Frank Reimann

Publications

• Signalling in the Gut Endocrine Axis
  Physiology & Behavior. Feb, 2017  |   Pubmed ID: 28257936
• Glucagon-Like Peptide 1 and Its Analogs Act in the Dorsal Raphe and Modulate Central Serotonin to Reduce Appetite and Body Weight
  Diabetes. Apr, 2017  |   Pubmed ID: 28057699
• Scaling It Down: New in Vitro Tools to Get the Balance Right
  The Biochemical Journal. Jan, 2017  |   Pubmed ID: 28008090
• Gut Hormone Regulation and Secretion Via FFA1 and FFA4
  Handbook of Experimental Pharmacology. 2017  |   Pubmed ID: 27873089
• Functional and Molecular Adaptations of Enteroendocrine L-Cells in Male Obese Mice Are Associated With Preservation of Pancreatic α-Cell Function and Prevention of Hyperglycemia
  Endocrinology. Oct, 2016  |   Pubmed ID: 27547850
• Angiotensin II Type 1 Receptor-Dependent GLP-1 and PYY Secretion in Mice and Humans
  Endocrinology. Oct, 2016  |   Pubmed ID: 27447725
• Transcriptomic Profiling of Pancreatic Alpha, Beta and Delta Cell Populations Identifies Delta Cells As a Principal Target for Ghrelin in Mouse Islets
  Diabetologia. Oct, 2016  |   Pubmed ID: 27390011
• Mechanisms Underlying Glucose-dependent Insulinotropic Polypeptide and Glucagon-like Peptide-1 Secretion
  Journal of Diabetes Investigation. Apr, 2016  |   Pubmed ID: 27186350
• Preproglucagon Neurons in the Hindbrain Have IL-6 Receptor-α and Show Ca2+ Influx in Response to IL-6
  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2016  |   Pubmed ID: 27097661
• Role of Enteroendocrine L-cells in Arginine Vasopressin-mediated Inhibition of Colonic Anion Secretion
  The Journal of Physiology. Sep, 2016  |   Pubmed ID: 27037495
• Proglucagon Promoter Cre-Mediated AMPK Deletion in Mice Increases Circulating GLP-1 Levels and Oral Glucose Tolerance
  PloS One. 2016  |   Pubmed ID: 27010458
• The Incretin Hormone Glucagon-like Peptide 1 Increases Mitral Cell Excitability by Decreasing Conductance of a Voltage-dependent Potassium Channel
  The Journal of Physiology. May, 2016  |   Pubmed ID: 26931093
• Stimulation of Incretin Secreting Cells
  Therapeutic Advances in Endocrinology and Metabolism. Feb, 2016  |   Pubmed ID: 26885360
• Peptide Production and Secretion in GLUTag, NCI-H716, and STC-1 Cells: a Comparison to Native L-cells
  Journal of Molecular Endocrinology. Apr, 2016  |   Pubmed ID: 26819328
• G Protein-coupled Receptors As New Therapeutic Targets for Type 2 Diabetes
  Diabetologia. Feb, 2016  |   Pubmed ID: 26661410
• Galanin Inhibits GLP-1 and GIP Secretion Via the GAL1 Receptor in Enteroendocrine L and K Cells
  British Journal of Pharmacology. Mar, 2016  |   Pubmed ID: 26661062
• The Effect of Encapsulated Glutamine on Gut Peptide Secretion in Human Volunteers
  Peptides. Mar, 2016  |   Pubmed ID: 26541888
• GLP1- and GIP-producing Cells Rarely Overlap and Differ by Bombesin Receptor-2 Expression and Responsiveness
  The Journal of Endocrinology. Jan, 2016  |   Pubmed ID: 26483393
• Enteroendocrine Cells: Chemosensors in the Intestinal Epithelium
  Annual Review of Physiology. 2016  |   Pubmed ID: 26442437
• The Effect of Bariatric Surgery on Gastrointestinal and Pancreatic Peptide Hormones
  Peptides. Mar, 2016  |   Pubmed ID: 26344355
• Signalling Pathways Involved in the Detection of Peptones by Murine Small Intestinal Enteroendocrine L-cells
  Peptides. Mar, 2016  |   Pubmed ID: 26215048
• High Fat Diet Impairs the Function of Glucagon-like Peptide-1 Producing L-cells
  Peptides. Mar, 2016  |   Pubmed ID: 26145551
• Lipid Derivatives Activate GPR119 and Trigger GLP-1 Secretion in Primary Murine L-cells
  Peptides. Mar, 2016  |   Pubmed ID: 26144594
• Distribution and Characterisation of Glucagon-like Peptide-1 Receptor Expressing Cells in the Mouse Brain
  Molecular Metabolism. Oct, 2015  |   Pubmed ID: 26500843
• Limited Impact on Glucose Homeostasis of Leptin Receptor Deletion from Insulin- or Proglucagon-expressing Cells
  Molecular Metabolism. Sep, 2015  |   Pubmed ID: 26413468
• Can Encapsulated Glutamine Increase GLP-1 Secretion, Improve Glucose Tolerance, and Reduce Meal Size in Healthy Volunteers? A Randomised, Placebo-controlled, Cross-over Trial
  Lancet (London, England). Feb, 2015  |   Pubmed ID: 26312890
• Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors
  Endocrinology. Nov, 2015  |   Pubmed ID: 26280129
• A Transcriptome-Led Exploration of Molecular Mechanisms Regulating Somatostatin-Producing D-Cells in the Gastric Epithelium
  Endocrinology. Nov, 2015  |   Pubmed ID: 26241122
• Corrigendum: Transcriptional Regulator PRDM12 is Essential for Human Pain Perception
  Nature Genetics. Aug, 2015  |   Pubmed ID: 26220135
• Farnesoid X Receptor Inhibits Glucagon-like Peptide-1 Production by Enteroendocrine L Cells
  Nature Communications. Jul, 2015  |   Pubmed ID: 26134028
• Effect of Reducing Portion Size at a Compulsory Meal on Later Energy Intake, Gut Hormones, and Appetite in Overweight Adults
  Obesity (Silver Spring, Md.). Jul, 2015  |   Pubmed ID: 26054049
• Transcriptional Regulator PRDM12 is Essential for Human Pain Perception
  Nature Genetics. Jul, 2015  |   Pubmed ID: 26005867
• Novel SCN9A Mutations Underlying Extreme Pain Phenotypes: Unexpected Electrophysiological and Clinical Phenotype Correlations
  The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2015  |   Pubmed ID: 25995458
• Submembrane ATP and Ca2+ Kinetics in α-cells: Unexpected Signaling for Glucagon Secretion
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2015  |   Pubmed ID: 25911612
• LKB1 and AMPKα1 Are Required in Pancreatic Alpha Cells for the Normal Regulation of Glucagon Secretion and Responses to Hypoglycemia
  Molecular Metabolism. Apr, 2015  |   Pubmed ID: 25830091
• Activation of the GLP-1 Receptors in the Nucleus of the Solitary Tract Reduces Food Reward Behavior and Targets the Mesolimbic System
  PloS One. 2015  |   Pubmed ID: 25793511
• Inhibition of the Malate-aspartate Shuttle in Mouse Pancreatic Islets Abolishes Glucagon Secretion Without Affecting Insulin Secretion
  The Biochemical Journal. May, 2015  |   Pubmed ID: 25731850
• Gut Chemosensing Mechanisms
  The Journal of Clinical Investigation. Mar, 2015  |   Pubmed ID: 25664852
• Targeting Development of Incretin-producing Cells Increases Insulin Secretion
  The Journal of Clinical Investigation. Jan, 2015  |   Pubmed ID: 25500886
• Stimulation of GLP-1 Secretion Downstream of the Ligand-gated Ion Channel TRPA1
  Diabetes. Apr, 2015  |   Pubmed ID: 25325736
• Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells
  Cell Reports. Nov, 2014  |   Pubmed ID: 25456122
• The Melanocortin-4 Receptor is Expressed in Enteroendocrine L Cells and Regulates the Release of Peptide YY and Glucagon-like Peptide 1 in Vivo
  Cell Metabolism. Dec, 2014  |   Pubmed ID: 25453189
• Clocking Up GLP-1: Considering Intestinal Rhythms in the Incretin Effect
  Diabetes. Nov, 2014  |   Pubmed ID: 25342730
• The Role of Gut Endocrine Cells in Control of Metabolism and Appetite
  Experimental Physiology. Sep, 2014  |   Pubmed ID: 25210110
• The Peutz-Jeghers Kinase LKB1 Suppresses Polyp Growth from Intestinal Cells of a Proglucagon-expressing Lineage in Mice
  Disease Models & Mechanisms. Nov, 2014  |   Pubmed ID: 25190708
• Na+ Current Properties in Islet α- and β-cells Reflect Cell-specific Scn3a and Scn9a Expression
  The Journal of Physiology. Nov, 2014  |   Pubmed ID: 25172946
• Reversible Changes in Pancreatic Islet Structure and Function Produced by Elevated Blood Glucose
  Nature Communications. Aug, 2014  |   Pubmed ID: 25145789
• Diabetes Recovery by Age-dependent Conversion of Pancreatic δ-cells into Insulin Producers
  Nature. Oct, 2014  |   Pubmed ID: 25141178
• GLP-1 Receptor Stimulation of the Lateral Parabrachial Nucleus Reduces Food Intake: Neuroanatomical, Electrophysiological, and Behavioral Evidence
  Endocrinology. Nov, 2014  |   Pubmed ID: 25116706
• LKB1 and AMPK Differentially Regulate Pancreatic β-cell Identity
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2014  |   Pubmed ID: 25070369
• Insulin-like Peptide 5 is an Orexigenic Gastrointestinal Hormone
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 25028498
• Fructose Stimulates GLP-1 but Not GIP Secretion in Mice, Rats, and Humans
  American Journal of Physiology. Gastrointestinal and Liver Physiology. Apr, 2014  |   Pubmed ID: 24525020
• Identification and Characterization of GLP-1 Receptor-expressing Cells Using a New Transgenic Mouse Model
  Diabetes. Apr, 2014  |   Pubmed ID: 24296712
• Generation of L Cells in Mouse and Human Small Intestine Organoids
  Diabetes. Feb, 2014  |   Pubmed ID: 24130334
• Role of KATP Channels in Glucose-regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes
  Cell Metabolism. Dec, 2013  |   Pubmed ID: 24315372
• Towards the Harnessing of Gut Feelings
  Current Opinion in Pharmacology. Dec, 2013  |   Pubmed ID: 24140240
• A Tag to Track Short Chain Fatty Acid Sensors
  Endocrinology. Oct, 2013  |   Pubmed ID: 24058154
• Oligopeptides Stimulate Glucagon-like Peptide-1 Secretion in Mice Through Proton-coupled Uptake and the Calcium-sensing Receptor
  Diabetologia. Dec, 2013  |   Pubmed ID: 24045836
• Molecular Mechanisms of Incretin Hormone Secretion
  Current Opinion in Pharmacology. Dec, 2013  |   Pubmed ID: 24035446
• The G Protein-coupled Receptor Family C Group 6 Subtype A (GPRC6A) Receptor is Involved in Amino Acid-induced Glucagon-like Peptide-1 Secretion from GLUTag Cells
  The Journal of Biological Chemistry. Feb, 2013  |   Pubmed ID: 23269670
• PPARβ/δ Affects Pancreatic β Cell Mass and Insulin Secretion in Mice
  The Journal of Clinical Investigation. Nov, 2012  |   Pubmed ID: 23093780
• Neurochemical Characterization of Body Weight-regulating Leptin Receptor Neurons in the Nucleus of the Solitary Tract
  Endocrinology. Oct, 2012  |   Pubmed ID: 22869346
• Overlap of Endocrine Hormone Expression in the Mouse Intestine Revealed by Transcriptional Profiling and Flow Cytometry
  Endocrinology. Jul, 2012  |   Pubmed ID: 22685263
• G-protein-coupled Receptors in Intestinal Chemosensation
  Cell Metabolism. Apr, 2012  |   Pubmed ID: 22482725
• Intestinal Sensing of Nutrients
  Handbook of Experimental Pharmacology. 2012  |   Pubmed ID: 22249821
• Short-chain Fatty Acids Stimulate Glucagon-like Peptide-1 Secretion Via the G-protein-coupled Receptor FFAR2
  Diabetes. Feb, 2012  |   Pubmed ID: 22190648
• Nutrient Detection by Incretin Hormone Secreting Cells
  Physiology & Behavior. Jun, 2012  |   Pubmed ID: 22182802
• Na(+)-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-dependent Incretin Secretion
  Diabetes. Jan, 2012  |   Pubmed ID: 22124465
• Interleukin-6 Enhances Insulin Secretion by Increasing Glucagon-like Peptide-1 Secretion from L Cells and Alpha Cells
  Nature Medicine. Oct, 2011  |   Pubmed ID: 22037645
• CCK Stimulation of GLP-1 Neurons Involves α1-adrenoceptor-mediated Increase in Glutamatergic Synaptic Inputs
  Diabetes. Nov, 2011  |   Pubmed ID: 21885869
• Glutamine Triggers and Potentiates Glucagon-like Peptide-1 Secretion by Raising Cytosolic Ca2+ and CAMP
  Endocrinology. Feb, 2011  |   Pubmed ID: 21209017
• Role of Phosphodiesterase and Adenylate Cyclase Isozymes in Murine Colonic Glucagon-like Peptide 1 Secreting Cells
  British Journal of Pharmacology. May, 2011  |   Pubmed ID: 21054345
• Congenital Insensitivity to Pain: Novel SCN9A Missense and In-frame Deletion Mutations
  Human Mutation. Sep, 2010  |   Pubmed ID: 20635406
• Leptin Directly Depolarizes Preproglucagon Neurons in the Nucleus Tractus Solitarius: Electrical Properties of Glucagon-like Peptide 1 Neurons
  Diabetes. Aug, 2010  |   Pubmed ID: 20522593
• GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-type Ca2+ Channel-dependent Exocytosis
  Cell Metabolism. Jun, 2010  |   Pubmed ID: 20519125
• Pain Perception is Altered by a Nucleotide Polymorphism in SCN9A
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2010  |   Pubmed ID: 20212137
• Molecular Mechanisms Underlying Nutrient Detection by Incretin-secreting Cells
  International Dairy Journal. Apr, 2010  |   Pubmed ID: 20204054
• Increased Liver Stiffness in Alcoholic Liver Disease: Differentiating Fibrosis from Steatohepatitis
  World Journal of Gastroenterology. Feb, 2010  |   Pubmed ID: 20180235
• Molecular Mechanisms Underlying Nutrient-stimulated Incretin Secretion
  Expert Reviews in Molecular Medicine. Jan, 2010  |   Pubmed ID: 20047700
• Hypogonadotropic Hypogonadism Due to a Novel Missense Mutation in the First Extracellular Loop of the Neurokinin B Receptor
  The Journal of Clinical Endocrinology and Metabolism. Oct, 2009  |   Pubmed ID: 19755480
• Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-associated Variants
  Diabetes. Sep, 2009  |   Pubmed ID: 19542200
• TAC3 and TACR3 Mutations in Familial Hypogonadotropic Hypogonadism Reveal a Key Role for Neurokinin B in the Central Control of Reproduction
  Nature Genetics. Mar, 2009  |   Pubmed ID: 19079066
• Oral Glutamine Increases Circulating Glucagon-like Peptide 1, Glucagon, and Insulin Concentrations in Lean, Obese, and Type 2 Diabetic Subjects
  The American Journal of Clinical Nutrition. Jan, 2009  |   Pubmed ID: 19056578
• Nutritional Regulation of Glucagon-like Peptide-1 Secretion
  The Journal of Physiology. Jan, 2009  |   Pubmed ID: 19001044
• Dissociation Between Sensing and Metabolism of Glucose in Sugar Sensing Neurones
  The Journal of Physiology. Jan, 2009  |   Pubmed ID: 18981030
• Glucose Sensing in L Cells: a Primary Cell Study
  Cell Metabolism. Dec, 2008  |   Pubmed ID: 19041768
• Extrahepatic Cholestasis Increases Liver Stiffness (FibroScan) Irrespective of Fibrosis
  Hepatology (Baltimore, Md.). Nov, 2008  |   Pubmed ID: 18836992
• No Differences in Mortality Between Users of Pancreatic-specific and Non-pancreatic-specific Sulphonylureas: a Cohort Analysis
  Diabetes, Obesity & Metabolism. Apr, 2008  |   Pubmed ID: 18093208
• An SCN9A Channelopathy Causes Congenital Inability to Experience Pain
  Nature. Dec, 2006  |   Pubmed ID: 17167479
• Sodium-coupled Glucose Cotransporters Contribute to Hypothalamic Glucose Sensing
  Diabetes. Dec, 2006  |   Pubmed ID: 17130483
• Mucolipin-1 is a Lysosomal Membrane Protein Required for Intracellular Lactosylceramide Traffic
  Traffic (Copenhagen, Denmark). Oct, 2006  |   Pubmed ID: 16978393
• Relapsing Diabetes Can Result from Moderately Activating Mutations in KCNJ11
  Human Molecular Genetics. Apr, 2005  |   Pubmed ID: 15718250
• Constitutive Ras Activity Induces Hippocampal Hypertrophy and Remodeling of Pyramidal Neurons in SynRas Mice
  Journal of Neuroscience Research. Sep, 2004  |   Pubmed ID: 15352209
• Open to Control--new Hope for Patients with Neonatal Diabetes
  The New England Journal of Medicine. Apr, 2004  |   Pubmed ID: 15115828
• A Novel Missense Mutation in AE1 Causing Autosomal Dominant Distal Renal Tubular Acidosis Retains Normal Transport Function but is Mistargeted in Polarized Epithelial Cells
  The Journal of Biological Chemistry. Apr, 2004  |   Pubmed ID: 14734552
• A Novel Glucose-sensing Mechanism Contributing to Glucagon-like Peptide-1 Secretion from the GLUTag Cell Line
  Diabetes. May, 2003  |   Pubmed ID: 12716745
• Differential Selectivity of Insulin Secretagogues: Mechanisms, Clinical Implications, and Drug Interactions
  Journal of Diabetes and Its Complications. Mar-Apr, 2003  |   Pubmed ID: 12623163
• Analysis of the Differential Modulation of Sulphonylurea Block of Beta-cell and Cardiac ATP-sensitive K+ (K(ATP)) Channels by Mg-nucleotides
  The Journal of Physiology. Feb, 2003  |   Pubmed ID: 12562963
• A New Subtype of Autosomal Dominant Diabetes Attributable to a Mutation in the Gene for Sulfonylurea Receptor 1
  Lancet (London, England). Jan, 2003  |   Pubmed ID: 12559865
• Sulfonylurea Stimulation of Insulin Secretion
  Diabetes. Dec, 2002  |   Pubmed ID: 12475777
• Glucose-sensing in Glucagon-like Peptide-1-secreting Cells
  Diabetes. Sep, 2002  |   Pubmed ID: 12196469