Etienne Lefai

Publications

• Feedback Loop Regulation of SCAP/SREBP-1 by MiR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth
  Cell Reports. Jan, 2017  |   Pubmed ID: 28122233
• Effects of Training and Detraining on Adiponectin Plasma Concentration and Muscle Sensitivity in Lean and Overweight Men
  European Journal of Applied Physiology. Dec, 2016  |   Pubmed ID: 27632382
• Transition from Physical Activity to Inactivity Increases Skeletal Muscle MiR-148b Content and Triggers Insulin Resistance
  Physiological Reports. Sep, 2016  |   Pubmed ID: 27597765
• Feedback Loop Regulation of SCAP/SREBP-1 by MiR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth
  Cell Reports. Aug, 2016  |   Pubmed ID: 27477273
• Inhibition of SOAT1 Suppresses Glioblastoma Growth Via Blocking SREBP-1-Mediated Lipogenesis
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2016  |   Pubmed ID: 27281560
• Multiple MicroRNA Regulation of Lipoprotein Lipase Gene Abolished by 3'UTR Polymorphisms in a Triglyceride-lowering Haplotype Harboring P.Ser474Ter
  Atherosclerosis. Mar, 2016  |   Pubmed ID: 26820803
• Human Skeletal Myotubes Display a Cell-autonomous Circadian Clock Implicated in Basal Myokine Secretion
  Molecular Metabolism. Nov, 2015  |   Pubmed ID: 26629407
• Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth
  Cancer Cell. Nov, 2015  |   Pubmed ID: 26555173
• Adipose Tissue-Derived Stem Cells From Obese Subjects Contribute to Inflammation and Reduced Insulin Response in Adipocytes Through Differential Regulation of the Th1/Th17 Balance and Monocyte Activation
  Diabetes. Jul, 2015  |   Pubmed ID: 25765019
• Effect of Enforced Physical Inactivity Induced by 60-day of Bed Rest on Hepatic Markers of NAFLD in Healthy Normal-weight Women
  Liver International : Official Journal of the International Association for the Study of the Liver. Jun, 2015  |   Pubmed ID: 25413107
• Insulin Resistance is Associated with MCP1-mediated Macrophage Accumulation in Skeletal Muscle in Mice and Humans
  PloS One. 2014  |   Pubmed ID: 25337938
• Myostatin Gene Inactivation Prevents Skeletal Muscle Wasting in Cancer
  Cancer Research. Dec, 2014  |   Pubmed ID: 25336187
• Exosomes Participate in the Alteration of Muscle Homeostasis During Lipid-induced Insulin Resistance in Mice
  Diabetologia. Oct, 2014  |   Pubmed ID: 25073444
• Proteomic Analysis of C2C12 Myoblast and Myotube Exosome-like Vesicles: a New Paradigm for Myoblast-myotube Cross Talk?
  PloS One. 2014  |   Pubmed ID: 24392111
• An APOA5 3' UTR Variant Associated with Plasma Triglycerides Triggers APOA5 Downregulation by Creating a Functional MiR-485-5p Binding Site
  American Journal of Human Genetics. Jan, 2014  |   Pubmed ID: 24387992
• Myotube-derived Exosomal MiRNAs Downregulate Sirtuin1 in Myoblasts During Muscle Cell Differentiation
  Cell Cycle (Georgetown, Tex.). 2014  |   Pubmed ID: 24196440
• A Liver Hif-2α-Irs2 Pathway Sensitizes Hepatic Insulin Signaling and is Modulated by Vegf Inhibition
  Nature Medicine. Oct, 2013  |   Pubmed ID: 24037094
• Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope with Increased Storage Demands of Obesity
  Diabetes. Nov, 2013  |   Pubmed ID: 23919961
• Phospholipase D Regulates the Size of Skeletal Muscle Cells Through the Activation of MTOR Signaling
  Cell Communication and Signaling : CCS. Aug, 2013  |   Pubmed ID: 23915343
• Activity Energy Expenditure is a Major Determinant of Dietary Fat Oxidation and Trafficking, but the Deleterious Effect of Detraining is More Marked Than the Beneficial Effect of Training at Current Recommendations
  The American Journal of Clinical Nutrition. Sep, 2013  |   Pubmed ID: 23902784
• Bis(monoacylglycero)phosphate Accumulation in Macrophages Induces Intracellular Cholesterol Redistribution, Attenuates Liver-X Receptor/ATP-Binding Cassette Transporter A1/ATP-binding Cassette Transporter G1 Pathway, and Impairs Cholesterol Efflux
  Arteriosclerosis, Thrombosis, and Vascular Biology. Aug, 2013  |   Pubmed ID: 23788762
• SREBP-1 Transcription Factors Regulate Skeletal Muscle Cell Size by Controlling Protein Synthesis Through Myogenic Regulatory Factors
  PloS One. 2012  |   Pubmed ID: 23226416
• Sirtuin 1 Regulates SREBP-1c Expression in a LXR-dependent Manner in Skeletal Muscle
  PloS One. 2012  |   Pubmed ID: 22984430
• TNF-α- and Tumor-induced Skeletal Muscle Atrophy Involves Sphingolipid Metabolism
  Skeletal Muscle. Jan, 2012  |   Pubmed ID: 22257771
• GPIHBP1 C89F Neomutation and Hydrophobic C-terminal Domain G175R Mutation in Two Pedigrees with Severe Hyperchylomicronemia
  The Journal of Clinical Endocrinology and Metabolism. Oct, 2011  |   Pubmed ID: 21816778
• Phospholipase D Regulates Myogenic Differentiation Through the Activation of Both MTORC1 and MTORC2 Complexes
  The Journal of Biological Chemistry. Jun, 2011  |   Pubmed ID: 21525000
• AMPK Phosphorylates and Inhibits SREBP Activity to Attenuate Hepatic Steatosis and Atherosclerosis in Diet-induced Insulin-resistant Mice
  Cell Metabolism. Apr, 2011  |   Pubmed ID: 21459323
• FTO is Increased in Muscle During Type 2 Diabetes, and Its Overexpression in Myotubes Alters Insulin Signaling, Enhances Lipogenesis and ROS Production, and Induces Mitochondrial Dysfunction
  Diabetes. Jan, 2011  |   Pubmed ID: 20943749
• Pdro, a Protein Associated with Late Endosomes and Lysosomes and Implicated in Cellular Cholesterol Homeostasis
  PloS One. Jun, 2010  |   Pubmed ID: 20544018
• Downregulation of Akt/mammalian Target of Rapamycin Pathway in Skeletal Muscle is Associated with Increased REDD1 Expression in Response to Chronic Hypoxia
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jun, 2010  |   Pubmed ID: 20237300
• Evidence for Mitochondrial Respiratory Deficiency in Rat Rhabdomyosarcoma Cells
  PloS One. 2010  |   Pubmed ID: 20072609
• A New Role for Sterol Regulatory Element Binding Protein 1 Transcription Factors in the Regulation of Muscle Mass and Muscle Cell Differentiation
  Molecular and Cellular Biology. Mar, 2010  |   Pubmed ID: 20028734
• The MicroRNA Signature in Response to Insulin Reveals Its Implication in the Transcriptional Action of Insulin in Human Skeletal Muscle and the Role of a Sterol Regulatory Element-binding Protein-1c/myocyte Enhancer Factor 2C Pathway
  Diabetes. Nov, 2009  |   Pubmed ID: 19720801
• Microarray Analyses of SREBP-1a and SREBP-1c Target Genes Identify New Regulatory Pathways in Muscle
  Physiological Genomics. Aug, 2008  |   Pubmed ID: 18559965
• Insulin Activates Human Sterol-regulatory-element-binding Protein-1c (SREBP-1c) Promoter Through SRE Motifs
  The Biochemical Journal. Nov, 2006  |   Pubmed ID: 16831124
• BRCA1 Affects Lipid Synthesis Through Its Interaction with Acetyl-CoA Carboxylase
  The Journal of Biological Chemistry. Feb, 2006  |   Pubmed ID: 16326698
• Regulation of SREBP-1 Expression and Transcriptional Action on HKII and FAS Genes During Fasting and Refeeding in Rat Tissues
  Journal of Lipid Research. Apr, 2005  |   Pubmed ID: 15627654
• Sterol Regulatory Element-binding Protein-1 Mediates the Effect of Insulin on Hexokinase II Gene Expression in Human Muscle Cells
  Diabetes. Feb, 2004  |   Pubmed ID: 14747281