Elizabeth L. Siegler T Cell Engineering Laboratory Mayo Clinic, Rochester Biography Publications Institution JoVE Articles Elizabeth L. Siegler has not added a biography. If you are Elizabeth L. Siegler and would like to personalize this page please email our Author Liaison for assistance. Publications Challenges of CAR T-cell Therapy in CLL: Lessons Learned Experimental Hematology. Feb, 2022 | Pubmed ID: 35150777 Targeting Cancer-Associated Fibroblasts in the Bone Marrow Prevents Resistance to CART-Cell Therapy in Multiple Myeloma Blood. Jan, 2022 | Pubmed ID: 35090171 Development of a Clinically Relevant Reporter for Chimeric Antigen Receptor T-cell Expansion, Trafficking, and Toxicity Cancer Immunology Research. 09, 2021 | Pubmed ID: 34244299 CART Cell Imaging: Paving the Way for Success in CART Cell Therapy Molecular Therapy Oncolytics. Mar, 2021 | Pubmed ID: 33816781 Resistance to CART Cell Therapy: Lessons Learned from the Treatment of Hematological Malignancies Leukemia & Lymphoma. 09, 2021 | Pubmed ID: 33682608 CRISPR Takes the Front Seat in CART-Cell Development BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. Mar, 2021 | Pubmed ID: 33638865 Leukemic Extracellular Vesicles Induce Chimeric Antigen Receptor T cell Dysfunction in Chronic Lymphocytic Leukemia Molecular Therapy : the Journal of the American Society of Gene Therapy. 04, 2021 | Pubmed ID: 33388419 CART Cell Toxicities: New Insight into Mechanisms and Management Clinical Hematology International. Dec, 2020 | Pubmed ID: 33409484 A Concise Review of Neurologic Complications Associated with Chimeric Antigen Receptor T-cell Immunotherapy Neurologic Clinics. 11, 2020 | Pubmed ID: 33040871 Neurotoxicity and Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy: Insights Into Mechanisms and Novel Therapies Frontiers in Immunology. 2020 | Pubmed ID: 32983132 ERK Activation in CAR T Cells Is Amplified by CD28-Mediated Increase in CD3ζ Phosphorylation IScience. Apr, 2020 | Pubmed ID: 32325413 Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model Claudia Manriquez Roman1,2,3,4,5, R. Leo Sakemura1,2, Brooke L. Kimball1,2, Fang Jin6, Roman H. Khadka6, Mohamad M. Adada1,2, Elizabeth L. Siegler1,2, Aaron J. Johnson6, Saad S. Kenderian1,2,6 1T Cell Engineering Laboratory, Mayo Clinic, Rochester, 2Division of Hematology, Mayo Clinic, Rochester, 3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 4Department of Molecular Medicine, Mayo Clinic, Rochester, 5Regenerative Sciences PhD Program, Mayo Clinic, Rochester, 6Department of Immunology, Mayo Clinic, Rochester JoVE 64535 Cancer Research Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography Reona Sakemura1,2, Michelle J. Cox1,2, Aditya Bansal3, Claudia Manriquez Roman1,2,4,5, Mehrdad Hefazi1,2, Cynthia J. Vernon3, Dianna L. Glynn3, Mukesh K. Pandey3, Timothy R. DeGrado3, Elizabeth L. Siegler1,2, Saad S. Kenderian1,2,5,6 1T Cell Engineering, Mayo Clinic, 2Division of Hematology, Mayo Clinic, 3Department of Radiology, Mayo Clinic, 4Regenerative Sciences PhD, Mayo Clinic, 5Department of Molecular Medicine, Mayo Clinic, 6Department of Immunology, Mayo Clinic JoVE 62334 Cancer Research
Assessment of Chimeric Antigen Receptor T Cell-Associated Toxicities Using an Acute Lymphoblastic Leukemia Patient-Derived Xenograft Mouse Model Claudia Manriquez Roman1,2,3,4,5, R. Leo Sakemura1,2, Brooke L. Kimball1,2, Fang Jin6, Roman H. Khadka6, Mohamad M. Adada1,2, Elizabeth L. Siegler1,2, Aaron J. Johnson6, Saad S. Kenderian1,2,6 1T Cell Engineering Laboratory, Mayo Clinic, Rochester, 2Division of Hematology, Mayo Clinic, Rochester, 3Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic, Rochester, 4Department of Molecular Medicine, Mayo Clinic, Rochester, 5Regenerative Sciences PhD Program, Mayo Clinic, Rochester, 6Department of Immunology, Mayo Clinic, Rochester JoVE 64535 Cancer Research
Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography Reona Sakemura1,2, Michelle J. Cox1,2, Aditya Bansal3, Claudia Manriquez Roman1,2,4,5, Mehrdad Hefazi1,2, Cynthia J. Vernon3, Dianna L. Glynn3, Mukesh K. Pandey3, Timothy R. DeGrado3, Elizabeth L. Siegler1,2, Saad S. Kenderian1,2,5,6 1T Cell Engineering, Mayo Clinic, 2Division of Hematology, Mayo Clinic, 3Department of Radiology, Mayo Clinic, 4Regenerative Sciences PhD, Mayo Clinic, 5Department of Molecular Medicine, Mayo Clinic, 6Department of Immunology, Mayo Clinic JoVE 62334 Cancer Research
