F. Edward Dudek

Publications

• Progressive, Seizure-Like, Spike-Wave Discharges Are Common in Both Injured and Uninjured Sprague-Dawley Rats: Implications for the Fluid Percussion Injury Model of Post-Traumatic Epilepsy
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2015  |   Pubmed ID: 26085641
• When and How Do Seizures Kill Neurons, and is Cell Death Relevant to Epileptogenesis?
  Advances in Experimental Medicine and Biology. 2014  |   Pubmed ID: 25012371
• Valnoctamide Enhances Phasic Inhibition: a Potential Target Mechanism for the Treatment of Benzodiazepine-refractory Status Epilepticus
  Epilepsia. Sep, 2014  |   Pubmed ID: 24995528
• Epilepsy Biomarkers
  Epilepsia. Aug, 2013  |   Pubmed ID: 23909854
• Issues Related to Development of Antiepileptogenic Therapies
  Epilepsia. Aug, 2013  |   Pubmed ID: 23909852
• Epilepsy Therapy Development: Technical and Methodologic Issues in Studies with Animal Models
  Epilepsia. Aug, 2013  |   Pubmed ID: 23909850
• Inhibition of the Prostaglandin Receptor EP2 Following Status Epilepticus Reduces Delayed Mortality and Brain Inflammation
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013  |   Pubmed ID: 23401547
• Unique Signaling Profiles of Positive Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Determine Differences in in Vivo Activity
  Biological Psychiatry. Mar, 2013  |   Pubmed ID: 23140665
• Finding a Better Drug for Epilepsy: Preclinical Screening Strategies and Experimental Trial Design
  Epilepsia. Nov, 2012  |   Pubmed ID: 22708847
• Mechanisms of Seizure-Induced Inflammation of the Brain: Many Possible Roles for Neuronal COX-2
  Epilepsy Currents / American Epilepsy Society. May, 2012  |   Pubmed ID: 22688923
• A Once-per-day, Drug-in-food Protocol for Prolonged Administration of Antiepileptic Drugs in Animal Models
  Epilepsia. Jan, 2012  |   Pubmed ID: 22092257
• Seizure Probability in Animal Models of Acquired Epilepsy: a Perspective on the Concept of the Preictal State
  Epilepsy Research. Dec, 2011  |   Pubmed ID: 22094446
• The Time Course of Acquired Epilepsy: Implications for Therapeutic Intervention to Suppress Epileptogenesis
  Neuroscience Letters. Jun, 2011  |   Pubmed ID: 21458536
• Interictal Spikes: Harbingers or Causes of Epilepsy?
  Neuroscience Letters. Jun, 2011  |   Pubmed ID: 21458535
• Repetitive Perforant-path Stimulation Induces Epileptiform Bursts in Minislices of Dentate Gyrus from Rats with Kainate-induced Epilepsy
  Journal of Neurophysiology. Feb, 2011  |   Pubmed ID: 21148094
• Axon Sprouting and Synaptic Reorganization of GABAergic Interneurons: a Focused Look at a General Question
  Epilepsy Currents / American Epilepsy Society. Sep, 2010  |   Pubmed ID: 20944824
• Primary and Secondary Mechanisms of Epileptogenesis in the Temporal Lobe: There is a Before and an After
  Epilepsy Currents / American Epilepsy Society. Sep, 2010  |   Pubmed ID: 20944823
• Is Neuronal Death Necessary for Acquired Epileptogenesis in the Immature Brain?
  Epilepsy Currents / American Epilepsy Society. Jul, 2010  |   Pubmed ID: 20697505
• Counterpoint to "what is an Epileptic Seizure?" by D'Ambrosio and Miller
  Epilepsy Currents / American Epilepsy Society. Jul, 2010  |   Pubmed ID: 20697504
• The Effect of the Cannabinoid-receptor Antagonist, SR141716, on the Early Stage of Kainate-induced Epileptogenesis in the Adult Rat
  Epilepsia. Jul, 2010  |   Pubmed ID: 20618417
• Continuous Electroencephalographic Monitoring with Radio-telemetry in a Rat Model of Perinatal Hypoxia-ischemia Reveals Progressive Post-stroke Epilepsy
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jan, 2010  |   Pubmed ID: 20053921
• EEG Spike Activity Precedes Epilepsy After Kainate-induced Status Epilepticus
  Epilepsia. Mar, 2010  |   Pubmed ID: 19845739
• Epileptogenesis: a New Twist on the Balance of Excitation and Inhibition
  Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2009  |   Pubmed ID: 19936137
• Both Synaptic and Intrinsic Mechanisms Underlie the Different Properties of Population Bursts in the Hippocampal CA3 Area of Immature Versus Adult Rats
  The Journal of Physiology. Dec, 2009  |   Pubmed ID: 19884320
• Microseizures in Human Neocortex: a Role for Ultra-small Seizures?
  Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2009  |   Pubmed ID: 19826511
• Is Modulation of Cortical Synapses After Brain Trauma Homeostatic? Or, Since when is Epilepsy Normal?
  Epilepsy Currents / American Epilepsy Society. Mar-Apr, 2009  |   Pubmed ID: 19421381
• Commentary: a Skeptical View of Experimental Gene Therapy to Block Epileptogenesis
  Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Apr, 2009  |   Pubmed ID: 19332326
• Development of Spontaneous Recurrent Seizures After Kainate-induced Status Epilepticus
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Feb, 2009  |   Pubmed ID: 19228963
• Single and Repetitive Paired-pulse Suppression: a Parametric Analysis and Assessment of Usefulness in Epilepsy Research
  Epilepsia. Apr, 2009  |   Pubmed ID: 19170733
• NMDA Receptor-mediated Long-term Alterations in Epileptiform Activity in Experimental Chronic Epilepsy
  Neuropharmacology. Feb, 2009  |   Pubmed ID: 18930747
• On the Role of Calcium and Potassium Currents in Circadian Modulation of Firing Rate in Rat Suprachiasmatic Nucleus Neurons: Multielectrode Dish Analysis
  Neuroscience Research. Sep, 2008  |   Pubmed ID: 18602427
• A New Potential AED, Carisbamate, Substantially Reduces Spontaneous Motor Seizures in Rats with Kainate-induced Epilepsy
  Epilepsia. Oct, 2008  |   Pubmed ID: 18494790
• In Search of a New and Improved Target for Antiepileptic Drugs: Sialic Acid?
  Epilepsy Currents / American Epilepsy Society. May-Jun, 2008  |   Pubmed ID: 18488062
• Circadian Difference in Firing Rate of Isolated Rat Suprachiasmatic Nucleus Neurons
  Neuroscience Letters. May, 2008  |   Pubmed ID: 18406526
• Antiepileptogenesis Therapy with Levetiracetam: Data from Kindling Versus Status Epilepticus Models
  Epilepsy Currents / American Epilepsy Society. Jan-Feb, 2008  |   Pubmed ID: 18265888
• Calcium Currents Burst Back: a Possible Role for Dendrites in Epileptogenesis
  Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2007  |   Pubmed ID: 17998977
• Neuropathogical Features of a Rat Model for Perinatal Hypoxic-ischemic Encephalopathy with Associated Epilepsy
  The Journal of Comparative Neurology. Dec, 2007  |   Pubmed ID: 17948865
• Development of Spontaneous Seizures After Experimental Status Epilepticus: Implications for Understanding Epileptogenesis
  Epilepsia. 2007  |   Pubmed ID: 17910596
• Epileptogenesis in the Dentate Gyrus: a Critical Perspective
  Progress in Brain Research. 2007  |   Pubmed ID: 17765749
• Unmasking Recurrent Excitation Generated by Mossy Fiber Sprouting in the Epileptic Dentate Gyrus: an Emergent Property of a Complex System
  Progress in Brain Research. 2007  |   Pubmed ID: 17765737
• Anticonvulsant Effects of Carbamazepine on Spontaneous Seizures in Rats with Kainate-induced Epilepsy: Comparison of Intraperitoneal Injections with Drug-in-food Protocols
  Epilepsia. Dec, 2007  |   Pubmed ID: 17711461
• How Does the Balance of Excitation and Inhibition Shift During Epileptogenesis?
  Epilepsy Currents / American Epilepsy Society. May-Jun, 2007  |   Pubmed ID: 17520084
• Laser Scanning Photostimulation: New Evidence for Enhanced Recurrent Excitation in a Model of Posttraumatic Epilepsy
  Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2006  |   Pubmed ID: 17260064
• Interictal Spikes and Epileptogenesis
  Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2006  |   Pubmed ID: 17260059
• Single-neuron Activity and Imaging During Epileptogenesis: What Can Be Seen and How Best to See It?
  Epilepsy Currents / American Epilepsy Society. Jul-Aug, 2006  |   Pubmed ID: 17260037
• How Independent Are Initiation, Propagation, and Termination of Epileptiform Activity?
  Epilepsy Currents / American Epilepsy Society. May-Jun, 2006  |   Pubmed ID: 16761072
• Changes in MIPSCs and SIPSCs After Kainate Treatment: Status Epilepticus-induced Neuronal Loss or Direct Activation of Kainate Receptors?
  Journal of Neurophysiology. Aug, 2006  |   Pubmed ID: 16672302
• Activation of Fos During Spontaneous Hippocampal Seizures in a Model of Temporal Lobe Epilepsy
  Epilepsy Currents / American Epilepsy Society. Mar-Apr, 2006  |   Pubmed ID: 16604204
• The Use of Radiotelemetry to Evaluate Electrographic Seizures in Rats with Kainate-induced Epilepsy
  Journal of Neuroscience Methods. Jul, 2006  |   Pubmed ID: 16564574
• Epilepsy and Reproductive Disorders: the Role of the Gonadotropin-releasing Hormone Network
  Epilepsy & Behavior : E&B. May, 2006  |   Pubmed ID: 16504591
• The Hyperinhibition Hypothesis in Epileptogenesis: an Assessment of the Evidence
  Epilepsy Currents / American Epilepsy Society. Jan-Feb, 2006  |   Pubmed ID: 16477315
• Efficient Unsupervised Algorithms for the Detection of Seizures in Continuous EEG Recordings from Rats After Brain Injury
  Journal of Neuroscience Methods. Apr, 2006  |   Pubmed ID: 16337006
• Chemoconvulsant Model of Chronic Spontaneous Seizures
  Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [et Al.]. May, 2005  |   Pubmed ID: 18428628
• Chronic Cortical Injury and Epileptogensis: a Possible Role for Intracellular Chloride Homeostasis
  Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2005  |   Pubmed ID: 16372061
• Are Altered Excitatory Synapses Found in Neuronal Migration Disorders?
  Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2005  |   Pubmed ID: 16175215
• Regulation of Brain Water: is There a Role for Aquaporins in Epilepsy?
  Epilepsy Currents / American Epilepsy Society. May-Jun, 2005  |   Pubmed ID: 16145616
• Do Interictal Spikes Drive Epileptogenesis?
  The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. Aug, 2005  |   Pubmed ID: 16061513
• Detection of Increased Local Excitatory Circuits in the Hippocampus During Epileptogenesis Using Focal Flash Photolysis of Caged Glutamate
  Epilepsia. 2005  |   Pubmed ID: 15987262
• Noise of the Slowly Inactivating Na Current in Suprachiasmatic Nucleus Neurons
  Neuroreport. Jun, 2005  |   Pubmed ID: 15931073
• Changes in MIPSCs and SIPSCs After Kainate Treatment: Evidence for Loss of Inhibitory Input to Dentate Granule Cells and Possible Compensatory Responses
  Journal of Neurophysiology. Aug, 2005  |   Pubmed ID: 15772233
• 5-HT1B Receptor-mediated Presynaptic Inhibition of GABA Release in the Suprachiasmatic Nucleus
  Journal of Neurophysiology. Jun, 2005  |   Pubmed ID: 15716370
• Use of Chronic Epilepsy Models in Antiepileptic Drug Discovery: the Effect of Topiramate on Spontaneous Motor Seizures in Rats with Kainate-induced Epilepsy
  Epilepsia. Jan, 2005  |   Pubmed ID: 15660763
• Electrophysiological Evidence Using Focal Flash Photolysis of Caged Glutamate That CA1 Pyramidal Cells Receive Excitatory Synaptic Input from the Subiculum
  Journal of Neurophysiology. May, 2005  |   Pubmed ID: 15601737
• Is There a "critical Period" for Intervention in Posttraumatic Epilepsy?
  Epilepsy Currents / American Epilepsy Society. Nov-Dec, 2004  |   Pubmed ID: 16059518
• Mossy Fiber Sprouting and Recurrent Excitation: Direct Electrophysiologic Evidence and Potential Implications
  Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2004  |   Pubmed ID: 16059495
• The Epileptic GABA(A) Receptor: a Target for Epileptogenesis and for New AEDs?
  Epilepsy Currents / American Epilepsy Society. Sep-Oct, 2004  |   Pubmed ID: 16059494
• Seizure-induced Neurogenesis and Epilepsy: Involvement of Ectopic Granule Cells?
  Epilepsy Currents / American Epilepsy Society. May-Jun, 2004  |   Pubmed ID: 16059464
• Update on Connexins and Gap Junctions in Neurons and Glia in the Mammalian Nervous System
  Brain Research. Brain Research Reviews. Dec, 2004  |   Pubmed ID: 15572172
• Hyperpolarization-activated Cation Channels in Human and Experimental Epilepsy: Do They Play a Role in Epileptogenesis?
  Epilepsy Currents / American Epilepsy Society. 3, 2004  |   Pubmed ID: 15562309
• Epilepsy and Synaptic Reorganization in a Perinatal Rat Model of Hypoxia-ischemia
  Epilepsia. Oct, 2004  |   Pubmed ID: 15461675
• GluR5 Kainate Receptors and Topiramate: A New Site of Action for Antiepileptic Drugs?
  Epilepsy Currents / American Epilepsy Society. Jan, 2004  |   Pubmed ID: 15346138
• Increased Excitatory Synaptic Activity and Local Connectivity of Hippocampal CA1 Pyramidal Cells in Rats with Kainate-induced Epilepsy
  Journal of Neurophysiology. Sep, 2004  |   Pubmed ID: 15084640
• Mechanism of Irregular Firing of Suprachiasmatic Nucleus Neurons in Rat Hypothalamic Slices
  Journal of Neurophysiology. Jan, 2004  |   Pubmed ID: 14715720
• Riluzole-sensitive Slowly Inactivating Sodium Current in Rat Suprachiasmatic Nucleus Neurons
  Journal of Neurophysiology. Feb, 2004  |   Pubmed ID: 14573554
• Loss of GABAergic Interneurons in Seizure-induced Epileptogenesis
  Epilepsy Currents / American Epilepsy Society. Sep, 2003  |   Pubmed ID: 15902313
• Does Hippocampal Neurogenesis After Kainate-induced Apoptosis In Neonatal Rats Replace Lost Neurons?
  Epilepsy Currents / American Epilepsy Society. Nov, 2003  |   Pubmed ID: 15346162
• Does Neuroprotection Prevent Epileptogenesis?
  Epilepsy Currents / American Epilepsy Society. Mar, 2003  |   Pubmed ID: 15309090
• Single-gene Mutation Leads to Localized Disruption of Cortical Interneuron Development and Increased Seizure Susceptibility
  Epilepsy Currents / American Epilepsy Society. May, 2003  |   Pubmed ID: 15309067
• High-frequency Oscillations and Neocortical Seizures: Do They Have a Role in Seizure Onset, and Which Mechanisms Generate Them?
  Epilepsy Currents / American Epilepsy Society. May, 2003  |   Pubmed ID: 15309065
• New Evidence for an Important Role of Endogenous GABA in Seizure Generation in the Immature Hippocampus
  Epilepsy Currents / American Epilepsy Society. Jul, 2003  |   Pubmed ID: 15309060
• GABA Receptor-mediated Inhibition of Neuronal Activity in Rat SCN in Vitro: Pharmacology and Influence of Circadian Phase
  Journal of Neurophysiology. Sep, 2003  |   Pubmed ID: 12750413
• Neuropeptide Y May Be an Endogenous Anticonvulsant in Hippocampus
  Epilepsy Currents / American Epilepsy Society. Jan, 2002  |   Pubmed ID: 15309180
• Selective Inhibitory Interneuron Loss Produces Chronic Hippocampal Hyperexcitability
  Epilepsy Currents / American Epilepsy Society. Jan, 2002  |   Pubmed ID: 15309178
• Role of Glial Cells in Seizures and Epilepsy: Intracellular Calcium Oscillations Sn Spatial Buffering
  Epilepsy Currents / American Epilepsy Society. Jul, 2002  |   Pubmed ID: 15309145
• Gap Junctions and Fast Oscillations: A Role in Seizures and Epileptogenesis?
  Epilepsy Currents / American Epilepsy Society. Jul, 2002  |   Pubmed ID: 15309144
• The Epileptic Neuron Redux
  Epilepsy Currents / American Epilepsy Society. Sep, 2002  |   Pubmed ID: 15309124
• Synaptic Reorganization in an Experimental Model of Posttraumatic Epilepsy
  Epilepsy Currents / American Epilepsy Society. Nov, 2002  |   Pubmed ID: 15309118
• Effects of Fluoxetine and TFMPP on Spontaneous Seizures in Rats with Pilocarpine-induced Epilepsy
  Epilepsia. Nov, 2002  |   Pubmed ID: 12423383
• The Search for Animal Models of Epileptogenesis and Pharmacoresistance: Are There Biologic Barriers to Simple Validation Strategies?
  Epilepsia. Nov, 2002  |   Pubmed ID: 12423376
• Reassessment of the Effects of Cycloheximide on Mossy Fiber Sprouting and Epileptogenesis in the Pilocarpine Model of Temporal Lobe Epilepsy
  Journal of Neurophysiology. Oct, 2002  |   Pubmed ID: 12364529
• The Course of Cellular Alterations Associated with the Development of Spontaneous Seizures After Status Epilepticus
  Progress in Brain Research. 2002  |   Pubmed ID: 12143370
• Episodic Bursting Activity and Response to Excitatory Amino Acids in Acutely Dissociated Gonadotropin-releasing Hormone Neurons Genetically Targeted with Green Fluorescent Protein
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2002  |   Pubmed ID: 11896170
• Network Interactions Mediated by New Excitatory Connections Between CA1 Pyramidal Cells in Rats with Kainate-induced Epilepsy
  Journal of Neurophysiology. Mar, 2002  |   Pubmed ID: 11877537
• Absence of Temporal Lobe Epilepsy Pathology in Dogs with Medically Intractable Epilepsy
  Journal of Veterinary Internal Medicine / American College of Veterinary Internal Medicine. Jan-Feb, 2002  |   Pubmed ID: 11822812
• Zinc and Epileptogenesis
  Epilepsy Currents / American Epilepsy Society. Nov, 2001  |   Pubmed ID: 15309193
• Cortical Dysplasia and Epileptogenesis: Models and Mechanisms
  Epilepsy Currents / American Epilepsy Society. Sep, 2001  |   Pubmed ID: 15309033