Edward R. O'Brien

Publications

• Glycogen Synthase Kinase-3β Inhibition Augments Diabetic Endothelial Progenitor Cell Abundance and Functionality Via Cathepsin B: a Novel Therapeutic Opportunity for Arterial Repair
  Diabetes. Apr, 2014  |   Pubmed ID: 24296714
• Circulating Endothelial Progenitor Cells and In-stent Restenosis: Friend, Foe, or None of the Above?
  The Canadian Journal of Cardiology. Jan, 2014  |   Pubmed ID: 24290519
• The Evolution of Coronary Stents: a Brief Review
  The Canadian Journal of Cardiology. Jan, 2014  |   Pubmed ID: 24286961
• Giant Saphenous Vein Graft Aneurysm Presenting As ST-elevation Myocardial Infarction
  Circulation Journal : Official Journal of the Japanese Circulation Society. 2014  |   Pubmed ID: 24284922
• Heat Shock Protein 27 Attenuates Neointima Formation and Accelerates Reendothelialization After Arterial Injury and Stent Implantation: Importance of Vascular Endothelial Growth Factor Up-regulation
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2014  |   Pubmed ID: 24142570
• Heat Shock Protein-27 Attenuates Foam Cell Formation and Atherogenesis by Down-regulating Scavenger Receptor-A Expression Via NF-κB Signaling
  Biochimica Et Biophysica Acta. Dec, 2013  |   Pubmed ID: 23939398
• The Effect of Statins on Circulating Endothelial Progenitor Cells in Humans: a Systematic Review
  Journal of Cardiovascular Pharmacology. Nov, 2013  |   Pubmed ID: 23933855
• Serum Heat Shock Protein 27 Levels Represent a Potential Therapeutic Target for Atherosclerosis: Observations from a Human Cohort and Treatment of Female Mice
  Journal of the American College of Cardiology. Oct, 2013  |   Pubmed ID: 23764828
• Response to Letter Regarding Article, "Bivalirudin for Primary Percutaneous Coronary Interventions: Outcome Assessment in the Ottawa STEMI Registry"
  Circulation. Cardiovascular Interventions. Apr, 2013  |   Pubmed ID: 23591426
• Neuroimmune Guidance Cue Semaphorin 3E is Expressed in Atherosclerotic Plaques and Regulates Macrophage Retention
  Arteriosclerosis, Thrombosis, and Vascular Biology. May, 2013  |   Pubmed ID: 23430613
• Chronic Over-expression of Heat Shock Protein 27 Attenuates Atherogenesis and Enhances Plaque Remodeling: a Combined Histological and Mechanical Assessment of Aortic Lesions
  PloS One. 2013  |   Pubmed ID: 23409070
• Circulating Endothelial Progenitor Cells in HIV Infection: a Systematic Review
  Trends in Cardiovascular Medicine. Aug, 2013  |   Pubmed ID: 23395428
• Extracellular HSP27 Acts As a Signaling Molecule to Activate NF-κB in Macrophages
  Cell Stress & Chaperones. Jan, 2013  |   Pubmed ID: 22851137
• Percutaneous Coronary Intervention with or Without On-site Coronary Artery Bypass Surgery: a Systematic Review and Meta-analysis
  International Journal of Cardiology. Jul, 2013  |   Pubmed ID: 22240768
• Bivalirudin for Primary Percutaneous Coronary Interventions: Outcome Assessment in the Ottawa STEMI Registry
  Circulation. Cardiovascular Interventions. Dec, 2012  |   Pubmed ID: 23149331
• Natural History and Management of Aortocoronary Saphenous Vein Graft Aneurysms: a Systematic Review of Published Cases
  Circulation. Oct, 2012  |   Pubmed ID: 23109515
• Reduction in Mortality As a Result of Direct Transport from the Field to a Receiving Center for Primary Percutaneous Coronary Intervention
  Journal of the American College of Cardiology. Oct, 2012  |   Pubmed ID: 23017532
• Transradial Versus Transfemoral Artery Approach for Coronary Angiography and Percutaneous Coronary Intervention in the Extremely Obese
  JACC. Cardiovascular Interventions. Aug, 2012  |   Pubmed ID: 22917453
• Transbrachial Insertion of an Intra-aortic Balloon Pump for High-risk Percutaneous Coronary Intervention
  Clinical Research in Cardiology : Official Journal of the German Cardiac Society. Oct, 2012  |   Pubmed ID: 22552835
• Infective Endocarditis Presenting As ST-elevation Myocardial Infarction: an Angiographic Diagnosis
  The Canadian Journal of Cardiology. Jul-Aug, 2012  |   Pubmed ID: 22381910
• Circulating Endothelial Progenitor Cell Levels Are Not Reduced in HIV-infected Men
  The Journal of Infectious Diseases. Mar, 2012  |   Pubmed ID: 22238473
• Coronary Stent Fracture
  CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne. Aug, 2011  |   Pubmed ID: 21444617
• Pre-procedural Atorvastatin Mobilizes Endothelial Progenitor Cells: Clues to the Salutary Effects of Statins on Healing of Stented Human Arteries
  PloS One. 2011  |   Pubmed ID: 21283543
• Cardiovascular Complications of Salmonella Enteritidis Infection
  The Canadian Journal of Cardiology. Oct, 2010  |   Pubmed ID: 20931102
• Heat Shock Protein 27: Clue to Understanding Estrogen-mediated Atheroprotection?
  Trends in Cardiovascular Medicine. Feb, 2010  |   Pubmed ID: 20656216
• Delayed Re-endothelialization with Rapamycin-coated Stents is Rescued by the Addition of a Glycogen Synthase Kinase-3beta Inhibitor
  Cardiovascular Research. May, 2010  |   Pubmed ID: 20167573
• Primary Percutaneous Coronary Angioplasty with and Without Eptifibatide in ST-segment Elevation Myocardial Infarction: a Safety and Efficacy Study of Integrilin-facilitated Versus Primary Percutaneous Coronary Intervention in ST-segment Elevation Myocardial Infarction (ASSIST)
  Circulation. Cardiovascular Interventions. Aug, 2009  |   Pubmed ID: 20031736
• Heat Shock Protein 27 Protects Against Atherogenesis Via an Estrogen-dependent Mechanism: Role of Selective Estrogen Receptor Beta Modulation
  Arteriosclerosis, Thrombosis, and Vascular Biology. Nov, 2009  |   Pubmed ID: 19729610
• Inhibition of Endothelial Progenitor Cell Glycogen Synthase Kinase-3beta Results in Attenuated Neointima Formation and Enhanced Re-endothelialization After Arterial Injury
  Cardiovascular Research. Jul, 2009  |   Pubmed ID: 19454488
• Extracellular Release of the Atheroprotective Heat Shock Protein 27 is Mediated by Estrogen and Competitively Inhibits AcLDL Binding to Scavenger Receptor-A
  Circulation Research. Jul, 2008  |   Pubmed ID: 18566345
• Letter by Hibbert Et Al Regarding Article, "Smooth Muscle Cells Healing Atherosclerotic Plaque Disruptions Are of Local, Not Blood, Origin in Apolipoprotein E Knockout Mice"
  Circulation. Apr, 2008  |   Pubmed ID: 18427139
• Contribution of Recipient-derived Cells in Allograft Neointima Formation and the Response to Stent Implantation
  PloS One. 2008  |   Pubmed ID: 18365026
• A Citywide Protocol for Primary PCI in ST-segment Elevation Myocardial Infarction
  The New England Journal of Medicine. Jan, 2008  |   Pubmed ID: 18199862
• Discovery of NM23-H2 As an Estrogen Receptor Beta-associated Protein: Role in Estrogen-induced Gene Transcription and Cell Migration
  The Journal of Steroid Biochemistry and Molecular Biology. Jan, 2008  |   Pubmed ID: 17964137
• The Interaction and Cellular Localization of HSP27 and ERbeta Are Modulated by 17beta-estradiol and HSP27 Phosphorylation
  Molecular and Cellular Endocrinology. May, 2007  |   Pubmed ID: 17350752
• NM23-H2, an Estrogen Receptor Beta-associated Protein, Shows Diminished Expression with Progression of Atherosclerosis
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Feb, 2007  |   Pubmed ID: 17272673
• Comparison of Early Mortality of Paramedic-diagnosed ST-segment Elevation Myocardial Infarction with Immediate Transport to a Designated Primary Percutaneous Coronary Intervention Center to That of Similar Patients Transported to the Nearest Hospital
  The American Journal of Cardiology. Nov, 2006  |   Pubmed ID: 17134623
• Comparison of Processing and Sectioning Methodologies for Arteries Containing Metallic Stents
  The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Jun, 2006  |   Pubmed ID: 16714423
• Regulation of Components of the Brain and Cardiac Renin-angiotensin Systems by 17beta-estradiol After Myocardial Infarction in Female Rats
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2006  |   Pubmed ID: 16455770
• Combined Angioplasty and Pharmacological Intervention Versus Thrombolysis Alone in Acute Myocardial Infarction (CAPITAL AMI Study)
  Journal of the American College of Cardiology. Aug, 2005  |   Pubmed ID: 16053952
• Modulation of Estrogen Signaling by the Novel Interaction of Heat Shock Protein 27, a Biomarker for Atherosclerosis, and Estrogen Receptor Beta: Mechanistic Insight into the Vascular Effects of Estrogens
  Arteriosclerosis, Thrombosis, and Vascular Biology. Mar, 2005  |   Pubmed ID: 15662019
• 17beta-estradiol Downregulates Tissue Angiotensin-converting Enzyme and ANG II Type 1 Receptor in Female Rats
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Mar, 2005  |   Pubmed ID: 15550614
• Novel Antiinflammatory Vascular Benefits of Systemic and Stent-based Delivery of Ethylisopropylamiloride
  Circulation. Dec, 2004  |   Pubmed ID: 15505102
• C-kit-immunopositive Vascular Progenitor Cells Populate Human Coronary In-stent Restenosis but Not Primary Atherosclerotic Lesions
  American Journal of Physiology. Heart and Circulatory Physiology. Aug, 2004  |   Pubmed ID: 15277195
• Antagonism of the Alpha4 Integrin Subunit Attenuates the Acute Inflammatory Response to Stent Implantation Yet is Insufficient to Prevent Late Intimal Formation
  Journal of Leukocyte Biology. Jun, 2004  |   Pubmed ID: 15020653
• Hospitalization Costs of Primary Stenting Versus Thrombolysis in Acute Myocardial Infarction: Cost Analysis of the Canadian STAT Study
  Circulation. Nov, 2003  |   Pubmed ID: 14597591