Elizabeth Jaffee Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center The Johns Hopkins University School of Medicine Biography Publications Institution JoVE Articles Elizabeth Jaffee has not added a biography. If you are Elizabeth Jaffee and would like to personalize this page please email our Author Liaison for assistance. Publications A Feasibility Study of Cyclophosphamide, Trastuzumab, and an Allogeneic GM-CSF-Secreting Breast Tumor Vaccine for HER2+ Metastatic Breast Cancer Cancer Immunology Research. Aug, 2014 | Pubmed ID: 25116755 PAK1 Mediates Pancreatic Cancer Cell Migration and Resistance to MET Inhibition The Journal of Pathology. Jul, 2014 | Pubmed ID: 25074413 Immunobiology of Radiotherapy: New Paradigms Radiation Research. Aug, 2014 | Pubmed ID: 25036983 A Safety and Feasibility Study of an Allogeneic Colon Cancer Cell Vaccine Administered with a Granulocyte-Macrophage Colony Stimulating Factor-Producing Bystander Cell Line in Patients with Metastatic Colorectal Cancer Annals of Surgical Oncology. Jun, 2014 | Pubmed ID: 24943235 Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation Cancer Immunology Research. Jul, 2014 | Pubmed ID: 24942756 Development of Thyroglobulin Antibodies After GVAX Immunotherapy is Associated with Prolonged Survival International Journal of Cancer. Journal International Du Cancer. May, 2014 | Pubmed ID: 24832153 Oncogenic Kras Activates a Hematopoietic-to-epithelial IL-17 Signaling Axis in Preinvasive Pancreatic Neoplasia Cancer Cell. May, 2014 | Pubmed ID: 24823639 Can We Predict Mutant Neoepitopes in Human Cancers for Patient-specific Vaccine Therapy? Cancer Immunology Research. Jun, 2014 | Pubmed ID: 24795140 Apoptosis-regulated Low-avidity Cancer-specific CD8(+) T Cells Can Be Rescued to Eliminate HER2/neu-expressing Tumors by Costimulatory Agonists in Tolerized Mice Cancer Immunology Research. Apr, 2014 | Pubmed ID: 24764578 A Listeria Vaccine and Depletion of T-regulatory Cells Activate Immunity Against Early Stage Pancreatic Intraepithelial Neoplasms and Prolong Survival of Mice Gastroenterology. Jun, 2014 | Pubmed ID: 24607504 Fusion Protein of Mutant B7-DC and Fc Enhances the Antitumor Immune Effect of GM-CSF-secreting Whole-cell Vaccine Journal of Immunotherapy (Hagerstown, Md. : 1997). Apr, 2014 | Pubmed ID: 24598447 Vaccine Therapy for Pancreatic Cancer Oncoimmunology. Dec, 2013 | Pubmed ID: 24498551 Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances Cancer Immunology Research. Jul, 2013 | Pubmed ID: 24409447 Mapping Patterns of Local Recurrence After Pancreaticoduodenectomy for Pancreatic Adenocarcinoma: a New Approach to Adjuvant Radiation Field Design International Journal of Radiation Oncology, Biology, Physics. Dec, 2013 | Pubmed ID: 24267969 Peptidases Released by Necrotic Cells Control CD8+ T Cell Cross-priming The Journal of Clinical Investigation. Nov, 2013 | Pubmed ID: 24216478 Harnessing Immune Responses in the Tumor Microenvironment: All Signals Needed Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2013 | Pubmed ID: 24097857 Low Total Lymphocyte Count is Associated with Poor Survival in Patients with Resected Pancreatic Adenocarcinoma Receiving a GM-CSF Secreting Pancreatic Tumor Vaccine Annals of Surgical Oncology. Dec, 2013 | Pubmed ID: 24046118 Evaluation of Ipilimumab in Combination with Allogeneic Pancreatic Tumor Cells Transfected with a GM-CSF Gene in Previously Treated Pancreatic Cancer Journal of Immunotherapy (Hagerstown, Md. : 1997). Sep, 2013 | Pubmed ID: 23924790 Next-generation Cancer Vaccine Approaches: Integrating Lessons Learned from Current Successes with Promising Biotechnologic Advances Journal of the National Comprehensive Cancer Network : JNCCN. Jul, 2013 | Pubmed ID: 23847215 Women in Oncology: Progress, Challenges, and Keys to Success American Society of Clinical Oncology Educational Book / ASCO. American Society of Clinical Oncology. Meeting. 2013 | Pubmed ID: 23714569 Immunotherapy in Preneoplastic Disease: Targeting Early Procarcinogenic Inflammatory Changes That Lead to Immune Suppression and Tumor Tolerance Annals of the New York Academy of Sciences. May, 2013 | Pubmed ID: 23651188 Role of Immune Cells and Immune-based Therapies in Pancreatitis and Pancreatic Ductal Adenocarcinoma Gastroenterology. Jun, 2013 | Pubmed ID: 23622132 Development of a Cytokine-modified Allogeneic Whole Cell Pancreatic Cancer Vaccine Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23359154 Personalized Chemotherapy Profiling Using Cancer Cell Lines from Selectable Mice Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2013 | Pubmed ID: 23340293 Effects of Genomic Changes in Hepatitis B Virus on Postoperative Recurrence and Survival in Patients with Hepatocellular Carcinoma Annals of Surgical Oncology. Apr, 2013 | Pubmed ID: 23104706 Evaluation of Predictive Variables in Locally Advanced Pancreatic Adenocarcinoma Patients Receiving Definitive Chemoradiation Practical Radiation Oncology. 2012 | Pubmed ID: 23585823 胰腺癌的疫苗。 Cancer Journal (Sudbury, Mass.). Nov, 2012 | Pubmed ID: 23187853 针对适当的规范性 T 细胞肿瘤免疫治疗的人口。 Oncoimmunology. Oct, 2012 | Pubmed ID: 23170276 Rapid Characterization of Candidate Biomarkers for Pancreatic Cancer Using Cell Microarrays (CMAs) Journal of Proteome Research. Nov, 2012 | Pubmed ID: 22985314 同时针对肿瘤细胞和诱导的 T 细胞反应的淡化,有效地抑制乳腺癌曲妥珠单抗耐药。 Cancer Research. Sep, 2012 | Pubmed ID: 22773664 规管在疫苗方法中使用环磷酰胺的 T 细胞调制: 当前的角度来看。 Cancer Research. Jul, 2012 | Pubmed ID: 22761338 膜联蛋白 A2 是胰腺肿瘤免疫治疗新抗原性目标。 Oncoimmunology. Jan, 2012 | Pubmed ID: 22720228 全细胞疫苗 — — 过去的进展和今后的战略。 Seminars in Oncology. Jun, 2012 | Pubmed ID: 22595050 发展新型临床前期胰腺癌的研究模型: 生物发光图像引导重点照射和原位移植瘤肿瘤监测。 Translational Oncology. Apr, 2012 | Pubmed ID: 22496923 肿瘤免疫原性的决定因素。 Nature Reviews. Cancer. Apr, 2012 | Pubmed ID: 22378190 贩运高亲和力表皮 2 纽特定 T 细胞到表皮 2/纽表示肿瘤后耗尽效应内存样规管的 T 细胞。 PloS One. 2012 | Pubmed ID: 22359647 减毒活李斯特菌疫苗 (澳新银行-100) 和表示 Mesothelin (CRS-207) 减毒活李斯特菌疫苗先进癌症: 第一阶段的安全和免疫诱导的研究。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2012 | Pubmed ID: 22147941 在肿瘤免疫治疗中定义的关键障碍。 Journal of Translational Medicine. 2011 | Pubmed ID: 22168571 创人类胰腺癌细胞中的 DNA 修复基因表达增加。 Pancreas. Jul, 2011 | Pubmed ID: 21633318 23 酪氨酸磷酸化依赖细胞表面本地化蛋白 A2 是入侵和胰腺癌转移所必需的。 PloS One. 2011 | Pubmed ID: 21572519 第 25 年度科学会议的国际社会的癌症生物治疗的审查。 Journal of Translational Medicine. 2011 | Pubmed ID: 21569425 Nondominant 的 CD8 T 细胞疫苗诱导的抗肿瘤免疫反应的主要参与者。 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2011 | Pubmed ID: 21346233 A Lethally Irradiated Allogeneic Granulocyte-macrophage Colony Stimulating Factor-secreting Tumor Vaccine for Pancreatic Adenocarcinoma. A Phase II Trial of Safety, Efficacy, and Immune Activation Annals of Surgery. Feb, 2011 | Pubmed ID: 21217520 CD8⁺ Foxp3⁺ 肿瘤浸润淋巴细胞会堆积在有效的抗肿瘤反应的上下文中。 International Journal of Cancer. Journal International Du Cancer. Aug, 2011 | Pubmed ID: 20857491 肿瘤抗原为目标的、 基于单克隆抗体的免疫治疗: 临床反应、 细胞免疫和 Immunoescape。 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2010 | Pubmed ID: 20697078 细胞疫苗的方法。 Cancer Journal (Sudbury, Mass.). Jul-Aug, 2010 | Pubmed ID: 20693840 紫杉醇增强了早期的树突状细胞成熟和功能通过 TLR4 信号转导小鼠。 Cellular Immunology. 2010 | Pubmed ID: 20346445 定时与环磷酰胺、 阿霉素、 同种异体粒细胞-巨噬细胞集落刺激因子分泌乳腺肿瘤疫苗的序贯治疗: 化疗剂量范围析因研究的安全性和免疫激活。 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2009 | Pubmed ID: 19805669 SMAD4 基因突变在胰腺癌组织中是与预后不良相关联。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2009 | Pubmed ID: 19584151 OX40 协同信号可以废除 Foxp3 + 监管 T 细胞介导的抑制肿瘤免疫。 International Journal of Cancer. Journal International Du Cancer. Aug, 2009 | Pubmed ID: 19455675 基因突变与胰腺癌组织中吸烟相关联。 Cancer Research. Apr, 2009 | Pubmed ID: 19351817 Exomic 测序标识 PALB2 作为胰腺癌易感基因。 Science (New York, N.Y.). Apr, 2009 | Pubmed ID: 19264984 使用作为癌症治疗肿瘤反应的 T 细胞。 Lancet. Feb, 2009 | Pubmed ID: 19231634 规管 T 细胞的有效消耗允许招募 Mesothelin 特定 CD8 T 细胞对 Mesothelin 表示对肿瘤的免疫反应鼠标胰腺癌。 Clinical and Translational Science. Dec, 2008 | Pubmed ID: 20357913 信号通路在人类胰腺癌揭示全球基因组分析的核心。 Science (New York, N.Y.). Sep, 2008 | Pubmed ID: 18772397 Analysis of Fluorouracil-based Adjuvant Chemotherapy and Radiation After Pancreaticoduodenectomy for Ductal Adenocarcinoma of the Pancreas: Results of a Large, Prospectively Collected Database at the Johns Hopkins Hospital Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2008 | Pubmed ID: 18640931 表皮-2/纽针对性的疫苗与抗体协会增强小鼠通过介导 Fc 激活的 DCs 的 CD8 T 细胞反应。 The Journal of Clinical Investigation. May, 2008 | Pubmed ID: 18398507 疫苗阻碍反流引起食管癌手术大鼠模型中的发展: 在开机自检巴雷特食管设置疫苗效果。 Digestive Diseases and Sciences. Nov, 2008 | Pubmed ID: 18343998 Allogeneic Granulocyte Macrophage Colony-stimulating Factor-secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: a Pilot Study of Safety, Feasibility, and Immune Activation Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2008 | Pubmed ID: 18316569 疫苗阻碍反流引起食管癌手术大鼠模型中的发展: 在 Pre 巴雷特食管设置疫苗的效力。 Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract. Jan, 2008 | Pubmed ID: 17957441 MORAb-009,针对肿瘤相关 Mesothelin 嵌合抗体的临床前评价。 Cancer Immunity. 2007 | Pubmed ID: 18088084 改变的细胞和体液免疫的突变的 P53 蛋白与加工突变体肽的头部和颈部癌症。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056201 Alphaviral 矢量转导树突状细胞是新生超量表达肿瘤的野生型小鼠成功治疗性疫苗。 Vaccine. Sep, 2007 | Pubmed ID: 17675184 血管内皮生长因子受体-2 抑制剂通过基于免疫机制可增强抗肿瘤免疫。 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2007 | Pubmed ID: 17606729 癌症研究和癌症生物学家: 为什么我们没再谈,但现在需要。 Cancer Research. Apr, 2007 | Pubmed ID: 17413003 Cytogenetic Characterization and Gene Expression Profiling in the Rat Reflux-induced Esophageal Tumor Model The Journal of Thoracic and Cardiovascular Surgery. Mar, 2007 | Pubmed ID: 17320581 Ectopic Expression of Vascular Cell Adhesion Molecule-1 As a New Mechanism for Tumor Immune Evasion Cancer Research. Feb, 2007 | Pubmed ID: 17308126 Mechanisms of Immune Evasion by Tumors Advances in Immunology. 2006 | Pubmed ID: 16730261 Ductal Access for Prevention and Therapy of Mammary Tumors Cancer Research. Jan, 2006 | Pubmed ID: 16423990 OX40 协同信号淡化 GM-CSF 全细胞疫苗注射,以克服对内源性肿瘤抗原的既定的 CD8 + T 细胞耐受性。 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2006 | Pubmed ID: 16393983 基因疫苗免疫治疗: 分子生物学革命了癌症免疫学的影响。 Molecular Cancer Therapeutics. Nov, 2005 | Pubmed ID: 16275985 结合多学科综合治疗的癌症疫苗。 Cancer Treatment and Research. 2005 | Pubmed ID: 16211873 利用细胞毒化疗的肿瘤疫苗的活动。 Cancer Research. Sep, 2005 | Pubmed ID: 16166275 融合到 Listeriolysin O 和李斯特菌交付增强免疫原性表皮-2/纽和揭示了在 FVB/N 鼠标随意抗原决定簇。 Journal of Immunology (Baltimore, Md. : 1950). Sep, 2005 | Pubmed ID: 16148111 过敏和胰腺癌的风险: 流行病学和生物机制的审查与 Meta 分析。 Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Aug, 2005 | Pubmed ID: 16103436 免疫治疗胰腺癌-科学驾驶的临床研究进展。 Nature Reviews. Cancer. Jun, 2005 | Pubmed ID: 15905855 招聘潜池高亲和力 CD8(+) T 细胞对肿瘤的免疫反应。 The Journal of Experimental Medicine. May, 2005 | Pubmed ID: 15883172 多样化的 CD8 + T 细胞反应,对患者的肾细胞癌抗原治疗自体粒细胞-巨噬细胞集落刺激因子基因转导肾肿瘤细胞疫苗。 Cancer Research. Feb, 2005 | Pubmed ID: 15705910 从肾细胞癌患者的肿瘤特异性 CD4 + T 细胞识别不同的共享的抗原。 International Journal of Cancer. Journal International Du Cancer. Jul, 2005 | Pubmed ID: 15704175 细胞因子修改同种异体全细胞胰腺肿瘤疫苗的研制。 Methods in Molecular Medicine. 2005 | Pubmed ID: 15542914 脂肪酸合酶抑制剂是纽 N 转基因小鼠乳腺癌化学预防。 Oncogene. Jan, 2005 | Pubmed ID: 15489885 增加乳腺癌肿瘤疫苗的效价: 联合免疫治疗方式。 Breast Disease. 2004 | Pubmed ID: 15687703 Mesothelin 特定 CD8(+) T 细胞反应提供证据证明跨吸体内的抗原递呈细胞接种疫苗的胰腺癌患者。 The Journal of Experimental Medicine. Aug, 2004 | Pubmed ID: 15289501 A Phase I Vaccine Safety and Chemotherapy Dose-finding Trial of an Allogeneic GM-CSF-secreting Breast Cancer Vaccine Given in a Specifically Timed Sequence with Immunomodulatory Doses of Cyclophosphamide and Doxorubicin Human Gene Therapy. Mar, 2004 | Pubmed ID: 15018740 对乳腺肿瘤疫苗: 进展中的工作。 Oncology (Williston Park, N.Y.). Sep, 2003 | Pubmed ID: 14569849 癌症疫苗: 一个旧的念头的年龄。 Cancer Biology & Therapy. Jul-Aug, 2003 | Pubmed ID: 14508095 表皮 2 纽特定单克隆抗体与表皮 2/纽针对性的粒细胞巨噬细胞集落刺激因子分泌全细胞疫苗接种增加,CD8 + T 细胞效应功能和无瘤生存在她-2/纽-转基因小鼠中的进行协作。 Journal of Immunology (Baltimore, Md. : 1950). Aug, 2003 | Pubmed ID: 12902523 Spatial Distribution of Tumor Vaccine Improves Efficacy The Laryngoscope. Aug, 2003 | Pubmed ID: 12897566 慢病毒介导的基因转移和既定的人类肿瘤抗原特异性细胞毒性 T 细胞和初级静态的 T 细胞中的表达。 Human Gene Therapy. Jul, 2003 | Pubmed ID: 12885348 主要组织相容性复合类二限制胞浆抗原的自体吞噬的演示文稿。 European Journal of Immunology. May, 2003 | Pubmed ID: 12731050 鉴定及其免疫显性大鼠表皮-2/纽 MHC I 类抗原表位提出从表皮 2/纽转基因小鼠的自发性乳腺肿瘤。 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2003 | Pubmed ID: 12682262 Exploration of Global Gene Expression Patterns in Pancreatic Adenocarcinoma Using CDNA Microarrays The American Journal of Pathology. Apr, 2003 | Pubmed ID: 12651607 Genetically Engineered Tumor Cell Vaccine in a Head and Neck Cancer Model The Laryngoscope. Mar, 2003 | Pubmed ID: 12616213 细胞凋亡,但没有坏死,肿瘤细胞疫苗诱导体内强效免疫应答。 International Journal of Cancer. Journal International Du Cancer. Jan, 2003 | Pubmed ID: 12455034 细胞因子修改肿瘤疫苗。 Surgical Oncology Clinics of North America. Jul, 2002 | Pubmed ID: 12487062 活还是不活: 这取决于应变片吗? Cancer Biology & Therapy. Jul-Aug, 2002 | Pubmed ID: 12432252 胰腺癌。 Current Problems in Cancer. Jul-Aug, 2002 | Pubmed ID: 12399802 胰腺癌的重点。 Cancer Cell. Jul, 2002 | Pubmed ID: 12150822 细胞因子基因修饰细胞为基础的癌症疫苗。 Methods in Molecular Medicine. 2002 | Pubmed ID: 11987781 Aberrant CpG Island Methylation in Cancer Cell Lines Arises in the Primary Cancers from Which They Were Derived Oncogene. Mar, 2002 | Pubmed ID: 11960385 肝转移的临床前小鼠模型 Kevin C. Soares1, Kelly Foley2, Kelly Olino1, Ashley Leubner2, Skye C. Mayo1, Ajay Jain1, Elizabeth Jaffee2, Richard D. Schulick3, Kiyoshi Yoshimura1,2, Barish Edil1,2, Lei Zheng1,2 1Department of Surgery, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 3Department of Surgery, University of Colorado Anschutz Medical Campus JoVE 51677 Medicine
肝转移的临床前小鼠模型 Kevin C. Soares1, Kelly Foley2, Kelly Olino1, Ashley Leubner2, Skye C. Mayo1, Ajay Jain1, Elizabeth Jaffee2, Richard D. Schulick3, Kiyoshi Yoshimura1,2, Barish Edil1,2, Lei Zheng1,2 1Department of Surgery, The Johns Hopkins University School of Medicine, 2Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, 3Department of Surgery, University of Colorado Anschutz Medical Campus JoVE 51677 Medicine