F. Edward Dudek Department of Neurosurgery University of Utah Biography Publications Institution JoVE Articles F. Edward Dudek has not added a biography. If you are F. Edward Dudek and would like to personalize this page please email our Author Liaison for assistance. Publications Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2015 | Pubmed ID: 26085641 When and How Do Seizures Kill Neurons, and is Cell Death Relevant to Epileptogenesis? Advances in Experimental Medicine and Biology. 2014 | Pubmed ID: 25012371 Valnoctamide Enhances Phasic Inhibition: a Potential Target Mechanism for the Treatment of Benzodiazepine-refractory Status Epilepticus Epilepsia. Sep, 2014 | Pubmed ID: 24995528 Epilepsy Biomarkers Epilepsia. Aug, 2013 | Pubmed ID: 23909854 Issues Related to Development of Antiepileptogenic Therapies Epilepsia. Aug, 2013 | Pubmed ID: 23909852 Epilepsy Therapy Development: Technical and Methodologic Issues in Studies with Animal Models Epilepsia. Aug, 2013 | Pubmed ID: 23909850 Inhibition of the Prostaglandin Receptor EP2 Following Status Epilepticus Reduces Delayed Mortality and Brain Inflammation Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23401547 Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in in Vivo Activity Biological Psychiatry. Mar, 2013 | Pubmed ID: 23140665 Finding a Better Drug for Epilepsy: Preclinical Screening Strategies and Experimental Trial Design Epilepsia. Nov, 2012 | Pubmed ID: 22708847 Mechanisms of Seizure-Induced Inflammation of the Brain: Many Possible Roles for Neuronal COX-2 Epilepsy Currents / American Epilepsy Society. May, 2012 | Pubmed ID: 22688923 A Once-per-day, Drug-in-food Protocol for Prolonged Administration of Antiepileptic Drugs in Animal Models Epilepsia. Jan, 2012 | Pubmed ID: 22092257 Seizure Probability in Animal Models of Acquired Epilepsy: a Perspective on the Concept of the Preictal State Epilepsy Research. Dec, 2011 | Pubmed ID: 22094446 The Time Course of Acquired Epilepsy: Implications for Therapeutic Intervention to Suppress Epileptogenesis Neuroscience Letters. Jun, 2011 | Pubmed ID: 21458536 Interictal Spikes: Harbingers or Causes of Epilepsy? Neuroscience Letters. Jun, 2011 | Pubmed ID: 21458535 Repetitive Perforant-path Stimulation Induces Epileptiform Bursts in Minislices of Dentate Gyrus from Rats with Kainate-induced Epilepsy Journal of Neurophysiology. Feb, 2011 | Pubmed ID: 21148094 Axon Sprouting and Synaptic Reorganization of GABAergic Interneurons: a Focused Look at a General Question Epilepsy Currents / American Epilepsy Society. Sep, 2010 | Pubmed ID: 20944824 Primary and Secondary Mechanisms of Epileptogenesis in the Temporal Lobe: There is a Before and an After Epilepsy Currents / American Epilepsy Society. Sep, 2010 | Pubmed ID: 20944823 Is Neuronal Death Necessary for Acquired Epileptogenesis in the Immature Brain? Epilepsy Currents / American Epilepsy Society. Jul, 2010 | Pubmed ID: 20697505 Counterpoint to "what is an Epileptic Seizure?" by D'Ambrosio and Miller Epilepsy Currents / American Epilepsy Society. Jul, 2010 | Pubmed ID: 20697504 The Effect of the Cannabinoid-receptor Antagonist, SR141716, on the Early Stage of Kainate-induced Epileptogenesis in the Adult Rat Epilepsia. Jul, 2010 | Pubmed ID: 20618417 Continuous Electroencephalographic Monitoring with Radio-telemetry in a Rat Model of Perinatal Hypoxia-ischemia Reveals Progressive Post-stroke Epilepsy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2010 | Pubmed ID: 20053921 EEG Spike Activity Precedes Epilepsy After Kainate-induced Status Epilepticus Epilepsia. Mar, 2010 | Pubmed ID: 19845739 Epileptogenesis: a New Twist on the Balance of Excitation and Inhibition Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2009 | Pubmed ID: 19936137 Both Synaptic and Intrinsic Mechanisms Underlie the Different Properties of Population Bursts in the Hippocampal CA3 Area of Immature Versus Adult Rats The Journal of Physiology. Dec, 2009 | Pubmed ID: 19884320 Microseizures in Human Neocortex: a Role for Ultra-small Seizures? Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2009 | Pubmed ID: 19826511 Is Modulation of Cortical Synapses After Brain Trauma Homeostatic? Or, Since when is Epilepsy Normal? Epilepsy Currents / American Epilepsy Society. Mar-Apr, 2009 | Pubmed ID: 19421381 Commentary: a Skeptical View of Experimental Gene Therapy to Block Epileptogenesis Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Apr, 2009 | Pubmed ID: 19332326 Development of Spontaneous Recurrent Seizures After Kainate-induced Status Epilepticus The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2009 | Pubmed ID: 19228963 Single and Repetitive Paired-pulse Suppression: a Parametric Analysis and Assessment of Usefulness in Epilepsy Research Epilepsia. Apr, 2009 | Pubmed ID: 19170733 NMDA Receptor-mediated Long-term Alterations in Epileptiform Activity in Experimental Chronic Epilepsy Neuropharmacology. Feb, 2009 | Pubmed ID: 18930747 On the Role of Calcium and Potassium Currents in Circadian Modulation of Firing Rate in Rat Suprachiasmatic Nucleus Neurons: Multielectrode Dish Analysis Neuroscience Research. Sep, 2008 | Pubmed ID: 18602427 A New Potential AED, Carisbamate, Substantially Reduces Spontaneous Motor Seizures in Rats with Kainate-induced Epilepsy Epilepsia. Oct, 2008 | Pubmed ID: 18494790 In Search of a New and Improved Target for Antiepileptic Drugs: Sialic Acid? Epilepsy Currents / American Epilepsy Society. May-Jun, 2008 | Pubmed ID: 18488062 Circadian Difference in Firing Rate of Isolated Rat Suprachiasmatic Nucleus Neurons Neuroscience Letters. May, 2008 | Pubmed ID: 18406526 Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling Versus Status Epilepticus Models Epilepsy Currents / American Epilepsy Society. Jan-Feb, 2008 | Pubmed ID: 18265888 Calcium Currents Burst Back: a Possible Role for Dendrites in Epileptogenesis Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2007 | Pubmed ID: 17998977 Neuropathogical Features of a Rat Model for Perinatal Hypoxic-ischemic Encephalopathy with Associated Epilepsy The Journal of Comparative Neurology. Dec, 2007 | Pubmed ID: 17948865 Development of Spontaneous Seizures After Experimental Status Epilepticus: Implications for Understanding Epileptogenesis Epilepsia. 2007 | Pubmed ID: 17910596 Epileptogenesis in the Dentate Gyrus: a Critical Perspective Progress in Brain Research. 2007 | Pubmed ID: 17765749 Unmasking Recurrent Excitation Generated by Mossy Fiber Sprouting in the Epileptic Dentate Gyrus: an Emergent Property of a Complex System Progress in Brain Research. 2007 | Pubmed ID: 17765737 Anticonvulsant Effects of Carbamazepine on Spontaneous Seizures in Rats with Kainate-induced Epilepsy: Comparison of Intraperitoneal Injections with Drug-in-food Protocols Epilepsia. Dec, 2007 | Pubmed ID: 17711461 How Does the Balance of Excitation and Inhibition Shift During Epileptogenesis? Epilepsy Currents / American Epilepsy Society. May-Jun, 2007 | Pubmed ID: 17520084 Laser Scanning Photostimulation: New Evidence for Enhanced Recurrent Excitation in a Model of Posttraumatic Epilepsy Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2006 | Pubmed ID: 17260064 Interictal Spikes and Epileptogenesis Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2006 | Pubmed ID: 17260059 Single-neuron Activity and Imaging During Epileptogenesis: What Can Be Seen and How Best to See It? Epilepsy Currents / American Epilepsy Society. Jul-Aug, 2006 | Pubmed ID: 17260037 How Independent Are Initiation, Propagation, and Termination of Epileptiform Activity? Epilepsy Currents / American Epilepsy Society. May-Jun, 2006 | Pubmed ID: 16761072 Changes in MIPSCs and SIPSCs After Kainate Treatment: Status Epilepticus-induced Neuronal Loss or Direct Activation of Kainate Receptors? Journal of Neurophysiology. Aug, 2006 | Pubmed ID: 16672302 Activation of Fos During Spontaneous Hippocampal Seizures in a Model of Temporal Lobe Epilepsy Epilepsy Currents / American Epilepsy Society. Mar-Apr, 2006 | Pubmed ID: 16604204 The Use of Radiotelemetry to Evaluate Electrographic Seizures in Rats with Kainate-induced Epilepsy Journal of Neuroscience Methods. Jul, 2006 | Pubmed ID: 16564574 Epilepsy and Reproductive Disorders: the Role of the Gonadotropin-releasing Hormone Network Epilepsy & Behavior : E&B. May, 2006 | Pubmed ID: 16504591 The Hyperinhibition Hypothesis in Epileptogenesis: an Assessment of the Evidence Epilepsy Currents / American Epilepsy Society. Jan-Feb, 2006 | Pubmed ID: 16477315 Efficient Unsupervised Algorithms for the Detection of Seizures in Continuous EEG Recordings from Rats After Brain Injury Journal of Neuroscience Methods. Apr, 2006 | Pubmed ID: 16337006 Chemoconvulsant Model of Chronic Spontaneous Seizures Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [et Al.]. May, 2005 | Pubmed ID: 18428628 Chronic Cortical Injury and Epileptogensis: a Possible Role for Intracellular Chloride Homeostasis Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2005 | Pubmed ID: 16372061 Are Altered Excitatory Synapses Found in Neuronal Migration Disorders? Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2005 | Pubmed ID: 16175215 Regulation of Brain Water: is There a Role for Aquaporins in Epilepsy? Epilepsy Currents / American Epilepsy Society. May-Jun, 2005 | Pubmed ID: 16145616 Do Interictal Spikes Drive Epileptogenesis? The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Aug, 2005 | Pubmed ID: 16061513 Detection of Increased Local Excitatory Circuits in the Hippocampus During Epileptogenesis Using Focal Flash Photolysis of Caged Glutamate Epilepsia. 2005 | Pubmed ID: 15987262 Noise of the Slowly Inactivating Na Current in Suprachiasmatic Nucleus Neurons Neuroreport. Jun, 2005 | Pubmed ID: 15931073 Changes in MIPSCs and SIPSCs After Kainate Treatment: Evidence for Loss of Inhibitory Input to Dentate Granule Cells and Possible Compensatory Responses Journal of Neurophysiology. Aug, 2005 | Pubmed ID: 15772233 5-HT1B Receptor-mediated Presynaptic Inhibition of GABA Release in the Suprachiasmatic Nucleus Journal of Neurophysiology. Jun, 2005 | Pubmed ID: 15716370 Use of Chronic Epilepsy Models in Antiepileptic Drug Discovery: the Effect of Topiramate on Spontaneous Motor Seizures in Rats with Kainate-induced Epilepsy Epilepsia. Jan, 2005 | Pubmed ID: 15660763 Electrophysiological Evidence Using Focal Flash Photolysis of Caged Glutamate That CA1 Pyramidal Cells Receive Excitatory Synaptic Input from the Subiculum Journal of Neurophysiology. May, 2005 | Pubmed ID: 15601737 Is There a "critical Period" for Intervention in Posttraumatic Epilepsy? Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2004 | Pubmed ID: 16059518 Mossy Fiber Sprouting and Recurrent Excitation: Direct Electrophysiologic Evidence and Potential Implications Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2004 | Pubmed ID: 16059495 The Epileptic GABA(A) Receptor: a Target for Epileptogenesis and for New AEDs? Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2004 | Pubmed ID: 16059494 Seizure-induced Neurogenesis and Epilepsy: Involvement of Ectopic Granule Cells? Epilepsy Currents / American Epilepsy Society. May-Jun, 2004 | Pubmed ID: 16059464 Update on Connexins and Gap Junctions in Neurons and Glia in the Mammalian Nervous System Brain Research. Brain Research Reviews. Dec, 2004 | Pubmed ID: 15572172 Hyperpolarization-activated Cation Channels in Human and Experimental Epilepsy: Do They Play a Role in Epileptogenesis? Epilepsy Currents / American Epilepsy Society. 3, 2004 | Pubmed ID: 15562309 Epilepsy and Synaptic Reorganization in a Perinatal Rat Model of Hypoxia-ischemia Epilepsia. Oct, 2004 | Pubmed ID: 15461675 GluR5 Kainate Receptors and Topiramate: A New Site of Action for Antiepileptic Drugs? Epilepsy Currents / American Epilepsy Society. Jan, 2004 | Pubmed ID: 15346138 Increased Excitatory Synaptic Activity and Local Connectivity of Hippocampal CA1 Pyramidal Cells in Rats with Kainate-induced Epilepsy Journal of Neurophysiology. Sep, 2004 | Pubmed ID: 15084640 Mechanism of Irregular Firing of Suprachiasmatic Nucleus Neurons in Rat Hypothalamic Slices Journal of Neurophysiology. Jan, 2004 | Pubmed ID: 14715720 Riluzole-sensitive Slowly Inactivating Sodium Current in Rat Suprachiasmatic Nucleus Neurons Journal of Neurophysiology. Feb, 2004 | Pubmed ID: 14573554 Loss of GABAergic Interneurons in Seizure-induced Epileptogenesis Epilepsy Currents / American Epilepsy Society. Sep, 2003 | Pubmed ID: 15902313 Does Hippocampal Neurogenesis After Kainate-induced Apoptosis In Neonatal Rats Replace Lost Neurons? Epilepsy Currents / American Epilepsy Society. Nov, 2003 | Pubmed ID: 15346162 Does Neuroprotection Prevent Epileptogenesis? Epilepsy Currents / American Epilepsy Society. Mar, 2003 | Pubmed ID: 15309090 Single-gene Mutation Leads to Localized Disruption of Cortical Interneuron Development and Increased Seizure Susceptibility Epilepsy Currents / American Epilepsy Society. May, 2003 | Pubmed ID: 15309067 High-frequency Oscillations and Neocortical Seizures: Do They Have a Role in Seizure Onset, and Which Mechanisms Generate Them? Epilepsy Currents / American Epilepsy Society. May, 2003 | Pubmed ID: 15309065 New Evidence for an Important Role of Endogenous GABA in Seizure Generation in the Immature Hippocampus Epilepsy Currents / American Epilepsy Society. Jul, 2003 | Pubmed ID: 15309060 GABA Receptor-mediated Inhibition of Neuronal Activity in Rat SCN in Vitro: Pharmacology and Influence of Circadian Phase Journal of Neurophysiology. Sep, 2003 | Pubmed ID: 12750413 Neuropeptide Y May Be an Endogenous Anticonvulsant in Hippocampus Epilepsy Currents / American Epilepsy Society. Jan, 2002 | Pubmed ID: 15309180 Selective Inhibitory Interneuron Loss Produces Chronic Hippocampal Hyperexcitability Epilepsy Currents / American Epilepsy Society. Jan, 2002 | Pubmed ID: 15309178 Role of Glial Cells in Seizures and Epilepsy: Intracellular Calcium Oscillations Sn Spatial Buffering Epilepsy Currents / American Epilepsy Society. Jul, 2002 | Pubmed ID: 15309145 Gap Junctions and Fast Oscillations: A Role in Seizures and Epileptogenesis? Epilepsy Currents / American Epilepsy Society. Jul, 2002 | Pubmed ID: 15309144 The Epileptic Neuron Redux Epilepsy Currents / American Epilepsy Society. Sep, 2002 | Pubmed ID: 15309124 Synaptic Reorganization in an Experimental Model of Posttraumatic Epilepsy Epilepsy Currents / American Epilepsy Society. Nov, 2002 | Pubmed ID: 15309118 Effects of Fluoxetine and TFMPP on Spontaneous Seizures in Rats with Pilocarpine-induced Epilepsy Epilepsia. Nov, 2002 | Pubmed ID: 12423383 The Search for Animal Models of Epileptogenesis and Pharmacoresistance: Are There Biologic Barriers to Simple Validation Strategies? Epilepsia. Nov, 2002 | Pubmed ID: 12423376 Reassessment of the Effects of Cycloheximide on Mossy Fiber Sprouting and Epileptogenesis in the Pilocarpine Model of Temporal Lobe Epilepsy Journal of Neurophysiology. Oct, 2002 | Pubmed ID: 12364529 The Course of Cellular Alterations Associated with the Development of Spontaneous Seizures After Status Epilepticus Progress in Brain Research. 2002 | Pubmed ID: 12143370 Episodic Bursting Activity and Response to Excitatory Amino Acids in Acutely Dissociated Gonadotropin-releasing Hormone Neurons Genetically Targeted with Green Fluorescent Protein The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002 | Pubmed ID: 11896170 Network Interactions Mediated by New Excitatory Connections Between CA1 Pyramidal Cells in Rats with Kainate-induced Epilepsy Journal of Neurophysiology. Mar, 2002 | Pubmed ID: 11877537 Absence of Temporal Lobe Epilepsy Pathology in Dogs with Medically Intractable Epilepsy Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine. Jan-Feb, 2002 | Pubmed ID: 11822812 Zinc and Epileptogenesis Epilepsy Currents / American Epilepsy Society. Nov, 2001 | Pubmed ID: 15309193 Cortical Dysplasia and Epileptogenesis: Models and Mechanisms Epilepsy Currents / American Epilepsy Society. Sep, 2001 | Pubmed ID: 15309033 Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System Andrew Zayachkivsky1, Mark J. Lehmkuhle2, F. Edward Dudek2 1Department of Neurosurgery, Yale University School of Medicine, 2Department of Neurosurgery, University of Utah JoVE 52554 Neuroscience
Long-term Continuous EEG Monitoring in Small Rodent Models of Human Disease Using the Epoch Wireless Transmitter System Andrew Zayachkivsky1, Mark J. Lehmkuhle2, F. Edward Dudek2 1Department of Neurosurgery, Yale University School of Medicine, 2Department of Neurosurgery, University of Utah JoVE 52554 Neuroscience