Elijah N. McCool Department of Chemistry Michigan State University Biography Publications Institution JoVE Articles Elijah N. McCool Elijah McCool is a Ph. D. candidate in the Chemistry Department, Michigan State University, in East Lansing, MI. He received his Bachelor of Science in Chemistry from The University of North Carolina at Chapel Hill. His training is in analytical chemistry and he is in his third year in Dr. Liangliang Sun’s research group. His current project focuses on coupling capillary zone electrophoresis to mass spectrometry for the separation, identification, and characterization of intact proteins in complex proteomes. Direct characterization of intact proteoforms using this platform allows for elucidation of protein-level genetic variation and proteoform specific post-translational modifications that are essential to important biological processes. He hopes to use zebrafish as a model organism to better understand dynamics of biologically significant proteoforms across various stages in early embryonic development. Publications Deep Top-Down Proteomics Using Capillary Zone Electrophoresis-Tandem Mass Spectrometry: Identification of 5700 Proteoforms from the Escherichia Coli Proteome Analytical Chemistry. May, 2018 | Pubmed ID: 29620868 Single-Shot Top-Down Proteomics with Capillary Zone Electrophoresis-Electrospray Ionization-Tandem Mass Spectrometry for Identification of Nearly 600 Escherichia Coli Proteoforms Analytical Chemistry. Nov, 2017 | Pubmed ID: 29064224 Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry Elijah N. McCool*1, Rachele Lubeckyj*1, Xiaojing Shen1, Qiang Kou2, Xiaowen Liu2,3, Liangliang Sun1 1Department of Chemistry, Michigan State University, 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, 3Center for Computational Biology and Bioinformatics, Indiana University School of Medicine JoVE 58644 Chemistry
Large-scale Top-down Proteomics Using Capillary Zone Electrophoresis Tandem Mass Spectrometry Elijah N. McCool*1, Rachele Lubeckyj*1, Xiaojing Shen1, Qiang Kou2, Xiaowen Liu2,3, Liangliang Sun1 1Department of Chemistry, Michigan State University, 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, 3Center for Computational Biology and Bioinformatics, Indiana University School of Medicine JoVE 58644 Chemistry
