Francesco A. Aprile

Publications

• Third Generation Antibody Discovery Methods: in Silico Rational Design
  Chemical Society Reviews. Oct, 2018   |   Pubmed ID: 30298157
• Targeting Amyloid Aggregation: An Overview of Strategies and Mechanisms
  International Journal of Molecular Sciences. Sep, 2018   |   Pubmed ID: 30205618
• Author Correction: The Molecular Chaperones DNAJB6 and Hsp70 Cooperate to Suppress α-synuclein Aggregation
  Scientific Reports. Aug, 2018   |   Pubmed ID: 30068912
• Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine
  ACS Chemical Biology. Aug, 2018   |   Pubmed ID: 29953201
• Cooperative Assembly of Hsp70 Subdomain Clusters
  Biochemistry. Jul, 2018   |   Pubmed ID: 29763298
• A Rationally Designed Hsp70 Variant Rescues the Aggregation-Associated Toxicity of Human IAPP in Cultured Pancreatic Islet β-Cells
  International Journal of Molecular Sciences. May, 2018   |   Pubmed ID: 29757200
• Delivery of Native Proteins into C. Elegans Using a Transduction Protocol Based on Lipid Vesicles
  Scientific Reports. Nov, 2017   |   Pubmed ID: 29118344
• A Water-Bridged Cysteine-Cysteine Redox Regulation Mechanism in Bacterial Protein Tyrosine Phosphatases
  Chem. Oct, 2017   |   Pubmed ID: 29094109
• The Molecular Chaperones DNAJB6 and Hsp70 Cooperate to Suppress α-synuclein Aggregation
  Scientific Reports. Aug, 2017   |   Pubmed ID: 28831037
• Sequence Specificity in the Entropy-Driven Binding of a Small Molecule and a Disordered Peptide
  Journal of Molecular Biology. Sep, 2017   |   Pubmed ID: 28743590
• Selective Targeting of Primary and Secondary Nucleation Pathways in Aβ42 Aggregation Using a Rational Antibody Scanning Method
  Science Advances. Jun, 2017   |   Pubmed ID: 28691099
• Methods of Probing the Interactions Between Small Molecules and Disordered Proteins
  Cellular and Molecular Life Sciences : CMLS. 09, 2017   |   Pubmed ID: 28631009
• Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation
  Molecular Cell. Mar, 2017   |   Pubmed ID: 28306505
• Inhibition of α-Synuclein Fibril Elongation by Hsp70 Is Governed by a Kinetic Binding Competition Between α-Synuclein Species
  Biochemistry. 03, 2017   |   Pubmed ID: 28230968
• A Natural Product Inhibits the Initiation of α-synuclein Aggregation and Suppresses Its Toxicity
  Proceedings of the National Academy of Sciences of the United States of America. 02, 2017   |   Pubmed ID: 28096355
• Structure of a Low-population Binding Intermediate in Protein-RNA Recognition
  Proceedings of the National Academy of Sciences of the United States of America. 06, 2016   |   Pubmed ID: 27286828
• Microfluidic Diffusion Viscometer for Rapid Analysis of Complex Solutions
  Analytical Chemistry. Apr, 2016   |   Pubmed ID: 26940224
• Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins Under Native Solution Conditions
  ACS Nano. Jan, 2016   |   Pubmed ID: 26678709
• Biophysical Approaches for the Study of Interactions Between Molecular Chaperones and Protein Aggregates
  Chemical Communications (Cambridge, England). Oct, 2015   |   Pubmed ID: 26328629
• Cell Surface Localised Hsp70 is a Cancer Specific Regulator of Clathrin-independent Endocytosis
  FEBS Letters. Sep, 2015   |   Pubmed ID: 26257049
• Rational Design of Antibodies Targeting Specific Epitopes Within Intrinsically Disordered Proteins
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2015   |   Pubmed ID: 26216991
• A Rational Design Strategy for the Selective Activity Enhancement of a Molecular Chaperone Toward a Target Substrate
  Biochemistry. Aug, 2015   |   Pubmed ID: 26192230
• Structural Characterization of Toxic Oligomers That Are Kinetically Trapped During α-synuclein Fibril Formation
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015   |   Pubmed ID: 25855634
• Structure and Dynamics of the Integrin LFA-1 I-domain in the Inactive State Underlie Its Inside-out/outside-in Signaling and Allosteric Mechanisms
  Structure (London, England : 1993). Apr, 2015   |   Pubmed ID: 25773142
• Structure of a Low-population Intermediate State in the Release of an Enzyme Product
  ELife. Jan, 2015   |   Pubmed ID: 25575179
• The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility
  Journal of Molecular Biology. Jan, 2015   |   Pubmed ID: 25451785
• NMR Characterization of the Conformational Fluctuations of the Human Lymphocyte Function-associated Antigen-1 I-domain
  Protein Science : a Publication of the Protein Society. Nov, 2014   |   Pubmed ID: 25147050
• Hsp70 Oligomerization is Mediated by an Interaction Between the Interdomain Linker and the Substrate-binding Domain
  PloS One. Month, 2013   |   Pubmed ID: 23840795
• Nanobodies Raised Against Monomeric α-synuclein Distinguish Between Fibrils at Different Maturation Stages
  Journal of Molecular Biology. Jul, 2013   |   Pubmed ID: 23557833
• Direct Observation of the Interconversion of Normal and Toxic Forms of α-synuclein
  Cell. May, 2012   |   Pubmed ID: 22632969