Articles by Felipe J. Núñez

In JoVE (1)

Иммунопреципитация родной Chromatin, с использованием Neurospheres опухоли мозга мышиных

Other Publications (1)

Cancer Research

Articles by Felipe J. Núñez in JoVE

Cancer Research

Иммунопреципитация родной Chromatin, с использованием Neurospheres опухоли мозга мышиных Flor M. Mendez¹, Felipe J. Núñez^1,2, Rocío I. Zorrilla-Veloz^3,4, Pedro R. Lowenstein^1,2, Maria G. Castro^1,2 ¹Department of Cell and Developmental Biology, University of Michigan Medical School, ²Department of Neurosurgery, University of Michigan Medical School, ³Cancer Research Summer Internship Program (CARSIP), Cancer Biology Program, University of Michigan Medical School, ⁴Department of Biology, University of Puerto Rico-Río Piedras Campus Эпигенетические механизмы часто изменяются в глиомы. Иммунопреципитации Chromatin может использоваться для изучения последствий генетических изменений в глиомы, которые в результате изменения гистона модификации, которые регулируют хроматина структуры и Джин транскрипции. Этот протокол описывает родной хроматина иммунопреципитации мышиных мозга опухоль neurospheres.

Other articles by Felipe J. Núñez on PubMed

Mutated Chromatin Regulatory Factors As Tumor Drivers in Cancer Cancer Research. | Pubmed ID: 28062403 Genes encoding proteins that regulate chromatin structure and DNA modifications [i.e., chromatin regulatory factors (CRF)] and genes encoding histone proteins harbor recurrent mutations in most human cancers. These mutations lead to modifications in tumor chromatin and DNA structure and an altered epigenetic state that contribute to tumorigenesis. Mutated CRFs have now been identified in most types of cancer and are increasingly regarded as novel therapeutic targets. In this review, we discuss DNA alterations in CRFs and how these influence tumor chromatin structure and function, which in turn leads to tumorigenesis. We also discuss the clinical implications and review concepts of targeted treatments for these mutations. Continued research on CRF mutations will be critical for our future understanding of cancer biology and the development and implementation of novel cancer therapies. Cancer Res; 77(2); 227-33. ©2017 AACR.

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