Eric B. Kmiec

Publications

• CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome
  Molecular Therapy. Nucleic Acids. Jun, 2017  |   Pubmed ID: 28624204
• To Cleave or Not to Cleave: Therapeutic Gene Editing with and Without Programmable Nucleases
  Nature Reviews. Drug Discovery. Apr, 2017  |   Pubmed ID: 28303022
• Insertional Mutagenesis by CRISPR/Cas9 Ribonucleoprotein Gene Editing in Cells Targeted for Point Mutation Repair Directed by Short Single-Stranded DNA Oligonucleotides
  PloS One. 2017  |   Pubmed ID: 28052104
• Analyses of Point Mutation Repair and Allelic Heterogeneity Generated by CRISPR/Cas9 and Single-stranded DNA Oligonucleotides
  Scientific Reports. Sep, 2016  |   Pubmed ID: 27609304
• Genetic Spell-checking: Gene Editing Using Single-stranded DNA Oligonucleotides
  Plant Biotechnology Journal. Feb, 2016  |   Pubmed ID: 26402400
• Regulation of Gene Editing Activity Directed by Single-Stranded Oligonucleotides and CRISPR/Cas9 Systems
  PloS One. 2015  |   Pubmed ID: 26053390
• Is the Age of Genetic Surgery Finally Upon Us?
  Surgical Oncology. Jun, 2015  |   Pubmed ID: 25936245
• The Position of DNA Cleavage by TALENs and Cell Synchronization Influences the Frequency of Gene Editing Directed by Single-stranded Oligonucleotides
  PloS One. 2014  |   Pubmed ID: 24788536
• Enrichment of Breast Cancer Stem-like Cells by Growth on Electrospun Polycaprolactone-chitosan Nanofiber Scaffolds
  International Journal of Nanomedicine. 2014  |   Pubmed ID: 24570583
• Combinatorial Gene Editing in Mammalian Cells Using SsODNs and TALENs
  Scientific Reports. Jan, 2014  |   Pubmed ID: 24445749
• Electrospun Fiber Membranes Enable Proliferation of Genetically Modified Cells
  International Journal of Nanomedicine. 2013  |   Pubmed ID: 23467983
• DNA Damage Response Pathway and Replication Fork Stress During Oligonucleotide Directed Gene Editing
  Molecular Therapy. Nucleic Acids. Apr, 2012  |   Pubmed ID: 23343929
• Proliferation of Genetically Modified Human Cells on Electrospun Nanofiber Scaffolds
  Molecular Therapy. Nucleic Acids. 2012  |   Pubmed ID: 23212298
• Oligonucleotide Delivery by Nucleofection Does Not Rescue the Reduced Proliferation Phenotype of Gene-edited Cells
  Nucleic Acid Therapeutics. Dec, 2012  |   Pubmed ID: 23072627
• Modifications of P53 and the DNA Damage Response in Cells Expressing Mutant Form of the Protein Huntingtin
  Journal of Molecular Neuroscience : MN. Oct, 2011  |   Pubmed ID: 21465263
• Strand Bias Influences the Mechanism of Gene Editing Directed by Single-stranded DNA Oligonucleotides
  Nucleic Acids Research. Jun, 2011  |   Pubmed ID: 21343181
• Gene Editing Activity on Extrachromosomal Arrays in C. Elegans Transgenics
  Gene. Apr, 2011  |   Pubmed ID: 21241788
• A Stable G-quartet Binds to a Huntingtin Protein Fragment Containing Expanded Polyglutamine Tracks
  Journal of Neuroscience Research. Feb, 2010  |   Pubmed ID: 19705452
• DNA Breakage Associated with Targeted Gene Alteration Directed by DNA Oligonucleotides
  Mutation Research. Oct, 2009  |   Pubmed ID: 19463835
• Regulation of Targeted Gene Repair by Intrinsic Cellular Processes
  BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. Feb, 2009  |   Pubmed ID: 19204988
• DNA Breakage and Induction of DNA Damage Response Proteins Precede the Appearance of Visible Mutant Huntingtin Aggregates
  Journal of Neuroscience Research. Feb, 2009  |   Pubmed ID: 18831068
• DNA Replication, Cell Cycle Progression and the Targeted Gene Repair Reaction
  Cell Cycle (Georgetown, Tex.). May, 2008  |   Pubmed ID: 18424915
• G-rich Oligonucleotides Alter Cell Cycle Progression and Induce Apoptosis Specifically in OE19 Esophageal Tumor Cells
  Oligonucleotides. 2008  |   Pubmed ID: 18321162
• Genetic Conversion of an SMN2 Gene to SMN1: a Novel Approach to the Treatment of Spinal Muscular Atrophy
  Experimental Cell Research. Feb, 2008  |   Pubmed ID: 18078930
• Recovery of Cell Cycle Delay Following Targeted Gene Repair by Oligonucleotides
  DNA Repair. Oct, 2007  |   Pubmed ID: 17560837
• Manipulation of Cell Cycle Progression Can Counteract the Apparent Loss of Correction Frequency Following Oligonucleotide-directed Gene Repair
  BMC Molecular Biology. Feb, 2007  |   Pubmed ID: 17284323
• Reduction of Gene Repair by Selenomethionine with the Use of Single-stranded Oligonucleotides
  BMC Molecular Biology. Jan, 2007  |   Pubmed ID: 17257432
• Multiple Roles for MSH2 in the Repair of a Deletion Mutation Directed by Modified Single-stranded Oligonucleotides
  Gene. Jan, 2007  |   Pubmed ID: 17113727
• Targeted Gene Repair Activates Chk1 and Chk2 and Stalls Replication in Corrected Cells
  DNA Repair. Apr, 2006  |   Pubmed ID: 16414312
• A Tolerance of DNA Heterology in the Mammalian Targeted Gene Repair Reaction
  Oligonucleotides. 2005  |   Pubmed ID: 16201904
• Reaction Parameters of Targeted Gene Repair in Mammalian Cells
  Molecular Biotechnology. Mar, 2005  |   Pubmed ID: 15767697
• Gene Repair in Mammalian Cells is Stimulated by the Elongation of S Phase and Transient Stalling of Replication Forks
  DNA Repair. Apr, 2005  |   Pubmed ID: 15725625
• Fluorescent Detection and Isolation of DNA Variants Using Stabilized RecA-coated Oligonucleotides
  Discovery Medicine. Apr, 2004  |   Pubmed ID: 20705000
• Double Displacement Loops (double D-loops) Are Templates for Oligonucleotide-directed Mutagenesis and Gene Repair
  Oligonucleotides. 2004  |   Pubmed ID: 15665595
• Camptothecin Enhances the Frequency of Oligonucleotide-directed Gene Repair in Mammalian Cells by Inducing DNA Damage and Activating Homologous Recombination
  Nucleic Acids Research. 2004  |   Pubmed ID: 15466591
• Modified Single-stranded Oligonucleotides Inhibit Aggregate Formation and Toxicity Induced by Expanded Polyglutamine
  Journal of Molecular Neuroscience : MN. 2004  |   Pubmed ID: 15456939
• Enhanced Oligonucleotide-directed Gene Targeting in Mammalian Cells Following Treatment with DNA Damaging Agents
  Experimental Cell Research. Oct, 2004  |   Pubmed ID: 15383324
• DNA Replication and Transcription Direct a DNA Strand Bias in the Process of Targeted Gene Repair in Mammalian Cells
  Journal of Cell Science. Aug, 2004  |   Pubmed ID: 15265980
• Genetic Re-engineering of Saccharomyces Cerevisiae RAD51 Leads to a Significant Increase in the Frequency of Gene Repair in Vivo
  Nucleic Acids Research. 2004  |   Pubmed ID: 15087488
• Enhancement of in Vivo Targeted Nucleotide Exchange by Nonspecific Carrier DNA
  Methods in Molecular Biology (Clifton, N.J.). 2004  |   Pubmed ID: 14769964
• Fluorescent Detection and Isolation of DNA Variants Using Stabilized RecA-coated Oligonucleotides
  Genome Research. Jan, 2004  |   Pubmed ID: 14672976
• The Effect of Hydroxyurea and Trichostatin a on Targeted Nucleotide Exchange in Yeast and Mammalian Cells
  Annals of the New York Academy of Sciences. Dec, 2003  |   Pubmed ID: 14751821
• Reduction of Htt Inclusion Formation in Strains of Saccharomyces Cerevisiae Deficient in Certain DNA Repair Functions: a Statistical Analysis of Phenotype
  Experimental Cell Research. Nov, 2003  |   Pubmed ID: 14597407
• Nuclease Activity of Saccharomyces Cerevisiae Mre11 Functions in Targeted Nucleotide Alteration
  Applied and Environmental Microbiology. Oct, 2003  |   Pubmed ID: 14532083
• Targeted Nucleotide Exchange in the CAG Repeat Region of the Human HD Gene
  Biochemical and Biophysical Research Communications. Oct, 2003  |   Pubmed ID: 14521962
• Targeted Gene Repair -- in the Arena
  The Journal of Clinical Investigation. Sep, 2003  |   Pubmed ID: 12952907
• The Development and Regulation of Gene Repair
  Nature Reviews. Genetics. Sep, 2003  |   Pubmed ID: 12951569
• Targeted Nucleotide Repair of Cyc1 Mutations in Saccharomyces Cerevisiae Directed by Modified Single-stranded DNA Oligonucleotides
  Genetics. Feb, 2003  |   Pubmed ID: 12618392
• The Synaptic Complex of RecA Protein Participates in Hybridization and Inverse Strand Exchange Reactions
  Biochemistry. Mar, 2003  |   Pubmed ID: 12614159
• Efficiency of Chimeraplast Gene Targeting by Direct Nuclear Injection Using a GFP Recovery Assay
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2003  |   Pubmed ID: 12597913
• DNA Pairing is an Important Step in the Process of Targeted Nucleotide Exchange
  Nucleic Acids Research. Feb, 2003  |   Pubmed ID: 12560486
• Nucleotide Replacement at Two Sites Can Be Directed by Modified Single-stranded Oligonucleotides in Vitro and in Vivo
  Biomolecular Engineering. Jan, 2003  |   Pubmed ID: 12485680
• Targeted Nucleotide Exchange in Saccharomyces Cerevisiae Directed by Short Oligonucleotides Containing Locked Nucleic Acids
  Chemistry & Biology. Oct, 2002  |   Pubmed ID: 12401492
• Rad51p and Rad54p, but Not Rad52p, Elevate Gene Repair in Saccharomyces Cerevisiae Directed by Modified Single-stranded Oligonucleotide Vectors
  Nucleic Acids Research. Jul, 2002  |   Pubmed ID: 12087156
• The 'biased' Evolution of Targeted Gene Repair
  Current Opinion in Molecular Therapeutics. Apr, 2002  |   Pubmed ID: 12044039
• Strand Bias in Targeted Gene Repair is Influenced by Transcriptional Activity
  Molecular and Cellular Biology. Jun, 2002  |   Pubmed ID: 11997519
• Targeted Gene Repair and Its Application to Neurodegenerative Disorders
  Neuron. Feb, 2002  |   Pubmed ID: 11856524