Articles by Emily Carbone in JoVE
Treating SCA1 Mice with Water-Soluble Compounds to Non-Specifically Boost Mitochondrial Function Austin Ferro1, Emily Carbone1, Evan Marzouk1, Asher Siegel2, Donna Nguyen1, Kailen Polley1, Jessilyn Hartman1, Kimberley Frederick2, Stephen Ives3, Sarita Lagalwar1 1Neuroscience Program, Skidmore College, 2Chemistry Department, Skidmore College, 3Health and Exercise Science Department, Skidmore College We present a biochemical and behavioral protocol to evaluate the efficacy of mitochondria-targeted water-soluble compounds for the treatment of Spinocerebellar ataxia type 1 (SCA1) and other cerebellar neurodegenerative diseases.
Other articles by Emily Carbone on PubMed
Assessing the Reliability and Validity of Direct Observation and Traffic Camera Streams to Measure Helmet and Motorcycle Use Injury Prevention : Journal of the International Society for Child and Adolescent Injury Prevention. Dec, 2015 | Pubmed ID: 25617341 There is a need to develop motorcycle helmet surveillance approaches that are less labour intensive than direct observation (DO), which is the commonly recommended but never formally validated approach, particularly in developing settings. This study sought to assess public traffic camera feeds as an alternative to DO, in addition to the reliability of DO under field conditions. DO had high inter-rater reliability, κ=0.88 and 0.84, respectively, for cycle type and helmet type, which reinforces its use as a gold standard. However, traffic camera-based data collection was found to be unreliable, with κ=0.46 and 0.53 for cycle type and helmet type. When bicycles, motorcycles and scooters were classified based on traffic camera streams, only 68.4% of classifications concurred with those made via DO. Given the current technology, helmet surveillance via traffic camera streams is infeasible, and there remains a need for innovative traffic safety surveillance approaches in low-income urban settings.