature. 07, 2019  |   Pubmed ID: 31341302
• A Symmetric Toggle Switch Explains the Onset of Random X Inactivation in Different Mammals
  Nature Structural & Molecular Biology. 05, 2019  |   Pubmed ID: 30962582
• Genomes of Ellobius Species Provide Insight into the Evolutionary Dynamics of Mammalian Sex Chromosomes
  Genome Research. Aug, 2016  |   Pubmed ID: 27510564
• Ordered Chromatin Changes and Human X Chromosome Reactivation by Cell Fusion-mediated Pluripotent Reprogramming
  Nature Communications. 2016  |   Pubmed ID: 27507283
• LINE-1 Activity in Facultative Heterochromatin Formation During X Chromosome Inactivation
  Cell. Jul, 2016  |   Pubmed ID: 27471971
• Structural Organization of the Inactive X Chromosome in the Mouse
  Nature. Jul, 2016  |   Pubmed ID: 27437574
• Random Monoallelic Expression of Genes on Autosomes: Parallels with X-chromosome Inactivation
  Seminars in Cell & Developmental Biology. Aug, 2016  |   Pubmed ID: 27101886
• Structural Fluctuations of the Chromatin Fiber Within Topologically Associating Domains
  Biophysical Journal. Mar, 2016  |   Pubmed ID: 27028634
• Maternal LSD1/KDM1A is an Essential Regulator of Chromatin and Transcription Landscapes During Zygotic Genome Activation
  ELife. 2016  |   Pubmed ID: 26836306
• HiC-Pro: an Optimized and Flexible Pipeline for Hi-C Data Processing
  Genome Biology. 2015  |   Pubmed ID: 26619908
• Structural and Functional Diversity of Topologically Associating Domains
  FEBS Letters. Oct, 2015  |   Pubmed ID: 26348399
• [The Legacy of Mary F. Lyon (1925-2014)]
  Médecine Sciences : M/S. Jun-Jul, 2015  |   Pubmed ID: 26152175
• X-chromosome Inactivation: New Insights into Cis and Trans Regulation
  Current Opinion in Genetics & Development. Apr, 2015  |   Pubmed ID: 26004255
• Correction: RNAi-Dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells
  PLoS Genetics. May, 2015  |   Pubmed ID: 25973973
• Systematic Discovery of Xist RNA Binding Proteins
  Cell. Apr, 2015  |   Pubmed ID: 25843628
• The Inactive X Chromosome is Epigenetically Unstable and Transcriptionally Labile in Breast Cancer
  Genome Research. Apr, 2015  |   Pubmed ID: 25653311
• Jarid2 Methylation Via the PRC2 Complex Regulates H3K27me3 Deposition During Cell Differentiation
  Molecular Cell. Mar, 2015  |   Pubmed ID: 25620564
• High-resolution 3D DNA FISH Using Plasmid Probes and Computational Correction of Optical Aberrations to Study Chromatin Structure at the Sub-megabase Scale
  Methods in Molecular Biology (Clifton, N.J.). 2015  |   Pubmed ID: 25555574
• Noncoding RNAs and Epigenetic Mechanisms During X-chromosome Inactivation
  Annual Review of Cell and Developmental Biology. 2014  |   Pubmed ID: 25000994
• X-chromosome Inactivation in Development and Cancer
  FEBS Letters. Aug, 2014  |   Pubmed ID: 24937141
• MOF-associated Complexes Ensure Stem Cell Identity and Xist Repression
  ELife. 2014  |   Pubmed ID: 24842875
• Predictive Polymer Modeling Reveals Coupled Fluctuations in Chromosome Conformation and Transcription
  Cell. May, 2014  |   Pubmed ID: 24813616
• Transgenerational Epigenetic Inheritance: Myths and Mechanisms
  Cell. Mar, 2014  |   Pubmed ID: 24679529
• Developmental Dynamics and Disease Potential of Random Monoallelic Gene Expression
  Developmental Cell. Feb, 2014  |   Pubmed ID: 24576422
• The Two Active X Chromosomes in Female ESCs Block Exit from the Pluripotent State by Modulating the ESC Signaling Network
  Cell Stem Cell. Feb, 2014  |   Pubmed ID: 24506884
• Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome
  Molecular Cell. Jan, 2014  |   Pubmed ID: 24462204
• [Initiation of X Chromosome Inactivation During Early Embryogenesis in Mice and in Humans]
  Bulletin De L'Académie Nationale De Médecine. Mar, 2013  |   Pubmed ID: 25163344
• Changes in the Organization of the Genome During the Mammalian Cell Cycle
  Genome Biology. 2013  |   Pubmed ID: 24368000
• RNAi-dependent and Independent Control of LINE1 Accumulation and Mobility in Mouse Embryonic Stem Cells
  PLoS Genetics. Nov, 2013  |   Pubmed ID: 24244175
• Cohesin-based Chromatin Interactions Enable Regulated Gene Expression Within Preexisting Architectural Compartments
  Genome Research. Dec, 2013  |   Pubmed ID: 24002784
• Live-cell Imaging Combined with Immunofluorescence, RNA, or DNA FISH to Study the Nuclear Dynamics and Expression of the X-inactivation Center
  Methods in Molecular Biology (Clifton, N.J.). 2013  |   Pubmed ID: 23979997
• The Pluripotent Genome in Three Dimensions is Shaped Around Pluripotency Factors
  Nature. Sep, 2013  |   Pubmed ID: 23883933
• Segmental Folding of Chromosomes: a Basis for Structural and Regulatory Chromosomal Neighborhoods?
  BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Sep, 2013  |   Pubmed ID: 23832846
• Epigenetic Functions of Smchd1 Repress Gene Clusters on the Inactive X Chromosome and on Autosomes
  Molecular and Cellular Biology. Aug, 2013  |   Pubmed ID: 23754746
• Cell Nucleus
  Current Opinion in Cell Biology. Jun, 2013  |   Pubmed ID: 23746906
• Small RNAs Derived from Structural Non-coding RNAs
  Methods (San Diego, Calif.). Sep, 2013  |   Pubmed ID: 23684746
• The Dynamics of Epigenetic Changes in a Range of Organisms
  Current Topics in Developmental Biology. 2013  |   Pubmed ID: 23587246
• Role and Control of X Chromosome Dosage in Mammalian Development
  Current Opinion in Genetics & Development. Apr, 2013  |   Pubmed ID: 23465885
• Unusual Chromatin Status and Organization of the Inactive X Chromosome in Murine Trophoblast Giant Cells
  Development (Cambridge, England). Feb, 2013  |   Pubmed ID: 23362347
• Recent Advances in X-chromosome Inactivation Research
  Current Opinion in Cell Biology. Dec, 2012  |   Pubmed ID: 23142477
• NcPRO-seq: a Tool for Annotation and Profiling of NcRNAs in SRNA-seq Data
  Bioinformatics (Oxford, England). Dec, 2012  |   Pubmed ID: 23044543
• HiTC: Exploration of High-throughput 'C' Experiments
  Bioinformatics (Oxford, England). Nov, 2012  |   Pubmed ID: 22923296
• Smchd1-dependent and -independent Pathways Determine Developmental Dynamics of CpG Island Methylation on the Inactive X Chromosome
  Developmental Cell. Aug, 2012  |   Pubmed ID: 22841499
• Spatial Partitioning of the Regulatory Landscape of the X-inactivation Centre
  Nature. May, 2012  |   Pubmed ID: 22495304
• Deep-sequencing Protocols Influence the Results Obtained in Small-RNA Sequencing
  PloS One. 2012  |   Pubmed ID: 22384282
• MicroRNA Regulation of Cbx7 Mediates a Switch of Polycomb Orthologs During ESC Differentiation
  Cell Stem Cell. Jan, 2012  |   Pubmed ID: 22226354
• Naive and Primed Murine Pluripotent Stem Cells Have Distinct MiRNA Expression Profiles
  RNA (New York, N.Y.). Feb, 2012  |   Pubmed ID: 22201644
• Fifty Years of X-inactivation Research
  Development (Cambridge, England). Dec, 2011  |   Pubmed ID: 22069183
• Deterministic and Stochastic Allele Specific Gene Expression in Single Mouse Blastomeres
  PloS One. 2011  |   Pubmed ID: 21731673
• Function of the Sex Chromosomes in Mammalian Fertility
  Cold Spring Harbor Perspectives in Biology. Oct, 2011  |   Pubmed ID: 21730045
• The Inactive X Chromosome Adopts a Unique Three-dimensional Conformation That is Dependent on Xist RNA
  Genes & Development. Jul, 2011  |   Pubmed ID: 21690198
• Evolutionary Diversity and Developmental Regulation of X-chromosome Inactivation
  Human Genetics. Aug, 2011  |   Pubmed ID: 21687993
• Regulation of X-chromosome Inactivation by the X-inactivation Centre
  Nature Reviews. Genetics. Jun, 2011  |   Pubmed ID: 21587299
• Live-cell Chromosome Dynamics and Outcome of X Chromosome Pairing Events During ES Cell Differentiation
  Cell. Apr, 2011  |   Pubmed ID: 21529716
• Eutherian Mammals Use Diverse Strategies to Initiate X-chromosome Inactivation During Development
  Nature. Apr, 2011  |   Pubmed ID: 21471966
• Rnf12--a Jack of All Trades in X Inactivation?
  PLoS Genetics. 2011  |   Pubmed ID: 21298029
• [Establishing Transcriptional Silencing of the X Chromosome During Early Embryogenesis]
  Biologie Aujourd'hui. 2010  |   Pubmed ID: 20950563
• Nuclear Organization and Dosage Compensation
  Cold Spring Harbor Perspectives in Biology. Nov, 2010  |   Pubmed ID: 20943757
• Girafe--an R/Bioconductor Package for Functional Exploration of Aligned Next-generation Sequencing Reads
  Bioinformatics (Oxford, England). Nov, 2010  |   Pubmed ID: 20861030
• Ten Years of Genetics and Genomics: What Have We Achieved and Where Are We Heading?
  Nature Reviews. Genetics. Oct, 2010  |   Pubmed ID: 20820184
• Dynamic Plasticity of Large-scale Chromatin Structure Revealed by Self-assembly of Engineered Chromosome Regions
  The Journal of Cell Biology. Sep, 2010  |   Pubmed ID: 20819934
• LINE-1 Activity in Facultative Heterochromatin Formation During X Chromosome Inactivation
  Cell. Jun, 2010  |   Pubmed ID: 20550932
• Epigenetic Mechanisms in Development and Disease
  Seminars in Cell & Developmental Biology. Apr, 2010  |   Pubmed ID: 20079450
• X Chromosome Inactivation: when Dosage Counts
  Cell. Nov, 2009  |   Pubmed ID: 19945374
• Lessons from Comparative Analysis of X-chromosome Inactivation in Mammals
  Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2009  |   Pubmed ID: 19802706
• Foreword: Coping with Sex Chromosome Imbalance
  Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 2009  |   Pubmed ID: 19760092
• Highly Dynamic and Sex-specific Expression of MicroRNAs During Early ES Cell Differentiation
  PLoS Genetics. Aug, 2009  |   Pubmed ID: 19714213
• High-resolution Analysis of Epigenetic Changes Associated with X Inactivation
  Genome Research. Aug, 2009  |   Pubmed ID: 19581487
• X Inactivation and the Complexities of Silencing a Sex Chromosome
  Current Opinion in Cell Biology. Jun, 2009  |   Pubmed ID: 19477626
• Dynamic Changes in Paternal X-chromosome Activity During Imprinted X-chromosome Inactivation in Mice
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009  |   Pubmed ID: 19273861
• Monomethylation of Histone H4-lysine 20 is Involved in Chromosome Structure and Stability and is Essential for Mouse Development
  Molecular and Cellular Biology. Apr, 2009  |   Pubmed ID: 19223465
• Kombinierte Immunfluoreszenz, Leuchtstoff In-situhybridation RNA Und DNA Leuchtstoff In-situhybridation Chromatin Änderungen, Transkriptionelle Aktivität, Nukleare Organisation Und Darstellung Inaktivierung Zu Studieren
  Methods in Molecular Biology (Clifton, N.J.). 2008  |   Pubmed ID: 18951174
• [Inactivation of X Chromosome: Cells Know How to Count Two X Chromosomes]
  Médecine Sciences : M/S. Jun-Jul, 2008  |   Pubmed ID: 18601875
• Chromosome Structural Proteins and RNA-mediated Epigenetic Silencing
  Developmental Cell. Jun, 2008  |   Pubmed ID: 18539109
• A Phosphorylated Subpopulation of the Histone Variant MacroH2A1 is Excluded from the Inactive X Chromosome and Enriched During Mitosis
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18227505
• X Inactive-specific Transcript RNA Coating and Genetic Instability of the X Chromosome in BRCA1 Breast Tumors
  Cancer Research. Jun, 2007  |   Pubmed ID: 17545591
• The Ins and Outs of Gene Regulation and Chromosome Territory Organisation
  Current Opinion in Cell Biology. Jun, 2007  |   Pubmed ID: 17467967
• Non-rigid Registration of 3D Multi-channel Microscopy Images of Cell Nuclei
  Medical Image Computing and Computer-assisted Intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2006  |   Pubmed ID: 17354977
• [Cross Talk Between the Xics]
  Médecine Sciences : M/S. Nov, 2006  |   Pubmed ID: 17101084
• Eine Neue Rolle Für Xist-RNA Bei Der Bildung Von Einem Repressiven Nukleare Fach in Dem Gene Rekrutiert Werden, Wenn Zum Schweigen Gebracht
  Genes & Development. Aug, 2006  |   Pubmed ID: 16912274
• Dosage Compensation in Mammals: Fine-tuning the Expression of the X Chromosome
  Genes & Development. Jul, 2006  |   Pubmed ID: 16847345
• Mouse Polycomb Proteins Bind Differentially to Methylated Histone H3 and RNA and Are Enriched in Facultative Heterochromatin
  Molecular and Cellular Biology. Apr, 2006  |   Pubmed ID: 16537902
• Transient Colocalization of X-inactivation Centres Accompanies the Initiation of X Inactivation
  Nature Cell Biology. Mar, 2006  |   Pubmed ID: 16434960
• Evidence for De Novo Imprinted X-chromosome Inactivation Independent of Meiotic Inactivation in Mice
  Nature. Nov, 2005  |   Pubmed ID: 16227973
• Delving into the Diversity of Facultative Heterochromatin: the Epigenetics of the Inactive X Chromosome
  Current Opinion in Genetics & Development. Oct, 2005  |   Pubmed ID: 16107314
• Initiation of Epigenetic Reprogramming of the X Chromosome in Somatic Nuclei Transplanted to a Mouse Oocyte
  EMBO Reports. Aug, 2005  |   Pubmed ID: 16007070
• Imprinted X-inactivation in Extra-embryonic Endoderm Cell Lines from Mouse Blastocysts
  Development (Cambridge, England). Apr, 2005  |   Pubmed ID: 15753215
• Differenzielle Histon H3 Lys-9 Und Lys-27 Methylierung Profile Auf Dem X-Chromosom
  Molecular and Cellular Biology. Jun, 2004  |   Pubmed ID: 15169908
• Recent Advances in X-chromosome Inactivation
  Current Opinion in Cell Biology. Jun, 2004  |   Pubmed ID: 15145348
• X-chromosome Inactivation in Mouse Embryonic Stem Cells: Analysis of Histone Modifications and Transcriptional Activity Using Immunofluorescence and FISH
  Methods in Enzymology. 2004  |   Pubmed ID: 14975321
• Epigenetic Dynamics of Imprinted X Inactivation During Early Mouse Development
  Science (New York, N.Y.). Jan, 2004  |   Pubmed ID: 14671313
• Rb-mediated Heterochromatin Formation and Silencing of E2F Target Genes During Cellular Senescence
  Cell. Jun, 2003  |   Pubmed ID: 12809602
• Role of Histone Methyltransferase G9a in CpG Methylation of the Prader-Willi Syndrome Imprinting Center
  The Journal of Biological Chemistry. Apr, 2003  |   Pubmed ID: 12586828
• Relationship of XIST Expression and Responses of Ovarian Cancer to Chemotherapy
  Molecular Cancer Therapeutics. Aug, 2002  |   Pubmed ID: 12492109
• Antisense RNA in Imprinting: Spreading Silence Through Air
  Trends in Genetics : TIG. Sep, 2002  |   Pubmed ID: 12175797
• Differentially Methylated Forms of Histone H3 Show Unique Association Patterns with Inactive Human X Chromosomes
  Nature Genetics. Jan, 2002  |   Pubmed ID: 11740495