Eleonora Mezzaroma Department of Pharmacotherapy and Outcome Science, School of Pharmacy Virginia Commonwealth University Biography Publications Institution JoVE Articles Eleonora Mezzaroma has not added a biography. If you are Eleonora Mezzaroma and would like to personalize this page please email our Author Liaison for assistance. Publications Assessment of Machine Perfusion Conditions for the Donation After Circulatory Death Heart Preservation Artificial Organs. Feb, 2022 | Pubmed ID: 35167122 The Interleukin-1 Receptor Type I Promotes the Development of Aging-associated Cardiomyopathy in Mice Cytokine. 03, 2022 | Pubmed ID: 35091314 The Inflammasome in Heart Failure Current Opinion in Physiology. Feb, 2021 | Pubmed ID: 34917871 Targeting the NLRP3 Inflammasome in Cardiovascular Diseases Pharmacology & Therapeutics. Dec, 2021 | Pubmed ID: 34906598 Improving Circulatory Death Donor Heart Function: A Novel Approach JTCVS Techniques. Oct, 2021 | Pubmed ID: 34647070 Refining Murine Heterotopic Heart Transplantation: A Model to Study Ischemia and Reperfusion Injury in Donation After Circulatory Death Hearts Animal Models and Experimental Medicine. 09, 2021 | Pubmed ID: 34557655 Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177 (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction Molecules (Basel, Switzerland). Jun, 2021 | Pubmed ID: 34207886 Mitigation of Radiation-Induced Lung and Heart Injuries in Mice by Oral Sepiapterin After Irradiation Radiation Research. 05, 2021 | Pubmed ID: 33822229 NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases Molecules (Basel, Switzerland). Feb, 2021 | Pubmed ID: 33673188 The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches JACC. Basic to Translational Science. Feb, 2021 | Pubmed ID: 33665514 Modulation of Interleukin-1 and -18 Mediated Injury in Donation After Circulatory Death Mouse Hearts The Journal of Surgical Research. 01, 2021 | Pubmed ID: 32896815 Targeting the NLRP3 Inflammasome to Reduce Warm Ischemic Injury in Donation After Circulatory Death Heart Clinical Transplantation. 10, 2020 | Pubmed ID: 32654189 Determinants of Cardiorespiratory Fitness Following Thoracic Radiotherapy in Lung or Breast Cancer Survivors The American Journal of Cardiology. 03, 2020 | Pubmed ID: 31928717 NLRP3 Inflammasome in Acute Myocardial Infarction Journal of Cardiovascular Pharmacology. 09, 2019 | Pubmed ID: 31356555 The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse Journal of Cardiovascular Pharmacology. 04, 2019 | Pubmed ID: 30747785 An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet-Induced Cardiac Dysfunction in Mice Journal of Cardiovascular Pharmacology. 12, 2018 | Pubmed ID: 30422890 Low-Density Lipoprotein Receptor-Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction JACC. Basic to Translational Science. Oct, 2017 | Pubmed ID: 30062170 Dietary Fat, Sugar Consumption, And Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction JACC. Basic to Translational Science. Oct, 2017 | Pubmed ID: 30062167 Reduction of Myocardial Ischemia-Reperfusion Injury by Inhibiting Interleukin-1 Alpha Journal of Cardiovascular Pharmacology. Mar, 2017 | Pubmed ID: 28267688 A Preclinical Translational Study of the Cardioprotective Effects of Plasma-Derived Alpha-1 Anti-trypsin in Acute Myocardial Infarction Journal of Cardiovascular Pharmacology. May, 2017 | Pubmed ID: 28195949 IPW-5371 Proves Effective As a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects Radiation Research. Nov, 2016 | Pubmed ID: 27841740 Biomarkers of Cardiac Injury in Patients Undergoing Thoracic Radiation Therapy International Journal of Cardiology. Nov, 2016 | Pubmed ID: 27552565 Targeting the Innate Immune Response to Improve Cardiac Graft Recovery After Heart Transplantation: Implications for the Donation After Cardiac Death International Journal of Molecular Sciences. Jun, 2016 | Pubmed ID: 27322252 Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia-Reperfusion Independent of Elastase Inhibition Journal of Cardiovascular Pharmacology. Jul, 2016 | Pubmed ID: 26945157 Inhibition of the NLRP3 Inflammasome Limits the Inflammatory Injury Following Myocardial Ischemia-reperfusion in the Mouse International Journal of Cardiology. Apr, 2016 | Pubmed ID: 26896627 A Mouse Model of Heart Failure with Preserved Ejection Fraction Due to Chronic Infusion of a Low Subpressor Dose of Angiotensin II American Journal of Physiology. Heart and Circulatory Physiology. Sep, 2015 | Pubmed ID: 26188021 A High-sugar and High-fat Diet Impairs Cardiac Systolic and Diastolic Function in Mice International Journal of Cardiology. Nov, 2015 | Pubmed ID: 26151718 Pharmacologic Inhibition of the NLRP3 Inflammasome Preserves Cardiac Function After Ischemic and Nonischemic Injury in the Mouse Journal of Cardiovascular Pharmacology. Jul, 2015 | Pubmed ID: 25915511 Role of Interleukin-1 in Radiation-Induced Cardiomyopathy Molecular Medicine (Cambridge, Mass.). Mar, 2015 | Pubmed ID: 25822795 Effects of Dimethyl Sulfoxide on the NLRP3 Inflammasome Immunobiology. Aug, 2015 | Pubmed ID: 25743943 Independent Roles of the Priming and the Triggering of the NLRP3 Inflammasome in the Heart Cardiovascular Research. Feb, 2015 | Pubmed ID: 25524927 The Inflammasome in Myocardial Injury and Cardiac Remodeling Antioxidants & Redox Signaling. May, 2015 | Pubmed ID: 25330141 Response to Letter Regarding Article, "targeting Interleukin-1 in Heart Disease" Circulation. Aug, 2014 | Pubmed ID: 25114193 Interleukin-1β Blockade Improves Left Ventricular Systolic/diastolic Function and Restores Contractility Reserve in Severe Ischemic Cardiomyopathy in the Mouse Journal of Cardiovascular Pharmacology. Jul, 2014 | Pubmed ID: 25006675 Letter by Mezzaroma, Et Al Regarding Article, "NLRP3 Inflammasome As a Therapeutic Target in Myocardial Infarction" International Heart Journal. 2014 | Pubmed ID: 24942779 Induction of MicroRNA-21 with Exogenous Hydrogen Sulfide Attenuates Myocardial Ischemic and Inflammatory Injury in Mice Circulation. Cardiovascular Genetics. Jun, 2014 | Pubmed ID: 24825878 Interleukin-18 As a Therapeutic Target in Acute Myocardial Infarction and Heart Failure Molecular Medicine (Cambridge, Mass.). Jun, 2014 | Pubmed ID: 24804827 Interleukin-18 Mediates Interleukin-1-induced Cardiac Dysfunction American Journal of Physiology. Heart and Circulatory Physiology. Apr, 2014 | Pubmed ID: 24531812 Formation of the Inflammasome in Acute Myocarditis International Journal of Cardiology. Feb, 2014 | Pubmed ID: 24439778 A Novel Pharmacologic Inhibitor of the NLRP3 Inflammasome Limits Myocardial Injury After Ischemia-reperfusion in the Mouse Journal of Cardiovascular Pharmacology. Apr, 2014 | Pubmed ID: 24336017 Targeting Interleukin-1 in Heart Disease Circulation. Oct, 2013 | Pubmed ID: 24146121 Comparative Cardiac Toxicity of Anthracyclines in Vitro and in Vivo in the Mouse PloS One. 2013 | Pubmed ID: 23516478 Interleukin-1β Blockade Improves Cardiac Remodelling After Myocardial Infarction Without Interrupting the Inflammasome in the Mouse Experimental Physiology. Mar, 2013 | Pubmed ID: 23180808 Inhibition of Apoptosis Signal-regulating Kinase 1 Reduces Myocardial Ischemia-reperfusion Injury in the Mouse Journal of the American Heart Association. Oct, 2012 | Pubmed ID: 23316291 GS-6201, a Selective Blocker of the A2B Adenosine Receptor, Attenuates Cardiac Remodeling After Acute Myocardial Infarction in the Mouse The Journal of Pharmacology and Experimental Therapeutics. Dec, 2012 | Pubmed ID: 22923737 Recombinant Human Interleukin-1 Receptor Antagonist Provides Cardioprotection During Myocardial Ischemia Reperfusion in the Mouse Cardiovascular Drugs and Therapy. Jun, 2012 | Pubmed ID: 22527620 Enhanced Interleukin-1 Activity Contributes to Exercise Intolerance in Patients with Systolic Heart Failure PloS One. 2012 | Pubmed ID: 22438931 A Mouse Model of Radiation-induced Cardiomyopathy International Journal of Cardiology. Apr, 2012 | Pubmed ID: 22340985 Alterations in the Interleukin-1/interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling Following Myocardial Infarction in the Mouse PloS One. 2011 | Pubmed ID: 22140485 The Inflammasome Promotes Adverse Cardiac Remodeling Following Acute Myocardial Infarction in the Mouse Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22106299 Altered Oxido-reductive State in the Diabetic Heart: Loss of Cardioprotection Due to Protein Disulfide Isomerase Molecular Medicine (Cambridge, Mass.). Sep-Oct, 2011 | Pubmed ID: 21637911 Alpha-1 Antitrypsin Inhibits Caspase-1 and Protects from Acute Myocardial Ischemia-reperfusion Injury Journal of Molecular and Cellular Cardiology. Aug, 2011 | Pubmed ID: 21600901 Left Ventricular Systolic Dysfunction Induced by Ventricular Ectopy: a Novel Model for Premature Ventricular Contraction-induced Cardiomyopathy Circulation. Arrhythmia and Electrophysiology. Aug, 2011 | Pubmed ID: 21576277 Right Ventricular Dysfunction Following Acute Myocardial Infarction in the Absence of Pulmonary Hypertension in the Mouse PloS One. Mar, 2011 | Pubmed ID: 21455304 Pharmacologic Inhibition of Phosphoinositide 3-kinase Gamma (PI3Kγ) Promotes Infarct Resorption and Prevents Adverse Cardiac Remodeling After Myocardial Infarction in Mice Journal of Cardiovascular Pharmacology. Dec, 2010 | Pubmed ID: 20881611 A Heterotopic Rat Heart Transplantation Model using Circulatory Death Donor Hearts Mohammed Quader1,2,3, Renee Cholyway1, Oluwatoyin Akande1, Jennifer Bradley1,2, Eleonora Mezzaroma4, Stefano Toldo2,5 1Division of Cardiothoracic Surgery, Department of Surgery, Virginia Commonwealth University, 2Pauley Heart Center, Virginia Commonwealth University Health System, 3Department of Surgery, McGuire Veterans Administration Medical Center, 4Department of Pharmacotherapy and Outcome Science, School of Pharmacy, Virginia Commonwealth University, 5Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University JoVE 63844 Medicine
A Heterotopic Rat Heart Transplantation Model using Circulatory Death Donor Hearts Mohammed Quader1,2,3, Renee Cholyway1, Oluwatoyin Akande1, Jennifer Bradley1,2, Eleonora Mezzaroma4, Stefano Toldo2,5 1Division of Cardiothoracic Surgery, Department of Surgery, Virginia Commonwealth University, 2Pauley Heart Center, Virginia Commonwealth University Health System, 3Department of Surgery, McGuire Veterans Administration Medical Center, 4Department of Pharmacotherapy and Outcome Science, School of Pharmacy, Virginia Commonwealth University, 5Division of Cardiology, Department of Internal Medicine, Virginia Commonwealth University JoVE 63844 Medicine
